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In two 14\u00a0d experiments, male and female C57BL\/6J mice, initial age 19\u00a0d, consumed a complete purified diet<jats:italic>ad libitum<\/jats:italic>or in restricted daily quantities, or had free access to an isoenergetic purified low-protein diet. A zero-time control group (age 19\u00a0d) was included in the second experiment. Serum interferon-\u03b3 was assessed in both experiments by sandwich ELISA and, in the second experiment, also by a bioassay based on inhibition of proliferation by WEHI-279 B lymphoma cells. The immunoassay detected interferon-\u03b3 inconsistently in all groups (range 0\u201314\u00a0pg\/ml; detection limits 1\u00b75 and 0\u00b77\u00a0pg\/ml in experiments 1 and 2, respectively). By contrast, interferon-\u03b3 bioactivity was found in all animals of each group (means 339, 499, 124 and 200\u00a0pg\/ml in zero-time controls, age-matched controls, low-protein and restricted intake groups, respectively; detection limit, 12\u00a0pg\/ml), and the mean serum bioactivity of each malnourished group was low compared with the age-matched control (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00\u00b705). The present study defines the physiological serum interferon-\u03b3 bioactivity of the adolescent mouse. Moreover, to the extent achievable by way of the blood, the results reflect the influence of metabolically diverse forms of acute malnutrition on the polarising type 1 cytokine profile within lymphoid microenvironments wherein immune responses arise. Therefore, the results suggest a mechanism underlying the cell-mediated inflammatory incompetence that characterises acute, prepubescent malnutrition.<\/jats:p>","DOI":"10.1017\/s0007114507352409","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T15:03:29Z","timestamp":1172070209000},"page":"528-534","source":"Crossref","is-referenced-by-count":9,"title":["Blood serum interferon-\u03b3 bioactivity is low in weanling mice subjected to acute deficits of energy or both protein and energy"],"prefix":"10.1017","volume":"97","author":[{"given":"Lyn M.","family":"Hillyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry 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Before and at various time intervals after the start of the meal, blood samples were analysed for glucose, insulin, triacylglycerol (TG), free glycerol (FG), free fatty acids (FFA) and cholesterol. Elevated postprandial glucose and insulin peaks were induced by the meals containing a larger amount of carbohydrate. The type of carbohydrate in the meal appeared to have little or no effect on the peak maximum. A small second glucose peak was seen at 2 h after the meals with P: MD &gt; 3\u00b71. The TG concentration in the blood showed a similar and rapid rise. After the meal containing the largest amount of simple sugars, the TG curve levelled off 1 h after the start of the meal and then remained at a nearly constant level (1\u00b75 mM). In contrast, a larger amount of complex carbohydrates induced a TG concentration which rapidly rose to a maximum of 1\u00b775 mM, and subsequently decreased slowly to somewhat below that of the simple sugar-rich meal at 4 h. The postprandial curves after the fat-rich meals showed a continuous rise of TG up to a maximum of about 2 mM at 2 h, and a subsequent slow decrease. FG and FFA all showed a rapid drop immediately after the start of the consumption of the meals, followed by a rebound at 1 h. The postprandial curves of total cholesterol, as well as the areas below the curve of both total cholesterol and free, unesterified cholesterol were lower after the carbohydrate-rich meals than after the fat-rich meals. This is attributed to the larger amount of cholesterol in the fat-rich meals.<\/jats:p>","DOI":"10.1079\/bjn19900090","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"37-51","source":"Crossref","is-referenced-by-count":12,"title":["Minor difference in postprandial responses of men between starch and sugar when replacing fat in a normal meal"],"prefix":"10.1017","volume":"63","author":[{"given":"J. M. M.","family":"Van Amelsvoort","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Van Stratum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Kraal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Lussenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Dubbelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114590000095_ref008","first-page":"227","volume-title":"Diet, Diabetes and