{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":39875,"items":[{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:53:36Z","timestamp":1777694016335,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500429"],"award-info":[{"award-number":["81500429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570500"],"award-info":[{"award-number":["81570500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>MicroRNAs (miRNAs) have been shown to be important for the pathogenesis of Crohn\u2019s disease (CD). Exclusive enteral nutrition (EEN) is an effective therapy for inducing remission in CD. We aimed to investigate the alteration of miRNAs expression profile in the terminal ileal mucosa of CD patients before and after EEN. Twenty-five patients and ten healthy individuals were included. MiRNAs expression profile was firstly assessed using microarray technology and then validation was performed by qRT-PCR. The correlations between miRNAs and CD activity index (CDAI) score and serum C\u2013reactive protein (CRP) level were also evaluated. Microarray analysis showed that mucosal miRNAs expression profile after EEN therapy was significantly changed compared with inflamed mucosa before treatment, and was most similar to the healthy one among all CD groups. Altered expressions of hsa-miR-192-5p, hsa-miR-423-3p, hsa-miR-99a-5p, hsa-miR-124-3p, hsa-miR-301a-5p, hsa-miR-495-5p, and hsa-let-7b-5p were confirmed by qRT-PCR. hsa-let-7b-5p was significantly correlated with serum CRP levels before and after EEN treatment (r = \u22120.518, p = 0.008, and r = \u22120.569, p = 0.003). Our study showed EEN induction therapy was associated with a trend for normalizing of the mucosal miRNAs expression profile, and expression of mucosal hsa-let-7b-5p was correlated with serum CRP level in patients with CD.<\/jats:p>","DOI":"10.3390\/nu8080519","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T10:40:33Z","timestamp":1471862433000},"page":"519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn\u2019s Disease"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-421X","authenticated-orcid":false,"given":"Zhen","family":"Guo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieshou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nri2340","article-title":"The genetics and immunopathogenesis of inflammatory bowel disease","volume":"8","author":"Cho","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/j.gastro.2013.05.050","article-title":"Beyond gene discovery in inflammatory bowel disease: The emerging role of epigenetics","volume":"145","author":"Ventham","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1053\/j.gastro.2010.07.040","article-title":"MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function","volume":"139","author":"McKenna","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2011.07.005","article-title":"MicroRNA regulation of intestinal epithelial tight junction permeability","volume":"141","author":"Ye","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fasseu, M., Treton, X., Guichard, C., Pedruzzi, E., Cazals-Hatem, D., Richard, C., Aparicio, T., Daniel, F., Soule, J.C., and Moreau, R. (2010). Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013160"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/archsurg.1973.01350200189039","article-title":"Experience with elemental diet in the treatment of inflammatory bowel disease. Is this primary therapy?","volume":"107","author":"Voitk","year":"1973","journal-title":"Arch. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2036.2009.04067.x","article-title":"The use of exclusive enteral nutrition for induction of remission in children with Crohn\u2019s disease demonstrates that disease phenotype does not influence clinical remission","volume":"30","author":"Buchanan","year":"2009","journal-title":"Aliment Pharmacol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/ibd.20238","article-title":"Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn\u2019s disease: A prospective study","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1007\/BF02062020","article-title":"Enteral nutrition for Crohn\u2019s disease in Japan","volume":"40","author":"Hiwatashi","year":"1997","journal-title":"Dis. Colon. Rectum."},{"key":"ref_13","first-page":"379","article-title":"Home elemental enteral hyperalimentation (HEEH) for the maintenance of remission in patients with Crohn\u2019s disease","volume":"28","author":"Hirakawa","year":"1993","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/01.MIB.0000161307.58327.96","article-title":"Impact of elemental diet on mucosal inflammation in patients with active Crohn\u2019s disease: Cytokine production and endoscopic and histological findings","volume":"11","author":"Yamamoto","year":"2005","journal-title":"Inflamm Bowel Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.nut.2009.06.011","article-title":"DNA-driven nutritional therapy of inflammatory bowel disease","volume":"25","author":"Lee","year":"2009","journal-title":"Nutrition"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1089\/omi.2008.0033","article-title":"Understanding the nutrigenomic definitions and concepts at the food-genome junction","volume":"12","author":"Subbiah","year":"2008","journal-title":"OMICS."},{"key":"ref_17","first-page":"16","article-title":"The emerging role of MicroRNAs in the regulation of gene expression by nutrients","volume":"6","year":"2013","journal-title":"J. Nutr. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jgh.12644","article-title":"Altered microRNAs expression in inflamed and non-inflamed terminal ileal mucosa of adult patients with active Crohn\u2019s disease","volume":"30","author":"Guo","year":"2015","journal-title":"J. Gastroenterol Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/0884533613487218","article-title":"Effect of exclusive enteral nutrition on health-related quality of life for adults with active Crohn\u2019s disease","volume":"28","author":"Guo","year":"2013","journal-title":"Nutr. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2567.2009.03092.x","article-title":"MicroRNA in the immune system, microRNA as an immune system","volume":"127","author":"Lu","year":"2009","journal-title":"Immunology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.med.59.053006.104707","article-title":"MicroRNAs in Cancer","volume":"60","author":"Garzon","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ibd.21691","article-title":"MicroRNAs in inflammatory bowel disease","volume":"18","author":"Pekow","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/ibd.21267","article-title":"Identification of microRNAs associated with ileal and colonic Crohn\u2019s disease","volume":"16","author":"Wu","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/014860710202600298","article-title":"Short-term efficacy of enteral nutrition in the treatment of active Crohn\u2019s disease: A randomized, controlled trial comparing nutrient formulas","volume":"26","author":"Sakurai","year":"2002","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.3748\/wjg.v19.i43.7652","article-title":"Use of exclusive enteral nutrition in adults with Crohn\u2019s disease: A review","volume":"19","author":"Gearry","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1586\/eci.13.12","article-title":"Exclusive enteral nutrition and induction of remission of active Crohn\u2019s disease in children","volume":"9","author":"Burgess","year":"2013","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.clnu.2013.10.009","article-title":"Exclusive enteral nutrition ameliorates mesenteric adipose tissue alterations in patients with active Crohn\u2019s disease","volume":"33","author":"Feng","year":"2014","journal-title":"Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1136\/gutjnl-2012-304213","article-title":"miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn\u2019s disease","volume":"63","author":"Huang","year":"2014","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbrc.2013.07.040","article-title":"miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn\u2019s disease","volume":"438","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3892\/ijmm.2012.894","article-title":"miR-200b is involved in intestinal fibrosis of Crohn\u2019s disease","volume":"29","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00428-012-1345-5","article-title":"PDCD4\/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis","volume":"462","author":"Ludwig","year":"2013","journal-title":"Virchows Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ibd.21359","article-title":"Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation","volume":"17","author":"Olaru","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.MIB.0000436954.70596.9b","article-title":"NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells","volume":"20","author":"Chuang","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1053\/j.gastro.2013.07.001","article-title":"MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis","volume":"145","author":"Koukos","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.nutr.25.050304.092639","article-title":"Regulation of gene transcription by botanicals: Novel regulatory mechanisms","volume":"25","author":"Shay","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1017\/S0029665108006988","article-title":"Genome-health nutrigenomics and nutrigenetics: Nutritional requirements or \u2018nutriomes\u2019 for chromosomal stability and telomere maintenance at the individual level","volume":"67","author":"Bull","year":"2008","journal-title":"Proc. Nutr. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Milenkovic, D., Deval, C., Gouranton, E., Landrier, J.F., Scalbert, A., Morand, C., and Mazur, A. (2012). Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: A new mechanism of the action of polyphenols. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029837"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/carcin\/bgp245","article-title":"n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon","volume":"30","author":"Davidson","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/jgh.12523","article-title":"Serum microRNA levels in patients with Crohn\u2019s disease during induction therapy by infliximab","volume":"29","author":"Fujioka","year":"2014","journal-title":"J. Gastroenterol. Hepatol."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/8\/519\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:28:56Z","timestamp":1760210936000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/8\/519"}},"issued":{"date-parts":[[2016,8,22]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8]]}},"alternative-id":["nu8080519"],"URL":"https:\/\/doi.org\/10.3390\/nu8080519","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2016,8,22]]}},{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:22:52Z","timestamp":1775503372234,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103852"],"award-info":[{"award-number":["82103852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230016"],"award-info":[{"award-number":["81230016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M663751"],"award-info":[{"award-number":["2019M663751"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009581","name":"Shaanxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["Sxwsjswzfcght2016-013"],"award-info":[{"award-number":["Sxwsjswzfcght2016-013"]}],"id":[{"id":"10.13039\/501100009581","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&amp;D Program of China","award":["2017YFC0907200, 2017YFC0907201"],"award-info":[{"award-number":["2017YFC0907200, 2017YFC0907201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The effects of zinc, copper, and selenium on human congenital heart defects (CHDs) remain unclear. This study aimed to investigate the associations of the maternal total, dietary, and supplemental intakes of zinc, copper, and selenium during pregnancy with CHDs. A hospital-based case-control study was performed, including 474 cases and 948 controls in Northwest China. Eligible participants waiting for delivery were interviewed to report their diets and characteristics in pregnancy. Mixed logistic regression was adopted to examine associations and interactions between maternal intakes and CHDs. Higher total intakes of zinc, selenium, zinc to copper ratio, and selenium to copper ratio during pregnancy were associated with lower risks of total CHDs and the subtypes, and the tests for trend were significant (all p &lt; 0.05). The significantly inverse associations with CHDs were also observed for dietary intakes of zinc, selenium, zinc to copper ratio, selenium to copper ratio, and zinc and selenium supplements use during pregnancy and in the first trimester. Moreover, high zinc and high selenium, even with low or high copper, showed a significantly reduced risk of total CHDs. Efforts to promote zinc and selenium intakes during pregnancy need to be strengthened to reduce the incidence of CHDs in the Chinese population.<\/jats:p>","DOI":"10.3390\/nu14051055","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:53:25Z","timestamp":1646261605000},"page":"1055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiaomei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-9623","authenticated-orcid":false,"given":"Binyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-0532","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"},{"name":"Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-8169","authenticated-orcid":false,"given":"Shaonong","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970\u20132017, updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/01.cir.0000437597.44550.5d","article-title":"Diagnosis and treatment of fetal cardiac disease: A scientific statement from the American Heart Association","volume":"129","author":"Donofrio","year":"2014","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jpeds.2018.08.040","article-title":"Prevalence of congenital heart disease at live birth in China","volume":"204","author":"Zhao","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mousa, A., Naqash, A., and Lim, S. (2019). Macronutrient and micronutrient intake during pregnancy: An overview of recent evidence. Nutrients, 11.","DOI":"10.3390\/nu11020443"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12011-007-8079-2","article-title":"Prenatal zinc deficiency: Influence on heart morphology and distribution of key heart proteins in a rat model","volume":"122","author":"Lopez","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2005.08.020","article-title":"Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos","volume":"40","author":"Lanoue","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/etc.247","article-title":"Toxicity of short-term copper exposure to early life stages of red sea bream","volume":"29","author":"Cao","year":"2010","journal-title":"Pagrus major. Environ. Toxicol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ojeda, M.L., Nogales, F., Romero-Herrera, I., and Carreras, O. (2021). Fetal programming is deeply related to maternal selenium status and oxidative balance; Experimental offspring health repercussions. Nutrients, 13.","DOI":"10.3390\/nu13062085"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1503\/cmaj.101095","article-title":"Maternal selenium status during early gestation and risk for preterm birth","volume":"183","author":"Rayman","year":"2011","journal-title":"Cmaj"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.acc.2018.05.004","article-title":"Selenium in complicated pregnancy. A review","volume":"86","author":"Zachara","year":"2018","journal-title":"Adv. Clin. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S1047951117002372","article-title":"Maternal and neonatal micronutrient levels in newborns with CHD","volume":"28","author":"Dilli","year":"2018","journal-title":"Cardiol. Young."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/pd.5551","article-title":"High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring","volume":"39","author":"Guo","year":"2019","journal-title":"Prenat. Diagn."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/bdra.23284","article-title":"Correlation between congenital heart defects and maternal copper and zinc concentrations","volume":"100","author":"Hu","year":"2014","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.envint.2017.05.017","article-title":"Associations between toxic and essential trace elements in maternal blood and fetal congenital heart defects","volume":"106","author":"Ou","year":"2017","journal-title":"Env. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"126662","DOI":"10.1016\/j.jtemb.2020.126662","article-title":"Element profiles in blood and teeth samples of children with congenital heart diseases in comparison with healthy ones","volume":"63","author":"Aypar","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1007\/s11356-019-04312-0","article-title":"Associations of trace elements in blood with the risk of isolated ventricular septum defects and abnormal cardiac structure in children","volume":"26","author":"Zhu","year":"2019","journal-title":"Env. Sci. Pollut. Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/07315724.1995.10718520","article-title":"Zinc intake and sources in the US adult population: 1976\u20131980","volume":"14","author":"Subar","year":"1995","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/jn\/119.6.916","article-title":"Bioavailability of and interactions between zinc and selenium in rats fed wheat grain intrinsically labeled with 65Zn and 75Se","volume":"119","author":"House","year":"1989","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00244-008-9190-x","article-title":"In vitro examination of interactions between copper and zinc uptake via the gastrointestinal tract of the rainbow trout (Oncorhynchus mykiss)","volume":"56","author":"Ojo","year":"2009","journal-title":"Arch. Env. Contam. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101746","DOI":"10.1016\/j.redox.2020.101746","article-title":"Copper interferes with selenoprotein synthesis and activity","volume":"37","author":"Schwarz","year":"2020","journal-title":"Redox. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2019.11.115","article-title":"Iron intake and iron status during pregnancy and risk of congenital heart defects: A case-control study","volume":"301","author":"Yang","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Yang, J., Kang, Y., Cheng, Y., Zeng, L., Yan, H., and Dang, S. (2019). Maternal dietary patterns during pregnancy and congenital heart defects: A case-control study. Int. J. Env. Res. Public Health, 16.","DOI":"10.3390\/ijerph16162957"},{"key":"ref_23","unstructured":"Zheng, L. (1996). Soil Trace Elements in China, Phoenix Science Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.3945\/jn.109.109579","article-title":"Women\u2019s dietary patterns change little from before to during pregnancy","volume":"139","author":"Crozier","year":"2009","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-3016.2006.00691.x","article-title":"Changes in dietary intake from the first to the second trimester of pregnancy","volume":"20","author":"Willett","year":"2006","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41430-020-0617-4","article-title":"Maternal dietary diversity during pregnancy and congenital heart defects: A case-control study","volume":"75","author":"Yang","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_27","first-page":"166","article-title":"Validity and reproducibility of a semi-quantitative food frequency questionnaire for use among pregnant women in rural China","volume":"17","author":"Cheng","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1017\/S1368980016002159","article-title":"Dietary intakes and dietary patterns among pregnant women in Northwest China","volume":"20","author":"Yang","year":"2017","journal-title":"Public Health Nutr."},{"key":"ref_29","unstructured":"Institute of Nutrition and Food Safety, China Center for Disease Control (2005). China Food Composition Book 2, Peking University Medical Press."},{"key":"ref_30","unstructured":"Institute of Nutrition and Food Safety, China Center for Disease Control (2009). China Food Composition Book 1, Peking University Medical Press. [2nd ed.]."},{"key":"ref_31","unstructured":"FAO, and FHI 360 (2016). Minimum Dietary Dieversity for Women: A Guide for Measurement, FAO."},{"key":"ref_32","unstructured":"Chinese Nutrition Society (2016). Chinese Dietary Guideline, People\u2019s Medical Publishing House."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijcard.2018.04.003","article-title":"Non-inheritable risk factors during pregnancy for congenital heart defects in offspring: A matched case-control study","volume":"264","author":"Feng","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pei, L., Kang, Y., Zhao, Y., and Yan, H. (2017). Prevalence and risk factors of congenital heart defects among live births: A population-based cross-sectional survey in Shaanxi province, Northwestern China. BMC Pediatr., 17.","DOI":"10.1186\/s12887-017-0784-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/oxfordjournals.aje.a115101","article-title":"The impact of confounder selection criteria on effect estimation","volume":"129","author":"Mickey","year":"1989","journal-title":"Am. J. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Nakamura, M., Miura, A., Nagahata, T., Shibata, Y., Okada, E., and Ojima, T. (2019). Low Zinc, Copper, and manganese intake is associated with depression and anxiety symptoms in the Japanese working population: Findings from the eating habit and well-being study. Nutrients, 11.","DOI":"10.3390\/nu11040847"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Iqbal, S., Ali, I., Rust, P., Kundi, M., and Ekmekcioglu, C. (2020). Selenium, zinc, and manganese status in pregnant women and its relation to maternal and child complications. Nutrients, 12.","DOI":"10.3390\/nu12030725"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3390\/molecules18033292","article-title":"Selenium in the environment, metabolism and involvement in body functions","volume":"18","author":"Mehdi","year":"2013","journal-title":"Molecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1753-4887.2006.tb00169.x","article-title":"Zinc deficiency in pregnancy and fetal outcome","volume":"64","author":"Shah","year":"2006","journal-title":"Nutr. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00394-016-1343-5","article-title":"Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats","volume":"57","author":"Juriol","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.freeradbiomed.2012.07.008","article-title":"Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice","volume":"53","author":"Kumar","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/jn\/129.7.1251","article-title":"A delicate balance: Homeostatic control of copper uptake and distribution","volume":"129","author":"Lee","year":"1999","journal-title":"J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/bdrb.20004","article-title":"Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc-finger transcription factor GATA-4","volume":"71","author":"Duffy","year":"2004","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/CIRCRESAHA.109.214130","article-title":"Zac1 is an essential transcription factor for cardiac morphogenesis","volume":"106","author":"Yuasa","year":"2010","journal-title":"Circ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.clnu.2003.09.010","article-title":"Oxidative stress in mothers who have conceived fetus with neural tube defects: The role of aminothiols and selenium","volume":"23","author":"Gibert","year":"2004","journal-title":"Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1385\/BTER:97:3:225","article-title":"Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: A preliminary study","volume":"97","author":"Cengiz","year":"2004","journal-title":"Biol. Trace. Elem. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1024\/0300-9831\/a000176","article-title":"Serum levels of some micronutrients and congenital malformations: A prospective cohort study in healthy saudi-arabian first-trimester pregnant women","volume":"83","author":"Hammouda","year":"2013","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.clnu.2018.11.002","article-title":"Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts","volume":"38","author":"Pi","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1093\/jn\/130.12.2903","article-title":"Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon","volume":"130","author":"Davis","year":"2000","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1289\/ehp.1001937","article-title":"Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh","volume":"119","author":"Pilsner","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-3016.2009.01070.x","article-title":"Reproducibility of reported nutrient intake and supplement use during a past pregnancy: A report from the Children\u2019s Oncology Group","volume":"24","author":"Bosco","year":"2010","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/aje\/154.12.1136","article-title":"Recall of diet during a past pregnancy","volume":"154","author":"Bunin","year":"2001","journal-title":"Am. J. Epidemiol."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/5\/1055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:48Z","timestamp":1760135448000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/5\/1055"}},"issued":{"date-parts":[[2022,3,2]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["nu14051055"],"URL":"https:\/\/doi.org\/10.3390\/nu14051055","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2022,3,2]]}},{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:06:16Z","timestamp":1776117976870,"version":"3.50.1"},"reference-count":104,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Dietary intake of multivitamins, zinc, polyphenols, omega fatty acids, and probiotics have all shown benefits in learning, spatial memory, and cognitive function. It is important to determine the most effective combination of antioxidants and\/or probiotics because regular ingestion of all nutraceuticals may not be practical. This study examined various combinations of nutrients to determine which may best enhance spatial memory and cognitive performance in the house cricket (Acheta domesticus (L.)). Methods: Based on the 31 possible combinations of multivitamins, zinc, polyphenols, omega-3 polyunsaturated fatty acids (PUFAs), and probiotics, 128 house crickets were divided into one control group and 31 experimental groups with four house crickets in each group. Over eight weeks, crickets were fed their respective nutrients, and an Alternation Test and Recognition Memory Test were conducted every week using a Y-maze to test spatial working memory. Results: The highest-scoring diets shared by both tests were the combination of multivitamins, zinc, and omega-3 fatty acids (VitZncPuf; Alternation: slope = 0.07226, Recognition Memory: slope = 0.07001), the combination of probiotics, polyphenols, multivitamins, zinc, and omega-3 PUFAs (ProPolVitZncPuf; Alternation: slope = 0.07182, Recognition Memory: slope = 0.07001), the combination of probiotics, multivitamins, zinc, and omega-3 PUFAs (ProVitZncPuf; Alternation: slope = 0.06999, Recognition Memory: slope = 0.07001), and the combination of polyphenols, multivitamins, zinc, and omega-3 PUFAs (PolVitZncPuf; Alternation: slope = 0.06873, Recognition Memory: slope = 0.06956). Conclusion: All of the nutrient combinations demonstrated a benefit over the control diet, but the most significant improvement compared to the control was found in the VitZncPuf, ProVitZncPuf, PolVitZncPuf, and ProPolVitZncPuf. Since this study found no significant difference between the performance and improvement of subjects within these four groups, the combination of multivitamins, zinc, and omega-3 fatty acids (VitZncPuf) was concluded to be the most effective option for improving memory and cognitive performance.<\/jats:p>","DOI":"10.3390\/nu13020362","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T12:28:31Z","timestamp":1611577711000},"page":"362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Most Effective Combination of Nutraceuticals for Improved Memory and Cognitive Performance in the House Cricket, Acheta domesticus"],"prefix":"10.3390","volume":"13","author":[{"given":"Samskruthi","family":"Madireddy","sequence":"first","affiliation":[{"name":"Independent Researcher, 1353 Tanaka Drive, San Jose, CA 95131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahithi","family":"Madireddy","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1377\/hlthaff.2015.0645","article-title":"Food insecurity and health outcomes","volume":"34","author":"Gundersen","year":"2015","journal-title":"Health Aff."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/DBP.0000000000000383","article-title":"Association of food insecurity with children\u2019s behavioral, emotional, and academic outcomes: A systematic review","volume":"38","author":"Shankar","year":"2017","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_3","unstructured":"Coleman-Jensen, A., Rabbitt, M.P., Gregory, C.A., and Singh, A. (2021, January 25). Household Food Security in the United States in 2016, Available online: https:\/\/www.ers.usda.gov\/webdocs\/publications\/84973\/err-237.pdf."},{"key":"ref_4","unstructured":"Gregory, C.A., and Coleman-Jensen, A. (2021, January 25). Food insecurity, Chronic Disease, and Health among Working-Age Adults, Available online: https:\/\/www.ers.usda.gov\/webdocs\/publications\/84467\/err-235.pdf."},{"key":"ref_5","first-page":"41","article-title":"The role of diet in maintaining strong brain health by taking the advantage of the gut-brain axis","volume":"7","author":"Madireddy","year":"2019","journal-title":"J. Food Nutr. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1570159X14666161026151545","article-title":"Polyphenols beyond barriers: A glimpse into the brain","volume":"15","author":"Figueira","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JAD-2011-111751","article-title":"The effects of multivitamins on cognitive performance: A systematic review and meta-analysis","volume":"29","author":"Grima","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.fshw.2019.03.006","article-title":"Diet and medical foods in Parkinson\u2019s disease","volume":"8","author":"Lange","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100141","DOI":"10.1016\/j.ynstr.2018.100141","article-title":"Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition","volume":"10","author":"Papalini","year":"2019","journal-title":"Neurobiol. Stress"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s12011-015-0597-8","article-title":"Influence of long-term zinc administration on spatial learning and exploratory activity in rats","volume":"172","author":"Piechal","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_11","first-page":"72","article-title":"Prevalence of poor mental health and cognitive status among middle-aged adults and its predictors in relation to polyphenols intake","volume":"26","author":"Rosli","year":"2019","journal-title":"Malays. J. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/aje\/kwm036","article-title":"Flavonoid intake and cognitive decline over a 10-year period","volume":"165","author":"Letenneur","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.29328\/journal.jnnd.1001026","article-title":"Protection from the pathogenesis of neurodegenerative disorders, including Alzheimer\u2019s disease, Amyotrophic Lateral Sclerosis, Huntington\u2019s disease, and Parkinson\u2019s diseases, through the mitigation of reactive oxygen species","volume":"3","author":"Madireddy","year":"2019","journal-title":"J. Neurosci. Neurol. Disord."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1042\/BCJ20160503C","article-title":"Molecular mechanisms of ROS production and oxidative stress in diabetes","volume":"473","author":"Newsholme","year":"2016","journal-title":"Biochem. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/1570159X11666131120232135","article-title":"Association of oxidative stress to the genesis of anxiety: Implications for possible therapeutic interventions","volume":"12","author":"Hassan","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/1389557518666181015151350","article-title":"Radicals, oxidative\/nitrosative stress and preeclampsia","volume":"19","author":"Taysi","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2016.02.016","article-title":"Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress","volume":"1637","author":"Akbar","year":"2016","journal-title":"Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Madireddy, S., and Madireddy, S. (2020). Regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia. Brain Sci., 10.","DOI":"10.3390\/brainsci10100742"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.1093\/ajcn\/81.1.313S","article-title":"Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruit polyphenolic compounds","volume":"81","author":"Joseph","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","first-page":"31","article-title":"Red wine, resveratrol, and Alzheimer\u2019s disease","volume":"2","author":"Lange","year":"2018","journal-title":"Mov. Nutr. Health Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/biof.1396","article-title":"Resveratrol, pterostilbene and dementia","volume":"44","author":"Lange","year":"2018","journal-title":"BioFactors"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2353\/ajpath.2009.090417","article-title":"Phenolic compounds prevent Alzheimer\u2019s pathology through different effects on the Amyloid-\u03b2 aggregation pathway","volume":"175","author":"Hamaguchi","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bbadis.2006.03.002","article-title":"Anti-amyloidogenic effects of antioxidants: Implications for the prevention and therapeutics of Alzheimer\u2019s disease","volume":"1762","author":"Ono","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2006.06.025","article-title":"Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets","volume":"545","author":"Ramassamy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Thapa, A., and Carroll, N.J. (2017). Dietary modulation of oxidative stress in Alzheimer\u2019s disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071583"},{"key":"ref_28","first-page":"109410","article-title":"Prebiotics and probiotics as potential therapy for cognitive impairment","volume":"134","author":"Ibarra","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/1756283X12459294","article-title":"Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation","volume":"6","author":"Hemarajata","year":"2013","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1600240","DOI":"10.1002\/mnfr.201600240","article-title":"Probiotics, gut microbiota, and their influence on host health and disease","volume":"61","author":"Delgado","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: The impact of the gut microbiota on brain and behavior","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.nut.2015.11.014","article-title":"Dietary fiber intake and depressive symptoms in Japanese employees: The furukawa nutrition and health study","volume":"32","author":"Miki","year":"2016","journal-title":"Nutrition"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1021\/acs.jafc.8b00456","article-title":"Food design to feed the human gut microbiota","volume":"66","author":"Ercolini","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_35","first-page":"506","article-title":"Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats","volume":"22","author":"Hadizadeh","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3389\/fnagi.2018.00416","article-title":"Probiotics and, prebiotics as a therapeutic strategy to improve memory in a model of middle-aged rats","volume":"10","author":"Borlongan","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12031-019-01288-x","article-title":"The association between neuropsychological function with serum vitamins A, D, and E and hs-CRP concentrations","volume":"68","author":"Bahrami","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_38","first-page":"806","article-title":"Long-term multivitamin supplementation and cognitive function in men: A randomized trial","volume":"159","author":"Gordstein","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_39","first-page":"CD011906","article-title":"Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life","volume":"12","author":"Rutjes","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/gerona\/59.10.M1041","article-title":"Effectiveness of nutritional supplements on cognitive functioning in elderly persons: A systematic review","volume":"59","author":"Manders","year":"2004","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"ref_41","first-page":"CD011905","article-title":"Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment","volume":"11","author":"McCleery","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Franceschelli, S., Pesce, M., Ferrone, A., De Lutiis, M.A., Patruno, A., Grilli, A., Felaco, M., and Speranza, L. (2014). Astaxanthin treatment confers protection against oxidative stress in U937 cells stimulated with lipopolysaccharide reducing O2-production. