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Nutr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to explore the relationship between dietary folate intake and serum Klotho levels in adults from aged 40 to 79\u2009years in the United States, seeking to elucidate the intricacies of their interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analyzing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2016. The survey research determined folate intake through a 24-h dietary recall and nutrient density modeling, and assessed Klotho levels using enzyme-linked immunosorbent assay (ELISA). The relationship between folate intake and Klotho levels was evaluated using weighted linear regression, and complemented by analysis via smoothed curve models for nuanced understanding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study encompassed 10,278 participants, with an average age of 57.64\u2009years, revealing a noteworthy positive correlation between dietary folate and serum Klotho levels. The regression coefficient stood at 0.11 (95% confidence interval, 0.05, 0.18) post-adjustment for various covariates. When dietary folate intake was categorized into quartiles, the second, third, and fourth quartiles exhibited statistically significant differences compared to the lowest quartile. This indicates that higher folate intake correlates with increased serum Klotho levels. These findings underscore the potential benefits of elevating folate intake to enhance serum Klotho levels. Stratified analysis indicated that this association was more pronounced among males aged 60\u2009years or older and individuals with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggest a significant correlation between increased dietary folate intake and elevated serum Klotho levels in adults aged 40\u201379\u2009years. Hinting at the potential nutritional influences on the aging process and associated health conditions. This calls for further exploration into the mechanisms and broader implications of this association.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1420087","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T04:54:42Z","timestamp":1720414482000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary folate intake and serum klotho levels in adults aged 40\u201379\u2009years: a cross-sectional study from the national health and nutrition examination survey 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Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1063517\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T12:44:53Z","timestamp":1673268293000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1063517\/full"}},"issued":{"date-parts":[[2023,1,9]]},"references-count":43,"alternative-id":["10.3389\/fnut.2022.1063517"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.1063517","ISSN":["2296-861X"],"issn-type":[{"type":"electronic","value":"2296-861X"}],"published":{"date-parts":[[2023,1,9]]},"article-number":"1063517"},{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:57:51Z","timestamp":1783198671253,"version":"3.54.6"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The EAT-Lancet diet (ELD) is a recommended dietary pattern for achieving simultaneous improvements in both individual health and environmental sustainability. While research on the association between ELD and colorectal cancer (CRC) remains scarce, the potential impact of nutrition on CRC prevention and progression is a topic of growing interest. This study aims to investigate the relationship between adherence to the ELD and the risk of CRC, shedding light on the role of nutrition in CRC prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 98,415 participants were included. A Diet History Questionnaire (DHQ) was used to collect dietary information, and an ELD score was used to assess adherence to ELD. Higher scores indicated greater adherence. Cox hazard regression analyses were conducted to examine whether there were associations between the ELD score and CRC risk. The restricted cubic spline (RCS) model was used to further explore the dose-response association between the ELD score and CRC incidence. Subgroup analyses were conducted to identify potential modifiers that interacted with ELD on CRC incidence, and sensitivity analyses were performed to evaluate the robustness of the established association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow-up of 8.82 years, a total of 1,054 CRC cases were documented. We found a statistically significant correlation between the ELD score and CRC risk (Q4 vs. Q1: HR 0.81, 95% CI 0.67\u20130.98; P for trend = 0.034) after adjusting for potential confounders. No statistically significant associations were discovered between ELD adherence and CRC by anatomical site. Subgroup analyses found no interactional factor, sensitivity analyses, and the RCS model showed a robustness and linearity association (P-linearity &amp;gt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that adherence to ELD contributes to the prevention of CRC.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2023.1264178","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:59:43Z","timestamp":1697702383000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Compliance with the EAT-Lancet diet and risk of colorectal cancer: a prospective cohort study in 98,415 American 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Nutr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Previous measurement error work that investigates the relationship between a nutritional biomarker and self-reported intake levels has typically been at a single time point, in a single treatment group, or with respect to basic patient demographics. Few studies have examined the measurement error structure in longitudinal randomized trials, and whether the error varies across time or group. This structure is crucial to understand, however, in order to correct for measurement error in self-reported outcomes and properly interpret the longitudinal effects of dietary interventions.