Atherosclerosis","author":"Jenkins","year":"1984"},{"key":"S0007114590000095_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/45.1.98"},{"key":"S0007114590000095_ref018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.60.3.473"},{"key":"S0007114590000095_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.1.93"},{"key":"S0007114590000095_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282710"},{"key":"S0007114590000095_ref013","doi-asserted-by":"crossref","first-page":"580","DOI":"10.5694\/j.1326-5377.1986.tb112314.x","article-title":"The glycaemic index of foods","volume":"144","author":"Thorburn","year":"1986","journal-title":"Medical Journal of Australia"},{"key":"S0007114590000095_ref016","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19890115"},{"key":"S0007114590000095_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.6.935"},{"key":"S0007114590000095_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/43.1.167"},{"key":"S0007114590000095_ref001","unstructured":"Commissie UCV (1984). Uitgebreide Voedingsmiddelentabel 1984. 's-Gravenhage: Voorlichtingsbureau voor de Voeding."},{"key":"S0007114590000095_ref002","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1986.10720110"},{"key":"S0007114590000095_ref003","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1986.10720144"},{"key":"S0007114590000095_ref004","first-page":"247","article-title":"Glucides simples glucides complexes","volume":"21","author":"Heraud","year":"1985","journal-title":"M\u00e9decine et Nutrition"},{"key":"S0007114590000095_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90554-3"},{"key":"S0007114590000095_ref010","doi-asserted-by":"publisher","DOI":"10.1159\/000391884"},{"key":"S0007114590000095_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(85)80003-2"},{"key":"S0007114590000095_ref015","first-page":"329","article-title":"Effect of different starchy foods in composite meals on gastric emptying rate and glucose metabolism. I. Comparisons between potatoes, rice and white beans","volume":"38C","author":"Torsdottir","year":"1984","journal-title":"Human Nutrition: Clinical Nutrition"},{"key":"S0007114590000095_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/43.4.516"},{"key":"S0007114590000095_ref019","first-page":"1","volume-title":"Latent Dyslipo- proteinemia and Atherosclerosis","author":"Zilversmit","year":"1984"}],"container-title":["British Journal of Nutrition"],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114590000095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T15:44:50Z","timestamp":1586274290000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114590000095\/type\/journal_article"}},"issued":{"date-parts":[[1990,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["S0007114590000095"],"URL":"https:\/\/doi.org\/10.1079\/bjn19900090","ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"published":{"date-parts":[[1990,1]]}},{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:10:15Z","timestamp":1750479015791},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6337,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>An experiment was conducted using steers cannulated at the rumen, duodenum and ileum to study the effects of increasing the levels of barley and fishmeal in straw-based diets. Diets A, B, C and D contained ammonia-treated straw, barley and fishmeal in the ratios, 67:33:0, 66:23:11, 53:47:0 and 52:36:12 (by weight) and were offered in daily amounts of 3\u00b79, 3\u00b79, 4\u00b78 and 4\u00b78 kg dry matter. The effects of barley were attributable to increased intakes of digestible organic matter and consequently to increased flows of microbial matter to the duodenum. There were no modifications in the balance of energy to nitrogen-yielding nutrients available for absorption. Introducing fishmeal into diets improved digestibility of cellulose and xylose by up to 6.7 and 4.7 % respectively, and shifted digestion towards the large intestine. Second, it increased amino acid N supply to the small intestine which averaged 52\u00b72, 63\u00b72, 68\u00b78 and 84\u00b70 g\/d with diets A, B, C and D. Some changes were also noted in the balance of amino acids absorbed. Consequently, the contribution of amino acids to metabolizable energy intake increased with the proportion of fishmeal in diets (0\u00b717, 0\u00b720, 0\u00b718 and 0\u00b721 for diets A, B, C and D).<\/jats:p><jats:p>Growth rates measured in heifers amounted to 259, 431, 522 and 615 g\/d for diets A, B, C and D. They appeared to be related to intestinal amino acid supply.