{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:07:01Z","timestamp":1763968021055},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid. An accurate cytological diagnosis is based on distinctive cytological features in combination with immunocytochemistry.<jats:italic>Methods<\/jats:italic>. A number of 83 fine needle aspirations, positive for papillary thyroid cancer (44 from thyroid nodules and 39 from cervical lymph nodes), were studied using Thin Layer Cytology. A panel of the immunomarkers Cytokeratin-19, Galectin-3, HBME1, CD-44, CD-56, and E-Cadherin was performed.<jats:italic>Results<\/jats:italic>. Positive expression of CK-19 was observed in 77 cases (92.7%), of Galectin-3 in 74 cases (89.1%), of HBME1 in 65 (78.3%), and of CD-44 in 72 cases (86.7%). Loss of expression of CD-56 was observed in 80 cases (96.4%) and of E-cadherin in 78 (93.9%).<jats:italic>Conclusions<\/jats:italic>. Our data suggest that Thin Layer Cytology increases the diagnostic accuracy in papillary carcinoma and seems to be a promising technique for further investigation of thyroid lesions permitting the possibility to use archive material. Positive immunoexpression of CK-19, Galectin-3, HBME-1, and CD-44 improves the diagnostic accuracy of papillary thyroid cancer. Furthermore, loss of E-cadherin and of CD-56 expression is a feature of malignancy.<\/jats:p>","DOI":"10.1155\/2010\/963926","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T19:32:56Z","timestamp":1288207976000},"page":"1-5","source":"Crossref","is-referenced-by-count":20,"title":["The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology"],"prefix":"10.1155","volume":"2010","author":[{"given":"Kalliopi","family":"Pazaitou-Panayiotou","sequence":"first","affiliation":[{"name":"Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, 2 Al Simeonidi Street, 54007 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"Mygdakos","sequence":"additional","affiliation":[{"name":"Department of Cytopathology, Theagenio Cancer Hospital, 2 Al Simeonidi Street, 54007 Thessaloniki, 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