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088359"},{"key":"ref_43","first-page":"37","article-title":"Dietary supplements for cognitive impairment","volume":"45","year":"2017","journal-title":"Actas Esp. Psiquiatr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-94-007-2199-9_6","article-title":"Vitamin C transport and its role in the central nervous system","volume":"56","author":"May","year":"2012","journal-title":"Subcell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1192\/bjp.bp.114.145177","article-title":"B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: Results from the B-VITAGE randomised, double-blind, placebo-controlled trial","volume":"205","author":"Almeida","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3945\/ajcn.113.076349","article-title":"Effects of homocysteine lowering with B vitamins on cognitive aging: Meta-analysis of 11 trials with cognitive data on 22,000 individuals","volume":"100","author":"Clarke","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-nutr-071715-050947","article-title":"Homocysteine, B vitamins, and cognitive impairment","volume":"36","author":"Smith","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3945\/an.115.012021","article-title":"Vitamin B-12 and cognition in children","volume":"7","author":"Venkatramanan","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Suh, S.W., Kim, H.S., Han, J.H., Bae, J.B., Oh, D.J., Han, J.W., and Kim, K.W. (2020). Efficacy of vitamins on cognitive function of non-demented people: A systematic review and meta-analysis. Nutrients, 12.","DOI":"10.3390\/nu12041168"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13230","DOI":"10.1038\/s41598-017-13189-3","article-title":"Vitamin D and cognitive function: A mendelian randomisation study","volume":"7","author":"Maddock","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1212\/WNL.0000000000003430","article-title":"Genetically decreased vitamin D and risk of Alzheimer disease","volume":"87","author":"Mokry","year":"2016","journal-title":"Neurology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exger.2017.01.019","article-title":"Does high dose vitamin D supplementation enhance cognition? A randomized trial in healthy adults","volume":"90","author":"Pettersen","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Farghali, M., Ruga, S., Morsanuto, V., and Uberti, F. (2020). Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review. Brain Sci., 10.","DOI":"10.3390\/brainsci10090660"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/nutrit\/nuz073","article-title":"Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: A systematic review and meta-analysis","volume":"78","author":"Alex","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_55","unstructured":"Hien, P.P. (2020). The role of diet in maintaining strong brain health by taking the advantage of the gut-brain axis. Advances in Food Science, Vide Leaf. [1st ed.]."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.plefa.2006.04.001","article-title":"Nutrition and theory of mind\u2014The role of polyunsaturated fatty acids (PUFA) in the development of theory of mind","volume":"75","author":"Karlsson","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Kuszewski, J.C., Wong, R.H.X., and Howe, P.R.C. (2017). Effects of long-chain omega-3 polyunsaturated fatty acids on endothelial vasodilator function and cognition\u2014Are they interrelated?. Nutrients, 9.","DOI":"10.3390\/nu9050487"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3945\/ajcn.113.079624","article-title":"Dietary lipids are differentially associated with hippocampal-dependent relational memory in prepubescent children","volume":"99","author":"Baym","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1113\/jphysiol.2012.230078","article-title":"\u2018Metabolic syndrome\u2019 in the brain: Deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition","volume":"590","author":"Agrawal","year":"2012","journal-title":"J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bhatia, H.S., Agrawal, R., Sharma, S., Huo, Y.-X., Ying, Z., and Gomez-Pinilla, F. (2011). Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028451"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nrn2421","article-title":"Brain foods: The effects of nutrients on brain function","volume":"9","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jn\/137.4.855","article-title":"Dietary (n23) fatty acids and brain development","volume":"137","author":"Innis","year":"2007","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ciappolino, V., Mazzocchi, A., Enrico, P., Syr\u00e9n, M.L., Delvecchio, G., Agostoni, C., and Brambilla, P. (2018). N-3 polyunsatured fatty acids in menopausal transition: A systematic review of depressive and cognitive disorders with accompanying vasomotor symptoms. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071849"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fneur.2017.00735","article-title":"Dietary iron repletion following early-life dietary iron deficiency does not correct regional volumetric or diffusion tensor changes in the developing pig brain","volume":"8","author":"Mudd","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.chc.2014.02.002","article-title":"Omega-3 fatty acid and nutrient deficits in adverse neurodevelopment and childhood behaviors","volume":"23","author":"Gow","year":"2014","journal-title":"Child Adolesc. Psychiatr. Clin."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fncel.2013.00144","article-title":"Fatting the brain: A brief of recent research","volume":"7","author":"Hussain","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neurobiolaging.2016.02.007","article-title":"Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome","volume":"41","author":"Sidhu","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2018.12.018","article-title":"The interaction of zinc and the blood-brain barrier under physiological and ischemic conditions","volume":"364","author":"Qi","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/emboj.2010.336","article-title":"Concerted action of zinc and ProSAP\/Shank in synaptogenesis and synapse maturation","volume":"30","author":"Grabrucker","year":"2011","journal-title":"EMBO J."},{"key":"ref_70","first-page":"1149","article-title":"Zinc deficiency is associated with depressive symptoms-results from the Berlin aging study II","volume":"72","author":"Jung","year":"2017","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Vela, G., Stark, P., Socha, M., Sauer, A.K., Hagmeyer, S., and Grabrucker, A.M. (2015). Zinc in gut-brain interaction in autism and neurological disorders. Neural Plast., 972791.","DOI":"10.1155\/2015\/972791"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1039\/c3mt20269k","article-title":"Synaptic Zn2+ homeostasis and its significance","volume":"5","author":"Takeda","year":"2013","journal-title":"Metallomics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12011-013-9766-9","article-title":"Oral zinc supplementation may improve cognitive function in schoolchildren","volume":"155","author":"Alves","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10534-015-9907-z","article-title":"Significance of the degree of synaptic Zn2+ signaling in cognition","volume":"29","author":"Takeda","year":"2016","journal-title":"Biometals"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12011-013-9762-0","article-title":"Psychological stress-induced lower serum zinc and zinc redistribution in rats","volume":"155","author":"Tao","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbr.2017.07.007","article-title":"Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper","volume":"333","author":"Manchester","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Yang, Y., Jing, X.-P., Zhang, S.-P., Gu, R.-X., Tang, F.-X., Wang, X.-L., Xiong, Y., Qiu, M., Sun, X.-Y., and Ke, D. (2013). High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055384"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jtemb.2016.03.003","article-title":"Significance of synaptic Zn2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition","volume":"38","author":"Tamano","year":"2016","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1098\/rspb.2010.2488","article-title":"Costs of memory: Lessons from \u2018mini\u2019 brains","volume":"278","author":"Burns","year":"2011","journal-title":"Proc. R. Soc. B"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mallory, H.S., Howard, A.F., and Weiss, M.R. (2016). Timing of Environmental Enrichment Affects Memory in the House Cricket, Acheta domesticus. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152245"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cne.10319","article-title":"Development of cricket mushroom bodies","volume":"452","author":"Malaterre","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0960-9822(02)00889-8","article-title":"Sensory inputs stimulate progenitor cell proliferation in an adult insect brain","volume":"12","author":"Strambi","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1096-4959(01)00525-5","article-title":"The common properties of neurogenesis in the adult brain: From invertebrates to vertebrates","volume":"132","author":"Cayre","year":"2002","journal-title":"Comp. Biochem. Phys. B"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00359-002-0303-0","article-title":"Lifetime olfactory memory in the cricket Gryllus bimaculatus","volume":"188","author":"Matsumoto","year":"2002","journal-title":"J. Comp. Physiol. A"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s13744-016-0391-0","article-title":"Immune priming, fat reserves, muscle mass and body weight of the house cricket is affected by diet composition","volume":"45","year":"2016","journal-title":"Neotrop. Entomol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jeb.12794","article-title":"Macronutrient intake regulates sexual conflict in decorated crickets","volume":"29","author":"Rapkin","year":"2016","journal-title":"J. Evol. Biol."},{"key":"ref_88","first-page":"2635","article-title":"Cranking up the heat: Relationships between energetically costly song features and the increase in thorax temperature in male crickets and katydids","volume":"220","author":"Erregger","year":"2017","journal-title":"J. Exp. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00359-016-1124-x","article-title":"How females of chirping and trilling field crickets integrate the \u2018what\u2019 and \u2018where\u2019 of male acoustic signals during decision making","volume":"202","author":"Gabel","year":"2016","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1242\/jeb.094482","article-title":"The behavioural effects of predator-induced stress responses in the cricket (Gryllus texensis): The upside of the stress response","volume":"216","author":"Adamo","year":"2013","journal-title":"J. Exp. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.anbehav.2018.02.007","article-title":"The \u2018hot male\u2019 hypothesis: Do female crickets prefer males with increased body temperature in mate choice scenarios?","volume":"138","author":"Erregger","year":"2018","journal-title":"Anim. Behav."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12011-008-8312-7","article-title":"The effect of severe zinc deficiency and zinc supplement on spatial learning and memory","volume":"130","author":"Boroujeni","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12011-018-1466-z","article-title":"Zinc-enriched yeast improves learning and memory impairments in zinc-deficient rats","volume":"189","author":"Zhang","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1542\/peds.2005-1172","article-title":"Efficacy of iron and\/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: A randomized, placebo-Controlled Trial","volume":"117","author":"Rico","year":"2006","journal-title":"Pediatrics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.phrs.2003.10.004","article-title":"Effect of vitamins C and E on cognitive function in mouse","volume":"49","author":"Arzi","year":"2004","journal-title":"Pharmacol. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/jnu.12201","article-title":"Effects of multivitamin supplements on cognitive function, serum homocysteine level, and depression of Korean older adults with mild cognitive impairment in care facilities","volume":"48","author":"Lee","year":"2016","journal-title":"J. Nurs. Scholarsh."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1179\/1476830514Y.0000000136","article-title":"B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia","volume":"19","author":"Cheng","year":"2016","journal-title":"Nutr. Neurosci."},{"key":"ref_98","first-page":"27","article-title":"A winning combination among polyphenols, probiotics, vitamins for improved memory and cognitive performance","volume":"9","author":"Madireddy","year":"2020","journal-title":"Int. J. Med. Res. Health Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1744-9081-7-21","article-title":"High fat diet intake during pre and periadolescence impairs learning of a conditioned place preference in adulthood","volume":"7","author":"Privitera","year":"2011","journal-title":"Behav. Brain Funct."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hajjar, T., Meng, G.Y., Rajion, M.A., Vidyadaran, S., Othman, F., Farjam, A.S., Li, T.A., and Ebrahimi, M. (2012). Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors (PPAR\u03b1 and PPAR\u03b3) gene expression in rats. BMC Neurosci., 13.","DOI":"10.1186\/1471-2202-13-109"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejphar.2007.11.081","article-title":"Fatty acids, lipid metabolism and Alzheimer pathology","volume":"585","author":"Hooijmans","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00075197-200403000-00008","article-title":"Polyunsaturated fatty acids and gene expression","volume":"7","author":"Lapillonne","year":"2004","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jnutbio.2009.11.003","article-title":"Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance","volume":"21","author":"Su","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_104","unstructured":"Menzel, R., and Benjamin, P.R. (2013). Chapter 41: Olfactory and visual learning in cockroaches and crickets. Invertebrate Learning and Memory, Springer."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/362\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:15:10Z","timestamp":1760159710000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/362"}},"issued":{"date-parts":[[2021,1,25]]},"references-count":104,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["nu13020362"],"URL":"https:\/\/doi.org\/10.3390\/nu13020362","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2021,1,25]]}},{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:53:00Z","timestamp":1768902780513,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82071841"],"award-info":[{"award-number":["82071841"]}]},{"name":"National Natural Science Foundation of China","award":["81901667"],"award-info":[{"award-number":["81901667"]}]},{"name":"National Natural Science Foundation of China","award":["2022-PUMCH-B-044"],"award-info":[{"award-number":["2022-PUMCH-B-044"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["82071841"],"award-info":[{"award-number":["82071841"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["81901667"],"award-info":[{"award-number":["81901667"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-044"],"award-info":[{"award-number":["2022-PUMCH-B-044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is chronic inflammatory disease. Although coffee impacts metabolism, no evidence has shown an association between coffee consumption and decreased risk for developing metabolic syndrome (MetS) among RA patients. Hence, we examined the association between coffee consumption and metabolic syndrome severity among 1094 participants with self-reported RA. Accordingly, patients with MetS z-scores of &lt;0 and \u22650 were designated as low- and high-risk groups, respectively. In the fully adjusted model, drinking over two cups of coffee daily was associated with a decrease in the MetS z-score (p = 0.04). Subgroup analysis showed that in the low-risk group, daily intake of &lt;2 cups of coffee was associated with low MetS z-scores (p = 0.003), scores (p = 0.03). Coffee intake was associated with low body mass index (p = 0.03 for 0\u20132 cups per day; p = 0.02 for &gt;2 cups per day) and low HOMA-IR (\u03b2, \u22122.62; 95%CI, \u22125.13 to \u22120.11; p = 0.04). Our study suggests that coffee, but not decaffeinated coffee consumption and total caffeine intake, is associated with MetS severity in RA.<\/jats:p>","DOI":"10.3390\/nu15010107","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:50:01Z","timestamp":1672109401000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between Coffee Consumption, Caffeine Intake, and Metabolic Syndrome Severity in Patients with Self-Reported Rheumatoid Arthritis: National Health and Nutrition Examination Survey 2003\u20132018"],"prefix":"10.3390","volume":"15","author":[{"given":"Shuolin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingdong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-7586","authenticated-orcid":false,"given":"Xuejun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/acr.23425","article-title":"Medical Expenditures and Earnings Losses Among US Adults With Arthritis in 2013","volume":"70","author":"Murphy","year":"2018","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/annrheumdis-2020-217344","article-title":"EULAR definition of difficult-to-treat rheumatoid arthritis","volume":"80","author":"Nagy","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gwinnutt, J.M., Wieczorek, M., Balanescu, A., A Bischoff-Ferrari, H., Boonen, A., Cavalli, G., de Souza, S., de Thurah, A., E Dorner, T., and Moe, R.H. (2022). 2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases. Ann. Rheum. Dis.","DOI":"10.1136\/annrheumdis-2021-222020"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2337\/diacare.28.9.2289","article-title":"The metabolic syndrome: Time for a critical appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes","volume":"28","author":"Kahn","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103117","DOI":"10.1016\/j.autrev.2022.103117","article-title":"Caffeine and rheumatoid arthritis: A complicated relationship","volume":"21","author":"Ingegnoli","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.diabet.2015.09.001","article-title":"Coffee consumption and risk of the metabolic syndrome: A meta-analysis","volume":"42","author":"Shang","year":"2016","journal-title":"Diabetes Metab"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7762\/cnr.2015.4.1.41","article-title":"Diet, sleep and metabolic syndrome among a legal Amazon population, Brazil","volume":"4","author":"Ferrari","year":"2015","journal-title":"Clin. Nutr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00394-014-0789-6","article-title":"Association of daily coffee and tea consumption and metabolic syndrome: Results from the Polish arm of the HAPIEE study","volume":"54","author":"Grosso","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/CIRCULATIONAHA.107.716159","article-title":"Dietary intake and the development of the metabolic syndrome: The Atherosclerosis Risk in Communities study","volume":"117","author":"Lutsey","year":"2008","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chang, C., Chang, Y., Liu, P., Chen, C.-Y., Tsai, Y.-S., and Wu, C.-H. (2012). Smoking, habitual tea drinking and metabolic syndrome in elderly men living in rural community: The Tianliao old people (TOP) study 02. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038874"},{"key":"ref_13","first-page":"710928","article-title":"Metabolic syndrome in rheumatoid arthritis","volume":"2013","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.metabol.2013.10.006","article-title":"An examination of sex and racial\/ethnic differences in the metabolic syndrome among adults: A confirmatory factor analysis and a resulting continuous severity score","volume":"63","author":"Gurka","year":"2014","journal-title":"Metabolism"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2337\/dc18-1079","article-title":"Use of a Metabolic Syndrome Severity Z Score to Track Risk During Treatment of Prediabetes: An Analysis of the Diabetes Prevention Program","volume":"41","author":"DeBoer","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1161\/STROKEAHA.120.028944","article-title":"Risk of Ischemic Stroke Increases Over the Spectrum of Metabolic Syndrome Severity","volume":"51","author":"DeBoer","year":"2020","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.cgh.2021.09.042","article-title":"Coffee Consumption Is Associated With Lower Liver Stiffness: A Nationally Representative Study","volume":"20","author":"Niezen","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cai, B., Zhou, M., Xiao, Q., Zou, H., and Zhu, X. (2022). L-shaped association between serum 25-Hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis. Rheumatology.","DOI":"10.1093\/rheumatology\/keac341"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"88531","DOI":"10.1007\/s11356-022-21973-6","article-title":"Association between electronic cigarettes use and whole blood cell among adults in the USA-a cross-sectional study of National Health and Nutrition Examination Survey analysis","volume":"29","author":"Wang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1001\/jama.299.19.2287","article-title":"Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome","volume":"299","author":"Holvoet","year":"2008","journal-title":"Jama"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.reprotox.2017.06.045","article-title":"Prenatal caffeine exposure induced high susceptibility to metabolic syndrome in adult female offspring rats and its underlying mechanisms","volume":"71","author":"Pei","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/jbcpp-2016-0090","article-title":"The effect of caffeine on energy balance","volume":"28","author":"Harpaz","year":"2017","journal-title":"J. Basic Clin. Physiol. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.physbeh.2006.01.027","article-title":"Metabolic effects of spices, teas, and caffeine","volume":"89","author":"Diepvens","year":"2006","journal-title":"Physiol. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ajcn\/79.1.40","article-title":"Metabolic effects of caffeine in humans: Lipid oxidation or futile cycling?","volume":"79","author":"Acheson","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1152\/ajpregu.00832.2005","article-title":"Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea","volume":"292","author":"Diepvens","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJMra1816604","article-title":"Coffee, Caffeine, and Health","volume":"383","author":"Hu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.clnu.2020.05.052","article-title":"Coffee consumption and risk of hypertension: A prospective analysis in the cohort study","volume":"40","author":"Miranda","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Grosso, G., Micek, A., Godos, J., Pajak, A., Sciacca, S., Bes-Rastrollo, M., Galvano, F., and Martinez-Gonzalez, M.A. (2017). Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose-Response Meta-Analysis. Nutrients, 9.","DOI":"10.3390\/nu9080890"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3109\/09637486.2014.940287","article-title":"Coffee components and cardiovascular risk: Beneficial and detrimental effects","volume":"65","author":"Godos","year":"2014","journal-title":"Int. J. Food. Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10408390500400009","article-title":"Coffee and health: A review of recent human research","volume":"46","author":"Higdon","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/rheumatology\/ken159","article-title":"Hypertension in rheumatoid arthritis","volume":"47","author":"Panoulas","year":"2008","journal-title":"Rheumatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/01.CIR.0000015126.83143.B4","article-title":"Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein","volume":"105","author":"Verma","year":"2002","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.0000061916.95736.E5","article-title":"C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle","volume":"107","author":"Wang","year":"2003","journal-title":"Circulation"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.amjhyper.2006.11.008","article-title":"Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats","volume":"20","author":"Suzuki","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrrheum.2014.121","article-title":"Rheumatoid arthritis and metabolic syndrome","volume":"10","author":"Kerekes","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1002\/art.22053","article-title":"Insulin resistance and impaired beta cell function in rheumatoid arthritis","volume":"54","author":"Dessein","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.autrev.2017.05.007","article-title":"Coffee and autoimmunity: More than a mere hot beverage!","volume":"16","author":"Sharif","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1001\/archinte.1987.00370110040005","article-title":"Serum lipoprotein in active rheumatoid arthritis and other chronic inflammatory arthritides. I. Relativity to inflammatory activity","volume":"147","author":"Svenson","year":"1987","journal-title":"Arch. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/archinte.1987.00370110045006","article-title":"Serum lipoprotein in active rheumatoid arthritis and other chronic inflammatory arthritides. II. Effects of anti-inflammatory and disease-modifying drug treatment","volume":"147","author":"Svenson","year":"1987","journal-title":"Arch. Intern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/ard.56.6.341","article-title":"Dyslipidemia and rheumatoid arthritis","volume":"56","author":"Situnayake","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/ard.56.6.374","article-title":"Effect of disease modifying agents on the lipid profiles of patients with rheumatoid arthritis","volume":"56","author":"Munro","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.numecd.2020.08.017","article-title":"Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials","volume":"30","author":"Du","year":"2020","journal-title":"Nutr. Metab Cardiovasc. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"801457","DOI":"10.1155\/2013\/801457","article-title":"Roles of chlorogenic Acid on regulating glucose and lipids metabolism: A review","volume":"2013","author":"Meng","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med. Ecam"}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/1\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:51:18Z","timestamp":1760147478000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/1\/107"}},"issued":{"date-parts":[[2022,12,26]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["nu15010107"],"URL":"https:\/\/doi.org\/10.3390\/nu15010107","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2022,12,26]]}},{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:12:56Z","timestamp":1760368376413,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cow\u2019s milk protein (CMP) allergy (CMPA) is the earliest and most common food allergy in children [...]<\/jats:p>","DOI":"10.3390\/nu14020299","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:33:04Z","timestamp":1641933184000},"page":"299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemically Defined Formulas, Symbiotics and Cow\u2019s Milk Protein Allergy"],"prefix":"10.3390","volume":"14","author":[{"given":"Jean-Pascal","family":"De Bandt","sequence":"first","affiliation":[{"name":"Service de Biochimie, H\u00f4pital Cochin, APHP.Centre\u2014Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"INSERM UMR-S 1124, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/WOX.0b013e3181defeb9","article-title":"World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow\u2019s Milk Allergy (DRACMA) Guidelines","volume":"3","author":"Fiocchi","year":"2010","journal-title":"World Allergy Organ. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/205741a0","article-title":"Evaluation of Chemical Diets as Nutrition for Man-in-Space","volume":"205","author":"Winitz","year":"1965","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ajcn\/nqz268","article-title":"Intact and hydrolyzed casein lead to similar ileal endogenous protein and amino acid flows in adult humans","volume":"111","author":"Deglaire","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/jaoac\/91.4.1002","article-title":"Comparison of digestibility and quality of intact proteins with their respective hydrolysates","volume":"91","author":"Potier","year":"2008","journal-title":"J. AOAC Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/368563a0","article-title":"Expression cloning of a mammalian proton-coupled oligopeptide transporter","volume":"368","author":"Fei","year":"1994","journal-title":"Nature"},{"key":"ref_6","first-page":"454","article-title":"Cryptosporidiosis induces a transient upregulation of the oligopeptides transporter (PepT1) activity in neonatal rats","volume":"232","author":"Marquet","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbagen.2014.05.011","article-title":"Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters","volume":"1850","author":"Newstead","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.mam.2012.11.003","article-title":"Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications","volume":"34","author":"Smith","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3945\/ajcn.2009.27474","article-title":"Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein","volume":"90","author":"Koopman","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","first-page":"E907","article-title":"Leucine kinetics are different during feeding with whole protein or oligopeptides","volume":"267","author":"Cayol","year":"1994","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ajcn\/67.1.124","article-title":"Pharmacokinetic assessment of an oligopeptide-based enteral formula in abdominal surgery patients","volume":"67","author":"Ziegler","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/ajcn\/33.10.2106","article-title":"Comparative study of nutritional adaptation to defined formula diets in rats","volume":"33","author":"Winborn","year":"1980","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.clnu.2015.04.015","article-title":"Impact of qualitative and quantitative variations in nitrogen supply on catch-up growth in food-deprived-refed young rats","volume":"35","author":"Bortolotti","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jpeds.2008.02.043","article-title":"Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid","volume":"153","author":"Burks","year":"2008","journal-title":"J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"Ding","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41575-021-00519-0","article-title":"Re-examining chemically defined liquid diets through the lens of the microbiome","volume":"18","author":"Toni","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00431-019-03397-6","article-title":"Probiotics for cow\u2019s milk protein allergy: A systematic review of randomized controlled trials","volume":"178","author":"Qamer","year":"2019","journal-title":"Eur. J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sorensen, K., Cawood, A., Gibson, G., Cooke, L., and Stratton, R. (2021). Amino Acid Formula Containing Synbiotics in Infants with Cow\u2019s Milk Protein Allergy: A Systematic Review and Meta-Analysis. Nutrients, 13.","DOI":"10.3390\/nu13030935"}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/2\/299\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:35:34Z","timestamp":1760366134000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/2\/299"}},"issued":{"date-parts":[[2022,1,11]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["nu14020299"],"URL":"https:\/\/doi.org\/10.3390\/nu14020299","ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"published":{"date-parts":[[2022,1,11]]}},{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:01:18Z","timestamp":1760058078286,"version":"build-2065373602"},"reference-count":100,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_189110","ETH-24 20-2"],"award-info":[{"award-number":["310030_189110","ETH-24 20-2"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ETH Research Grant","award":["310030_189110","ETH-24 20-2"],"award-info":[{"award-number":["310030_189110","ETH-24 20-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Maternal overnutrition critically influences offspring\u2019s long-term metabolic and cognitive health. While prior research indicates maternal diet can disrupt hippocampal function, the specific impact on spatial memory remains unclear. Methods: Female mice were fed a high-fat diet (HFD) for nine weeks before and during pregnancy. Offspring were weaned onto a standard diet and tested at postnatal day 90 using the dry maze, a spatial reference memory task. Results: HFD-exposed offspring exhibited significant learning acquisition impairments, with prolonged latencies in locating hidden rewards and diminished within-session improvements compared to controls. During the probe trial, they spent significantly less time in the target quadrant, indicating long-term spatial memory retention deficits. Notably, these cognitive impairments occurred independently of body weight differences at testing. Discussion: This study uniquely demonstrates that maternal HFD exposure induces specific spatial memory deficits in adult offspring, potentially through neurodevelopmental alterations preceding metabolic dysfunction. The results highlight the importance of prenatal nutrition in shaping cognitive outcomes later in life. Conclusions: These findings extend our understanding of how prenatal nutrition impacts cognitive aging and disease susceptibility. Given rising obesity rates among women of reproductive age, this research underscores the urgent need for targeted interventions to mitigate the intergenerational effects of maternal overnutrition on brain function.<\/jats:p>","DOI":"10.3390\/nu17060988","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:31:42Z","timestamp":1741764702000},"page":"988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Programming the Brain: How Maternal Overnutrition Shapes Cognitive Aging in Offspring"],"prefix":"10.3390","volume":"17","author":[{"given":"Pratheba","family":"Kandasamey","sequence":"first","affiliation":[{"name":"Institute for Neuroscience, Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-008X","authenticated-orcid":false,"given":"Daria","family":"Peleg-Raibstein","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience, Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland"},{"name":"Neuroscience Center Zurich, University of Zurich\/ETH Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"unstructured":"World Health Organization (WHO) (2025, March 04). 1 March 2024. Obesity and Overweight Fact Sheet. (In English).","key":"ref_1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The Epidemiology of Obesity: A Big Picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/bmj.301.6746.259","article-title":"Fetal and placental size and risk of hypertension in adult life","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1113\/jphysiol.2004.081992","article-title":"Early origins of obesity: Programming the appetite regulatory system","volume":"565","author":"McMillen","year":"2005","journal-title":"J. Physiol."},{"key":"ref_6","first-page":"433","article-title":"Obesity Before, During, and After Pregnancy: A Review and Comparison of Five National Guidelines","volume":"33","author":"Kominiarek","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/aje\/kwk030","article-title":"Epidemiologic evidence for the fetal overnutrition hypothesis: Findings from the mater-university study of pregnancy and its outcomes","volume":"165","author":"Lawlor","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1542\/peds.114.1.e29","article-title":"Predicting preschooler obesity at birth: The role of maternal obesity in early pregnancy","volume":"114","author":"Whitaker","year":"2004","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1111\/nure.12059","article-title":"Role of maternal adiposity prior to and during pregnancy in cognitive and psychiatric problems in offspring","volume":"71","year":"2013","journal-title":"Nutr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1034\/j.1600-0412.2003.00090.x","article-title":"Maternal prepregnancy body mass index and psychomotor development in children","volume":"82","author":"Neggers","year":"2003","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10995-012-0964-4","article-title":"The impact of prepregnancy obesity on children\u2019s cognitive test scores","volume":"17","author":"Tanda","year":"2013","journal-title":"Matern. Child. Health J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1542\/peds.2010-0651","article-title":"Intrauterine effects of maternal prepregnancy overweight on child cognition and behavior in 2 cohorts","volume":"127","author":"Brion","year":"2011","journal-title":"Pediatrics"},{"doi-asserted-by":"crossref","unstructured":"Buss, C., Entringer, S., Davis, E.P., Hobel, C.J., Swanson, J.M., Wadhwa, P.D., and Sandman, C.A. (2012). Impaired executive function mediates the association between maternal pre-pregnancy body mass index and child ADHD symptoms. PLoS ONE, 7, (In English).","key":"ref_13","DOI":"10.1371\/journal.pone.0037758"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1469-7610.2009.02133.x","article-title":"Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children","volume":"51","author":"Rodriguez","year":"2010","journal-title":"J. Child. Psychol. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.ijo.0803741","article-title":"Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: Evidence from three prospective pregnancy cohorts","volume":"32","author":"Rodriguez","year":"2008","journal-title":"Int. J. Obes."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12017-008-8043-0","article-title":"Impact of energy intake and expenditure on neuronal plasticity","volume":"10","author":"Stranahan","year":"2008","journal-title":"Neuromol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.3233\/JAD-2011-111073","article-title":"Cognitive function and decline in obesity","volume":"30","author":"Sellbom","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"unstructured":"WHO (2025, March 04). Nutrition Counselling During Pregnancy. Available online: https:\/\/www.who.int\/tools\/elena\/interventions\/nutrition-counselling-pregnancy.","key":"ref_18"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbr.2012.05.027","article-title":"Maternal high-fat diet in mice programs emotional behavior in adulthood","volume":"233","author":"Luca","year":"2012","journal-title":"Behav. Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0031-9384(95)00110-5","article-title":"A comparison of rats and mice in a swimming pool place task and matching to place task: Some surprising differences","volume":"58","author":"Whishaw","year":"1995","journal-title":"Physiol. Behav."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbr.2010.01.020","article-title":"Evaluating spatial memory function in mice: A within-subjects comparison between the water maze test and its adaptation to dry land","volume":"209","author":"Hauser","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/1028415X.2018.1432096","article-title":"Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL\/6 mice","volume":"22","author":"Wolfrum","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e911","DOI":"10.1038\/tp.2016.176","article-title":"Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition","volume":"6","author":"Sarker","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_24","first-page":"5","article-title":"The impact of dietary energy intake on cognitive aging","volume":"2","author":"Mattson","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e20161459","DOI":"10.1542\/peds.2016-1459","article-title":"Parental Obesity and Early Childhood Development","volume":"139","author":"Yeung","year":"2017","journal-title":"Pediatrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/pd.4932","article-title":"Maternal obesity and neurodevelopmental and psychiatric disorders in offspring","volume":"37","author":"Edlow","year":"2017","journal-title":"Prenat. Diagn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/aur.1586","article-title":"Maternal metabolic risk factors for autism spectrum disorder-An analysis of electronic medical records and linked birth data","volume":"9","author":"Connolly","year":"2016","journal-title":"Autism Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S1880","DOI":"10.3945\/ajcn.110.001107","article-title":"Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age","volume":"94","author":"Campoy","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpeds.2016.05.013","article-title":"The Role of Nutrition in Brain Development: The Golden Opportunity of the \u201cFirst 1000 Days\u201d","volume":"175","author":"Cusick","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100281","DOI":"10.1016\/j.bbih.2021.100281","article-title":"Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring","volume":"15","author":"Bordeleau","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"doi-asserted-by":"crossref","unstructured":"Bordeleau, M., Comin, C.H., Fern\u00e1ndez de Coss\u00edo, L., Lacabanne, C., Freitas-Andrade, M., Gonz\u00e1lez Ib\u00e1\u00f1ez, F., Raman-Nair, J., Wakem, M., Chakravarty, M., and Costa, L.d.F. (2022). Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring. Commun. Biol., 5.","key":"ref_31","DOI":"10.1038\/s42003-021-02947-9"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/nutrit\/nuaa020","article-title":"Relationship of maternal high-fat diet during pregnancy and lactation to offspring health","volume":"79","author":"Filip","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/path.4468","article-title":"Prenatal high-fat diet alters the cerebrovasculature and clearance of \u03b2-amyloid in adult offspring","volume":"235","author":"Hawkes","year":"2015","journal-title":"J. Pathol."},{"doi-asserted-by":"crossref","unstructured":"Peleg-Raibstein, D. (2021). Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging. Front. Neurosci., 15, (In English).","key":"ref_34","DOI":"10.3389\/fnins.2021.645569"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12974-024-03030-w","article-title":"Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring","volume":"21","author":"Shiadeh","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"bqaa214","DOI":"10.1210\/endocr\/bqaa214","article-title":"Maternal High-Fat Diet Multigenerationally Impairs Hippocampal Synaptic Plasticity and Memory in Male Rat Offspring","volume":"162","author":"Lin","year":"2021","journal-title":"Endocrinology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2014.03.005","article-title":"Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats","volume":"40","author":"Boitard","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ijdevneu.2009.08.005","article-title":"High fat diet-induced maternal obesity alters fetal hippocampal development","volume":"27","author":"Niculescu","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"doi-asserted-by":"crossref","unstructured":"Hu, X., An, J., Ge, Q., Sun, M., Zhang, Z., Cai, Z., Tan, R., Ma, T., and Lu, H. (2022). Maternal High-Fat Diet Reduces Type-2 Neural Stem Cells and Promotes Premature Neuronal Differentiation during Early Postnatal Development. Nutrients, 14, (In English).","key":"ref_39","DOI":"10.3390\/nu14142813"},{"doi-asserted-by":"crossref","unstructured":"Fabianov\u00e1, K., Babe\u013eov\u00e1, J., Fabian, D., Popovi\u010dov\u00e1, A., Marton\u010d\u00edkov\u00e1, M., Ra\u010dek, A., and Ra\u010dekov\u00e1, E. (2022). Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner. Int. J. Mol. Sci., 23.","key":"ref_40","DOI":"10.3390\/ijms23105564"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1096\/fj.09-144014","article-title":"Enduring consequences of maternal obesity for brain inflammation and behavior of offspring","volume":"24","author":"Bilbo","year":"2010","journal-title":"FASEB"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2009.04.002","article-title":"Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet","volume":"35","author":"White","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuint.2010.05.015","article-title":"Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring","volume":"57","author":"Tozuka","year":"2010","journal-title":"Neurochem. Int."},{"doi-asserted-by":"crossref","unstructured":"Urbonaite, G., Knyzeliene, A., Bunn, F.S., Smalskys, A., and Neniskyte, U. (2022). The impact of maternal high-fat diet on offspring neurodevelopment. Front. Neurosci., 16.","key":"ref_44","DOI":"10.3389\/fnins.2022.909762"},{"doi-asserted-by":"crossref","unstructured":"Sarker, G., and Peleg-Raibstein, D. (2018). Maternal Overnutrition Induces Long-Term Cognitive Deficits Across Several Generations. Nutrients, 11, (In English).","key":"ref_45","DOI":"10.3390\/nu11010007"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1096\/fj.08-124784","article-title":"Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring","volume":"23","author":"Tozuka","year":"2009","journal-title":"FASEB"},{"doi-asserted-by":"crossref","unstructured":"Frankowska, M., Sur\u00f3wka, P., Gawli\u0144ska, K., Borczyk, M., Korosty\u0144ski, M., Filip, M., and Smaga, I. (2024). A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex. Front. Mol. Neurosci., 16.","key":"ref_47","DOI":"10.3389\/fnmol.2023.1303718"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/npp.2014.313","article-title":"Dissociable deficits of executive function caused by gestational adversity are linked to specific transcriptional changes in the prefrontal cortex","volume":"40","author":"Grissom","year":"2015","journal-title":"Neuropsychopharmacology"},{"doi-asserted-by":"crossref","unstructured":"Wu, T., Deng, S., Li, W.-G., Yu, Y., Li, F., and Mao, M. (2013). Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats. PLoS ONE, 8.","key":"ref_49","DOI":"10.1371\/journal.pone.0078876"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-007-1008-4","article-title":"Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: Reduction in the behavioral responses to repeated amphetamine administration","volume":"197","author":"Naef","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1111\/ejn.16184","article-title":"Obesity in pregnancy-Long-term effects on offspring hypothalamic-pituitary-adrenal axis and associations with placental cortisol metabolism: A systematic review","volume":"58","author":"Volqvartz","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"bqad090","DOI":"10.1210\/endocr\/bqad090","article-title":"Maternal High-Fat Diet Multigenerationally Programs HPA Function and Behaviors in Male Rat Offspring","volume":"164","author":"Lin","year":"2023","journal-title":"Endocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.psyneuen.2018.12.003","article-title":"Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring","volume":"102","author":"Niu","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.psyneuen.2018.06.015","article-title":"Maternal high fat diet alters offspring epigenetic regulators, amygdala glutamatergic profile and anxiety","volume":"96","author":"Glendining","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroscience.2014.04.012","article-title":"Maternal high-fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring","volume":"272","author":"Sasaki","year":"2014","journal-title":"Neuroscience"},{"doi-asserted-by":"crossref","unstructured":"Chen, H., Simar, D., and Morris, M.J. (2009). Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: Interaction with postnatal nutritional environment. PLoS ONE, 4, (In English).","key":"ref_56","DOI":"10.1371\/journal.pone.0006259"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R1056","DOI":"10.1152\/ajpregu.00117.2007","article-title":"Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring","volume":"293","author":"Roy","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cell.2014.01.008","article-title":"Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding","volume":"156","author":"Vogt","year":"2014","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.physbeh.2015.06.008","article-title":"Effects of high-fat diet exposure on learning & memory","volume":"152","author":"Cordner","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/CS20190266","article-title":"Placental function in maternal obesity","volume":"134","author":"Kelly","year":"2020","journal-title":"Clin. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1053\/plac.2002.0773","article-title":"The role of the placenta in fetal programming\u2014A review","volume":"23","author":"Godfrey","year":"2002","journal-title":"Placenta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.psyneuen.2015.06.012","article-title":"Maternal high-fat diet acts as a stressor increasing maternal glucocorticoids\u2019 signaling to the fetus and disrupting maternal behavior and brain activation in C57BL\/6J mice","volume":"60","author":"Bellisario","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0166-4328(93)90131-9","article-title":"Animal models of normal aging: Relationship between cognitive decline and markers in hippocampal circuitry","volume":"57","author":"Gallagher","year":"1993","journal-title":"Behav. Brain Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neurobiolaging.2003.12.001","article-title":"Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum","volume":"25","author":"Geinisman","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1037\/0735-7044.121.3.559","article-title":"Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory","volume":"121","author":"Sanderson","year":"2007","journal-title":"Behav. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0197-4580(88)80117-9","article-title":"Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders","volume":"9","author":"Geinisman","year":"1988","journal-title":"Neurobiol. Aging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1073\/pnas.96.9.5280","article-title":"Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway","volume":"96","author":"Bach","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.psych.093008.100359","article-title":"Structural Plasticity and Hippocampal Function","volume":"61","author":"Leuner","year":"2010","journal-title":"Annu. Rev. Psychol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tics.2012.04.005","article-title":"Memory aging and brain maintenance","volume":"16","author":"Nyberg","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pneurobio.2009.10.001","article-title":"The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders","volume":"89","author":"Nithianantharajah","year":"2009","journal-title":"Progress. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000457136","article-title":"The interplay between maternal nutrition and stress during pregnancy: Issues and considerations","volume":"70","author":"Lindsay","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.psyneuen.2014.12.008","article-title":"Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding","volume":"53","author":"Larrieu","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tips.2013.01.001","article-title":"The promise of N-acetylcysteine in neuropsychiatry","volume":"34","author":"Berk","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/nutrit\/nuy007","article-title":"Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: Considerations for future research","volume":"76","author":"McKee","year":"2018","journal-title":"Nutr. Rev."},{"doi-asserted-by":"crossref","unstructured":"Sarker, G., Litwan, K., Kastli, R., and Peleg-Raibstein, D. (2019). Maternal overnutrition during critical developmental periods leads to different health adversities in the offspring: Relevance of obesity, addiction and schizophrenia. Sci. Rep., 9, (In English).","key":"ref_76","DOI":"10.1038\/s41598-019-53652-x"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: Procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","year":"2001","journal-title":"Brain Research. Brain Res. Rev."},{"doi-asserted-by":"crossref","unstructured":"Bizon, J.L., Foster, T.C., Alexander, G.E., and Glisky, E.L. (2012). Characterizing cognitive aging of working memory and executive function in animal models. Front. Aging Neurosci., 4, (In English).","key":"ref_80","DOI":"10.3389\/fnagi.2012.00019"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pneurobio.2012.01.007","article-title":"Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity","volume":"96","author":"Foster","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1523\/JNEUROSCI.12-01-00021.1992","article-title":"The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro","volume":"12","author":"Davis","year":"1992","journal-title":"J. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: Central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neuroscience.2010.12.037","article-title":"Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring","volume":"176","author":"Naef","year":"2011","journal-title":"Neuroscience"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/oby.21306","article-title":"Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring","volume":"23","author":"Rivera","year":"2015","journal-title":"Obesity"},{"doi-asserted-by":"crossref","unstructured":"Guillaumin, M.C., and Peleg-Raibstein, D.J.N. (2023). Maternal over-and malnutrition and increased risk for addictive and eating disorders in the offspring. Nutrients, 15.","key":"ref_87","DOI":"10.3390\/nu15051095"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41398-018-0243-2","article-title":"Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition","volume":"8","author":"Sarker","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1210\/en.2010-0505","article-title":"Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes","volume":"151","author":"Vucetic","year":"2010","journal-title":"Endocrinology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1096\/fj.10-178392","article-title":"Maternal \u201cjunk-food\u201d feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring","volume":"25","author":"Ong","year":"2011","journal-title":"FASEB"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.biopsych.2008.06.007","article-title":"Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet","volume":"64","author":"Teegarden","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/bdr2.1173","article-title":"The impact of junk foods on the adolescent brain","volume":"109","author":"Reichelt","year":"2017","journal-title":"Birth Defects Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1037\/a0013600","article-title":"Relation of reward from food intake and anticipated food intake to obesity: A functional magnetic resonance imaging study","volume":"117","author":"Stice","year":"2008","journal-title":"J. Abnorm. Psychol."},{"doi-asserted-by":"crossref","unstructured":"Patterson, Z.R., and Abizaid, A.B. (2013). Stress induced obesity: Lessons from rodent models of stress. Front. Neurosci., 7.","key":"ref_94","DOI":"10.3389\/fnins.2013.00130"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10547","DOI":"10.1073\/pnas.1820810116","article-title":"Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs","volume":"116","author":"Sarker","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2020.01.023","article-title":"Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring","volume":"447","author":"Cirulli","year":"2020","journal-title":"Neuroscience"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1204529","article-title":"Interventions shown to aid executive function development in children 4 to 12 years old","volume":"333","author":"Diamond","year":"2011","journal-title":"Science"},{"doi-asserted-by":"crossref","unstructured":"Novick, J.M., Bunting, M.F., Dougherty, M.R., and Engle, R.W. (2019). 143Review of the Evidence on, and Fundamental Questions About, Efforts to Improve Executive Functions, Including Working Memory. Cognitive and Working Memory Training: Perspectives from Psychology, Neuroscience, and Human Development, Oxford University Press.","key":"ref_98","DOI":"10.1093\/oso\/9780199974467.003.0008"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107337","DOI":"10.1016\/j.ntt.2024.107337","article-title":"Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD","volume":"102","author":"Howard","year":"2024","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1111\/j.1460-9568.2007.05505.x","article-title":"Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats","volume":"25","author":"Glenn","year":"2007","journal-title":"Eur. J. Neurosci."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/6\/988\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:50:57Z","timestamp":1760028657000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/6\/988"}},"issued":{"date-parts":[[2025,3,12]]},"references-count":100,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["nu17060988"],"URL":"https:\/\/doi.org\/10.3390\/nu17060988","ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"published":{"date-parts":[[2025,3,12]]}},{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:40:11Z","timestamp":1759034411824,"version":"3.44.0"},"reference-count":99,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>The human gut microbiota constitutes the microbial ecosystem within the human gut. It consists of trillions of mostly prokaryotic microorganisms living in the gut lumen, which have an active metabolic role in the regulation of many host functions, including vitamin synthesis and energy extraction from indigestible fiber. Host diet is the main driver of gut microbial composition and metabolic output. Athletes and athletic individuals often supplement their diet with legal nutritional supplements to enhance performance, especially at the elite level. This review summarizes and critically comments on key evidence of the effects of the most common athletic nutritional supplements on the human gut microbiota, based on the most recent literature. We cover suggested changes in bacterial diversity or the relative abundance of specific bacterial taxa and effects of nutritional supplementation on bacterial metabolism. We focus on the molecular pathways involved, we discuss contrasting results and inconsistencies, and we note limitations and challenges in the field. 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Sofias 114, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The Impact of the Gut Microbiota on Human Health: An Integrative View","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-Gut Microbiota Metabolic Interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","article-title":"Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans","volume":"164","author":"Sender","year":"2016","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The Human Intestinal Microbiome in Health and Disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal Interactions of the Intestinal Microbiota and Immune System","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.immunol.021908.132657","article-title":"Regulatory Lymphocytes and Intestinal Inflammation","volume":"27","author":"Izcue","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/BJ20110326","article-title":"Intestinal Absorption of Water-Soluble Vitamins in Health and Disease","volume":"437","author":"Said","year":"2011","journal-title":"Biochem. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional Interactions between the Gut Microbiota and Host Metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet Rapidly and Reproducibly Alters the Human Gut Microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How Informative Is the Mouse for Human Gut Microbiota Research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kieser, S., Zdobnov, E.M., and Trajkovski, M. (2022). Comprehensive Mouse Microbiota Genome Catalog Reveals Major Difference to Its Human Counterpart. PLoS Comput. Biol., 18.","DOI":"10.1371\/journal.pcbi.1009947"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chom.2021.12.003","article-title":"The Mouse Gastrointestinal Bacteria Catalogue Enables Translation between the Mouse and Human Gut Microbiotas via Functional Mapping","volume":"30","author":"Forster","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zeppa, S.D., Agostini, D., Gervasi, M., Annibalini, G., Amatori, S., Ferrini, F., Sisti, D., Piccoli, G., Barbieri, E., and Sestili, P. (2020). Mutual Interactions among Exercise, Sport Supplements and Microbiota. Nutrients, 12.","DOI":"10.3390\/nu12010017"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/cvr\/cvz135","article-title":"The Intestinal Microbiota and Cardiovascular Disease","volume":"115","author":"Katsimichas","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1136\/gutjnl-2013-306541","article-title":"Exercise and Associated Dietary Extremes Impact on Gut Microbial Diversity","volume":"63","author":"Clarke","year":"2014","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3945\/ajcn.117.158816","article-title":"Quantity and Source of Dietary Protein Influence Metabolite Production by Gut Microbiota and Rectal Mucosa Gene Expression: A Randomized, Parallel, Double-Blind Trial in Overweight Humans","volume":"106","author":"Beaumont","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bel Lassen, P., Belda, E., Prifti, E., Dao, M.C., Specque, F., Henegar, C., Rinaldi, L., Wang, X., Kennedy, S.P., and Zucker, J.D. (2021). Protein Supplementation during an Energy-Restricted Diet Induces Visceral Fat Loss and Gut Microbiota Amino Acid Metabolism Activation: A Randomized Trial. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-94916-9"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Moreno-P\u00e9rez, D., Bressa, C., Bail\u00e9n, M., Hamed-Bousdar, S., Naclerio, F., Carmona, M., P\u00e9rez, M., Gonz\u00e1lez-Soltero, R., Montalvo-Lominchar, M.G., and Caraba\u00f1a, C. (2018). Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study. Nutrients, 10.","DOI":"10.3390\/nu10030337"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.nut.2015.01.004","article-title":"Oral Supplementation with L-Glutamine Alters Gut Microbiota of Obese and Overweight Adults: A Pilot Study","volume":"31","author":"Zambom","year":"2015","journal-title":"Nutrition"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1039\/D4FO00428K","article-title":"Effect of Inulin, Galacto-Oligosaccharides, and Polyphenols on the Gut Microbiota, with a Focus on Akkermansia Muciniphila","volume":"15","author":"Tian","year":"2024","journal-title":"Food Funct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3945\/ajcn.110.000075","article-title":"Prebiotic Evaluation of Cocoa-Derived Flavanols in Healthy Humans by Using a Randomized, Controlled, Double-Blind, Crossover Intervention Study","volume":"93","author":"Tzounis","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3945\/ajcn.111.027847","article-title":"Influence of Red Wine Polyphenols and Ethanol on the Gut Microbiota Ecology and Biochemical Biomarkers","volume":"95","author":"Murri","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12815","DOI":"10.1021\/jf2028686","article-title":"Six-Week Consumption of a Wild Blueberry Powder Drink Increases Bifidobacteria in the Human Gut","volume":"59","author":"Vendrame","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102158","DOI":"10.1016\/j.cdnut.2024.102158","article-title":"Effects of a Flavonoid-Rich Blackcurrant Beverage on Markers of the Gut-Brain Axis in Healthy Females: Secondary Findings From a 4-Week Randomized Crossover Control Trial","volume":"8","author":"Gillies","year":"2024","journal-title":"Curr. Dev. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2315633","DOI":"10.1080\/19490976.2024.2315633","article-title":"Gut Enterotype-Dependent Modulation of Gut Microbiota and Their Metabolism in Response to Xanthohumol Supplementation in Healthy Adults","volume":"16","author":"Jamieson","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/ajcn\/nqz075","article-title":"Effects of Aronia Berry (Poly)Phenols on Vascular Function and Gut Microbiota: A Double-Blind Randomized Controlled Trial in Adult Men","volume":"110","author":"Istas","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41467-024-46116-y","article-title":"Effect of Gut Microbiome Modulation on Muscle Function and Cognition: The PROMOTe Randomised Controlled Trial","volume":"15","author":"Bowyer","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Otten, A.T., Bourgonje, A.R., Peters, V., Alizadeh, B.Z., Dijkstra, G., and Harmsen, H.J.M. (2021). Vitamin c Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut\u2014A Pilot Study. Antioxidants, 10.","DOI":"10.3390\/antiox10081278"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e1875774","DOI":"10.1080\/19490976.2021.1875774","article-title":"Effects of Colon-Targeted Vitamins on the Composition and Metabolic Activity of the Human Gut Microbiome\u2014A Pilot Study","volume":"13","author":"Pham","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbi.2025.03.032","article-title":"Gut Microbiota Links Vitamin C Supplementation to Enhanced Mental Vitality in Healthy Young Adults with Suboptimal Vitamin C Status: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"128","author":"Sim","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103964","DOI":"10.1016\/j.numecd.2025.103964","article-title":"Vitamin E Ameliorates Blood Cholesterol Level and Alters Gut Microbiota Composition: A Randomized Controlled Trial","volume":"35","author":"Chen","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134989","DOI":"10.1016\/j.foodchem.2022.134989","article-title":"Effect of Two-Week Red Beetroot Juice Consumption on Modulation of Gut Microbiota in Healthy Human Volunteers\u2014A Pilot Study","volume":"406","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.clnu.2024.11.023","article-title":"Beetroot Juice Intake Positively Influenced Gut Microbiota and Inflammation but Failed to Improve Functional Outcomes in Adults with Long COVID: A Pilot Randomized Controlled Trial","volume":"43","author":"Calvani","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Dai, A., Hoffman, K., Xu, A.A., Gurwara, S., White, D.L., Kanwal, F., Jang, A., El-Serag, H.B., Petrosino, J.F., and Jiao, L. (2023). The Association between Caffeine Intake and the Colonic Mucosa-Associated Gut Microbiota in Humans\u2014A Preliminary Investigation. Nutrients, 15.","DOI":"10.3390\/nu15071747"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, S., Salazar, N., Ruiz-Saavedra, S., G\u00f3mez-Mart\u00edn, M., de los Reyes-Gavil\u00e1n, C.G., and Gueimonde, M. (2020). Long-Term Coffee Consumption Is Associated with Fecal Microbial Composition in Humans. Nutrients, 12.","DOI":"10.3390\/nu12051287"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shearer, J., Shah, S., MacInnis, M.J., Shen-Tu, G., and Mu, C. (2024). Dose-Responsive Effects of Iron Supplementation on the Gut Microbiota in Middle-Aged Women. Nutrients, 16.","DOI":"10.3390\/nu16060786"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1550-2783-9-45","article-title":"Probiotic Supplementation Affects Markers of Intestinal Barrier, Oxidation, and Inflammation in Trained Men; a Randomized, Double-Blinded, Placebo-Controlled Trial","volume":"9","author":"Lamprecht","year":"2012","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Roberts, J.D., Suckling, C.A., Peedle, G.Y., Murphy, J.A., Dawkins, T.G., and Roberts, M.G. (2016). An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic\/Prebiotic, Antioxidant Intervention. Nutrients, 8.","DOI":"10.3390\/nu8110733"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e14276","DOI":"10.14814\/phy2.14276","article-title":"UCC118 Supplementation Reduces Exercise-Induced Gastrointestinal Permeability and Remodels the Gut Microbiome in Healthy Humans","volume":"7","author":"Axelrod","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lee, M.C., Hsu, Y.J., Chen, M.T., Kuo, Y.W., Lin, J.H., Hsu, Y.C., Huang, Y.Y., Li, C.M., Tsai, S.Y., and Hsia, K.C. (2024). Efficacy of Lactococcus Lactis Subsp. Lactis LY-66 and Lactobacillus Plantarum PL-02 in Enhancing Explosive Strength and Endurance: A Randomized, Double-Blinded Clinical Trial. Nutrients, 16.","DOI":"10.3390\/nu16121921"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1136\/gutjnl-2017-314968","article-title":"A Randomised Trial of the Effect of Omega-3 Polyunsaturated Fatty Acid Supplements on the Human Intestinal Microbiota","volume":"67","author":"Watson","year":"2018","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pu, S., Khazanehei, H., Jones, P.J., and Khafipour, E. (2016). Interactions between Obesity Status and Dietary Intake of Monounsaturated and Polyunsaturated Oils on Human Gut Microbiome Profiles in the Canola Oil Multicenter Intervention Trial (COMIT). Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01612"},{"key":"ref_44","unstructured":"(2025, May 27). NIH Dietary Supplements for Exercise and Athletic Performance: Fact Sheet for Consumers, Available online: https:\/\/ods.od.nih.gov\/factsheets\/ExerciseAndAthleticPerformance-HealthProfessional\/."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jand.2015.12.006","article-title":"Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance","volume":"116","author":"Thomas","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1080\/02640414.2011.619204","article-title":"Dietary Protein for Athletes: From Requirements to Optimum Adaptation","volume":"29","author":"Phillips","year":"2011","journal-title":"J. Sports Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2903\/j.efsa.2012.2557","article-title":"Scientific Opinion on Dietary Reference Values for Protein","volume":"10","author":"Agostoni","year":"2012","journal-title":"EFSA J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12970-017-0189-4","article-title":"International Society of Sports Nutrition Position Stand: Protein and Exercise","volume":"14","author":"Kerksick","year":"2017","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nolte, S., Kr\u00fcger, K., Lenz, C., and Zentgraf, K. (2023). Optimizing the Gut Microbiota for Individualized Performance Development in Elite Athletes. Biology, 12.","DOI":"10.3390\/biology12121491"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/1389203719666180514145437","article-title":"Dietary Protein and Gut Microbiota Composition and Function","volume":"20","author":"Zhao","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2174\/1389203721666200212095503","article-title":"Gastrointestinal Interaction between Dietary Amino Acids and Gut Microbiota: With Special Emphasis on Host Nutrition","volume":"21","author":"Abdallah","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.clnu.2018.09.016","article-title":"High-Protein Diets for Weight Management: Interactions with the Intestinal Microbiota and Consequences for Gut Health. A Position Paper by the My New Gut Study Group","volume":"38","author":"Blachier","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Beaumont, M., Roura, E., Lambert, W., Turni, C., Michiels, J., and Chalvon-Demersay, T. (2022). Selective Nourishing of Gut Microbiota with Amino Acids: A Novel Prebiotic Approach?. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1066898"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, Function and Diversity of the Healthy Human Microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.1073\/pnas.2000047117","article-title":"Microbial Tryptophan Metabolites Regulate Gut Barrier Function via the Aryl Hydrocarbon Receptor","volume":"117","author":"Scott","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2014.10.032","article-title":"Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells","volume":"9","author":"Chimerel","year":"2014","journal-title":"Cell Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s42255-025-01246-5","article-title":"Human Gut Microbial Aromatic Amino Acid and Related Metabolites Prevent Obesity through Intestinal Immune Control","volume":"7","author":"Jiang","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"G1030","DOI":"10.1152\/ajpgi.00149.2010","article-title":"Colon Luminal Content and Epithelial Cell Morphology Are Markedly Modified in Rats Fed with a High-Protein Diet","volume":"299","author":"Andriamihaja","year":"2010","journal-title":"Am. J. Physiol.\u2014Gastrointest. Liver Physiol."},{"key":"ref_60","first-page":"68","article-title":"Cysteine-Derived Hydrogen Sulfide and Gut Health: A Matter of Endogenous or Bacterial Origin","volume":"22","author":"Blachier","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ebner, F., W\u00f6ckel, A., Schwentner, L., Blettner, M., Janni, W., Kreienberg, R., and Wischnewsky, M. (2019). Does the Number of Removed Axillary Lymphnodes in High Risk Breast Cancer Patients Influence the Survival?. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5292-2"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wu, S., Bhat, Z.F., Gounder, R.S., Ahmed, I.A.M., Al-Juhaimi, F.Y., Ding, Y., and Bekhit, A.E.D.A. (2022). Effect of Dietary Protein and Processing on Gut Microbiota\u2014A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14030453"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gutjnl-2020-323715","article-title":"Dietary Macronutrients and the Gut Microbiome: A Precision Nutrition Approach to Improve Cardiometabolic Health","volume":"71","author":"Jardon","year":"2022","journal-title":"Gut"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1038\/s41564-024-01856-x","article-title":"Gut Physiology and Environment Explain Variations in Human Gut Microbiome Composition and Metabolism","volume":"9","author":"Laursen","year":"2024","journal-title":"Nat. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1113\/jphysiol.2013.267419","article-title":"Vitamin C and E Supplementation Hampers Cellular Adaptation to Endurance Training in Humans: A Double-Blind, Randomised, Controlled Trial","volume":"592","author":"Paulsen","year":"2014","journal-title":"J. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Paulsen, G., Cumming, K.T., Hamarsland, H., B\u00f8rsheim, E., Berntsen, S., and Raastad, T. (2014). Can Supplementation with Vitamin C and E Alter Physiological Adaptations to Strength Training?. BMC Sports Sci. Med. Rehabil., 6.","DOI":"10.1186\/2052-1847-6-28"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1365-201X.1997.00198.x","article-title":"Effects of Ubiquinone-10 Supplementation and High Intensity Training on Physical Performance in Humans","volume":"161","author":"Malm","year":"1997","journal-title":"Acta Physiol. Scand."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09646","article-title":"Bifidobacteria Can Protect from Enteropathogenic Infection through Production of Acetate","volume":"469","author":"Fukuda","year":"2011","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kawabata, K., Yoshioka, Y., and Terao, J. (2019). Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols. Molecules, 24.","DOI":"10.3390\/molecules24020370"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jnutbio.2018.04.001","article-title":"Impact of Tart Cherries Polyphenols on the Human Gut Microbiota and Phenolic Metabolites in Vitro and in Vivo","volume":"59","author":"Pottgen","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1007\/s00394-017-1542-8","article-title":"Decaffeinated Green and Black Tea Polyphenols Decrease Weight Gain and Alter Microbiome Populations and Function in Diet-Induced Obese Mice","volume":"57","author":"Henning","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mao, T., Zhang, Y., Kaushik, R., and Mohan, M.S. (2024). Effects of Polyphenols on Gut Microbiota and Inflammatory Markers in Individuals with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit. Rev. Food Sci. Nutr.","DOI":"10.1080\/10408398.2024.2436644"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.humic.2018.07.002","article-title":"Linking Gut Redox to Human Microbiome","volume":"10","author":"Million","year":"2018","journal-title":"Hum. Microbiome J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.niox.2005.08.002","article-title":"Gastrointestinal Bacteria Generate Nitric Oxide from Nitrate and Nitrite","volume":"13","author":"Sobko","year":"2005","journal-title":"Nitric Oxide\u2014Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tiso, M., and Schechter, A.N. (2015). Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria under Physiological Conditions. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127490"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","article-title":"Creatine and Creatinine Metabolism","volume":"80","author":"Wyss","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2237952","DOI":"10.1080\/15502783.2023.2237952","article-title":"International Society of Sports Nutrition Position Stand: Coffee and Sports Performance","volume":"20","author":"Lowery","year":"2023","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/ptr.6185","article-title":"Guarana (Paullinia Cupana Mart.) Alters Gut Microbiota and Modulates Redox Status, Partially via Caffeine in Wistar Rats","volume":"32","author":"Moresco","year":"2018","journal-title":"Phyther. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1038\/s41564-024-01858-9","article-title":"Coffee Consumption Is Associated with Intestinal Lawsonibacter Asaccharolyticus Abundance and Prevalence across Multiple Cohorts","volume":"9","author":"Manghi","year":"2024","journal-title":"Nat. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e05273-22","DOI":"10.1128\/spectrum.05273-22","article-title":"The Effect of Oral Iron Supplementation on Gut Microbial Composition: A Secondary Analysis of a Double-Blind, Randomized Controlled Trial among Cambodian Women of Reproductive Age","volume":"11","author":"Nearing","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_81","first-page":"1","article-title":"Effects of Anxiety, Stress and Perceived Social Support on Depression and Loneliness Among Older People During the COVID-19 Pandemic: A Cross-Sectional Path Analysis","volume":"61","author":"Farhang","year":"2024","journal-title":"Sage J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2441775","DOI":"10.1080\/15502783.2024.2441775","article-title":"International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids","volume":"22","author":"Heileson","year":"2025","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zou, B., Zhao, D., Zhou, S., Kang, J.X., and Wang, B. (2025). Insight into the Effects of Omega-3 Fatty Acids on Gut Microbiota: Impact of a Balanced Tissue Omega-6\/Omega-3 Ratio. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1575323"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biochi.2017.06.015","article-title":"Exogenous Fatty Acid Metabolism in Bacteria","volume":"141","author":"Yao","year":"2017","journal-title":"Biochimie"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e70713","DOI":"10.1096\/fj.202500752RR","article-title":"Human Gut Microbes Produce EPA- and DHA-Derived Oxylipins, but Not N-Acyl-Ethanolamines, from Fish Oil","volume":"39","author":"Roussel","year":"2025","journal-title":"FASEB J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert Consensus Document: The International Scientific Association for Probiotics and Prebiotics Consensus Statement on the Scope and Appropriate Use of the Term Probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2185034","DOI":"10.1080\/19490976.2023.2185034","article-title":"Emerging Issues in Probiotic Safety: 2023 Perspectives","volume":"15","author":"Merenstein","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/19490976.2019.1586039","article-title":"Probiotics in the Next-Generation Sequencing Era","volume":"11","author":"Suez","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","article-title":"Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features","volume":"174","author":"Zmora","year":"2018","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1600240","DOI":"10.1002\/mnfr.201600240","article-title":"Probiotics, Gut Microbiota, and Their Influence on Host Health and Disease","volume":"61","author":"Delgado","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00243.2009","article-title":"Probiotic Bacteria and Intestinal Epithelial Barrier Function","volume":"298","author":"Ohland","year":"2010","journal-title":"Am. J. Physiol.\u2014Gastrointest. Liver Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"You, Y., Chen, Y., Wei, M., Tang, M., Lu, Y., Zhang, Q., and Cao, Q. (2024). Mediation Role of Recreational Physical Activity in the Relationship between the Dietary Intake of Live Microbes and the Systemic Immune-Inflammation Index: A Real-World Cross-Sectional Study. Nutrients, 16.","DOI":"10.3390\/nu16060777"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41430-018-0135-9","article-title":"A Review of Probiotic Supplementation in Healthy Adults: Helpful or Hype?","volume":"73","author":"Khalesi","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/19390211.2023.2293842","article-title":"Effect of Probiotic Supplementation on Gut Microbiota and Sport Performance in Athletes and Physically Active Individuals: A Systematic Review","volume":"21","author":"Porepp","year":"2024","journal-title":"J. Diet. Suppl."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jshs.2022.12.012","article-title":"A Systematic Scoping Review of Study Methodology for Randomized Controlled Trials Investigating Probiotics in Athletic and Physically Active Populations","volume":"13","author":"Mohr","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1758-2229.13145","article-title":"The Use of Different 16S RRNA Gene Variable Regions in Biogeographical Studies","volume":"15","author":"Varliero","year":"2023","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Aladid, R., Fern\u00e1ndez-Barat, L., Alcaraz-Serrano, V., Bueno-Freire, L., V\u00e1zquez, N., Pastor-Ib\u00e1\u00f1ez, R., Palomeque, A., Oscanoa, P., and Torres, A. (2023). Determining the Most Accurate 16S RRNA Hypervariable Region for Taxonomic Identification from Respiratory Samples. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-30764-z"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2388085","DOI":"10.1080\/15502783.2024.2388085","article-title":"Do Probiotics Mitigate GI-Induced Inflammation and Perceived Fatigue in Athletes? A Systematic Review","volume":"21","author":"Kearns","year":"2024","journal-title":"J. Int. Soc. Sports Nutr."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/19\/3071\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:10:53Z","timestamp":1759032653000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/19\/3071"}},"issued":{"date-parts":[[2025,9,26]]},"references-count":99,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["nu17193071"],"URL":"https:\/\/doi.org\/10.3390\/nu17193071","ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"published":{"date-parts":[[2025,9,26]]}},{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:11:01Z","timestamp":1760764261074,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["2015\/19\/B\/NZ9\/01054."],"award-info":[{"award-number":["2015\/19\/B\/NZ9\/01054."]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Growing evidence highlights the beneficial effects of flavonoids, including anthocyanins, as key components in reducing cardiovascular risk, and emphasizes that incorporating anthocyanin-rich fruits into the daily diet significantly impacts public health. Methods: The effect of bioactive polyphenols from raspberry fruit (RBF) on molecular pathways in inflammation was studied in activated RAW 264.7 macrophages and their protective potential against endothelial dysfunction was analyzed using TNF-\u03b1-induced human umbilical vein endothelial cells (HUVECs). Results: The results have shown that RBF extract, along with its anthocyanin and polyphenol fractions, has a significant anti-inflammatory effect in macrophage cell culture by inhibiting the LPS-induced expression of pro-inflammatory genes, including IL-6, IL-1\u03b2, TNF-\u03b1, and NF-\u03baB. Moreover, RBF and both fractions have demonstrated a protective effect on endothelial function by decreasing the expression of several inflammation-related genes and adhesion molecules, such as IL-6, IL-1\u03b2, VCAM-1, ICAM-1, and SELE, in TNF-\u03b1-induced HUVECs. Conclusions: The consumption of RBF and\/or polyphenol-rich extracts may help prevent the onset of early atherosclerosis. This is attributed to their ability to improve inflammation status and enhance vascular endothelial function. Given the strong anti-inflammatory properties of RBF, incorporating them into a daily diet could significantly reduce the risk of non-communicable diseases related to inflammation.<\/jats:p>","DOI":"10.3390\/nu17203257","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:33:22Z","timestamp":1760632402000},"page":"3257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory Effect of Raspberry (Rubus idaeus L.) 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Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: A dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1172\/JCI75005","article-title":"Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression","volume":"127","author":"Rahman","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/ATVBAHA.118.310958","article-title":"Novel antiatherosclerotic therapies","volume":"39","author":"Libby","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_8","first-page":"262","article-title":"The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation","volume":"269","author":"Celermajer","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMra1203528","article-title":"Behavioral and dietary risk factors for noncommunicable diseases","volume":"369","author":"Ezzati","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mam.2017.05.002","article-title":"Berry anthocyanin intake and cardiovascular health","volume":"61","author":"Cassidy","year":"2018","journal-title":"Mol. Aspects. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3945\/an.115.009639","article-title":"Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links","volume":"7","author":"Sandhu","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1039\/c1fo10047e","article-title":"Raspberry juice consumption, oxidative stress and reduction of atherosclerosis risk factors in hypercholesterolemic golden Syrian hamsters","volume":"2","author":"Suh","year":"2011","journal-title":"Food Funct."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0973-1296.75885","article-title":"The antihypertensive effect of ethyl acetate extract from red raspberry fruit in hypertensive rats","volume":"7","author":"Jia","year":"2011","journal-title":"Pharmacogn. Mag."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103568","DOI":"10.1016\/j.jff.2019.103568","article-title":"Raspberry (Rubus idaeus L.) fruit extract decreases oxidation markers, improves lipid metabolism and reduces adipose tissue inflammation in hypertrophied 3T3-L1 adipocytes","volume":"62","author":"Kowalska","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1021\/jf203456w","article-title":"Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model","volume":"60","author":"Li","year":"2012","journal-title":"J. Agric. Food. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.foodchem.2013.10.032","article-title":"Cranberries (Oxycoccus quadripetalus) inhibit adipogenesis and lipogenesis in 3T3-L1 cells","volume":"148","author":"Kowalska","year":"2014","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kowalska, K., Dembczy\u0144ski, R., Go\u0142\u0105bek, A., Olkowicz, M., and Olejnik, A. (2021). ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction. Nutrients, 13.","DOI":"10.3390\/nu13030885"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/CS20080196","article-title":"Role of TNF-alpha in vascular dysfunction","volume":"116","author":"Zhang","year":"2009","journal-title":"Clin. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Speer, H., D\u2019Cunha, N.M., Alexopoulos, N.I., McKune, A.J., and Naumovski, N. (2020). Anthocyanins and Human Health-A Focus on Oxidative Stress, Inflammation and Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9050366"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Stevens, T.W., Khalaf, F.K., Soehnlen, S., Hegde, P., Storm, K., Meenakshisundaram, C., Dworkin, L.D., Malhotra, D., Haller, S.T., and Kennedy, D.J. (2022). Dirty Jobs: Macrophages at the Heart of Cardiovascular Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071579"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/nutrit\/nuu066","article-title":"Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-\u03baB and mitogen-activated protein kinase signaling cascades","volume":"73","author":"Vendrame","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1038\/srep06234","article-title":"Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis","volume":"4","author":"Li","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jnutbio.2013.12.001","article-title":"Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-\u03baB independent of NRF2-mediated mechanism","volume":"25","author":"Lee","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00011-010-0183-7","article-title":"Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells","volume":"59","author":"Zhang","year":"2010","journal-title":"Inflamm. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.foodchem.2017.01.097","article-title":"Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db\/db) mice","volume":"227","author":"Noratto","year":"2017","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e114790","DOI":"10.1371\/journal.pone.0114790","article-title":"Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet","volume":"9","author":"Mykkanen","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000497226","article-title":"Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes","volume":"74","author":"Schell","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.freeradbiomed.2020.02.004","article-title":"Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-\u03b3 gene expression in metabolic syndrome subjects","volume":"150","author":"Aboonabi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/genes4020101","article-title":"The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation","volume":"4","author":"Moens","year":"2013","journal-title":"Genes"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Land Lail, H., Feresin, R.G., Hicks, D., Stone, B., Price, E., and Wanders, D. (2021). Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models. Nutrients, 13.","DOI":"10.3390\/nu13020334"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"785220","DOI":"10.3389\/fphar.2021.785220","article-title":"Roles of Macrophages in Atherogenesis","volume":"12","author":"Farahi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.numecd.2012.06.005","article-title":"Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial","volume":"23","author":"Zhu","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1021\/jf1029515","article-title":"Cyanidin-3-O-glucoside protection against TNF-a-induced endothelial dysfunction: Involvement of nuclear factor-\u0138B signaling","volume":"58","author":"Speciale","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5582\/bst.2016.01056","article-title":"Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia","volume":"10","author":"Yang","year":"2016","journal-title":"Biosci. Trends"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nutres.2010.06.016","article-title":"Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome","volume":"30","author":"Basu","year":"2010","journal-title":"Nutr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/ptr.5154","article-title":"Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome","volume":"28","author":"Jeong","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1039\/C9FO01426H","article-title":"Dietary berries, insulin resistance and type 2 diabetes: An overview of human feeding trials","volume":"10","author":"Calvano","year":"2019","journal-title":"Food Funct."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/20\/3257\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:43:56Z","timestamp":1760762636000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/20\/3257"}},"issued":{"date-parts":[[2025,10,16]]},"references-count":37,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["nu17203257"],"URL":"https:\/\/doi.org\/10.3390\/nu17203257","ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"published":{"date-parts":[[2025,10,16]]}},{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:03:07Z","timestamp":1760234587878,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010566","name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI-0067-2018"],"award-info":[{"award-number":["PI-0067-2018"]}],"id":[{"id":"10.13039\/501100010566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Coronary heart disease is one of the main causes of morbimortality around the world. Patients that survive a coronary event suffer a high risk of readmission, relapse and mortality, attributed to the sub-optimal control of cardiovascular risk factors (CVRF), which highlights the need to improve secondary prevention strategies aimed at improving their lifestyle and adherence to treatment. Through a randomized controlled clinical trial, this study aims to evaluate the effect of an intervention involving an online health application supported by a mobile telephone or tablet (mHealth) on lifestyle (diet, physical activity, and tobacco consumption) and treatment adherence among people with coronary heart disease after percutaneous coronary intervention. The sample will comprise 240 subjects (120 in each arm: intervention and usual care). They are assessed immediately and nine months after their hospital discharge about sociodemographic, clinical, CVRF, lifestyle, and treatment adherence characteristics. The educative intervention, involving a follow-up and self-monitoring, will be performed using an online mHealth tool consisting of an application for mobile phones and tablets. The quantitative primary outcomes from the two groups will be compared using an analysis of covariance (ANCOVA) adjusted for age and gender. A multivariate analysis will be performed to examine the association of the intervention with lifestyle habits, the control of CVRFs, and outcomes after discharge in terms of the use of health services, emergency visits, cardiovascular events and readmissions.<\/jats:p>","DOI":"10.3390\/nu13061818","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T04:30:46Z","timestamp":1622089846000},"page":"1818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lifestyle and Treatment Adherence Intervention after a Coronary Event Based on an Interactive Web Application (EVITE): Randomized Controlled Clinical Trial Protocol"],"prefix":"10.3390","volume":"13","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"Bernal-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Faculty of Nursing and Physiotherapy, University of C\u00e1diz, 11009 C\u00e1diz, Spain"},{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Calle-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Cardiology Unit, Puerta del Mar Hospital, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-0478","authenticated-orcid":false,"given":"Alejandro","family":"Guti\u00e9rrez-Barrios","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Cardiology Unit, Puerta del Mar Hospital, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Cardiology Unit, Puerta del Mar Hospital, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Solano-Mulero","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Puerta del Mar Hospital, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Rodr\u00edguez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Physiotherapy, University of C\u00e1diz, 11009 C\u00e1diz, Spain"},{"name":"Biomedicine, Biotechnology and Public Health Department, University of Cadiz, 11003 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-0761","authenticated-orcid":false,"given":"Josep A.","family":"Tur","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands, IDISBA & CIBEROBN, 07122 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-474X","authenticated-orcid":false,"given":"Rafael","family":"V\u00e1zquez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Cardiology Unit, Puerta del Mar Hospital, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-6031","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Santi-Cano","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Physiotherapy, University of C\u00e1diz, 11009 C\u00e1diz, Spain"},{"name":"Institute of Biomedical Research and Innovation of C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"},{"name":"Research Group on Nutrition, Molecular, Pathophysiological and Social Issues, University of C\u00e1diz, 11009 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, March 06). The Top 10 Causes of Death. Fact Sheets 2020. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e002837","DOI":"10.1136\/bmjopen-2013-002837","article-title":"Modelling the impact of specific food policy options on coronary heart disease and stroke deaths in Ireland","volume":"3","author":"Kabir","year":"2013","journal-title":"BMJ Open"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMra1210816","article-title":"Drug-Eluting Coronary-Artery Stents","volume":"368","author":"Stefanini","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.recesp.2012.10.019","article-title":"Actualizaci\u00f3n en cardiopat\u00eda isqu\u00e9mica y cuidados cr\u00edticos cardiol\u00f3gicos","volume":"66","author":"Peris","year":"2013","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.recesp.2011.09.009","article-title":"Mortalidad a largo plazo y reingreso hospitalario tras infarto agudo de miocardio: Un estudio de seguimiento de ocho a\u00f1os","volume":"65","author":"Cordero","year":"2012","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2047487319893035","article-title":"Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology","volume":"27","author":"Piepoli","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s40273-020-00936-0","article-title":"Novel Treatment Strategies for Secondary Prevention of Cardiovascular Disease: A Systematic Review of Cost-Effectiveness","volume":"38","author":"Marquina","year":"2020","journal-title":"PharmacoEconomics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/heartjnl-2017-312809","article-title":"Cost-effectiveness of cardiac rehabilitation: A systematic review","volume":"104","author":"Shields","year":"2018","journal-title":"Heart"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1093\/eurheartj\/ehs210","article-title":"Cost-effectiveness of optimizing prevention in patients with coronary heart disease: The EUROASPIRE III health economics project","volume":"33","author":"Kotseva","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/eurheartj\/ehs092","article-title":"European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"33","author":"Perk","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(08)60868-5","article-title":"Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: A paired, cluster-randomised controlled trial","volume":"371","author":"Wood","year":"2008","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijnurstu.2018.04.012","article-title":"Effectiveness of nurse-led patient-centered care behavioral risk modification on secondary prevention of coronary heart disease: A systematic review","volume":"84","author":"Chiang","year":"2018","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCOUTCOMES.111.961573","article-title":"Community Outreach and Cardiovascular Health (COACH) Trial: A randomized, controlled trial of nurse practitioner\/community health worker cardiovascular disease risk reduction in urban community health centers","volume":"4","author":"Allen","year":"2011","journal-title":"Cardiovasc. Qual. Outcomes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1136\/heartjnl-2013-303989","article-title":"Effect of a nurse-coordinated prevention programme on cardiovascular risk after an acute coronary syndrome: Main results of the RESPONSE randomised trial","volume":"99","author":"Jorstad","year":"2013","journal-title":"Heart"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103415","DOI":"10.1016\/j.ijnurstu.2019.103415","article-title":"The role of community-based nursing interventions in improving outcomes for individuals with cardiovascular disease: A systematic review","volume":"100","author":"Han","year":"2019","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_18","unstructured":"International Telecommunication Union (2021, March 06). Measuring the Information Society Report. Available online: http:\/\/www.itu.int\/en\/ITU-D\/Statistics\/Documents\/publications\/mis2014\/MIS2014_without_Annex_4.Pdf."},{"key":"ref_19","unstructured":"International Telecommunication Union (2021, March 06). Digital Trends in Europe 2021. Society Report. Available online: https:\/\/www.itu.int\/pub\/D-IND."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIR.0000000000000232","article-title":"Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A scientific statement from the American Heart Association","volume":"132","author":"Burke","year":"2015","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e002239","DOI":"10.1161\/JAHA.115.002239","article-title":"mActive: A Randomized Clinical Trial of an Automated mHealth Intervention for Physical Activity Promotion","volume":"4","author":"Martin","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1001\/jama.2015.10945","article-title":"Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients with Coronary Heart Disease","volume":"314","author":"Chow","year":"2015","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1001\/jamainternmed.2015.7667","article-title":"Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease","volume":"176","author":"Thakkar","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ehjqcco\/qcw018","article-title":"The role of mHealth for improving medication adherence in patients with cardiovascular disease: A systematic review","volume":"2","author":"Gandapur","year":"2016","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e202165","DOI":"10.1001\/jamanetworkopen.2020.2165","article-title":"Effect of Smartphone-Enabled Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial Infarction: A randomized clinical trial","volume":"3","author":"Treskes","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1177\/2047487320905717","article-title":"Long-term follow-up with a smartphone application improves exercise capacity post cardiac rehabilitation: A randomized controlled trial","volume":"27","author":"Lunde","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ahj.2016.05.005","article-title":"Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study","volume":"178","author":"Johnston","year":"2016","journal-title":"Am. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cjca.2016.08.017","article-title":"Effect of Mobile Health Interventions on the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis","volume":"33","author":"Gandhi","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/2047487317750913","article-title":"Effectiveness, acceptability and usefulness of mobile applications for cardiovascular disease self-management: Systematic review with meta-synthesis of quantitative and qualitative data","volume":"25","author":"Coorey","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/jan.14272","article-title":"Effect of eHealth cardiac rehabilitation on health outcomes of coronary heart disease patients: A systematic review and meta-analysis","volume":"76","author":"Su","year":"2019","journal-title":"J. Adv. Nurs."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"i1174","DOI":"10.1136\/bmj.i1174","article-title":"Guidelines for reporting of health interventions using mobile phones: Mobile health (mHealth) evidence reporting and assessment (mERA) checklist","volume":"352","author":"Agarwal","year":"2016","journal-title":"BMJ"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Gonz\u00e1lez, M.A., Garc\u00eda-Arellano, A., Toledo, E., Salas-Salvad\u00f3, J., Buil-Cosiales, P., Corella, D., Covas, M.I., Schroder, H., Ar\u00f3s, F., and G\u00f3mez-Gracia, E. (2012). A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects: The PREDIMED Trial. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043134"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1017\/S0007114509993837","article-title":"Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain","volume":"103","author":"Zazpe","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/oxfordjournals.aje.a116966","article-title":"Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Men","volume":"139","author":"Elosua","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00005768-200008000-00011","article-title":"Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Women","volume":"32","author":"Elosua","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1037\/0003-066X.47.9.1102","article-title":"In search of how people change: Applications to addictive behaviors","volume":"47","author":"Prochaska","year":"1992","journal-title":"Am. Psychol."},{"key":"ref_38","unstructured":"Miller, W., and Rollnick, S. (2013). Motivational Interviewing: Preparing People for Change, Guilford Publicatins, Inc.. [3rd ed.]."},{"key":"ref_39","first-page":"1","article-title":"Gu\u00edas alimentarias para la poblaci\u00f3n espa\u00f1ola (SENC, 2016); la nueva pir\u00e1mide de la alimentaci\u00f3n saludable","volume":"33","author":"Bartrina","year":"2016","journal-title":"Nutr. Hosp."},{"key":"ref_40","unstructured":"Dub\u00e9, L., Bechara, A., Dagher, A., Drewnowski, A., Lebel, J., James, P., and Yada, R.Y. (2010). Stealth interventions for obesity prevention and control: Motivating behavior change. Obesity Prevention: The Role of Brain and Society on Individual Behavior, Academic Press. Chapter 25."},{"key":"ref_41","first-page":"169","article-title":"Social Foundations of Thought and Action: A Social-Cognitive View","volume":"12","author":"Locke","year":"1987","journal-title":"Acad. Manag. Rev."},{"key":"ref_42","unstructured":"World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic Report of a WHO Consultation on Obesity, World Health Organization. Technical Report Series."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0306-4603(78)90024-2","article-title":"Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment","volume":"3","year":"1978","journal-title":"Addict. Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0212-6567(00)78460-5","article-title":"Valor de los cuestionarios breves en la predicci\u00f3n del abandono del tabaco en atenci\u00f3n primaria","volume":"25","author":"Martin","year":"2000","journal-title":"Atenci\u00f3n Primaria"},{"key":"ref_46","unstructured":"Spanish Food Composition Database (2021, March 06). Ministry of Science and Innovation. Spanish Agency for Food Safety and Nutrition. Ministry of Health, Social Services and Equality. Available online: https:\/\/www.bedca.net\/bdpub\/."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00005650-198601000-00007","article-title":"Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence","volume":"24","author":"Morisky","year":"1986","journal-title":"Med. Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1097\/00005082-200609000-00015","article-title":"Knowing Your Risk Factors for Coronary Heart Disease Improves Adherence to Advice on Lifestyle Changes and Medication","volume":"21","author":"Fridlund","year":"2006","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.genhosppsych.2011.11.005","article-title":"Mokken scaling analysis of the Hospital Anxiety and Depression Scale in individuals with cardiovascular disease","volume":"34","author":"Cosco","year":"2012","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/heart.83.6.641","article-title":"Measuring the health related quality of life of people with ischaemic heart disease","volume":"83","author":"Dempster","year":"2000","journal-title":"Heart"},{"key":"ref_51","unstructured":"(2021, April 06). WHO-Five Well-Being Index. Available online: http:\/\/www.who-5.org\/."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"King, A.C., Hekler, E.B., Grieco, L.A., Winter, S.J., Sheats, J.L., Buman, M., Banerjee, B., Robinson, T.N., and Cirimele, J. (2013). Harnessing Different Motivational Frames via Mobile Phones to Promote Daily Physical Activity and Reduce Sedentary Behavior in Aging Adults. 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This is a retrospective cohort study with an average follow-up of 5 years. Participants between 21 and 75 years old and without a history of cardiovascular disease and proteinuria were enrolled. CVH metrics, including smoking, diet, physical activity, blood pressure, body mass index (BMI), cholesterol, and fasting glucose, were assessed by questionnaires, physical examination, and blood analysis. Proteinuria was assessed by dipstick measurement. During the follow-up period, 169,366 participants were enrolled, and 1481 subjects developed proteinuria. A higher number of ideal CVH metrics was related to a lower risk of proteinuria after adjustment. Among the components of CVH metrics, ideal blood pressure (HR = 0.33, 95% CI = 0.25\u20130.43), fasting glucose (HR = 0.17, 95% CI = 0.12\u20130.22), and BMI (HR = 0.20, 95% CI = 0.15\u20130.27) had beneficial effects on proteinuria. Despite no significant benefit of diet score, the corresponding lower sodium intake showed a lower risk of proteinuria (HR = 0.58, 95% CI = 0.43\u20130.79). Incident proteinuria was inversely related to the number of ideal CVH metrics. CVH metrics may be a predictor of proteinuria, and achieving a higher number of ideal scores should be recommended as a proteinuria prevention strategy.<\/jats:p>","DOI":"10.3390\/nu14194040","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"4040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between Ideal Cardiovascular Health and Incident Proteinuria: A 5 Year Retrospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Yu-Min","family":"He","sequence":"first","affiliation":[{"name":"Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-230X","authenticated-orcid":false,"given":"Wei-Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Wei","family":"Kao","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Division of Geriatric Medicine, 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-0462","authenticated-orcid":false,"given":"Hui-Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-288X","authenticated-orcid":false,"given":"Tao-Chun","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Division of Geriatric Medicine, Department of Family and 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meta-analysis of treatment effects in randomised clinical trials","volume":"7","author":"Heerspink","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.kint.2020.10.012","article-title":"The case for early identification and intervention of chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"99","author":"Shlipak","year":"2021","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2215\/CJN.09741110","article-title":"Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes","volume":"6","author":"Bello","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","first-page":"13","article-title":"Proteinuria and its relation to cardiovascular disease","volume":"7","author":"Currie","year":"2013","journal-title":"Int. J. Nephrol. Renov. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/sj.ki.5000284","article-title":"The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population","volume":"69","author":"Irie","year":"2006","journal-title":"Kidney Int."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Perkovic, V., Verdon, C., Ninomiya, T., Barzi, F., Cass, A., Patel, A., Jardine, M., Gallagher, M., Turnbull, F., and Chalmers, J. (2008). The relationship between proteinuria and coronary risk: A systematic review and meta-analysis. PLoS Med., 5.","DOI":"10.1371\/journal.pmed.0050207"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1560","DOI":"10.1097\/MD.0000000000001560","article-title":"Effects of ACEIs versus ARBs on proteinuria or albuminuria in primary hypertension: A meta-analysis of randomized trials","volume":"94","author":"Xu","year":"2015","journal-title":"Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.1523-1755.2000.00284.x","article-title":"Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population","volume":"58","author":"Halimi","year":"2000","journal-title":"Kidney Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e511","DOI":"10.1210\/clinem\/dgaa026","article-title":"Relationship of body mass index and waist circumference with risk of new-onset proteinuria in hypertensive patients","volume":"105","author":"Liu","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/nep.12112","article-title":"Prevalence and risk factors for proteinuria: T he N ational K idney F oundation of M alaysia L ifecheck H ealth S creening programme","volume":"18","author":"Ong","year":"2013","journal-title":"Nephrology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/01.ASN.0000018406.20282.C8","article-title":"Risk factors for proteinuria in a large, multiracial, southeast Asian population","volume":"13","author":"Ramirez","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1046\/j.1523-1755.2002.00506.x","article-title":"Influence of smoking and obesity on the development of proteinuria","volume":"62","author":"Tozawa","year":"2002","journal-title":"Kidney Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association\u2019s strategic Impact Goal through 2020 and beyond","volume":"121","author":"Hong","year":"2010","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/CIRCULATIONAHA.111.049122","article-title":"Ideal cardiovascular health and mortality from all causes and diseases of the circulatory system among adults in the United States","volume":"125","author":"Ford","year":"2012","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00125-016-4003-7","article-title":"The association of ideal cardiovascular health with incident type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis","volume":"59","author":"Joseph","year":"2016","journal-title":"Diabetologia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1681\/ASN.2012070642","article-title":"Cardiovascular risk factors in CKD associate with both ESRD and mortality","volume":"24","author":"Muntner","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/ije\/dyw282","article-title":"Cohort Profile: The Taiwan MJ Cohort: Half a million Chinese with repeated health surveillance data","volume":"46","author":"Wu","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_21","unstructured":"(2022, August 04). MJ Health Resource Center. Available online: http:\/\/www.mjhrf.org\/main\/page\/resource\/en\/#resource08."