<\/jats:p>","DOI":"10.1079\/bjn19890061","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"601-619","source":"Crossref","is-referenced-by-count":8,"title":["Nutrient supply and growth of cattle offered straw-based diets"],"prefix":"10.1017","volume":"62","author":[{"given":"Isabelle","family":"Ortigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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(1980). Variations of net requirements for cattle growth with liveweight, liveweight gain, breed and sex. Annales de Zootechnie 29, no. hors s\u00e9rie, 99\u2013118.","DOI":"10.1051\/animres:19800506"},{"key":"S0007114589001443_ref003","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19860062"},{"key":"S0007114589001443_ref010","doi-asserted-by":"publisher","DOI":"10.1258\/002367782780935832"},{"key":"S0007114589001443_ref013","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19820038"},{"key":"S0007114589001443_ref014","doi-asserted-by":"publisher","DOI":"10.1071\/AR9740613"},{"key":"S0007114589001443_ref015","first-page":"386","volume-title":"Control of Digestion and Metabolism in Ruminants","author":"Egan","year":"1986"},{"key":"S0007114589001443_ref018","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19820085"},{"key":"S0007114589001443_ref056","first-page":"78","article-title":"Influence of sodium hydroxide pretreatment and starch content on apparent digestibilities of separate cell wall carbohydrates fed to sheep","volume":"56","author":"Ternrud","year":"1986","journal-title":"Zeitschrift f\u00fcr Tierphysiologie, Tierern\u00e4hrung und Futtermittelkunde"},{"key":"S0007114589001443_ref022","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(84)81396-X"},{"key":"S0007114589001443_ref023","first-page":"343","volume-title":"IVth International Symposium on Protein Metabolism and Nutrition","volume":"2","author":"Low","year":"1983"},{"key":"S0007114589001443_ref027","first-page":"10A","article-title":"The use of inert ruthenium-phenanthroline as a digesta particulate marker in sheep","volume":"33","author":"MacRae","year":"1974","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114589001443_ref012","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19820138"},{"key":"S0007114589001443_ref029","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19850105"},{"key":"S0007114589001443_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600059207"},{"key":"S0007114589001443_ref031","first-page":"351","volume-title":"Protein Metabolism and Nutrition","author":"Mason","year":"1980"},{"key":"S0007114589001443_ref032","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19800110"},{"key":"S0007114589001443_ref033","unstructured":"Mulvany P. (1981). Dairy cow condition scoring. National Institute for Research in Dairying Technical Leaflet paper no. 4468. Reading: National Institute for Research in Dairying."},{"key":"S0007114589001443_ref034","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600028392"},{"key":"S0007114589001443_ref035","first-page":"103","volume-title":"Protein Contribution of Feedstuffs for Ruminants: Application to Feed Formulation","author":"Oldham","year":"1981"},{"key":"S0007114589001443_ref036","doi-asserted-by":"publisher","DOI":"10.2527\/jas1986.6351624x"},{"key":"S0007114589001443_ref037","unstructured":"Ortigues I. (1987). Nutrient supply, growth and calorimetric efficiency in heifers offered straw rich diets. PhD Thesis, University of Reading."},{"key":"S0007114589001443_ref055","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029900013108"},{"key":"S0007114589001443_ref038","first-page":"437","article-title":"Nutrient supply in growing cattle offered straw diets supplemented with barley or fishmeal","volume":"42","author":"Ortigues","year":"1986","journal-title":"Animal Production"},{"key":"S0007114589001443_ref039","first-page":"65","volume-title":"Energy 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of Agriculture Handbook","author":"Goering","year":"1970"},{"key":"S0007114589001443_ref024","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19830052"},{"key":"S0007114589001443_ref008","first-page":"274","article-title":"Endogenous non-protein-nitrogen compounds in the intestinal tract of monogastric animals","volume":"36","author":"Buraczewski","year":"1986","journal-title":"Archive in Animal Nutrition"},{"key":"S0007114589001443_ref002","volume-title":"Report of the Protein Group of the Agricultural Research Council Working Party on the Nutrient Requirements of Ruminants.","year":"1984"},{"key":"S0007114589001443_ref011","first-page":"122","volume-title":"Control of Digestion and Metabolism in Ruminants","author":"Cotta","year":"1986"},{"key":"S0007114589001443_ref017","first-page":"277","volume-title":"Digestion and Metabolism in the Ruminant","author":"Faichney","year":"1975"}],"container-title":["British Journal of