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Using two longitudinal randomized controlled trials with internal longitudinal validation data (urinary biomarkers and self-reported values), we examine the relationship between urinary sodium and self-reported sodium and whether this relationship changes as a function of time and\/or treatment condition. We do this by building a mixed effects regression model, allowing for a flexible error variance-covariance structure, and testing all possible interactions between time, treatment condition, and self-reported intake.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Using a backward selection approach, we arrived at the same final model for both validation data sets. We found no evidence that measurement error changes as a function of self-reported sodium. However, we did find evidence that urinary sodium can differ by time or treatment condition even when conditioning on self-reported values.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In longitudinal nutritional intervention trials it is possible that measurement error differs across time and treatment groups. It is important for researchers to consider this possibility and not just assume non-differential measurement error. Future studies should consider data collection strategies to account for the potential dynamic nature of measurement error, such as collecting internal validation data across time and treatment groups when possible.<\/jats:p>","DOI":"10.3389\/fnut.2020.581439","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T05:41:56Z","timestamp":1606455716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing Measurement Error in Dietary Sodium in Longitudinal Intervention Studies"],"prefix":"10.3389","volume":"7","author":[{"given":"Adam","family":"Pittman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth 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Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The current study investigated the value of urine selenium (Se) concentration as a biomarker of population Se status in rural sub-Saharan Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Urine and plasma Se concentrations were measured among children aged 6\u201359\u2009months (<jats:italic>n<\/jats:italic>\u2009=\u2009608) and women of reproductive age (WRA, <jats:italic>n<\/jats:italic>\u2009=\u2009781) living in rural Zimbabwe (Murehwa, Shamva, and Mutasa districts) and participating in a pilot national micronutrient survey. Selenium concentrations were measured by inductively coupled plasma-mass spectrometry (ICP-MS), and urine concentrations were corrected for hydration status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median (Q1, Q3) urine Se concentrations were 8.4\u2009\u03bcg\/L (5.3, 13.5) and 10.5\u2009\u03bcg\/L (6.5, 15.2) in children and WRA, respectively. There was moderate evidence for a relationship between urine Se concentration and plasma Se concentration in children (<jats:italic>p<\/jats:italic>\u2009=\u20090.0236) and WRA (<jats:italic>p<\/jats:italic>\u2009=\u2009&amp;lt; 0.0001), but the relationship had poor predictive value. Using previously defined thresholds for optimal activity of iodothyronine deiodinase (IDI), there was an association between deficiency when indicated by plasma Se concentrations and urine Se concentrations among WRA, but not among children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Urine Se concentration poorly predicted plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status in this context. Further research is warranted at wider spatial scales to determine the value of urine Se as a biomarker when there is greater heterogeneity in Se exposure.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1288748","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:27:19Z","timestamp":1707280039000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status"],"prefix":"10.3389","volume":"11","author":[{"given":"Beaula","family":"Mutonhodza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mavis P.","family":"Dembedza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J. 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Africa","volume":"136","author":"Benemariya","year":"1993","journal-title":"Sci Total Environ."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0889-1575(91)90019-3","article-title":"Selenium intakes of children from Malawi and Papua New Guinea consuming plant-based diets","volume":"6","author":"Donovan","year":"1992","journal-title":"J Trace Elem Electrolytes Health Dis."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep00072","article-title":"Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi","volume":"1","author":"Chilimba","year":"2011","journal-title":"Sci Rep."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s40795-015-0036-4","article-title":"Soil type influences crop mineral composition in Malawi","volume":"505","author":"Joy","year":"2015","journal-title":"Sci Total Environ"},{"year":"2020","key":"ref58"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1080\/10408398.2020.1844636","article-title":"A review of micronutrient deficiencies and analysis of maize contribution to nutrient requirements of women and children in eastern and southern Africa","volume":"62","author":"Galani","year":"2022","journal-title":"Crit Rev Food Sci Nutr."