{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":1,"items":[{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:52:42Z","timestamp":1773183162389,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1178,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Merck & Co."},{"name":"Iroko"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.jacc.2009.11.091","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T04:51:56Z","timestamp":1274849516000},"page":"2446-2455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":149,"title":["Effect of Early, Pre-Hospital Initiation of High Bolus Dose Tirofiban in Patients With ST-Segment Elevation Myocardial Infarction on Short- and Long-Term Clinical Outcome"],"prefix":"10.1016","volume":"55","author":[{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnoud W.J.","family":"van 't Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Dill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton","family":"Heestermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochem W.","family":"van Werkum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend","family":"Mosterd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"van Houwelingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra C.","family":"Koopmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter R.","family":"Stella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2009.11.091_bib1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/01.CIR.91.7.1923","article-title":"Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion","volume":"91","author":"Simes","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2009.11.091_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9149(96)00217-2","article-title":"Meta-analysis of five reported studies on the relation of early coronary patency grades with mortality and outcomes after acute myocardial infarction","volume":"78","author":"Anderson","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2009.11.091_bib3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0002-8703(03)00326-0","article-title":"Primary percutaneous transluminal coronary angioplasty accelerates early myocardial reperfusion compared to thrombolytic therapy in patients with acute myocardial infarction","volume":"146","author":"Zeymer","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2009.11.091_bib4","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1056\/NEJM199303113281002","article-title":"A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction","volume":"328","author":"Zijlstra","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2009.11.091_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(06)68148-8","article-title":"Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infarction: quantitative review of randomised trials","volume":"367","author":"Keeley","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2009.11.091_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jacc.2004.02.059","article-title":"Ability of anti-glycoprotein IIb\/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions","volume":"44","author":"Goto","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2009.11.091_bib7","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/01.CIR.0000157138.02645.11","article-title":"Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study","volume":"111","author":"Gurbel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2009.11.091_bib8","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.jacc.2003.07.017","article-title":"A randomized trial comparing primary infarct artery stenting with or without abciximab in acute myocardial infarction","volume":"42","author":"Antoniucci","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2009.11.091_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0140-6736(08)61235-0","article-title":"Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial","volume":"372","author":"van 't Hof","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2009.11.091_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4244\/EIJV3I3A67","article-title":"Ongoing tirofiban in myocardial infarction evaluation (On-TIME) 2 trial: rationale and study design","volume":"3","author":"van 't Hof","year":"2007","journal-title":"EuroInterv"},{"key":"10.1016\/j.jacc.2009.11.091_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0735-1097(88)90158-1","article-title":"Thrombolysis in Myocardial Infarction (TIMI) Trial\u2014phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase","volume":"11","author":"Rao","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2009.11.091_bib12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.thromres.2008.01.021","article-title":"Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction","volume":"122","author":"Heestermans","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacc.2009.11.091_bib13","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/j.1538-7836.2009.03573.x","article-title":"Marked reduction of early stent thrombosis with pre-hospital initiation of high-dose tirofiban in ST-segment elevation myocardial infarction","volume":"7","author":"Heestermans","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacc.2009.11.091_bib14","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/CIRCULATIONAHA.108.818617","article-title":"Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial","volume":"119","author":"Mehilli","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2009.11.091_bib15","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMoa0706816","article-title":"Facilitated PCI in patients with ST-elevation myocardial infarction","volume":"358","author":"Ellis","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2009.11.091_bib16","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJM200106213442503","article-title":"Platelet glycoprotein IIb\/IIIa inhibition with coronary stenting for acute myocardial infarction","volume":"344","author":"Montalescot","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2009.11.091_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/eurheartj\/ehn480","article-title":"Long-term effectiveness of early administration of glycoprotein IIb\/IIIa agents to real-world patients undergoing primary percutaneous interventions: results of a registry study in an ST-elevation myocardial infarction network","volume":"30","author":"Ortolani","year":"2009","journal-title":"Eur Heart J"}],"container-title":["Journal of the American College of Cardiology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971001154X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971001154X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:38:22Z","timestamp":1760013502000},"score":10.005638,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510971001154X"}},"issued":{"date-parts":[[2010,6]]},"references-count":17,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S073510971001154X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2009.11.091","ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Early, Pre-Hospital Initiation of High Bolus Dose Tirofiban in Patients With ST-Segment Elevation Myocardial Infarction on Short- and Long-Term Clinical Outcome","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2009.11.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}],"items-per-page":20,"query":{"start-index":0,"search-terms":"S073510971001154X"}}}