Nutrition"],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114589001443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T19:22:06Z","timestamp":1558293726000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114589001443\/type\/journal_article"}},"issued":{"date-parts":[[1989,11]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["S0007114589001443"],"URL":"https:\/\/doi.org\/10.1079\/bjn19890061","ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"published":{"date-parts":[[1989,11]]}},{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T15:46:57Z","timestamp":1648568817795},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":13642,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1969,11]]},"DOI":"10.1079\/bjn19690082","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T19:49:52Z","timestamp":1116532192000},"page":"f1-f2","source":"Crossref","is-referenced-by-count":0,"title":["BJN volume 23 issue 4 Cover and Front matter"],"prefix":"10.1017","volume":"23","member":"56","published-online":{"date-parts":[[2007,3,9]]},"container-title":["British Journal of Nutrition"],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114569000821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T15:48:18Z","timestamp":1559404098000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114569000821\/type\/journal_article"}},"issued":{"date-parts":[[1969,11]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1969,11]]}},"alternative-id":["S0007114569000821"],"URL":"https:\/\/doi.org\/10.1079\/bjn19690082","ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"published":{"date-parts":[[1969,11]]}},{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:55:35Z","timestamp":1725566135884},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2002,7,1]]},"DOI":"10.1079\/bjnbjn2002587","type":"journal-article","created":{"date-parts":[[2003,2,26]],"date-time":"2003-02-26T17:47:22Z","timestamp":1046281642000},"page":"51-56","source":"Crossref","is-referenced-by-count":0,"title":["Divalent metal inhibition of non-haem iron uptake across the rat duodenal brush border membrane"],"prefix":"10.1017","volume":"88","author":[{"given":"M.W.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.B.","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Debnam 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Nutrition"],"deposited":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:04:01Z","timestamp":1428624241000},"score":0.0,"resource":{"primary":{"URL":"http:\/\/www.ingentaselect.com\/rpsv\/cgi-bin\/cgi?ini=xref&body=linker&reqdoi=10.1079\/BJNBJN2002587"}},"issued":{"date-parts":[[2002,7,1]]},"references-count":0,"journal-issue":{"issue":"1"},"alternative-id":["0007-1145(20020701)88:1L.51;1-"],"URL":"https:\/\/doi.org\/10.1079\/bjnbjn2002587","ISSN":["1475-2662","0007-1145"],"issn-type":[{"value":"1475-2662","type":"electronic"},{"value":"0007-1145","type":"print"}],"published":{"date-parts":[[2002,7,1]]}},{"indexed":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T05:52:30Z","timestamp":1693029150167},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":7921,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>1. Six growing pigs (30\u201375 kg) were fed on semi-purified diets containing either 30 g maize oil\/kg diet (LFM), 30 g soya-bean oil-tallow mixture (1:1, w\/w)\/kg diet (LFST) or 160 g soya-bean oil-tallow mixture (1:1, ww)\/kg diet (HFST) without and with the addition of guar gum (40g\/kg diet).<\/jats:p><jats:p>2. Plasma glucose and insulin concentrations following twice daily feeding at 09.00 and 21.00 h were measured, during 24 h periods, in blood sampled from a permanent indwelling vena cava catheter.<\/jats:p><jats:p>3. The source and level of dietary fat had no significant effect on pre-prandial plasma glucose or insulin concentrations except for insulin with diet LFST in the morning (P&lt;0.05). Addition of guar gum to the diets had no significant effect on pre-prandial plasma glucose and insulin levels.<\/jats:p><jats:p>4. The peak post-prandial plasma glucose and insulin levels were not significantly affected by dietary fat. 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The time taken to reach the peak post-prandial plasma glucose and insulin concentrations was not significantly affected by dietary fat but it was increased by the addition of guar gum, although the differences were not always significant.<\/jats:p>","DOI":"10.1079\/bjn19850089","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"27-35","source":"Crossref","is-referenced-by-count":23,"title":["The effect of guar gum and level and source of dietary fat on glucose tolerance in growing pigs"],"prefix":"10.1017","volume":"54","author":[{"given":"Ian E.","family":"Sambrook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna 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