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"454","DOI":"10.4314\/sajas.v42i5.2","article-title":"Selenium concentration of maize grain in South Africa and possible factors influencing the concentration","volume":"42","author":"Courtman","year":"2012","journal-title":"S Afr J Anim Sci"},{"year":"2018","author":"Gondwe","key":"ref61"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"6336","DOI":"10.1111\/ijfs.15979","article-title":"Linkages between soil, crop, livestock, and human selenium status in sub-Saharan Africa: a scoping review","volume":"57","author":"Mutonhodza","year":"2022","journal-title":"Int J Food Sci Technol"},{"volume-title":"Soils of Zimbabwe","year":"1991","author":"Nyamapfene","key":"ref63"},{"year":"1994","author":"Fordyce","key":"ref64"},{"first-page":"183","year":"2015","author":"Nyakudya","key":"ref65"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jtemb.2011.10.001","article-title":"Plasma selenium concentrations in pregnant women in two countries with contrasting soil selenium levels","volume":"25","author":"Gibson","year":"2011","journal-title":"J Trace Elem Med Biol."}],"container-title":["Frontiers in Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1288748\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:27:24Z","timestamp":1707280044000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1288748\/full"}},"issued":{"date-parts":[[2024,2,7]]},"references-count":66,"alternative-id":["10.3389\/fnut.2024.1288748"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1288748","ISSN":["2296-861X"],"issn-type":[{"type":"electronic","value":"2296-861X"}],"published":{"date-parts":[[2024,2,7]]},"article-number":"1288748"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:53Z","timestamp":1753891733670,"version":"3.41.2"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to explore the association between flavonoids intake and chronic low back pain (CLBP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey. Dietary flavonoids intake was assessed using a two-day recall questionnaire on dietary intake. CLBP was defined based of self-reported question. Weighted univariate and multivariate logistic regression models were performed to evaluate the relationship between flavonoids intake and CLBP. Additionally, subgroup analyses were conducted based on age, sedentary behavior time, arthritis, depression, and sleep disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,136 adults were included, and 460 participants developed CLBP. After adjusting confounders, compared with the lowest total flavonoids intake tertile (reference group), flavonoids intake with highest tertile (&amp;gt;170\u2009mg) was associated with reduced odds of CLBP [odds ratio (OR) =0.74, 95% confidence interval (CI): 0.57\u20130.95]. This relationship of flavonoids intake with CLBP remained statistically significant among participants aged \u226545\u2009years (OR\u2009=\u20090.52, 95%CI: 0.35\u20130.76), with sedentary behavior time of &amp;gt;3\u2009h (OR\u2009=\u20090.60, 95%CI: 0.41\u20130.86), with arthritis (OR\u2009=\u20090.51, 95%CI: 0.29\u20130.90), depression (OR\u2009=\u20090.48, 95%CI: 0.24\u20130.98), and sleep disorder (OR\u2009=\u20090.27, 95%CI: 0.12\u20130.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher flavonoids intake was found to be negatively associated with the likelihood of CLBP. For the general adult population, consuming foods rich in flavonoids may be linked to a reduced risk of CLBP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1436461","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:26:15Z","timestamp":1727965575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between dietary intake of flavonoids and chronic low back pain: a cross-sectional study"],"prefix":"10.3389","volume":"11","author":[{"given":"Haibin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sizhe","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1155225","DOI":"10.3389\/fpubh.2023.1155225","article-title":"Exercise intervention for patients with chronic low Back pain: a systematic review and network Meta-analysis","volume":"11","author":"Li","year":"2023","journal-title":"Front Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"04006","DOI":"10.7189\/jogh.14.04006","article-title":"Evaluation of three decades of the burden of low Back pain in China before Covid-19: estimates from the global burden of disease database 2019","volume":"14","author":"Xu","year":"2024","journal-title":"J Glob Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.3390\/ijerph18083969","article-title":"The relationship between change of weight and chronic low Back pain in population over 50 years of age: a Nationwide cross-sectional study","volume":"18","author":"Lee","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/acr.22619","article-title":"Symptoms of depression and risk of new episodes of low Back pain: a systematic review and Meta-analysis","volume":"67","author":"Pinheiro","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e45760","DOI":"10.7759\/cureus.45760","article-title":"Chronic low Back pain: prevalence, impact on quality of life, and predictors of future disability","volume":"15","author":"Alfalogy","year":"2023","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/ijms24010208","article-title":"Discogenic low Back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.3390\/ijms24119236","article-title":"Effects of flavonoids on Cancer, cardiovascular and neurodegenerative diseases: role of Nf-\u039ab signaling pathway","volume":"24","author":"Barreca","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"111466","DOI":"10.1016\/j.biopha.2021.111466","article-title":"Rhizoma Drynariae Total flavonoids inhibit the inflammatory response and matrix degeneration via Mapk pathway in a rat degenerative cervical intervertebral disc model","volume":"138","author":"Zhao","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.joca.2020.11.006","article-title":"Senolytic agent quercetin ameliorates intervertebral disc degeneration via the Nrf2\/Nf-\u039ab