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrneph.2012.42","article-title":"Proteinuria should be used as a surrogate in CKD","volume":"8","author":"Cravedi","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"314251","DOI":"10.1155\/2012\/314251","article-title":"Progress in pathogenesis of proteinuria","volume":"2012","author":"Zhang","year":"2012","journal-title":"Int. J. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.dsx.2018.12.006","article-title":"Metabolic syndrome and its components are related to a higher risk for albuminuria and proteinuria: Evidence from a meta-analysis on 10,603,067 subjects from 57 studies","volume":"13","author":"Rashidbeygi","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2169\/internalmedicine.56.8006","article-title":"Association between overall lifestyle changes and the incidence of proteinuria: A population-based, cohort study","volume":"56","author":"Wakasugi","year":"2017","journal-title":"Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ndt\/gfaa224","article-title":"Healthy lifestyle reduces incidence of trace\/positive proteinuria and rapid kidney function decline after 2 years: From the Japan Ningen Dock study","volume":"36","author":"Okada","year":"2021","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/01.HYP.0000145180.38707.84","article-title":"Pathophysiology of hypertensive renal damage: Implications for therapy","volume":"44","author":"Bidani","year":"2004","journal-title":"Hypertension"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/0003-4819-154-8-201104190-00335","article-title":"Systematic review: Blood pressure target in chronic kidney disease and proteinuria as an effect modifier","volume":"154","author":"Upadhyay","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2016.09.007","article-title":"Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy","volume":"10","author":"Czajka","year":"2016","journal-title":"Redox Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/0101-2800.20170001","article-title":"Obesity and kidney disease: Hidden consequences of the epidemic","volume":"39","author":"Kovesdy","year":"2017","journal-title":"Braz. J. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semnephrol.2012.12.006","article-title":"Obesity and kidney disease: Potential mechanisms","volume":"Volume 33","author":"Wickman","year":"2013","journal-title":"Seminars in Nephrology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.kint.2016.12.034","article-title":"Obesity and kidney disease: From population to basic science and the search for new therapeutic targets","volume":"92","author":"Sowers","year":"2017","journal-title":"Kidney Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e003192","DOI":"10.1161\/JAHA.116.003192","article-title":"Relationship of the American Heart Association\u2019s Impact Goals (Life\u2019s Simple 7) with risk of chronic kidney disease: Results from the Atherosclerosis Risk in Communities (ARIC) Cohort Study","volume":"5","author":"Rebholz","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2215\/CJN.09320913","article-title":"Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study","volume":"9","author":"Rahman","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jacc.2017.05.043","article-title":"Oxidative stress and cardiovascular risk: Obesity, diabetes, smoking, and pollution: Part 3 of a 3-part series","volume":"70","author":"Niemann","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2215\/CJN.00700111","article-title":"Cigarette smoking and the association with glomerular hyperfiltration and proteinuria in healthy middle-aged men","volume":"6","author":"Maeda","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10157-020-01914-8","article-title":"The role of cigarette smoking on new-onset of chronic kidney disease in a Japanese population without prior chronic kidney disease: Iki epidemiological study of atherosclerosis and chronic kidney disease (ISSA-CKD)","volume":"24","author":"Ito","year":"2020","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ndt\/gfw452","article-title":"Cigarette smoking and chronic kidney disease in the general population: A systematic review and meta-analysis of prospective cohort studies","volume":"32","author":"Xia","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/aje\/kwp442","article-title":"Physical activity and albuminuria","volume":"171","author":"Robinson","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Martens, R.J.H., van der Berg, J.D., Stehouwer, C.D.A., Henry, R.M.A., Bosma, H., Dagnelie, P.C., van Dongen, M.C.J.M., Eussen, S.J.P.M., Schram, M.T., and Sep, S.J.S. (2018). Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage: The Maastricht Study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195306"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e007725","DOI":"10.1161\/JAHA.117.007725","article-title":"Physical activity in the prevention and treatment of coronary artery disease","volume":"7","author":"Winzer","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cirillo, M., Cavallo, P., Zulli, E., Villa, R., Veneziano, R., Costanzo, S., Magnacca, S., Di Castelnuovo, A., Iacoviello, L., and Moli-Sani Study, I. (2021). Sodium Intake and Proteinuria\/Albuminuria in the Population\u2014Observational, Cross-Sectional Study. Nutrients, 13.","DOI":"10.3390\/nu13041255"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1681\/ASN.2015010022","article-title":"Urinary sodium and potassium excretion and CKD progression","volume":"27","author":"He","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.phrs.2016.03.037","article-title":"Sodium intake, RAAS-blockade and progressive renal disease","volume":"107","author":"Navis","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Garofalo, C., Borrelli, S., Provenzano, M., De Stefano, T., Vita, C., Chiodini, P., Minutolo, R., Nicola, L.D., and Conte, G. (2018). Dietary salt restriction in chronic kidney disease: A meta-analysis of randomized clinical trials. Nutrients, 10.","DOI":"10.3390\/nu10060732"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S2213-8587(14)70030-0","article-title":"Effects of sodium restriction and hydrochlorothiazide on RAAS blockade efficacy in diabetic nephropathy: A randomised clinical trial","volume":"2","author":"Kwakernaak","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ajcn\/nqz146","article-title":"Dietary patterns and risk of incident chronic kidney disease: The Atherosclerosis Risk in Communities study","volume":"110","author":"Hu","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1053\/j.ajkd.2016.05.019","article-title":"DASH (Dietary Approaches to Stop Hypertension) diet and risk of subsequent kidney disease","volume":"68","author":"Rebholz","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000522147","article-title":"Change in cardiovascular health metrics and risk for proteinuria development: Analysis of a nationwide population-based database","volume":"53","author":"Suzuki","year":"2022","journal-title":"Am. J. 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NATPRO was established in 2005 by Professor Maitree Suttajit, Mahasarakham University with the aim of building research networking on natural products. NATPRO 2, 3 and 4 were subsequently organized by Naresuan University, Rangsit University and Chiang Mai University in 2008, 2011 and 2012, respectively. [...]<\/jats:p>","DOI":"10.3390\/nu6104115","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T10:24:07Z","timestamp":1412936647000},"page":"4115-4164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Report on the Fifth International Conference on Natural Products for Health and Beauty (NATPRO 5) Held in Thailand, 6\u20138th May, 2014"],"prefix":"10.3390","volume":"6","author":[{"given":"Supayang","family":"Voravuthikunchai","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6546-7742","authenticated-orcid":false,"given":"Peter","family":"Howe","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy,  University of Newcastle, Callaghan, NSW 2308, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,10]]},"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/6\/10\/4115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:16:47Z","timestamp":1760217407000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/6\/10\/4115"}},"issued":{"date-parts":[[2014,10,10]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["nu6104115"],"URL":"https:\/\/doi.org\/10.3390\/nu6104115","ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"published":{"date-parts":[[2014,10,10]]}},{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:20:27Z","timestamp":1780406427001,"version":"3.54.1"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Little is known about the macronutrient intake status of adult Chinese people. This cross-sectional study assessed the macronutrient intake status of adults (aged \u226520 years) by comparing their intake level of macronutrients against the Dietary Reference Intakes (DRI). It further explored the associations between macronutrient intake status and age groups, genders, education levels, smoking status, drinking frequency, social classes, knowledge of Chinese Dietary Guidelines 2016 (CDGs), healthy diet priorities, and areas (urban and rural) within two regions (northern and southern). The analysis includes the dietary intake data of 7860 Chinese adults, with complete data entries in the China Health and Nutrition 2011 survey. Dietary data were obtained through the 24 h recall method. More than half had carbohydrate intake below the recommended level of intake, and more than half had fat intake above the recommended level of intake. There were significant associations between three macronutrient intakes and education levels, social classes, healthy diet priorities, areas, and regions. Disparities in macronutrient consumptions revealed geographical and socioeconomic variations in dietary patterns, as well as risks for many different noncommunicable diseases. Public health and nutrition interventions should take notice of regional differences in dietary intake and place more emphasis on vulnerable populations including women, rural residents, and people with lower education level.<\/jats:p>","DOI":"10.3390\/nu13093044","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:07:28Z","timestamp":1630382848000},"page":"3044","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Disparities in Adults\u2019 Macronutrient Intake Status: Results from the China Health and Nutrition 2011 Survey"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-5018","authenticated-orcid":false,"given":"Yajie","family":"Zhao","sequence":"first","affiliation":[{"name":"International Agro-Informatics Laboratory, Department of Agricultural Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Araki","sequence":"additional","affiliation":[{"name":"International Agro-Informatics Laboratory, Department of Agricultural Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"ref_1","unstructured":"Joint WHO\/FAO Expert, Consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases. World Health Organ. Tech. Rep. Ser., 916, 1\u2013149."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1464-5491.2009.02798.x","article-title":"Adherence to a Mediterranean Diet and Glycaemic Control in Type 2 Diabetes Mellitus","volume":"26","author":"Esposito","year":"2009","journal-title":"Diabet. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/ejcn.2012.37","article-title":"Effects of Higher- versus Lower-Protein Diets on Health Outcomes: A Systematic Review and Meta-Analysis","volume":"66","author":"Santesso","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Schwingshackl, L., and Hoffmann, G. (2013). Long-Term Effects of Low-Fat Diets Either Low or High in Protein on Cardiovascular and Metabolic Risk Factors: A Systematic Review and Meta-Analysis. Nutr. J., 12.","DOI":"10.1186\/1475-2891-12-48"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nielsen, J.V., and Joensson, E.A. (2008). Low-Carbohydrate Diet in Type 2 Diabetes: Stable Improvement of Bodyweight and Glycemic Control during 44 Months Follow-Up. Nutr. Metab., 5.","DOI":"10.1186\/1743-7075-5-14"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3746\/pnf.2020.25.3.233","article-title":"Effect of Different Dietary Approaches in Comparison with High\/Low-Carbohydrate Diets on Systolic and Diastolic Blood Pressure in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis","volume":"25","author":"Abbasnezhad","year":"2020","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3945\/ajcn.2009.27725","article-title":"Meta-Analysis of Prospective Cohort Studies Evaluating the Association of Saturated Fat with Cardiovascular Disease","volume":"91","author":"Sun","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Billingsley, H.E., Carbone, S., and Lavie, C.J. (2018). Dietary Fats and Chronic Noncommunicable Diseases. Nutrients, 10.","DOI":"10.3390\/nu10101385"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Burger, K.N.J., Beulens, J.W.J., van der Schouw, Y.T., Sluijs, I., Spijkerman, A.M.W., Sluik, D., Boeing, H., Kaaks, R., Teucher, B., and Dethlefsen, C. (2012). Dietary Fiber, Carbohydrate Quality and Quantity, and Mortality Risk of Individuals with Diabetes Mellitus. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043127"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1017\/S0007114514001627","article-title":"Low-Carbohydrate Diets and Cardiovascular and Total Mortality in Japanese: A 29-Year Follow-up of NIPPON DATA80","volume":"112","author":"Nakamura","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1016\/S2468-2667(18)30135-X","article-title":"Dietary Carbohydrate Intake and Mortality: A Prospective Cohort Study and Meta-Analysis","volume":"3","author":"Seidelmann","year":"2018","journal-title":"Lancet Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ho, F.K., Gray, S.R., Welsh, P., Petermann-Rocha, F., Foster, H., Waddell, H., Anderson, J., Lyall, D., Sattar, N., and Gill, J.M.R. (2020). Associations of Fat and Carbohydrate Intake with Cardiovascular Disease and Mortality: Prospective Cohort Study of UK Biobank Participants. BMJ, 368.","DOI":"10.1136\/bmj.m688"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Song, F., and Cho, M.S. (2017). Geography of Food Consumption Patterns between South and North China. Foods, 6.","DOI":"10.3390\/foods6050034"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.6090\/jarq.38.213","article-title":"Function of traditional foods and food culture in China","volume":"38","author":"Li","year":"2004","journal-title":"JARQ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/1753-0407.13015","article-title":"The Jiangnan Diet, a Healthy Diet Pattern for Chinese","volume":"12","author":"Wang","year":"2020","journal-title":"J. Diabetes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S2213-8587(19)30152-4","article-title":"The Dietary Transition and Its Association with Cardiometabolic Mortality among Chinese Adults, 1982\u20132012: A Cross-Sectional Population-Based Study","volume":"7","author":"He","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chang, X., DeFries, R.S., Liu, L., and Davis, K. (2018). Understanding Dietary and Staple Food Transitions in China from Multiple Scales. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195775"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1079\/PHN2002370","article-title":"Understanding the Nutrition Transition: Measuring Rapid Dietary Changes in Transitional Countries","volume":"5","author":"Popkin","year":"2002","journal-title":"Public Health Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1017\/S0007114513003917","article-title":"Longitudinal Analysis of Dietary Patterns in Chinese Adults from 1991 to 2009","volume":"111","author":"Batis","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_20","unstructured":"(2021, July 30). China Health and Nutrition Survey (CHNS). Available online: http:\/\/www.cpc.unc.edu\/projects\/china\/about\/proj_desc\/survey."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/obr.12124","article-title":"Dynamics of the Chinese Diet and the Role of Urbanicity, 1991\u20132011: Chinese Diet\u2019s, 1991\u20132011","volume":"15","author":"Zhai","year":"2014","journal-title":"Obes. Rev."},{"key":"ref_22","unstructured":"Yang, Y. (2002). China Food Composition Table. Peking: China Institute of Nutriton and Food Safety, China CDC."},{"key":"ref_23","unstructured":"Chinese Nutrition Society (2013). Dietary Guidelines Chinese Residents, Xizang People Publisher. (In Chinese)."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"On behalf of the China Kadoorie Biobank (CKB) Collaborative Group, Im, P.K., Millwood, I.Y., Guo, Y., Du, H., Chen, Y., Bian, Z., Tan, Y., Guo, Z., and Wu, S. (2019). Patterns and Trends of Alcohol Consumption in Rural and Urban Areas of China: Findings from the China Kadoorie Biobank. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-6502-1"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Conklin, A.I., Forouhi, N.G., Surtees, P., Wareham, N.J., and Monsivais, P. (2015). Gender and the Double Burden of Economic and Social Disadvantages on Healthy Eating: Cross-Sectional Study of Older Adults in the EPIC-Norfolk Cohort. BMC Public Health, 15.","DOI":"10.1186\/s12889-015-1895-y"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Meyer, K.B., and Simons, J. (2021). Good Attitudes Are Not Good Enough: An Ethnographical Approach to Investigate Attitude-Behavior Inconsistencies in Sustainable Choice. Foods, 10.","DOI":"10.3390\/foods10061317"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1079\/PHN2001294","article-title":"The unique aspect of the nutrition transition in South Korea: The retention of healthful elements in their traditional diet","volume":"5","author":"Lee","year":"2002","journal-title":"Public Health Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Yang, X., Fang, Y., Zhang, J., Yang, Z., Wang, Z., Liu, A., He, L., Sun, J., and Lian, Y. (2020). Trends and Disparities of Energy Intake and Macronutrient Composition in China: A Series of National Surveys, 1982\u20132012. Nutrients, 12.","DOI":"10.21203\/rs.3.rs-29148\/v1"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nilsen, L., Hopstock, L.A., Skeie, G., Grimsgaard, S., and Lundblad, M.W. (2021). The Educational Gradient in Intake of Energy and Macronutrients in the General Adult and Elderly Population: The Troms\u00f8 Study 2015\u20132016. Nutrients, 13.","DOI":"10.3390\/nu13020405"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Saw, S.-H., and Wong, J. (2009). New Trends in China\u2019s Regional Economic Development. Regional Economic Development in China, ISEAS Publishing.","DOI":"10.1355\/9789812309426"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10389-012-0510-2","article-title":"Economic Impact of Adopting a Healthy Diet in Canada","volume":"20","author":"Mukhopadhyay","year":"2012","journal-title":"J. Public Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/01.HYP.0000128243.06502.bc","article-title":"Blood Pressure Differences Between Northern and Southern Chinese: Role of Dietary Factors: The International Study on Macronutrients and Blood Pressure","volume":"43","author":"Zhao","year":"2004","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0140-6736(13)61097-1","article-title":"Rapid Health Transition in China, 1990\u20132010: Findings from the Global Burden of Disease Study 2010","volume":"381","author":"Yang","year":"2013","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/135498303200041359","article-title":"Thinking habits into action: The role of knowledge and process in questioning household consumption practices","volume":"8","author":"Hobson","year":"2003","journal-title":"Local Environ."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shan, Z., Guo, Y., Hu, F.B., Liu, L., and Qi, Q. (2020). Association of Low-Carbohydrate and Low-Fat Diets with Mortality among US Adults. JAMA Intern. Med., 180.","DOI":"10.1001\/jamainternmed.2019.6980"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.nut.2018.08.009","article-title":"Diet Quality, Physical Activity, and Their Association with Metabolic Syndrome in Korean Adults","volume":"59","author":"Kim","year":"2019","journal-title":"Nutrition"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1079\/PHN2001296","article-title":"The Underweight\/Overweight Household: An Exploration of Household Sociodemographic and Dietary Factors in China","volume":"5","author":"Doak","year":"2002","journal-title":"Public Health Nutr."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/3044\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:55:52Z","timestamp":1760165752000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/3044"}},"issued":{"date-parts":[[2021,8,30]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["nu13093044"],"URL":"https:\/\/doi.org\/10.3390\/nu13093044","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2021,8,30]]}},{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:18:41Z","timestamp":1780492721043,"version":"3.54.1"},"reference-count":89,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["No. 2021YFC2103005"],"award-info":[{"award-number":["No. 2021YFC2103005"]}]},{"name":"Ministry of Science and Technology of China","award":["No. 2022C02043"],"award-info":[{"award-number":["No. 2022C02043"]}]},{"name":"provincial key R and D plan of Zhejiang Province","award":["No. 2021YFC2103005"],"award-info":[{"award-number":["No. 2021YFC2103005"]}]},{"name":"provincial key R and D plan of Zhejiang Province","award":["No. 2022C02043"],"award-info":[{"award-number":["No. 2022C02043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Acute liver failure (ALF) refers to the occurrence of massive hepatocyte necrosis in a short time, with multiple complications, including inflammatory response, hepatic encephalopathy, and multiple organ failure. Additionally, effective therapies for ALF are lacking. There exists a relationship between the human intestinal microbiota and liver, so intestinal microbiota modulation may be a strategy for therapy of hepatic diseases. In previous studies, fecal microbiota transplantation (FMT) from fit donors has been used to modulate intestinal microbiota widely. Here, we established a mouse model of lipopolysaccharide (LPS)\/D-galactosamine (D-gal) induced ALF to explore the preventive and therapeutic effects of FMT, and its mechanism of action. We found that FMT decreased hepatic aminotransferase activity and serum total bilirubin levels, and decreased hepatic pro-inflammatory cytokines in LPS\/D-gal challenged mice (p &lt; 0.05). Moreover, FMT gavage ameliorated LPS\/D-gal induced liver apoptosis and markedly reduced cleaved caspase-3 levels, and improved histopathological features of the liver. FMT gavage also restored LPS\/D-gal-evoked gut microbiota dysbiosis by modifying the colonic microbial composition, improving the abundance of unclassified_o_Bacteroidales (p &lt; 0.001), norank_f_Muribaculaceae (p &lt; 0.001), and Prevotellaceae_UCG-001 (p &lt; 0.001), while reducing that of Lactobacillus (p &lt; 0.05) and unclassified_f_Lachnospiraceae (p &lt; 0.05). Metabolomics analysis revealed that FMT significantly altered LPS\/D-gal induced disordered liver metabolites. Pearson\u2019s correlation revealed strong correlations between microbiota composition and liver metabolites. Our findings suggest that FMT ameliorate ALF by modulating gut microbiota and liver metabolism, and can used as a potential preventive and therapeutic strategy for ALF.<\/jats:p>","DOI":"10.3390\/nu15051149","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T01:59:10Z","timestamp":1677463150000},"page":"1149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Integrated Analysis of Gut Microbiome and Liver Metabolome to Evaluate the Effects of Fecal Microbiota Transplantation on Lipopolysaccharide\/D-galactosamine-Induced Acute Liver Injury in Mice"],"prefix":"10.3390","volume":"15","author":[{"given":"Chunchun","family":"Yuan","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Fan","sequence":"additional","affiliation":[{"name":"Hangzhou Academy of Agricultural Sciences, Hangzhou 310004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Ye","sequence":"additional","affiliation":[{"name":"Hainan Institute of Zhejiang University, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan Institute of Zhejiang University, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzi","family":"Wu","sequence":"additional","affiliation":[{"name":"Hainan Institute of Zhejiang University, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixin","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1056\/NEJMra1914900","article-title":"Acute-on-Chronic Liver Failure","volume":"382","author":"Arroyo","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hu, J., Ying, H., Zheng, Y., Ma, H., Li, L., and Zhao, Y. (2022). Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy. Antioxidants, 11.","DOI":"10.3390\/antiox11061070"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.intimp.2018.06.004","article-title":"Dopamine alleviated acute liver injury induced by lipopolysaccharide\/d-galactosamine in mice","volume":"61","author":"Zhou","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1001\/jama.2021.12742","article-title":"Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU","volume":"326","author":"Han","year":"2021","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/s41598-021-81263-y","article-title":"Fecal transplantation alleviates acute liver injury in mice through regulating Treg\/Th17 cytokines balance","volume":"11","author":"Liu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1126\/science.abe6729","article-title":"Enterically derived high-density lipoprotein restrains liver injury through the portal vein","volume":"373","author":"Han","year":"2021","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/hep.24239","article-title":"Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice","volume":"53","author":"Stuart","year":"2011","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3748\/wjg.15.3086","article-title":"An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure","volume":"15","author":"Alvarez","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"605065","DOI":"10.3389\/fphar.2020.605065","article-title":"Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2\/HO-1 and NLRP3 Pathways in Mice","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The Human Intestinal Microbiome in Health and Disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1136\/gutjnl-2016-312729","article-title":"Gut microbiome and liver diseases","volume":"65","author":"Tilg","year":"2016","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111000","DOI":"10.1016\/j.biopha.2020.111000","article-title":"Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats","volume":"133","author":"Jiang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The gut-liver axis and the intersection with the microbiome","volume":"15","author":"Tripathi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2084306","DOI":"10.1080\/19490976.2022.2084306","article-title":"Gut microbiota differs between treatment outcomes early after fecal microbiota transplantation against recurrent Clostridioides difficile infection","volume":"14","author":"Wei","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.biotechadv.2016.08.003","article-title":"The Gut Microbiota, A Treasure for Human Health","volume":"34","author":"Li","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s13238-018-0541-8","article-title":"Microbiota transplantation: Concept, methodology and strategy for its modernization","volume":"9","author":"Zhang","year":"2018","journal-title":"Protein Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1056\/NEJMc1803103","article-title":"Fecal microbiota transplantation for primary clostridium difficile infection","volume":"378","author":"Juul","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.3748\/wjg.v23.i38.6983","article-title":"Fecal microbiota transplantation prevents hepatic encephalopathy in rats with carbon tetrachloride-induced acute hepatic dysfunction","volume":"23","author":"Wang","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1053\/j.gastro.2013.08.058","article-title":"Therapeutic potential of fecal microbiota transplantation","volume":"145","author":"Smits","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jcmgh.2020.11.002","article-title":"Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury","volume":"11","author":"Schneider","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","article-title":"Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice","volume":"66","author":"Ferrere","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1053\/j.gastro.2014.01.020","article-title":"Interactions between the intestinal microbiome and liver diseases","volume":"146","author":"Schnabl","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41401-019-0330-9","article-title":"Fecal microbiota transplantation improves metabolism and gut microbiome composition in db\/db mice","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: Highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1099\/00207713-44-4-846","article-title":"Taxonomic Note: A Place for DNA-DNA Reassociation and 16S rRNA Sequence Analysis in the Present Species Definition in Bacteriology","volume":"44","author":"Stackebrandt","year":"1994","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/pr050364w","article-title":"High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B","volume":"5","author":"Yang","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.scitotenv.2017.06.071","article-title":"Tributyl phosphate impairs the urea cycle and alters liver pathology and metabolism in mice after short-term exposure based on a metabonomics study","volume":"603\u2013604","author":"Zhou","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9932099","DOI":"10.1155\/2021\/9932099","article-title":"Protective Role of 4-Octyl Itaconate in Murine LPS\/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42530","DOI":"10.18632\/oncotarget.6466","article-title":"Oleoylethanolamide; an endogenous PPAR-alpha ligand, attenuates liver fibrosis targeting hepatic stellate cells","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3\u2014Key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s10620-007-9994-y","article-title":"A Role of Cell Apoptosis in Lipopolysaccharide (LPS)-induced Nonlethal Liver Injury in D-galactosamine (D-GalN)-sensitized Rats","volume":"53","author":"Liu","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal","year":"2010","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4037\/aacnacc2016324","article-title":"Acute Liver Failure","volume":"27","author":"Grek","year":"2016","journal-title":"AACN Adv. Crit. Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-4800(68)90042-7","article-title":"Experimental hepatitis induced by D-galactosamine","volume":"9","author":"Keppler","year":"1968","journal-title":"Exp. Mol. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0192623318801574","article-title":"M1\/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats","volume":"46","author":"Rahman","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"688780","DOI":"10.3389\/fphys.2021.688780","article-title":"Gut Microbiota and Chemical-Induced Acute Liver Injury","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/MCO.0000000000000488","article-title":"Fecal microbial transplantation: An update","volume":"21","author":"Bouri","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e00434-18","DOI":"10.1128\/AEM.00434-18","article-title":"Fecal Microbiota Transplantation in Experimental Ulcerative Colitis Reveals Associated Gut Microbial and Host Metabolic Reprogramming","volume":"84","author":"Yan","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_39","unstructured":"Farhana, A., and Khan, Y.S. (2022). Biochemistry; Lipopolysaccharide, StatPearls Publishing."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20861","DOI":"10.1074\/jbc.M002896200","article-title":"Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1","volume":"275","author":"Yang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"L769","DOI":"10.1152\/ajplung.00137.2005","article-title":"Endotoxin-induced acute lung injury requires interaction with the liver. American Journal of physiology","volume":"289","author":"Siore","year":"2005","journal-title":"Lung Cell. Mol. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/DDDT.S286104","article-title":"Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal\/LPS in Mice","volume":"15","author":"Li","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5871431","DOI":"10.1155\/2018\/5871431","article-title":"Sophocarpine attenuates LPS-induced liver injury and improves survival of mice through suppressing oxidative stress, inflammation, and apoptosis","volume":"2018","author":"Jiang","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.biopha.2017.11.083","article-title":"Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation","volume":"96","author":"Xiong","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s10753-014-9886-1","article-title":"Protective effects of Lactobacillus plantarum NDC 75017 against lipopolysaccharide-induced liver injury in mice","volume":"37","author":"Peng","year":"2014","journal-title":"Inflammation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1007\/s00253-020-10749-y","article-title":"Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates D-galactosamine-induced acute liver injury in rats","volume":"104","author":"Zhuge","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1053\/gast.2000.9364","article-title":"Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure","volume":"119","author":"Streetz","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"R1202","DOI":"10.1152\/ajpregu.2000.278.5.R1202","article-title":"LPS-induced liver injury in d-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor","volume":"278","author":"Nowak","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"R1196","DOI":"10.1152\/ajpregu.2000.278.5.R1196","article-title":"Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-\u03b1 and not by Fas ligand","volume":"278","author":"Josephs","year":"2000","journal-title":"Am. J. Physiology. Regul. Integr. Comp. Physiol."},{"key":"ref_50","first-page":"1220","article-title":"Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models","volume":"146","author":"Leist","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.20282","article-title":"Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-ay obese mice","volume":"40","author":"Masaki","year":"2004","journal-title":"Hepatology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.ejcn.1602127","article-title":"Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: Results of a pilot study","volume":"59","author":"Daubioul","year":"2005","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10620-011-1887-4","article-title":"Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis","volume":"57","author":"Malaguarnera","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13287-017-0524-3","article-title":"Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure","volume":"8","author":"Zhang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3748\/wjg.v13.i3.462","article-title":"Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure","volume":"13","author":"Yang","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature10213","article-title":"Human nutrition, the gut microbiome and the immune system","volume":"474","author":"Kau","year":"2011","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jgh.15729","article-title":"New perspective on fecal microbiota transplantation in liver diseases","volume":"37","author":"Suk","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.7150\/ijbs.46405","article-title":"The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases","volume":"16","author":"Yang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ajg.2013.59","article-title":"Fecal microbiota transplantation for Clostridium difficile infection: Systematic review and meta-analysis","volume":"108","author":"Kassam","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.crohns.2014.08.006","article-title":"Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis","volume":"8","author":"Colman","year":"2014","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_66","first-page":"79","article-title":"Fecal microbiota transplantation and its potential therapeutic uses in gastrointestinal disorders","volume":"5","author":"Heath","year":"2018","journal-title":"North. Clin. Istanb."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Grigor\u2019eva, I.N. (2020). Gallstone Disease, Obesity and the Firmicutes\/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis. J. Personalized Med., 11.","DOI":"10.3390\/jpm11010013"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41598-017-01271-9","article-title":"Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1136\/gut.2007.133603","article-title":"High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota","volume":"57","author":"Zoetendal","year":"2008","journal-title":"Gut"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.foodres.2018.08.088","article-title":"Investigations of Bacteroides spp. towards next-generation probiotics","volume":"116","author":"Tan","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14405","DOI":"10.1038\/srep14405","article-title":"Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micres.2014.11.002","article-title":"Effects of cyclophosphamide on immune system and gut microbiota in mice","volume":"171","author":"Xu","year":"2014","journal-title":"Microbiol. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","article-title":"The Genus Alistipes: Gut Bacteria with Emerging Implications to Inflammation, Cancer, and Mental Health","volume":"11","author":"Parker","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cgh.2018.07.022","article-title":"Association Between Intestinal Microbiota Collected at Hospital Admission and Outcomes of Patients With Cirrhosis","volume":"17","author":"Bajaj","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000360010","article-title":"Expansion of urease-and uricase-containing, indole-and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD","volume":"39","author":"Wong","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Vacca, M., Celano, G., Calabrese, F.M., Portincasa, P., Gobbetti, M., and De Angelis, M. (2020). The Controversial Role of Human Gut Lachnospiraceae. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040573"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.numecd.2012.02.007","article-title":"Gut\u2013liver axis: The impact of gut microbiota on non alcoholic fatty liver disease","volume":"22","author":"Compare","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3389\/fmicb.2019.00789","article-title":"Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/1751-7915.13750","article-title":"Probiotic Lactobacillus casei Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders","volume":"15","author":"Yan","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3177\/jnsv.64.192","article-title":"L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice","volume":"64","author":"Sato","year":"2018","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"805","DOI":"10.7150\/thno.50230","article-title":"Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation","volume":"11","author":"Hu","year":"2021","journal-title":"Theranostics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/gutjnl-2018-317423","article-title":"Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity","volume":"69","author":"Herzog","year":"2020","journal-title":"Gut"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2337\/diab.45.8.1003","article-title":"Hexosamines and insulin resistance","volume":"45","author":"McClain","year":"1996","journal-title":"Diabetes"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3389\/fimmu.2020.01157","article-title":"The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice","volume":"11","author":"Weinhage","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1389450118666170125144557","article-title":"Cytochrome P450 Structure; Function and Clinical Significance: A Review","volume":"19","author":"Manikandan","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"113204","DOI":"10.1016\/j.biopha.2022.113204","article-title":"Gut microbiota combined with metabolomics reveal the mechanism of curcumol on liver fibrosis in mice","volume":"152","author":"Zheng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10787-014-0223-y","article-title":"Dual inhibition of arachidonic acid pathway by mulberry leaf extract","volume":"23","author":"Chauhan","year":"2015","journal-title":"Inflammopharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jnutbio.2017.09.017","article-title":"Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology","volume":"52","author":"Khadge","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/c3fo60551e","article-title":"The role of n-6 and n-3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease","volume":"5","author":"Monteiro","year":"2014","journal-title":"Food Funct."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1149\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:41:31Z","timestamp":1760121691000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/5\/1149"}},"issued":{"date-parts":[[2023,2,24]]},"references-count":89,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["nu15051149"],"URL":"https:\/\/doi.org\/10.3390\/nu15051149","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2023,2,24]]}},{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:18:39Z","timestamp":1778426319119,"version":"3.51.4"},"reference-count":75,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"Intramural Research Program, National Institute on Aging, National Institutes of Health","doi-asserted-by":"publisher","award":["Z01-AG000513"],"award-info":[{"award-number":["Z01-AG000513"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: The aim of this study is to determine if protein intake, diet quality, or engagement in physical activity mediate the relationship between sleep quality or duration and handgrip strength. Methods: The sample consisted of 2171 middle-aged persons examined in the 2013\u20132017 Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) prospective cohort study. Those with sleep apnea (n = 222) and missing data were excluded, resulting in an analytical sample of 1308. Handgrip strength, an objectively measured variable, was determined using a Jamar Hydraulic Hand Dynamometer and expressed relative to body mass index (based on measured height and weight). Sleep quality and duration were measured using the Pittsburgh Sleep Quality Index questionnaire. Protein intake was calculated from two 24 h recalls collected using the USDA Automated Multiple-Pass Method and expressed as g per kg of body weight. Diet quality was assessed using the Healthy Eating Index (HEI) and the energy-adjusted Dietary Inflammatory Index (e-DII). Physical activity was self-reported and expressed as meeting the Life Simple 7 criterion (\u2265150 min\/week, 0\u2013149 min\/week, 0 min\/week). Mediation analysis was conducted using the Hayes PROCESS macro, model #4, for SPSS Version 4.2. Adjustment for the self-reported covariates of age (years); sex at birth (male, female); race (African American, White); poverty status (&lt;125% or &gt;125% US HHS Poverty Guidelines); current cigarette smoker (yes, no); marijuana, opiate, and\/or cocaine user (yes, no); medical conditions including diabetes, hypertension, and\/or metabolic syndrome (yes, no); and mean energy (kcal, only protein model) was performed. Results: Protein intake, expressed as g per kg of body weight, mediated the relationship between sleep quality and sleep duration and handgrip strength (indirect effect = \u22120.0017 \u00b1 0.0006, CI 95% (\u22120.0030, \u22120.0006, p &lt; 0.05); indirect effect = 0.0057 \u00b1 0.0019, CI 95% (0.0023, 0.0098, p &lt; 0.05, respectively)). Diet quality, as measured using the HEI, mediated the relationship between sleep duration and handgrip strength (indirect effect = 0.0013 \u00b1 0.0007, CI 95% (0.0001, 0.0030, p &lt; 0.05). Conclusions: Protein intake and a healthy diet mediate the relationship between sleep and handgrip strength, suggesting that these factors may play a role in preserving muscle strength.<\/jats:p>","DOI":"10.3390\/nu17111900","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:09:12Z","timestamp":1748840952000},"page":"1900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein Intake and Diet Quality Mediate the Relationship Between Sleep and Handgrip Strength in Adults in the HANDLS Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-3386","authenticated-orcid":false,"given":"Marie Fanelli","family":"Kuczmarski","sequence":"first","affiliation":[{"name":"Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE 19711, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-7042","authenticated-orcid":false,"given":"Elizabeth","family":"Orsega-Smith","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE 19711, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-4523","authenticated-orcid":false,"given":"May A.","family":"Beydoun","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele K.","family":"Evans","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-4778","authenticated-orcid":false,"given":"Alan B.","family":"Zonderman","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.5664\/jcsm.9476","article-title":"Sleep is essential to health: An American Academy of Sleep Medicine position statement","volume":"17","author":"Ramar","year":"2021","journal-title":"J. Clin. Sleep Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"National Center for Health Statistics (2022). QuickStats: Percentage of Adults Aged \u2265 18 Years Who Sleep <7 Hours on Average in a 24-Hour Period, by Sex and Age Group\u2014National Health Interview Survey, United States, 2020. MMWR Morb. Mortal. Wkly. Rep., 71, 393.","DOI":"10.15585\/mmwr.mm7110a6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101788","DOI":"10.1016\/j.smrv.2023.101788","article-title":"The interrelationship between sleep, diet, and glucose metabolism","volume":"69","author":"Darimont","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41043-024-00500-y","article-title":"Hand grip strength as a proposed new vital sign of health: A narrative review of evidences","volume":"43","author":"Vaishya","year":"2024","journal-title":"J. Health Popul. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.diabet.2017.07.005","article-title":"The association between handgrip strength and sleep duration in Japanese patients with type 2 diabetes","volume":"45","author":"Hamasaki","year":"2019","journal-title":"Diabetes Metab."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhang, T., Luo, J., Chen, S., and Zhang, D. (2023). Association between Sleep Duration and Grip Strength in U.S. Older Adults: An NHANES Analysis (2011\u20132014). Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20043416"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s41999-020-00399-8","article-title":"Association between muscle strength and sleep quality and duration among middle-aged and older adults: A systematic review","volume":"12","author":"Pana","year":"2021","journal-title":"Eur. Geriatr. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.5535\/arm.2018.42.6.822","article-title":"Sleep Quality and Attention May Correlate with Hand Grip Strength: FARM Study","volume":"42","author":"Lee","year":"2018","journal-title":"Ann. Rehabil. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Laredo-Aguilera, J.A., Carmona-Torres, J.M., Cobo-Cuenca, A.I., Garcia-Pinillos, F., and Latorre-Roman, P.A. (2019). Handgrip Strength is Associated with Psychological Functioning, Mood and Sleep in Women over 65 Years. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16050873"},{"key":"ref_10","unstructured":"Watson, R.R., and Preedy, V.R. (2020). Chapter 22\u2014The Influence of Diet on Sleep. Neurological Modulation of Sleep, Academic Press."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S0029665117003974","article-title":"Sleep and dietary habits in the urban environment: The role of chrono-nutrition","volume":"77","author":"Pot","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101430","DOI":"10.1016\/j.smrv.2021.101430","article-title":"Association between diet and sleep quality: A systematic review","volume":"57","author":"Godos","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3945\/an.115.008623","article-title":"Short sleep duration and dietary intake: Epidemiologic evidence, mechanisms, and health implications","volume":"6","author":"Dashti","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3945\/ajcn.115.124669","article-title":"Higher-protein diets improve indexes of sleep in energy-restricted overweight and obese adults: Results from 2 randomized controlled trials","volume":"103","author":"Zhou","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jand.2022.01.007","article-title":"Diet Composition and Objectively Assessed Sleep Quality: A Narrative Review","volume":"122","author":"Wilson","year":"2022","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/jhn.12709","article-title":"Diet and sleep health: A scoping review of intervention studies in adults","volume":"33","author":"Burrows","year":"2020","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_17","first-page":"e367","article-title":"Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement from the American Heart Association","volume":"134","author":"Grandner","year":"2016","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.sleh.2022.07.006","article-title":"Association between short sleep duration and intake of sugar and sugar-sweetened beverages: A systematic review and meta-analysis of observational studies","volume":"9","author":"Shahdadian","year":"2023","journal-title":"Sleep Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s12603-018-1006-8","article-title":"Dietary Protein Intake and Overall Diet Quality Are Associated with Handgrip Strength in African American and White Adults","volume":"22","author":"Pohlig","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/21551197.2022.2070321","article-title":"Intakes of Total and Branched-Chain Essential Amino Acids are Positively Associated with Handgrip Strength in African American and White Urban Younger and Older Adults","volume":"41","author":"Kuczmarski","year":"2022","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pikosky, M.A., Cifelli, C.J., Agarwal, S., and Fulgoni III, V.L. (2022). Association of Dietary Protein Intake and Grip Strength Among Adults Aged 19+ Years: NHANES 2011\u20132014 Analysis. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.873512"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, M.H., Choi, M.K., and Bae, Y.J. (2023). Relationship between protein intake and grip strength in qualitative and quantitative aspects among the elderly in Korea: Results from the Korea National Health and Nutrition Examination Survey. BMC Geriatr., 23.","DOI":"10.1186\/s12877-023-04016-8"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1093\/jn\/nxab288","article-title":"Dietary Protein Intake Is Positively Associated with Appendicular Lean Mass and Handgrip Strength among Middle-Aged US Adults","volume":"151","author":"Jun","year":"2021","journal-title":"J. Nutr."},{"key":"ref_24","first-page":"e43595","article-title":"The Effect of Physical Activity on Sleep Quality and Sleep Disorder: A Systematic Review","volume":"15","author":"Alnawwar","year":"2023","journal-title":"Cureus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101426","DOI":"10.1016\/j.smrv.2021.101426","article-title":"Daily associations between sleep and physical activity: A systematic review and meta-analysis","volume":"57","author":"Atoui","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s12529-019-09810-6","article-title":"Daily Associations Between Sleep and Physical Activity","volume":"26","author":"Mead","year":"2019","journal-title":"Int. J. Behav. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jsr.12078","article-title":"Exercise and sleep in community-dwelling older adults: Evidence for a reciprocal relationship","volume":"23","author":"Dzierzewski","year":"2014","journal-title":"J. Sleep Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jbmt.2016.08.017","article-title":"Handgrip strength and associated sociodemographic and lifestyle factors: A systematic review of the adult population","volume":"21","author":"Silva","year":"2017","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s40279-018-0952-y","article-title":"Handgrip Strength and Health in Aging Adults","volume":"48","author":"McGrath","year":"2018","journal-title":"Sports Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10522-015-9631-7","article-title":"Live strong and prosper: The importance of skeletal muscle strength for healthy ageing","volume":"17","author":"McLeod","year":"2016","journal-title":"Biogerontology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/jama.281.6.558","article-title":"Midlife hand grip strength as a predictor of old age disability","volume":"281","author":"Rantanen","year":"1999","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1159\/000501203","article-title":"Effects of Exercise Training on Handgrip Strength in Older Adults: A Meta-Analytical Review","volume":"65","author":"Labott","year":"2019","journal-title":"Gerontology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.17352\/aggr.000011","article-title":"The influence of physical activity on handgrip strength of elderly","volume":"4","author":"Bilajac","year":"2019","journal-title":"Arch. Gerontol. Geriatr. Res."},{"key":"ref_34","first-page":"267","article-title":"Healthy aging in neighborhoods of diversity across the life span (HANDLS): Overcoming barriers to implementing a longitudinal, epidemiologic, urban study of health, race, and socioeconomic status","volume":"20","author":"Evans","year":"2010","journal-title":"Ethn. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2236551","DOI":"10.1080\/07853890.2023.2236551","article-title":"Relationship between Non-Energy-Adjusted and Energy-Adjusted Dietary Inflammatory Index and the Healthy Eating Index-2015: An analysis of the National Health and Nutrition Examination Survey (NHANES) 2015\u20132018","volume":"55","author":"DiNatale","year":"2023","journal-title":"Ann. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1017\/S1368980013002115","article-title":"Designing and developing a literature-derived, population-based dietary inflammatory index","volume":"17","author":"Shivappa","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100036","DOI":"10.59717\/j.xinn-med.2023.100036","article-title":"The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function","volume":"1","author":"Zheng","year":"2023","journal-title":"Innov. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3945\/jn.113.183079","article-title":"The Healthy Eating Index-2010 is a valid and reliable measure of diet quality according to the 2010 Dietary Guidelines for Americans","volume":"144","author":"Guenther","year":"2014","journal-title":"J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ajcn\/88.2.324","article-title":"The US Department of Agriculture Automated Multiple-Pass Method reduces bias in the collection of energy intakes","volume":"88","author":"Moshfegh","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_41","unstructured":"US Department of Agriculture (2024, November 03). Food and Nutrient Database for Dietary Studies, Available online: https:\/\/www.ars.usda.gov\/northeast-area\/beltsville-md-bhnrc\/beltsville-human-nutrition-research-center\/food-surveys-research-group\/docs\/fndds-download-databases\/."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ajcn\/36.5.936","article-title":"A short questionnaire for the measurement of habitual physical activity in epidemiological studies","volume":"36","author":"Baecke","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jad.2023.04.083","article-title":"Life\u2019s simple 7 and its association with trajectories in depressive symptoms among urban middle-aged adults","volume":"333","author":"Beydoun","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCULATIONAHA.121.053730","article-title":"American Heart Association\u2019s Life\u2019s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease","volume":"145","author":"Hasbani","year":"2022","journal-title":"Circulation"},{"key":"ref_45","unstructured":"US Department of Health and Human Services (2025, January 20). The 2004 HHS Poverty Guidelines, Available online: https:\/\/aspe.hhs.gov\/2004-hhs-poverty-guidelines."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.amepre.2015.05.025","article-title":"Grip Strength as a Marker of Hypertension and Diabetes in Healthy Weight Adults","volume":"49","author":"Mainous","year":"2015","journal-title":"Am. J. Prev. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wen, Y., Liu, T., Ma, C., Fang, J., Zhao, Z., Luo, M., Xia, Y., Zhao, Y., and Ji, C. (2022). Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.996645"},{"key":"ref_48","unstructured":"Hayes, A.F. (2022). Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach, Guilford Press. [3rd ed.]."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ausmj.2017.02.001","article-title":"The Analysis of Mechanisms and Their Contingencies: PROCESS versus Structural Equation Modeling","volume":"25","author":"Hayes","year":"2017","journal-title":"Australas. Mark. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5664\/jcsm.8112","article-title":"Sleep duration is associated with healthy diet scores and meal patterns: Results from the population-based EpiHealth study","volume":"16","author":"Lemming","year":"2020","journal-title":"J. Clin. Sleep Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Stefan, L., Radman, I., Podnar, H., and Vrgoc, G. (2018). Sleep Duration and Sleep Quality Associated with Dietary Index in Free-Living Very Old Adults. Nutrients, 10.","DOI":"10.3390\/nu10111748"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"846","DOI":"10.7326\/0003-4819-141-11-200412070-00008","article-title":"Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite","volume":"141","author":"Spiegel","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.psyneuen.2016.09.014","article-title":"Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans","volume":"74","author":"Cedernaes","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1002\/oby.20683","article-title":"Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women","volume":"22","author":"Stern","year":"2014","journal-title":"Obesity"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3945\/ajcn.114.086579","article-title":"Sex and race differences in caloric intake during sleep restriction in healthy adults","volume":"100","author":"Spaeth","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.nutres.2015.11.009","article-title":"Anti-inflammatory Dietary Inflammatory Index scores are associated with healthier scores on other dietary indices","volume":"36","author":"Wirth","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wu, L., Shi, Y., Kong, C., Zhang, J., and Chen, S. (2022). Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults. Nutrients, 14.","DOI":"10.3390\/nu14214553"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s10803-024-06328-z","article-title":"The Association Between Children\u2019s Dietary Inflammatory Index (C-DII) and Nutrient Adequacy with Gastrointestinal Symptoms, Sleep Habits, and Autistic Traits","volume":"55","author":"Zare","year":"2025","journal-title":"J. Autism Dev. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"107789","DOI":"10.1016\/j.maturitas.2023.107789","article-title":"Handgrip strength, physical activity and incident mild cognitive impairment and dementia","volume":"176","author":"Werneck","year":"2023","journal-title":"Maturitas"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.sleh.2020.10.002","article-title":"Poor sleep quality and physical performance in older adults","volume":"7","author":"Denison","year":"2021","journal-title":"Sleep Health"},{"key":"ref_61","first-page":"1108","article-title":"Current Cigarette Smoking Among Adults\u2014United States, 2005\u20132013","volume":"63","author":"Jamal","year":"2014","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_62","unstructured":"Food and Nutrition Service (2025, February 13). US Department of Agriculture. Average Healthy Eating Index-2010 Scores for Americans by Age Group, WWEIA-NHANES 2011\u20132012, Available online: https:\/\/www.fns.usda.gov\/sites\/default\/files\/media\/file\/HEI2010_Age_Groups_2011_2012.pdf."},{"key":"ref_63","unstructured":"National Research Council (1989). Recommended Dietary Allowances. Chapter: Protein and Amino Acids, The National Academies Press. [10th ed.]."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Carbone, J.W., and Pasiakos, S.M. (2019). Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit. Nutrients, 11.","DOI":"10.3390\/nu11051136"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2519\/jospt.2018.7851","article-title":"Hand-Grip Strength: Normative Reference Values and Equations for Individuals 18 to 85 Years of Age Residing in the United States","volume":"48","author":"Wang","year":"2018","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2147\/CIA.S194543","article-title":"Grip Strength: An Indispensable Biomarker for Older Adults","volume":"14","author":"Bohannon","year":"2019","journal-title":"Clin. Interv. Aging"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Pan, P.J., Hsu, N.W., Lee, M.J., Lin, Y.Y., Tsai, C.C., and Lin, W.S. (2022). Physical fitness and its correlation with handgrip strength in active community-dwelling older adults. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-21736-w"},{"key":"ref_68","first-page":"171","article-title":"The Effect of Gender and Arm Anatomical Position on the Hand Grip Strength and Fatigue Resistance during Sustained Maximal Handgrip Effort","volume":"12","author":"Almashaqbeh","year":"2022","journal-title":"J. Biomed. Phys. Eng."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"afac324","DOI":"10.1093\/ageing\/afac324","article-title":"Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort\u2014A comparison to the EWGSOP2 cut-off points","volume":"52","author":"Huemer","year":"2023","journal-title":"Age Ageing"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1002\/jcsm.13586","article-title":"Factors associated with handgrip strength across the life course: A systematic review","volume":"15","author":"Ribeiro","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Cho, E., Soh, H.S., Lee, J.R., Yun, J., Bae, W.K., and Lee, H. (2023). Association between smoking status and handgrip strength in Korean male adults: Based on Korea National Health and Nutrition Examination Survey 2016\u20132019. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1212946"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"zsy057","DOI":"10.1093\/sleep\/zsy057","article-title":"Agreement between self-reported and objectively measured sleep duration among white, black, Hispanic, and Chinese adults in the United States: Multi-Ethnic Study of Atherosclerosis","volume":"41","author":"Jackson","year":"2018","journal-title":"Sleep"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpsychores.2016.03.017","article-title":"Biological and psychological correlates of self-reported and objective sleep measures","volume":"84","author":"Jackowska","year":"2016","journal-title":"J. Psychosom. Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Howes, E.M., Parker, M.K., Misyak, S.A., DiFeliceantonio, A.G., Davy, B.M., Brown, L.E.C., and Hedrick, V.E. (2024). The Impact of Weight Bias and Stigma on the 24 h Dietary Recall Process in Adults with Overweight and Obesity: A Pilot Study. Nutrients, 16.","DOI":"10.3390\/nu16020191"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1249\/MSS.0b013e3182a0595f","article-title":"Comparison of self-reported versus accelerometer-measured physical activity","volume":"46","author":"Dyrstad","year":"2014","journal-title":"Med. Sci. Sports Exerc."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/11\/1900\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:44:50Z","timestamp":1760031890000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/11\/1900"}},"issued":{"date-parts":[[2025,5,31]]},"references-count":75,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["nu17111900"],"URL":"https:\/\/doi.org\/10.3390\/nu17111900","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2025,5,31]]}},{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:22:05Z","timestamp":1785468125045,"version":"3.56.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R00DK104066"],"award-info":[{"award-number":["R00DK104066"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The alveolar epithelia of the lungs require manganese (Mn) as an essential nutrient, but also provide an entry route for airborne Mn that can cause neurotoxicity. Transporters involved in Mn uptake by alveolar epithelial cells are unknown. Recently, two members of the Zrt- and Irt-like protein (ZIP) family of metal transporters, ZIP8 and ZIP14, have been identified as crucial Mn importers in vivo. ZIP8 is by far most abundantly expressed in the lungs, whereas ZIP14 expression in the lungs is low compared to other tissues. We hypothesized that Mn uptake by alveolar epithelial cells is primarily mediated by ZIP8. To test our hypothesis, we used A549 cells, a type II alveolar cell line. Mirroring the in vivo situation, A549 cells expressed higher levels of ZIP8 than cell models for the liver, intestines, and kidney. Quantification of ZIP8 and ZIP14 revealed a strong enrichment of ZIP8 over ZIP14 in A549 cells. Using siRNA technology, we identified ZIP8 and ZIP14 as the major transporters mediating Mn uptake by A549 cells. To our surprise, knockdown of either ZIP8 or ZIP14 impaired Mn accumulation to a similar extent, which we traced back to similar amounts of ZIP8 and ZIP14 at the plasma membrane. Our study highlights the importance of both ZIP8 and ZIP14 in Mn metabolism of alveolar epithelial cells.<\/jats:p>","DOI":"10.3390\/nu11071473","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:20:26Z","timestamp":1561720826000},"page":"1473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-0132","authenticated-orcid":false,"given":"Ivo F.","family":"Scheiber","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neftali Ortega","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"ref_1","first-page":"199","article-title":"Manganese in health and disease","volume":"13","author":"Avila","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"ref_2","unstructured":"Wedler, F.C. (1994). Biochemical and nutritional role of manganese: An overview. Manganese Health Dis., 1\u201337."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Peres, T.V., Schettinger, M.R., Chen, P., Carvalho, F., Avila, D.S., Bowman, A.B., and Aschner, M. (2016). \u201cManganese-induced neurotoxicity: A review of its behavioral consequences and neuroprotective strategies\u201d. BMC Pharmacol. Toxicol., 17.","DOI":"10.1186\/s40360-016-0099-0"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.3390\/ijerph120707519","article-title":"Manganese-Induced Parkinsonism and Parkinson\u2019s Disease: Shared and Distinguishable Features","volume":"12","author":"Kwakye","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/ajcn\/60.6.949","article-title":"Sex affects manganese absorption and retention by humans from a diet adequate in manganese","volume":"60","author":"Finley","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02802395","article-title":"True absorption and endogenous fecal excretion of manganese in relation to its dietary supply in growing rats","volume":"10","author":"Weigand","year":"1986","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1152\/ajplegacy.1966.211.1.203","article-title":"Dependence of manganese turnover on intake","volume":"211","author":"Britton","year":"1966","journal-title":"Am. J. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/jn\/122.6.1300","article-title":"Varying levels of manganese and iron affect absorption and gut endogenous losses of manganese by rats","volume":"122","author":"Davis","year":"1992","journal-title":"J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/toxsci\/60.2.242","article-title":"Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats","volume":"60","author":"Dorman","year":"2001","journal-title":"Toxicol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0317167100039482","article-title":"Long term exposure to manganese in rural well water has no neurological effects","volume":"22","author":"Vieregge","year":"1995","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/taap.2000.9073","article-title":"Direct olfactory transport of inhaled manganese ((54)MnCl(2)) to the rat brain: Toxicokinetic investigations in a unilateral nasal occlusion model","volume":"169","author":"Brenneman","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1080\/00984100290071630","article-title":"Olfactory transport: A direct route of delivery of inhaled manganese phosphate to the rat brain","volume":"65","author":"Dorman","year":"2002","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0022-2275(20)41642-6","article-title":"Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids","volume":"32","author":"Schmitz","year":"1991","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.resp.2007.06.011","article-title":"Alveolar epithelial transport in the adult lung","volume":"159","author":"Dobbs","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"174306","DOI":"10.1155\/2011\/174306","article-title":"Ion transport by pulmonary epithelia","volume":"2011","author":"Hollenhorst","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.biocel.2013.08.009","article-title":"Alveolar epithelial cells: Master regulators of lung homeostasis","volume":"45","author":"Guillot","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/1753465810396539","article-title":"The airway epithelium: More than just a structural barrier","volume":"5","author":"Tam","year":"2011","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"L1247","DOI":"10.1152\/ajplung.00450.2005","article-title":"Manganese and iron transport across pulmonary epithelium","volume":"290","author":"Heilig","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.ajhg.2015.11.002","article-title":"Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8","volume":"97","author":"Boycott","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ajhg.2015.11.003","article-title":"SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation","volume":"97","author":"Park","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1038\/ncomms11601","article-title":"Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia","volume":"7","author":"Tuschl","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/mol.107.043588","article-title":"Slc39a14 gene encodes ZIP14, a metal\/bicarbonate symporter: Similarities to the ZIP8 transporter","volume":"73","author":"Girijashanker","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1124\/mol.106.024521","article-title":"ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: Characterization of transporter properties","volume":"70","author":"He","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"C862","DOI":"10.1152\/ajpcell.00479.2010","article-title":"ZIP14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron","volume":"301","author":"Sparkman","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"34032","DOI":"10.1074\/jbc.M112.367284","article-title":"ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10545-016-0010-6","article-title":"A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders","volume":"40","author":"Riley","year":"2017","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ymgme.2018.04.002","article-title":"Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies","volume":"124","author":"Rodan","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zeglam, A., Abugrara, A., and Kabuka, M. (2018). Autosomal-recessive iron deficiency anemia, dystonia and hypermanganesemia caused by new variant mutation of the manganese transporter gene SLC39A14. Acta. Neurol. Belg.","DOI":"10.1007\/s13760-018-1024-7"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13023-018-0758-x","article-title":"Hypermanganesemia due to mutations in SLC39A14: Further insights into Mn deposition in the central nervous system","volume":"13","author":"Darling","year":"2018","journal-title":"Orphanet. J. Rare. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e3012","DOI":"10.1002\/jgm.3012","article-title":"A novel mutation in SLC39A14 causing hypermanganesemia associated with infantile onset dystonia","volume":"20","author":"Juneja","year":"2018","journal-title":"J. Gene Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"G171","DOI":"10.1152\/ajpgi.00021.2014","article-title":"Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function","volume":"308","author":"Guthrie","year":"2015","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Scheiber, I.F., Wu, Y., Morgan, S.E., and Zhao, N. (2019). The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. J. Biol. Chem.","DOI":"10.1074\/jbc.RA119.008762"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16605","DOI":"10.1074\/jbc.M117.804989","article-title":"Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production","volume":"292","author":"Liu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1172\/JCI90896","article-title":"Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity","volume":"127","author":"Lin","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/excr.1998.4172","article-title":"Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism","volume":"243","author":"Foster","year":"1998","journal-title":"Exp. Cell Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"32141","DOI":"10.1074\/jbc.M110.143248","article-title":"ZRT\/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin","volume":"285","author":"Zhao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_39","first-page":"477","article-title":"Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro","volume":"18","author":"Mei","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gordon, S.J.V., Fenker, D.E., Vest, K.E., and Padilla-Benavides, T. (2019). Manganese influx and expression of ZIP8 is essential in primary myoblasts and contributes to activation of SOD2. Metallomics.","DOI":"10.1101\/494542"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1053\/j.gastro.2012.02.046","article-title":"The zinc transporter ZIP14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice","volume":"142","author":"Aydemir","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10534-014-9765-0","article-title":"Cellular localization and developmental changes of ZIP8, ZIP14 and transferrin receptor 1 in the inner ear of rats","volume":"27","author":"Ding","year":"2014","journal-title":"Biometals"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1039\/C5TX00424A","article-title":"Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)","volume":"5","author":"Zang","year":"2016","journal-title":"Toxicol. Res. (Camb)"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"G351","DOI":"10.1152\/ajpgi.00103.2018","article-title":"Manganese transport and toxicity in polarized WIF-B hepatocytes","volume":"315","author":"Thompson","year":"2018","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"L1127","DOI":"10.1152\/ajplung.00057.2008","article-title":"The human zinc transporter SLC39A8 (ZIP8) is critical in zinc-mediated cytoprotection in lung epithelia","volume":"294","author":"Besecker","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1189\/jlb.1208759","article-title":"Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells","volume":"86","author":"Aydemir","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhao, N., Zhang, A.S., Wortham, A.M., Jue, S., Knutson, M.D., and Enns, C.A. (2017). The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14. Nutrients, 9.","DOI":"10.3390\/nu9121335"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1074\/jbc.RA118.006816","article-title":"Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn(2+) is driven by an active Ca(2+)-coupled exchange","volume":"294","author":"Levy","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1038\/s41598-018-21464-0","article-title":"Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders","volume":"8","author":"Choi","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/7\/1473\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:01:59Z","timestamp":1760187719000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/7\/1473"}},"issued":{"date-parts":[[2019,6,28]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["nu11071473"],"URL":"https:\/\/doi.org\/10.3390\/nu11071473","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2019,6,28]]}},{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:03:18Z","timestamp":1768006998757,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIBEROBN","award":["CB12\/03\/30002"],"award-info":[{"award-number":["CB12\/03\/30002"]}]},{"name":"CIBEROBN","award":["RTI2018-102205-B-I00"],"award-info":[{"award-number":["RTI2018-102205-B-I00"]}]},{"name":"CIBEROBN","award":["IJC2019-040796-I"],"award-info":[{"award-number":["IJC2019-040796-I"]}]},{"name":"Government of Navarra (Obekit-PT024 and Microbiota-PI035 projects)","award":["CB12\/03\/30002"],"award-info":[{"award-number":["CB12\/03\/30002"]}]},{"name":"Government of Navarra (Obekit-PT024 and Microbiota-PI035 projects)","award":["RTI2018-102205-B-I00"],"award-info":[{"award-number":["RTI2018-102205-B-I00"]}]},{"name":"Government of Navarra (Obekit-PT024 and Microbiota-PI035 projects)","award":["IJC2019-040796-I"],"award-info":[{"award-number":["IJC2019-040796-I"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["CB12\/03\/30002"],"award-info":[{"award-number":["CB12\/03\/30002"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["RTI2018-102205-B-I00"],"award-info":[{"award-number":["RTI2018-102205-B-I00"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["IJC2019-040796-I"],"award-info":[{"award-number":["IJC2019-040796-I"]}]},{"name":"Juan de la Cierva- Incorporaci\u00f3n","award":["CB12\/03\/30002"],"award-info":[{"award-number":["CB12\/03\/30002"]}]},{"name":"Juan de la Cierva- Incorporaci\u00f3n","award":["RTI2018-102205-B-I00"],"award-info":[{"award-number":["RTI2018-102205-B-I00"]}]},{"name":"Juan de la Cierva- Incorporaci\u00f3n","award":["IJC2019-040796-I"],"award-info":[{"award-number":["IJC2019-040796-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and aims: Obesity is a public health problem. The usual treatment is a reduction in calorie intake and an increase in energy expenditure, but not all individuals respond equally to these treatments. Epigenetics could be a factor that contributes to this heterogeneity. The aim of this research was to determine the association between DNA methylation at baseline and the percentage of BMI loss (%BMIL) after two dietary interventions, in order to design a prediction model to evaluate %BMIL based on methylation data. Methods and Results: Spanish participants with overweight or obesity (n = 306) were randomly assigned to two lifestyle interventions with hypocaloric diets: one moderately high in protein (MHP) and the other low in fat (LF) for 4 months (Obekit study; ClinicalTrials.gov ID: NCT02737267). Basal DNA methylation was analyzed in white blood cells using the Infinium MethylationEPIC array. After identifying those methylation sites associated with %BMIL (p &lt; 0.05 and SD &gt; 0.1), two weighted methylation sub-scores were constructed for each diet: 15 CpGs were used for the MHP diet and 11 CpGs for the LF diet. Afterwards, a total methylation score was made by subtracting the previous sub-scores. These data were used to design a prediction model for %BMIL through a linear mixed effect model with the interaction between diet and total score. Conclusion: Overall, DNA methylation predicts the %BMIL of two 4-month hypocaloric diets and was able to determine which type of diet is the most appropriate for each individual. The results of this pioneer study confirm that epigenetic biomarkers may be further used for precision nutrition and the design of personalized dietary strategies against obesity.<\/jats:p>","DOI":"10.3390\/nu15245023","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T06:01:07Z","timestamp":1701842467000},"page":"5023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Predictive Tool Based on DNA Methylation Data for Personalized Weight Loss through Different Dietary Strategies: A Pilot Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Nereyda","family":"Garc\u00eda-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-8457","authenticated-orcid":false,"given":"Jos\u00e9","family":"Riezu-Boj","sequence":"additional","affiliation":[{"name":"Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-6941","authenticated-orcid":false,"given":"J.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4795","authenticated-orcid":false,"given":"Sonia","family":"Garc\u00eda-Calz\u00f3n","sequence":"additional","affiliation":[{"name":"Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-9916","authenticated-orcid":false,"given":"Ferm\u00edn","family":"Milagro","sequence":"additional","affiliation":[{"name":"Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de la Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn), Carlos III Health Institute, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization Obesity and Overweight (2023, August 23). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159019","DOI":"10.1016\/j.bbalip.2021.159019","article-title":"Epigenetic regulation of inflammatory factors in adipose tissue","volume":"1866","author":"Jung","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ymeth.2020.06.022","article-title":"Modern epigenetics methods in biological research","volume":"187","author":"Li","year":"2021","journal-title":"Methods"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13098-022-00947-1","article-title":"Recent progress in epigenetics of obesity","volume":"14","author":"Wu","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1017\/S0007114521000374","article-title":"Diets, nutrients, genes and the microbiome: Recent advances in personalized nutrition","volume":"126","author":"Matusheski","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_6","first-page":"405","article-title":"La epigen\u00e9tica. Sus mecanismos y significado en la regulaci\u00f3n g\u00e9nica","volume":"31","year":"2020","journal-title":"Cuad. Bio\u00e9tica"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1111\/dom.13333","article-title":"Genetic, epigenetic and transcriptional variations at NFATC2IP locus with weight loss in response to diet interventions: The POUNDS Lost Trial","volume":"20","author":"Sun","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/15592294.2019.1595297","article-title":"DNA methylation markers in obesity, metabolic syndrome, and weight loss","volume":"14","author":"Samblas","year":"2019","journal-title":"Epigenetics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biochi.2020.02.006","article-title":"The complex interplay between DNA methylation and miRNAs in gene expression regulation","volume":"173","author":"Fuso","year":"2020","journal-title":"Biochimie"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bbagrm.2019.06.008","article-title":"m6A methylation modulates adipogenesis through JAK2-STAT3-C\/EBP\u03b2 signaling","volume":"1862","author":"Wu","year":"2019","journal-title":"Biochim. Biophys. Acta BBA-Gene Regul. Mech."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.14336\/AD.2021.0904","article-title":"DNA Methylation Modulates Aging Process in Adipocytes","volume":"13","author":"Xie","year":"2022","journal-title":"Aging Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Czoga\u0142a, W., Strojny, W., Schab, M., Grabowska, A., Miklusiak, K., Kowalczyk, W., \u0141azarczyk, A., Tomasik, P., and Skocze\u0144, S. (2021). FTO and PLAG1 Genes Expression and FTO Methylation Predict Changes in Circulating Levels of Adipokines and Gastrointestinal Peptides in Children. Nutrients, 13.","DOI":"10.3390\/nu13103585"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/15592294.2019.1625670","article-title":"The role of DNA methylation in thermogenic adipose biology","volume":"14","author":"Xiao","year":"2019","journal-title":"Epigenetics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in Human Obesity and Type 2 Diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mahmoud, A.M. (2022). An overview of epigenetics in obesity: Th role of lifestyle and therapeutic interventions. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031341"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lecorguill\u00e9, M., Teo, S., and Phillips, C.M. (2021). Maternal dietary quality and dietary inflammation associated with offspring growth, placental development, and DNA methylation. Nutrients, 13.","DOI":"10.3390\/nu13093130"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ungaro, P., Nettore, I.C., Franchini, F., Palatucci, G., Muscogiuri, G., Colao, A., and Macchia, P.E. (2022). Epigenome Modulation Induced by Ketogenic Diets. Nutrients, 14.","DOI":"10.3390\/nu14153245"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pcad.2018.12.012","article-title":"Precision Medicine in Weight Loss and Healthy Living","volume":"62","author":"Severin","year":"2019","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/MCO.0000000000000836","article-title":"Genetic and epigenetic nutritional interactions influencing obesity risk and adiposity outcomes","volume":"25","author":"Milagro","year":"2022","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Reguero, M., de Cedr\u00f3n, M.G., Wagner, S., Reglero, G., Quintela, J.C., and de Molina, A.R. (2021). Precision nutrition to activate thermogenesis as a complementary approach to target obesity and associated-meta-bolic-disorders. Cancers, 13.","DOI":"10.3390\/cancers13040866"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1093\/jn\/nxaa280","article-title":"More Nutrition Precision, Better Decisions for the Health of Our Nation","volume":"150","author":"Stover","year":"2020","journal-title":"J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_23","unstructured":"World Health Organization (2023, August 23). Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/topic-details\/GHO\/body-mass-index."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Houseman, E.A., Accomando, W.P., Koestler, D.C., Christensen, B.C., Marsit, C.J., Nelson, H.H., Wiencke, J.K., and Kelsey, K.T. (2012). DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinform., 13.","DOI":"10.1186\/1471-2105-13-86"},{"key":"ref_26","unstructured":"Lindsey, C. (2023, August 23). Stat Softw Components. Boston College Department of Economics. VSELECT: Stata Module to Perform Linear Regression Variable Selection. Available online: https:\/\/ideas.repec.org\/c\/boc\/bocode\/s457808.html."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13148-021-01162-x","article-title":"Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: An EWAS in multi-ethnic Asian individuals","volume":"13","author":"Chen","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/CIRCRESAHA.119.315397","article-title":"Body mass index drives changes in DNA methylation: A longitudinal study","volume":"125","author":"Sun","year":"2019","journal-title":"Circ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41392-023-01333-7","article-title":"Epigenetic regulation in metabolic diseases: Mechanisms and advances in clinical study","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Salas-Perez, F., Assmann, T.S., Ramos-Lopez, O., Mart\u00ednez, J.A., Riezu-Boj, J.I., and Milagro, F.I. (2023). Crosstalk between Gut Microbiota and Epigenetic Markers in Obesity Development: Relationship between Ruminococcus, BMI, and MACROD2\/SEL1L2 Methylation. Nutrients, 15.","DOI":"10.3390\/nu15071550"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"D\u0142uski, D.F., Woli\u0144ska, E., and Skrzypczak, M. (2021). Epigenetic changes in gestational diabetes mellitus. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147649"},{"key":"ref_32","first-page":"2708","article-title":"Methylation of WWOX gene promotes proliferation of osteosarcoma cells","volume":"25","author":"Liu","year":"2020","journal-title":"J. Buon."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Muhammad, J.S., Eladl, M.A., and Khoder, G. (2019). Helicobacter pylori-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction. Pathogens, 8.","DOI":"10.3390\/pathogens8010023"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"41903","DOI":"10.1038\/srep41903","article-title":"DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: A genome-wide analysis from non-obese and obese patients","volume":"7","author":"Crujeiras","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nabais, M.F., Gadd, D.A., Hannon, E., Mill, J., McRae, A.F., and Wray, N.R. (2023). An overview of DNA methylation-derived trait score methods and applications. Genome Biol., 24.","DOI":"10.1186\/s13059-023-02855-7"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1016\/j.clnu.2021.09.039","article-title":"ESPEN guideline on hospital nutrition","volume":"40","author":"Thibault","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.endinu.2020.05.003","article-title":"Abordaje cl\u00ednico integral SEEN de la obesidad en la edad adulta","volume":"68","author":"Herrera","year":"2021","journal-title":"Endocrinol. Diabetes Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2022.12.014","article-title":"Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI","volume":"110","author":"Do","year":"2023","journal-title":"Am. J. Hum. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13073-022-01053-7","article-title":"Gut microbiota predicts body fat change following a low-energy diet: A PREVIEW intervention study","volume":"14","author":"Jian","year":"2022","journal-title":"Genome Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"112170","DOI":"10.1016\/j.nut.2023.112170","article-title":"Role of beta-2 adrenergic receptor polymorphism (rs1042714) on body weight and glucose metabolism response to a meal-replacement hypocaloric diet","volume":"116","author":"Izaola","year":"2023","journal-title":"Nutrition"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110547","DOI":"10.1016\/j.nut.2019.06.027","article-title":"Interaction between genes involved in energy intake regulation and diet in obesity","volume":"67\u201368","author":"Crovesy","year":"2019","journal-title":"Nutrition"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ajcn\/nqz286","article-title":"Modeling of an integrative prototype based on genetic, phenotypic, and environmental information for personalized prescription of energy-restricted diets in overweight\/obese subjects","volume":"111","author":"Cuervo","year":"2020","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/24\/5023\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:34:06Z","timestamp":1760132046000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/24\/5023"}},"issued":{"date-parts":[[2023,12,6]]},"references-count":42,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["nu15245023"],"URL":"https:\/\/doi.org\/10.3390\/nu15245023","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2023,12,6]]}},{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T14:25:05Z","timestamp":1784471105201,"version":"3.55.0"},"reference-count":49,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Faculty of Medicine Research Fund","doi-asserted-by":"publisher","award":["MC037-2565"],"award-info":[{"award-number":["MC037-2565"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Attention deficit hyperactivity disorder (ADHD) significantly affects the well-being of medical students in various aspects. Sugar-sweetened beverages (SSBs) pose a potential risk of ADHD. Our study aimed to determine the prevalence of ADHD symptoms and the association between consumption of added sugar in common beverages and ADHD symptoms in Thai medical students. An online cross-sectional survey was conducted among medical students at Chiang Mai University from May 2022 to April 2023. The consumption of added sugar from common beverages in Thailand was assessed using the Thai Adolescence Sugar Sweetened Beverage Intake (THASSI) questionnaire. An Adult ADHD Self-Report Scale (ASRS) score \u2265 3 identified the presence of ADHD symptoms. Multivariable logistic regression was used for the analysis. Of 441 participants, 29.9% had ADHD symptoms. Daily consumption of added sugar from beverages higher than 25 g\/day showed an increased risk of ADHD symptoms (adjusted odds ratio (OR) 1.80, 95%CI 1.15 to 2.84, p = 0.011). The same trend was observed when using the sex-specific cutoff points (adjusted OR 1.73, 95%CI 1.10 to 2.73, p = 0.018). Higher consumption of added sugar from beverages may increase the risk of ADHD symptoms in Thai medical students. This finding supports the implementation of health policies that promote healthy consumption behaviors among medical students.<\/jats:p>","DOI":"10.3390\/nu15204395","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:10:19Z","timestamp":1697530219000},"page":"4395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is the Consumption of Added Sugar from Common Beverages Associated with the Presence of Attention Deficit Hyperactivity Disorder Symptoms in Thai Medical Students?"],"prefix":"10.3390","volume":"15","author":[{"given":"Nalinee","family":"Yingchankul","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chompimaksorn","family":"Panuspanudechdamrong","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuthakul","family":"Techapipatchai","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphakorn","family":"Chanmuang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pintira","family":"Netsiri","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-0991","authenticated-orcid":false,"given":"Nuntaporn","family":"Karawekpanyawong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-8387","authenticated-orcid":false,"given":"Krittai","family":"Tanasombatkul","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-6254","authenticated-orcid":false,"given":"Phichayut","family":"Phinyo","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(15)00238-X","article-title":"Attention Deficit Hyperactivity Disorder","volume":"387","author":"Thapar","year":"2016","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Magnus, W., Nazir, S., Anilkumar, A.C., and Shaban, K. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1037\/abn0000100","article-title":"Progression of Impairment in Adolescents with Attention-Deficit\/Hyperactivity Disorder through the Transition out of High School: Contributions of Parent Involvement and College Attendance","volume":"125","author":"Howard","year":"2016","journal-title":"J. Abnorm. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/jamapsychiatry.2016.0465","article-title":"Evaluation of the Persistence, Remission, and Emergence of Attention-Deficit\/Hyperactivity Disorder in Young Adulthood","volume":"73","author":"Polanczyk","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s42843-023-00077-w","article-title":"Adult ADHD: Underdiagnosis of a Treatable Condition","volume":"49","author":"Diaz","year":"2023","journal-title":"J. Health Serv. Psychol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1001\/jama.2019.15372","article-title":"Change in Prevalence of Disabilities and Accommodation Practices Among US Medical Schools, 2016 vs 2019","volume":"322","author":"Meeks","year":"2019","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Karawekpanyawong, N., Wongpakaran, T., Wongpakaran, N., Boonnag, C., Siritikul, S., Chalanunt, S., and Kuntawong, P. (2021). Impact of Perceived Social Support on the Relationship between ADHD and Depressive Symptoms among First Year Medical Students: A Structural Equation Model Approach. Children, 8.","DOI":"10.3390\/children8050401"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2147\/AMEP.S398196","article-title":"Attention Deficit Hyperactivity Disorder in Medical Learners and Physicians and a Potentially Helpful Educational Tool","volume":"14","author":"Im","year":"2023","journal-title":"Adv. Med. Educ. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00702-021-02309-z","article-title":"ADHD at the Workplace: ADHD Symptoms, Diagnostic Status, and Work-Related Functioning","volume":"128","author":"Fuermaier","year":"2021","journal-title":"J. Neural Transm."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sedgwick-M\u00fcller, J.A., M\u00fcller-Sedgwick, U., Adamou, M., Catani, M., Champ, R., Gudj\u00f3nsson, G., Hank, D., Pitts, M., Young, S., and Asherson, P. (2022). University Students with Attention Deficit Hyperactivity Disorder (ADHD): A Consensus Statement from the UK Adult ADHD Network (UKAAN). BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-03898-z"},{"key":"ref_11","first-page":"10","article-title":"The Quality of Life of Adults with Attention Deficit Hyperactivity Disorder: A Systematic Review","volume":"9","author":"Agarwal","year":"2012","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mp.2011.138","article-title":"The Genetics of Attention Deficit\/Hyperactivity Disorder in Adults, a Review","volume":"17","author":"Franke","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1177\/1087054716646452","article-title":"The Association of Lifestyle Factors and ADHD in Children","volume":"24","author":"Holton","year":"2020","journal-title":"J. Atten. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2147\/AMEP.S334155","article-title":"Association of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder Traits with Depression and Empathy Among Medical Students","volume":"12","author":"Watanabe","year":"2021","journal-title":"Adv. Med. Educ. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neubiorev.2018.02.014","article-title":"Sleep in Adults with ADHD: Systematic Review and Meta-Analysis of Subjective and Objective Studies","volume":"89","author":"Mitchell","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jad.2019.04.061","article-title":"Dietary Patterns and Attention Deficit\/Hyperactivity Disorder (ADHD): A Systematic Review and Meta-Analysis","volume":"252","author":"Quinte","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102512","DOI":"10.1016\/j.ctim.2020.102512","article-title":"Sugar Consumption, Sugar Sweetened Beverages and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis","volume":"53","author":"Asjodi","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yu, C.-J., Du, J.-C., Chiou, H.-C., Feng, C.-C., Chung, M.-Y., Yang, W., Chen, Y.-S., Chien, L.-C., Hwang, B., and Chen, M.-L. (2016). Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit\/Hyperactivity Disorder. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13070678"},{"key":"ref_19","first-page":"e2756","article-title":"Sugar Beverages and Dietary Sodas Impact on Brain Health: A Mini Literature Review","volume":"10","author":"Anjum","year":"2018","journal-title":"Cureus"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.acap.2014.11.006","article-title":"Energy Drinks and Youth Self-Reported Hyperactivity\/Inattention Symptoms","volume":"15","author":"Schwartz","year":"2015","journal-title":"Acad. Pediatr."},{"key":"ref_21","first-page":"e15163","article-title":"Stimulant Usage by Medical Students for Cognitive Enhancement: A Systematic Review","volume":"13","author":"Plumber","year":"2021","journal-title":"Cureus"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Harris, P.A., Taylor, R., Minor, B.L., Elliott, V., Fernandez, M., O\u2019Neal, L., McLeod, L., Delacqua, G., Delacqua, F., and Kirby, J. (2019). The REDCap Consortium: Building an International Community of Software Platform Partners. J. Biomed. Inform., 95.","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"ref_23","first-page":"218","article-title":"Validity and Reliability of Adult ADHD Self-Report Scale Thai Version (ASRS-V1.1 TH)","volume":"29","author":"Kiatrungrit","year":"2017","journal-title":"Shanghai Arch. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00127-017-1453-2","article-title":"The Relationship between Financial Difficulty and Childhood Symptoms of Attention Deficit\/Hyperactivity Disorder: A UK Longitudinal Cohort Study","volume":"53","author":"Russell","year":"2018","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/1087054713517543","article-title":"The Role of Parental Education in the Relation between ADHD Symptoms and Executive Functions in Children","volume":"19","author":"Tillman","year":"2015","journal-title":"J. Atten. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.sleh.2018.01.001","article-title":"Sleep in a Large, Multi-University Sample of College Students: Sleep Problem Prevalence, Sex Differences, and Mental Health Correlates","volume":"4","author":"Becker","year":"2018","journal-title":"Sleep Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.31887\/DCNS.2020.22.2\/gsmall","article-title":"Brain Health Consequences of Digital Technology Use","volume":"22","author":"Small","year":"2020","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_28","unstructured":"Hongsanun, W., and Kitreerawutiwong, N. (2020). Development of a Thai Adolescent Sugar Sweetened Beverage Intake Questionnaire (THASSI). [Ph.D. Thesis, Naresuan University]."},{"key":"ref_29","unstructured":"(2023, October 10). How Much Sugar Is Too Much?. Available online: https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/sugar\/how-much-sugar-is-too-much."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.comppsych.2012.06.001","article-title":"Agreement between Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and the Proposed DSM-V Attention Deficit Hyperactivity Disorder Diagnostic Criteria: An Exploratory Study","volume":"54","author":"Ghanizadeh","year":"2013","journal-title":"Compr. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S0033291704002892","article-title":"The World Health Organization Adult ADHD Self-Report Scale (ASRS): A Short Screening Scale for Use in the General Population","volume":"35","author":"Kessler","year":"2005","journal-title":"Psychol. Med."},{"key":"ref_32","first-page":"8","article-title":"The Prevalence of Attention Deficit Hyperactivity Disorder in Iran: An Updated Systematic Review","volume":"35","author":"Shariati","year":"2021","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1176\/appi.ap.34.3.220","article-title":"Prevalence of ADHD Diagnosis and Nonmedical Prescription Stimulant Use in Medical Students","volume":"34","author":"Tuttle","year":"2010","journal-title":"Acad. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1590\/1516-4446-2017-2429","article-title":"By the Book: ADHD Prevalence in Medical Students Varies with Analogous Methods of Addressing DSM Items","volume":"40","author":"Mattos","year":"2018","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4314\/ajpsy.v14i4.5","article-title":"Attention Deficit Hyperactivity Disorder Symptom Self-Report among Medical Students in Eldoret, Kenya","volume":"14","author":"Atwoli","year":"2011","journal-title":"Afr. J. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-014-0776-y","article-title":"Dietary Sugars: Their Detection by the Gut\u2013Brain Axis and Their Peripheral and Central Effects in Health and Diseases","volume":"54","author":"Ochoa","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1080\/10408398.2020.1747046","article-title":"High-Fat or High-Sugar Diets as Trigger Inflammation in the Microbiota-Gut-Brain Axis","volume":"61","author":"Jamar","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation Pathways: A General Review","volume":"127","author":"Shabab","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"ref_40","first-page":"e20828","article-title":"The Cognitive-Enhancing Outcomes of Caffeine and L-Theanine: A Systematic Review","volume":"13","author":"Ortiz","year":"2021","journal-title":"Cureus"},{"key":"ref_41","first-page":"323","article-title":"Complementary and Alternative Medical Therapies for Children with Attention-Deficit\/Hyperactivity Disorder (ADHD)","volume":"16","author":"Pellow","year":"2011","journal-title":"Altern. Med. Rev. J. Clin. Ther."},{"key":"ref_42","first-page":"127","article-title":"The Influence of Components of Diet on the Symptoms of ADHD in Children","volume":"63","author":"Konikowska","year":"2012","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08039488.2014.921933","article-title":"Diet in the Treatment of ADHD in Children\u2014A Systematic Review of the Literature","volume":"69","author":"Andersen","year":"2015","journal-title":"Nord. J. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0140-6736(07)61306-3","article-title":"Food Additives and Hyperactive Behaviour in 3-Year-Old and 8\/9-Year-Old Children in the Community: A Randomised, Double-Blinded, Placebo-Controlled Trial","volume":"370","author":"McCann","year":"2007","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/0009922810384728","article-title":"Dietary Sensitivities and ADHD Symptoms: Thirty-Five Years of Research","volume":"50","author":"Stevens","year":"2011","journal-title":"Clin. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cortese, S. (2019). The Association between ADHD and Obesity: Intriguing, Progressively More Investigated, but Still Puzzling. Brain Sci., 9.","DOI":"10.3390\/brainsci9100256"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1176\/appi.ajp.2015.15020266","article-title":"Association Between ADHD and Obesity: A Systematic Review and Meta-Analysis","volume":"173","author":"Cortese","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1123\/jpah.2018-0215","article-title":"Physical Activity, Screen Time, and Sleep in Children With ADHD","volume":"16","author":"Tandon","year":"2019","journal-title":"J. Phys. Act. Health"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/DBP.0000000000000539","article-title":"Cognitively Stimulating Activities, Physical Activity, and Attention-Deficit Hyperactivity Disorder Symptom Incidence in Children: A Prospective Study","volume":"39","author":"Peralta","year":"2018","journal-title":"J. Dev. Behav. Pediatr. JDBP"}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4395\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:08:08Z","timestamp":1760130488000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4395"}},"issued":{"date-parts":[[2023,10,17]]},"references-count":49,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15204395"],"URL":"https:\/\/doi.org\/10.3390\/nu15204395","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2023,10,17]]}},{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T21:38:17Z","timestamp":1778362697071,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Head and neck cancer (HNC) includes oral cavity cancer (OCC), pharyngeal cancer (PC), and laryngeal cancer (LC). It is one of the most frequent cancers in the world. Smoking and alcohol consumption are the typical well-known predictors of HNC. Human papillomavirus (HPV) is an increasing etiological factor for oropharyngeal cancer (OPC). Moreover, food and nutrition play an important role in HNC etiology. According to the World Cancer Research Fund and the American Institute for Cancer Research, an intake of non-starchy vegetables and fruits could decrease HNC risk. The carotenoids included in vegetables and fruits are well-known antioxidants which have anti-mutagenic and immune regulatory functions. Numerous studies have shown the relationship between carotenoid intake and a lower HNC risk, but the role of carotenoids in HNC risk is not well defined. The goal of this review is to present the current literature regarding the relationship between various carotenoids and HNC risk.<\/jats:p>","DOI":"10.3390\/nu14010088","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:06:54Z","timestamp":1640567214000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Association between Carotenoids and Head and Neck Cancer Risk"],"prefix":"10.3390","volume":"14","author":[{"given":"Adam","family":"Brewczy\u0144ski","sequence":"first","affiliation":[{"name":"I Radiation and Clinical Oncology Department of Maria Sk\u0142odowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-2969","authenticated-orcid":false,"given":"Beata","family":"Jab\u0142o\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Surgery, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Kentnowski","sequence":"additional","affiliation":[{"name":"I Radiation and Clinical Oncology Department of Maria Sk\u0142odowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Mrowiec","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Surgery, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Sk\u0142adowski","sequence":"additional","affiliation":[{"name":"I Radiation and Clinical Oncology Department of Maria Sk\u0142odowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-5664","authenticated-orcid":false,"given":"Tomasz","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"I Radiation and Clinical Oncology Department of Maria Sk\u0142odowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1158\/1055-9965.EPI-15-0053","article-title":"Carotenoid Intake from Natural Sources and Head and Neck Cancer: A Systematic Review and Meta-analysis of Epidemiological Studies","volume":"24","author":"Leoncini","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10654-015-0036-3","article-title":"Carotenoid intake and head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"31","author":"Leoncini","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_3","unstructured":"IARC (2021, December 08). List of Classifications by Cancer Sites with Sufficient or Limited Evidence in Humans. Volumes 1\u2013109., Available online: http:\/\/monographs.iarc.fr\/ENG\/Classification\/index.php."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Brewczy\u0144ski, A., Jab\u0142o\u0144ska, B., Mazurek, A., Mrochem-Kwarciak, J., Mrowiec, S., \u015anietura, M., Kentnowski, M., Ko\u0142osza, Z., Sk\u0142adowski, K., and Rutkowski, T. (2021). Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated Oropharyngeal Cancer. Cancers, 13.","DOI":"10.3390\/cancers13133256"},{"key":"ref_5","unstructured":"World Cancer Research Fund \/ American Institute for Cancer Research (2007). Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective, World Cancer Research Fund International."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"257S","DOI":"10.1093\/jn\/134.1.257S","article-title":"Carotenoid Action on the Immune Response","volume":"134","author":"Chew","year":"2004","journal-title":"J. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1349-7006.2006.00232.x","article-title":"Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits","volume":"97","author":"Suzuki","year":"2006","journal-title":"Cancer Sci."},{"key":"ref_8","unstructured":"Prasad, M.P., Krishna, T.P., Pasricha, S., Quereshi, M.A., and Krishnaswamy, K. (1995). Diet and oral cancer\u2014A case control study. Asia Pac. J. Clin. Nutr., 4."},{"key":"ref_9","first-page":"441","article-title":"Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet","volume":"1","author":"Zheng","year":"1992","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_10","first-page":"45","article-title":"A case-control study of oral cancer in Beijing, People\u2019s Republic of China. Associations with nutrient intakes, foods and food groups","volume":"29","author":"Zheng","year":"1993","journal-title":"Oral Oncol."},{"key":"ref_11","first-page":"9","article-title":"Smoking, alcohol, dentition and diet in the epidemiology of oral cancer","volume":"28","author":"Marshall","year":"1992","journal-title":"Oral Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<122::AID-IJC19>3.0.CO;2-2","article-title":"Selected micronutrients and oral and pharyngeal cancer","volume":"86","author":"Negri","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jnci\/85.6.465","article-title":"Racial Differences in Risk of Oral and Pharyngeal Cancer: Alcohol, Tobacco, and Other Determinants","volume":"85","author":"Day","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/01635589009514096","article-title":"Diet and oral and pharyngeal cancer among blacks","volume":"14","author":"Gridley","year":"1990","journal-title":"Nutr. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/jnci\/80.15.1237","article-title":"Dietary Factors in Oral and Pharyngeal Cancer","volume":"80","author":"McLaughlin","year":"1988","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/ijc.2910440406","article-title":"Diet and pharyngeal cancer","volume":"44","author":"Rossing","year":"1989","journal-title":"Int. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1368-8375(99)00050-0","article-title":"Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: A case-control in Uruguay","volume":"36","author":"Oreggia","year":"2000","journal-title":"Oral Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1024991618398","article-title":"Micronutrients and laryngeal cancer risk in Italy and Switzerland: A case\u2013control study","volume":"14","author":"Bidoli","year":"2003","journal-title":"Cancer Causes Control."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1368-8375(98)00061-X","article-title":"Diet and risk of cancer of the upper aerodigestive tract\u2014II. Nutrients","volume":"35","author":"Ronco","year":"1999","journal-title":"Oral Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1038\/bjc.2013.667","article-title":"Foods, nutrients and the risk of oral and pharyngeal cancer","volume":"109","author":"Bravi","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00005537-199706000-00011","article-title":"Genetic susceptibility to head and neck cancer: Interaction between nutrition and mutagen sensitivity","volume":"107","author":"Schantz","year":"1997","journal-title":"Laryngoscope"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1002\/cncr.10560","article-title":"The role of diet and specific micronutrients in the etiology of oral carcinoma","volume":"94","author":"Petridou","year":"2002","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/01635589309514271","article-title":"Oral and pharyngeal cancer, diet, smoking, alcohol, and serum vitamin a and \u03b2-carotene levels: A case-control study in men","volume":"20","author":"Kune","year":"1993","journal-title":"Nutr. Cancer"},{"key":"ref_24","first-page":"514","article-title":"Laryngeal cancer in women: Tobacco, alcohol, nutritional, and hormonal factors","volume":"12","author":"Gallus","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00051300","article-title":"Diet and cancers of the larynx and hypopharynx: The IARC multi-center study in southwestern Europe","volume":"7","author":"Riboli","year":"1996","journal-title":"Cancer Causes Control."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Britton, G., Liaaen-Jensen, S., and Pfander, H. (2004). Carotenoids: Handbook, Verlag Birkh\u00e4user.","DOI":"10.1007\/978-3-0348-7836-4"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1351\/pac200678081551","article-title":"Distribution and metabolism of dietary carotenoids in humans as a criterion for development of nutritional supplements","volume":"78","author":"Khachik","year":"2006","journal-title":"Pure Appl. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/07315724.1999.10718880","article-title":"Beta-carotene and other carotenoids as antioxidants","volume":"18","author":"Paiva","year":"1999","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/oxfordjournals.aje.a115071","article-title":"Carotene intake and the risk of laryngeal cancer in coastal texas","volume":"128","author":"Mackerras","year":"1988","journal-title":"Am. J. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ijc.2910470105","article-title":"Nutrition and cancer of the oral cavity and pharynx in north-east italy","volume":"47","author":"Franceschi","year":"1991","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ije\/20.1.39","article-title":"Dietary Indicators of Oral and Pharyngeal Cancer","volume":"20","author":"Negri","year":"1991","journal-title":"Int. J. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/sj.bjc.6690400","article-title":"Food groups, oils and butter, and cancer of the oral cavity and pharynx","volume":"80","author":"Franceschi","year":"1999","journal-title":"Br. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/01635589209514171","article-title":"Diet, smoking, and alcohol in cancer of the larynx: A case-control study","volume":"17","author":"Freudenheim","year":"1992","journal-title":"Nutr. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"(2007). Djuric; Ronis; Fowler; Ren; Duffy Levels of Fat-Soluble Micronutrients and 2,6-Cyclolycopene-1,5-Diol in Head and Neck Cancer Patients. Int. J. Vitam. Nutr. Res., 77, 382\u2013388.","DOI":"10.1024\/0300-9831.77.6.382"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/ijc.23319","article-title":"Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study","volume":"122","author":"Freedman","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3945\/ajcn.114.106096","article-title":"Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study","volume":"102","author":"Maasland","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E396","DOI":"10.1002\/ijc.29219","article-title":"Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study","volume":"136","author":"Maasland","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1002\/cncr.28778","article-title":"Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma","volume":"120","author":"Arthur","year":"2014","journal-title":"Cancer"},{"key":"ref_39","first-page":"1","article-title":"Pretreatment Dietary Patterns, Serum Carotenoids and Tocopherols Influence Tumor Immune Response in Head and Neck Squamous Cell Carcinoma","volume":"11","author":"Argirion","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/bjc.2012.413","article-title":"Dietary intakes of carotenoids and other nutrients in the risk of nasopharyngeal carcinoma: A case\u2013control study in Italy","volume":"107","author":"Polesel","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_41","first-page":"11245451","article-title":"Randomized trial of supplemental beta-carotene to prevent second head and neck cancer","volume":"61","author":"Mayne","year":"2001","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/07315724.2004.10719340","article-title":"Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers","volume":"23","author":"Mayne","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1200\/JCO.2005.05.514","article-title":"Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients","volume":"23","author":"Bairati","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/01635580701397590","article-title":"Acute Adverse Effects of Radiation Therapy and Local Recurrence in Relation to Dietary and Plasma Beta Carotene and Alpha Tocopherol in Head and Neck Cancer Patients","volume":"59","author":"Meyer","year":"2007","journal-title":"Nutr. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/1471-2407-9-458","article-title":"Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: A prospective study","volume":"9","author":"Sakhi","year":"2009","journal-title":"BMC Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/01635580903441188","article-title":"Postradiotherapy Plasma Lutein, \u03b1-Carotene, and \u03b2-Carotene Are Positively Associated With Survival in Patients With Head and Neck Squamous Cell Carcinoma","volume":"62","author":"Sakhi","year":"2010","journal-title":"Nutr. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"\u00c1vila-Rom\u00e1n, J., Garc\u00eda-Gil, S., Rodr\u00edguez-Luna, A., Motilva, V., and Talero, E. (2021). Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids. Mar. Drugs, 19.","DOI":"10.3390\/md19100531"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mel\u00e9ndez-Mart\u00ednez, A.J., Stinco, C.M., and Mapelli-Brahm, P. (2019). Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene. Nutrients, 11.","DOI":"10.3390\/nu11051093"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2018.04.004","article-title":"A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health","volume":"70","author":"Avalos","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Silva, S.C., Ferreira, I.C.F.R., Dias, M.M., and Barreiro, M.F. (2020). Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis. Molecules, 25.","DOI":"10.3390\/molecules25153406"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13659-020-00244-2","article-title":"Carotenoids: Potent to Prevent Diseases Review","volume":"10","author":"Bhatt","year":"2020","journal-title":"Nat. Prod. Bioprospecting"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S0007114518003045","article-title":"Correlates of the difference in plasma carotenoid concentrations between men and women","volume":"121","author":"Allore","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1017\/S0007114516003056","article-title":"Carotenoids as biomarkers of fruit and vegetable intake in men and women","volume":"116","author":"Couillard","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"125631","DOI":"10.1016\/j.foodchem.2019.125631","article-title":"Novel protocol optimized for microalgae lutein used as food additives","volume":"307","author":"Low","year":"2020","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Marzocco, S., Singla, R.K., and Capasso, A. (2021). Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer. Molecules, 26.","DOI":"10.3390\/molecules26175333"},{"key":"ref_56","first-page":"372","article-title":"Likopen\u2014Wystepowanie, w\u0142a\u015bciwo\u015bci oraz potencjalne zastosowanie [Lycopene\u2014Occurrence, properties and applications]","volume":"57","author":"Belter","year":"2011","journal-title":"Postepy Biochem."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/1\/88\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:53:43Z","timestamp":1760169223000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/1\/88"}},"issued":{"date-parts":[[2021,12,26]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["nu14010088"],"URL":"https:\/\/doi.org\/10.3390\/nu14010088","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2021,12,26]]}},{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T19:07:45Z","timestamp":1763233665565,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We aim to evaluate whether calcium and vitamin D intake is associated with  25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men.  Serum PTH and 25-OH-Vitamin D3 were measured in 195 healthy elderly men (mean age: 73.31 \u00b1 5.10 year). Food intake was quantified using a dietetic scale. Participants with  25-OH-Vitamin D3 levels \u2265 30 ng\/mL (75 nmol\/L) and a calcium intake of  800\u20131200 mg\/day exhibited the lowest PTH levels (41.49 \u00b1 16.72 ng\/mL). The highest PTH levels (75.60 \u00b1 14.16 ng\/mL) were observed in the &lt;30 ng\/mL group 25-OH-Vitamin D3 with a calcium intake &gt;1200 mg\/day. No significant differences in the serum PTH levels based on the serum 25-OH-Vitamin D3 levels were observed among participants with a calcium intake of 800\u20131200 mg\/day. Serum PTH was inversely correlated with serum 25-OH-Vitamin D3 in the entire patient sample (r = \u22120.288, p = 0.019). No differences in any of the three densitometry techniques were observed between any of the age groups in the 800\u20131200 mg\/day and &gt;1200 mg\/day calcium intake groups. PTH levels correlate negatively with serum 25-OH-Vitamin D3 levels, and neither calcium nor vitamin D intake exert a strong influence on either of the two parameters.<\/jats:p>","DOI":"10.3390\/nu5124924","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T12:02:38Z","timestamp":1386158558000},"page":"4924-4937","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-182X","authenticated-orcid":false,"given":"Jose","family":"Moran","sequence":"first","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Lopez-Arza","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Lavado-Garcia","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pedrera-Canal","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purificacion","family":"Rey-Sanchez","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0610-3839","authenticated-orcid":false,"given":"Francisco","family":"Rodriguez-Velasco","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Pedrera-Zamorano","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy,  University of Extremadura, Caceres 10003, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(07)61342-7","article-title":"Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: A meta-analysis","volume":"370","author":"Tang","year":"2007","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Moreiras-Varela, O. (2011). Tablas de Composici\u00f3n de Alimentos, Editorial Piramide."},{"key":"ref_3","first-page":"390","article-title":"Dietary intake and nutritional risk among free-living elderly people in Palma de Mallorca","volume":"9","author":"Tur","year":"2005","journal-title":"J. Nutr. Health Aging"},{"key":"ref_4","first-page":"1354","article-title":"Trends in energy and nutrient intake and risk of inadequate intakes in Catalonia, Spain (1992\u20132003)","volume":"10","author":"Salvador","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.nut.2008.01.006","article-title":"Seemingly paradoxical seasonal influences on vitamin D status in nursing-home elderly people from a Mediterranean area","volume":"24","author":"Blanco","year":"2008","journal-title":"Nutrition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI109516","article-title":"Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: Effect of age and dietary calcium","volume":"64","author":"Gallagher","year":"1979","journal-title":"J. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1210\/jcem-67-4-644","article-title":"The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects","volume":"67","author":"Lips","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","unstructured":"Lu, K.C. (2013). Bone Loss: Risk Factors, Detection and Prevention, Nova Science Publishers."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1530\/EJE-11-0184","article-title":"Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: The STRAMBO study","volume":"165","author":"Chaitou","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jsbmb.2005.06.020","article-title":"The vitamin D requirement in health and disease","volume":"97","author":"Heaney","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s001980050030","article-title":"Prevalence of vitamin D insufficiency in an adult normal population","volume":"7","author":"Chapuy","year":"1997","journal-title":"Osteoporos. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Heaney","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1001\/jama.294.18.2336","article-title":"Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake","volume":"294","author":"Steingrimsdottir","year":"2005","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/jcem.86.3.7327","article-title":"A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: Baseline data from the multiple outcomes of raloxifene evaluation clinical trial","volume":"86","author":"Lips","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","first-page":"4125","article-title":"Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population","volume":"85","author":"Harris","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2165\/00002512-200724120-00005","article-title":"Optimal vitamin D status for the prevention and treatment of osteoporosis","volume":"24","author":"Holick","year":"2007","journal-title":"Drugs Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1210\/jc.2010-1886","article-title":"Relationship between vitamin D, parathyroid hormone, and bone health","volume":"96","author":"Sai","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/gerona\/60.11.1414","article-title":"25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults","volume":"60","author":"Maggio","year":"2005","journal-title":"J. Gerontol. A"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1210\/jc.2002-021064","article-title":"Age-related changes in the 25-hydroxyvitamin D vs. parathyroid hormone relationship suggest a different reason why older adults require more vitamin D","volume":"88","author":"Vieth","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hup.984","article-title":"Ultrasound bone mass in schizophrenic patients on antipsychotic therapy","volume":"24","year":"2009","journal-title":"Hum. Psychopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1359\/jbmr.081242","article-title":"Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults","volume":"24","author":"Kiel","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.nut.2009.02.007","article-title":"Effect of beer drinking on ultrasound bone mass in women","volume":"25","year":"2009","journal-title":"Nutrition"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1056\/NEJM197908233010827","article-title":"Serum levels of beta-2-microglobulin\u2014A new marker of activity in Crohn\u2019s disease","volume":"301","author":"Descos","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"ref_24","first-page":"121","article-title":"Intake of vitamins and minerals. Euronut SENECA investigators","volume":"45","author":"Cruz","year":"1991","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000078374","article-title":"Mineral and vitamin status in elderly persons from Northwest Spain consuming an Atlantic variant of the Mediterranean diet","volume":"48","author":"Vaquero","year":"2004","journal-title":"Ann. Nutr. Metab."},{"key":"ref_26","first-page":"1175","article-title":"Food habits and nutritional status of elderly people living in a Spanish Mediterranean city","volume":"26","author":"Rodriguez","year":"2011","journal-title":"Nutr. Hosp."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1359\/jbmr.1997.12.12.2119","article-title":"Age-related (type II) femoral neck osteoporosis in men: Biochemical evidence for both hypovitaminosis D- and androgen deficiency-induced bone resorption","volume":"12","author":"Boonen","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.beem.2011.06.007","article-title":"Worldwide vitamin D status","volume":"25","author":"Lips","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3177\/jnsv.55.453","article-title":"Improvement of vitamin D status in Japanese institutionalized elderly by supplementation with 800 IU of vitamin D(3)","volume":"55","author":"Kuwabara","year":"2009","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/ajcn\/65.1.67","article-title":"Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women","volume":"65","author":"Harris","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0781.2012.00649.x","article-title":"Vitamin D deficiency in South Europe: Effect of smoking and aging","volume":"28","author":"Grant","year":"2012","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijcard.2011.08.042","article-title":"Association between vitamin D deficiency and heart failure in the elderly","volume":"152","author":"Gil","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/ageing\/30.6.467","article-title":"Hypovitaminosis D and \u2018functional hypoparathyroidism\u2019-the NoNoF (Nottingham Neck of Femur) study","volume":"30","author":"Sahota","year":"2001","journal-title":"Age Ageing"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00198-006-0084-3","article-title":"Vitamin D insufficiency and the blunted PTH response in established osteoporosis: The role of magnesium deficiency","volume":"17","author":"Sahota","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.326.7387.469","article-title":"Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: Randomised double blind controlled trial","volume":"326","author":"Trivedi","year":"2003","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bone.2007.10.003","article-title":"Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake","volume":"42","author":"Adami","year":"2008","journal-title":"Bone"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2265.2010.03779.x","article-title":"Discrepant influence of vitamin D status on parathyroid hormone and bone mass after two years of calcium supplementation","volume":"73","author":"Chailurkit","year":"2010","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jbmr.1790","article-title":"Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: Analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHAENS IV-3, 2009 and V-1, 2010)","volume":"28","author":"Joo","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-2362.2003.01127.x","article-title":"Assessment of vitamin D and calcium status in healthy adult Austrians","volume":"33","author":"Kudlacek","year":"2003","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00198-010-1507-8","article-title":"Bone health in healthy Indian population aged 50 years and above","volume":"22","author":"Marwaha","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF02672505","article-title":"Vitamin D and bone mineral density","volume":"8","author":"Collins","year":"1998","journal-title":"Osteoporos. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0029-1211456","article-title":"Lower serum 25-hydroxyvitamin D is associated with increased bone resorption markers and lower bone density at the proximal femur in normal females: A population-based study","volume":"104","author":"Scharla","year":"1996","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/01639360903140130","article-title":"Use of calcium, folate, and vitamin D(3)-fortified milk for 6 months improves nutritional status but not bone mass or turnover, in a group of Australian aged care residents","volume":"28","author":"Grieger","year":"2009","journal-title":"J. Nutr. 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However, the relationship is still inconclusive as it is likely to be interfered with by substantial confounding factors and potential reverse causality. The present study aimed to investigate causal correlation of the two diseases by a Mendelian randomization (MR) study and further elucidate the underlying molecular mechanisms. Methods: With the biggest summary datasets of a genome-wide association study (GWAS) in the East Asian population, we conducted a two-sample, bidirectional MR study to assess the causal correlation between shrimp allergy (SA) and MDD. Subsequently, we identified the pleiotropic genes\u2019 susceptibility to the two diseases at whole-genome and tissue-specific levels, respectively. Enriched GO sets and KEGG pathways were also discovered to elucidate the potential underlying mechanisms. Results: With the most suitable MR method, SA was identified as a causal risk factor for MDD based on three different groups of independent genetic instruments, respectively (p &lt; 2.81 \u00d7 10\u22122). In contrast, we did not observe a significant causal effect of MDD on SA. The GWAS-pairwise program successfully identified seven pleiotropic genetic variants (PPA3 &gt; 0.8), indicating that the two diseases indeed have a shared genetic basis. At a whole-genome level, the MAGMA program identified 44 pleiotropic genes, which were enriched in allergy-related pathways, such as antigen processing and presentation pathway (p = 1.46 \u00d7 10\u22122). In brain-specific tissue, the S-MultiXcan program found 17 pleiotropic genes that were significantly enriched in immune-related pathways and GO sets, including asthma-related pathway, T-cell activation-related, and major histocompatibility complex protein-related GO sets. Regarding whole-blood tissue, the program identified six pleiotropic genes that are significantly enriched in tolerance induction-related GO sets. Conclusions: The present study for the first time indicated a significant causal effect of SA on the occurrence of MDD, but the reverse was not true. Enrichment analyses of pleiotropic genes at whole-genome and tissue-specific levels implied the involvement of allergy and immune-related pathways in the shared genetic mechanism of the two diseases. Elucidating the causal effect and the acting direction may be beneficial in reducing the incidence rate of MDD for the massive group of SA patients in the East Asian region.<\/jats:p>","DOI":"10.3390\/nu16010079","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T04:40:44Z","timestamp":1703565644000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Positive Causal Effect of Shrimp Allergy on Major Depressive Disorder Mediated by Allergy- and Immune-Related Pathways in the East Asian Population"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-4684","authenticated-orcid":false,"given":"Shitao","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China"},{"name":"School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia Yanlai","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Toronto, Toronto, ON M5S 1A1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-7035","authenticated-orcid":false,"given":"Sek Ying","family":"Chair","sequence":"additional","affiliation":[{"name":"Croucher Laboratory for Human Genomics, Asia-Pacific Genomic and Genetic Nursing Centre, The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-5791","authenticated-orcid":false,"given":"Wai Tong","family":"Chien","sequence":"additional","affiliation":[{"name":"Croucher Laboratory for Human Genomics, Asia-Pacific Genomic and Genetic Nursing Centre, The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-0504","authenticated-orcid":false,"given":"Guangming","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-4917","authenticated-orcid":false,"given":"Mary Miu Yee","family":"Waye","sequence":"additional","affiliation":[{"name":"Croucher Laboratory for Human Genomics, Asia-Pacific Genomic and Genetic Nursing Centre, The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jaci.2021.10.018","article-title":"Food allergy across the globe","volume":"148","author":"Sampath","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"De Martinis, M., Sirufo, M.M., Suppa, M., and Ginaldi, L. (2020). New Perspectives in Food Allergy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041474"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management","volume":"141","author":"Sicherer","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jaip.2018.10.046","article-title":"Association Between Asthma and Depression: A National Cohort Study","volume":"7","author":"Choi","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s40273-021-01019-4","article-title":"The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)","volume":"39","author":"Greenberg","year":"2021","journal-title":"PharmacoEconomics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s40273-021-01040-7","article-title":"The Growing Burden of Major Depressive Disorders (MDD): Implications for Researchers and Policy Makers","volume":"39","author":"Proudman","year":"2021","journal-title":"PharmacoEconomics"},{"key":"ref_7","unstructured":"World Health Organization (2022). Risk Assessment of Food Allergens, World Health Organization. Part 1\u2014Review and validation of Codex Alimentarius priority allergen list through risk assessment."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/cea.13163","article-title":"Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy","volume":"48","author":"Smeekens","year":"2018","journal-title":"Clin. Exp. Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.iac.2017.09.002","article-title":"Epidemiology of Food Allergy","volume":"38","author":"Dunlop","year":"2018","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"676903","DOI":"10.3389\/falgy.2021.676903","article-title":"Seafood Allergy in Asia: Geographical Specificity and Beyond","volume":"2","author":"Wai","year":"2021","journal-title":"Front. Allergy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/1469-7610.00403","article-title":"Genetic association between atopy and behavioral symptoms in middle childhood","volume":"39","author":"Wamboldt","year":"1998","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1067\/mai.2003.1546","article-title":"Presence of atopy in first-degree relatives as a predictor of a female proband\u2019s depression: Results from the Northern Finland 1966 Birth Cohort","volume":"111","author":"Timonen","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jad.2017.12.008","article-title":"Temporal distribution of suicide mortality: A systematic review","volume":"228","author":"Galvao","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.psychres.2004.02.005","article-title":"Is seasonality of suicides stronger in victims with hospital-treated atopic disorders?","volume":"126","author":"Timonen","year":"2004","journal-title":"Psychiatry Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1346-8138.2001.tb00125.x","article-title":"Changes in the seasonal dependence of atopic dermatitis in Japan","volume":"28","author":"Uenishi","year":"2001","journal-title":"J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/cea.14010","article-title":"Investigating the causal relationship between allergic disease and mental health","volume":"51","author":"Joyce","year":"2021","journal-title":"Clin. Exp. Allergy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10654-021-00757-1","article-title":"Mendelian randomisation for mediation analysis: Current methods and challenges for implementation","volume":"36","author":"Carter","year":"2021","journal-title":"Eur. J. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: A guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaci.2020.10.039","article-title":"Current insights into the genetics of food allergy","volume":"147","author":"Kanchan","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2222.2008.03111.x","article-title":"Familial aggregation of food allergy and sensitization to food allergens: A family-based study","volume":"39","author":"Tsai","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_21","first-page":"e124","article-title":"Heredity of food allergies in an unselected child population: An epidemiological survey from Finland","volume":"22","author":"Hiltunen","year":"2011","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: Review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1017\/S0033291721000441","article-title":"The genetic basis of major depression","volume":"51","author":"Kendall","year":"2021","journal-title":"Psychol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00125-020-05253-x","article-title":"An atlas on risk factors for type 2 diabetes: A wide-angled Mendelian randomisation study","volume":"63","author":"Yuan","year":"2020","journal-title":"Diabetologia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S2215-0366(21)00286-8","article-title":"Associations between plasma fatty acid concentrations and schizophrenia: A two-sample Mendelian randomisation study","volume":"8","author":"Jones","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jacc.2022.02.018","article-title":"Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study","volume":"79","author":"Chong","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"742411","DOI":"10.3389\/fendo.2021.742411","article-title":"Uric Acid Mediated the Association Between BMI and Postmenopausal Breast Cancer Incidence: A Bidirectional Mendelian Randomization Analysis and Prospective Cohort Study","volume":"12","author":"Feng","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"108542","DOI":"10.1016\/j.diabres.2020.108542","article-title":"Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis","volume":"171","author":"Hu","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/hep.31537","article-title":"Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data","volume":"73","author":"Ponce","year":"2021","journal-title":"Hepatology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41598-017-18241-w","article-title":"Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR\/DQ gene region","volume":"8","author":"Khor","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/jamapsychiatry.2021.2099","article-title":"The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study","volume":"78","author":"Giannakopoulou","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Loh","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s41065-018-0057-5","article-title":"Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations","volume":"155","author":"Wang","year":"2018","journal-title":"Hereditas"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations: Update for summer 2023","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2307\/2171753","article-title":"Instrumental Variables Regression with Weak Instruments","volume":"65","author":"Staiger","year":"1997","journal-title":"Econometrica"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hep.32183","article-title":"Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study","volume":"75","author":"Chen","year":"2022","journal-title":"Hepatology"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hemani, G., Tilling, K., and Davey Smith, G. (2017). Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet., 13.","DOI":"10.1101\/117101"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ng.3570","article-title":"Detection and interpretation of shared genetic influences on 42 human traits","volume":"48","author":"Pickrell","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"de Leeuw, C.A., Mooij, J.M., Heskes, T., and Posthuma, D. (2015). MAGMA: Generalized gene-set analysis of GWAS data. PLoS Comput. Biol., 11.","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Barbeira, A.N., Pividori, M., Zheng, J., Wheeler, H.E., Nicolae, D.L., and Im, H.K. (2019). Integrating predicted transcriptome from multiple tissues improves association detection. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1007889"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS J. Integr. Biol."},{"key":"ref_44","first-page":"264","article-title":"Prevalence of fish and shellfish allergy: A systematic review","volume":"133","author":"Moonesinghe","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2016.12.006","article-title":"Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese","volume":"603","author":"Rao","year":"2017","journal-title":"Gene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"144901","DOI":"10.1016\/j.gene.2020.144901","article-title":"Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder","volume":"755","author":"Rao","year":"2020","journal-title":"Gene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.gene.2018.09.025","article-title":"Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model","volume":"679","author":"Rao","year":"2018","journal-title":"Gene"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2016.02.045","article-title":"Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry","volume":"138","author":"Gupta","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.3390\/ijerph10115364","article-title":"The impact of family history of allergy on risk of food allergy: A population-based study of infants","volume":"10","author":"Koplin","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1038\/ncomms7304","article-title":"Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children","volume":"6","author":"Hong","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chang, J.-C., Kuo, H.-C., Hsu, T.-Y., Ou, C.-Y., Liu, C.-A., Chuang, H., Liang, H.-M., Huang, H.-W., and Yang, K.D. (2013). Different genetic associations of the IgE production among fetus, infancy and childhood. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070362"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Furuya, T.K., Jacob, C.E., Tomit, M.T.P., Camacho, L.C.C., Ramos, M.F.K.P., Eluf-Neto, J., Alves, V.A.F., Zilberstein, B., Cecconello, I., and Ribeiro, U. (2018). Association between Polymorphisms in Inflammatory Response-Related Genes and the Susceptibility, Progression and Prognosis of the Diffuse Histological Subtype of Gastric Cancer. Genes, 9.","DOI":"10.3390\/genes9120631"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ni1554","article-title":"CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator","volume":"9","author":"Cai","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41576-020-00292-x","article-title":"Deciphering cell\u2013cell interactions and communication from gene expression","volume":"22","author":"Armingol","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Andreotti, A.H., Schwartzberg, P.L., Joseph, R.E., and Berg, L.J. (2010). T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a002287"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"102842","DOI":"10.1016\/j.isci.2021.102842","article-title":"Targeting ITK signaling for T cell-mediated diseases","volume":"24","author":"Weeks","year":"2021","journal-title":"iScience"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1039\/C8FO01604F","article-title":"The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.bbadis.2015.07.012","article-title":"Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis","volume":"1852","author":"Wen","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-022-00917-7","article-title":"USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation","volume":"19","author":"Zhuang","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.0713360","article-title":"A novel immunomodulatory function of PHLPP1: Inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages","volume":"95","author":"Alamuru","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2337\/db20-0635","article-title":"CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARalpha","volume":"70","author":"Zayed","year":"2021","journal-title":"Diabetes"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nri.2016.111","article-title":"Food allergy: Immune mechanisms, diagnosis and immunotherapy","volume":"16","author":"Yu","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biopsych.2014.10.014","article-title":"Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients","volume":"78","author":"Black","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsych.2017.08.005","article-title":"Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study","volume":"83","author":"Holmes","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gpb.2019.05.002","article-title":"Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder","volume":"17","author":"Tao","year":"2019","journal-title":"Genom. Proteom. Bioinform."}],"container-title":["Nutrients"],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/1\/79\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:59Z","timestamp":1760132519000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/1\/79"}},"issued":{"date-parts":[[2023,12,26]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["nu16010079"],"URL":"https:\/\/doi.org\/10.3390\/nu16010079","ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"published":{"date-parts":[[2023,12,26]]}}],"items-per-page":20,"query":{"start-index":0,"search-terms":null}}}