Axis","volume":"29","author":"Shao","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"13693","DOI":"10.18632\/aging.205251","article-title":"The antioxidant Glycitin protects against intervertebral disc degeneration through antagonizing inflammation and oxidative stress in nucleus pulposus cells","volume":"15","author":"Zhao","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/cbdv.201600060","article-title":"Natural flavonoids as promising analgesic candidates: a systematic review","volume":"13","author":"Xiao","year":"2016","journal-title":"Chem Biodivers"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.2174\/1570159x20666220812122437","article-title":"The emerging role of quercetin in the treatment of chronic pain","volume":"20","author":"Liu","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"762","DOI":"10.3390\/molecules25030762","article-title":"Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development","volume":"25","author":"Ferraz","year":"2020","journal-title":"Molecules"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e12954","DOI":"10.1111\/jfbc.12954","article-title":"The modulatory effect and the mechanism of flavonoids on obesity","volume":"43","author":"Song","year":"2019","journal-title":"J Food Biochem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1080\/10408398.2022.2057914","article-title":"Flavonoids for depression and anxiety: a systematic review and Meta-analysis","volume":"63","author":"Jia","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1186\/s12888-023-05029-8","article-title":"Association between dietary Anthocyanidins intake and depression among us adults: a cross-sectional study (Nhanes, 2007\u20132010 and 2017\u20132018)","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/acr.22890","article-title":"Epidemiology of chronic low Back pain in US adults: data from the 2009\u20132010 National Health and nutrition examination survey","volume":"68","author":"Shmagel","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1186\/s12889-023-15870-x","article-title":"Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Public Health"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1071465","DOI":"10.3389\/fendo.2022.1071465","article-title":"Systemic immune-inflammation index is associated with diabetic kidney disease in type 2 diabetes mellitus patients: evidence from NHANES 2011\u20132018","volume":"13","author":"Guo","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1309835","DOI":"10.3389\/fimmu.2023.1309835","article-title":"The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among U.S. adults with rheumatoid arthritis: results from NHANES 1999\u20132020","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.clnu.2022.09.007","article-title":"Fish consumption, Omega-3 fatty acid intake, and risk of pain: the seniors-Enrica-1 cohort","volume":"41","author":"Carballo-Casla","year":"2022","journal-title":"Clin Nutr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.3390\/nu12103075","article-title":"Effects of nutritional interventions in the control of musculoskeletal pain: an integrative review","volume":"12","author":"Mendon\u00e7a","year":"2020","journal-title":"Nutrients"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12937-022-00780-2","article-title":"Major dietary patterns in relation to chronic low Back pain; a cross-sectional study from Rancd cohort","volume":"21","author":"Pasdar","year":"2022","journal-title":"Nutr J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1039\/d3fo00242j","article-title":"Dietary flavonoid intake is associated with a lower risk of diabetic nephropathy in us adults: data from Nhanes 2007\u20132008, 2009\u20132010, and 2017\u20132018","volume":"14","author":"Liu","year":"2023","journal-title":"Food Funct"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00784-024-05561-1","article-title":"The relationship of dietary flavonoids and periodontitis in us population: a cross-sectional Nhanes analysis","volume":"28","author":"Liu","year":"2024","journal-title":"Clin Oral Investig"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/nu10070950","article-title":"Dietary flavonoids and the risk of colorectal Cancer: an updated Meta-analysis of epidemiological studies","volume":"10","author":"Chang","year":"2018","journal-title":"Nutrients"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e1041","DOI":"10.1212\/wnl.0000000000012454","article-title":"Long-term dietary flavonoid intake and subjective cognitive decline in us men and women","volume":"97","author":"Yeh","year":"2021","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.spinee.2016.05.007","article-title":"Therapeutic effects of Naringin on degenerative human nucleus pulposus cells for Discogenic low Back pain","volume":"16","author":"Li","year":"2016","journal-title":"Spine J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1248\/bpb.28.527","article-title":"Inhibitory effects of Naringenin on tumor growth in human Cancer cell lines and sarcoma S-180-implanted mice","volume":"28","author":"Kanno","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"875","DOI":"10.31616\/asj.2019.0073","article-title":"Evaluation of anti-inflammatory and regenerative efficiency of Naringin and Naringenin in degenerated human nucleus pulposus cells: biological and molecular modeling studies","volume":"13","author":"Devraj","year":"2019","journal-title":"Asian Spine J"}],"container-title":["Frontiers in Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1436461\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:26:18Z","timestamp":1727965578000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1436461\/full"}},"issued":{"date-parts":[[2024,10,3]]},"references-count":30,"alternative-id":["10.3389\/fnut.2024.1436461"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1436461","ISSN":["2296-861X"],"issn-type":[{"type":"electronic","value":"2296-861X"}],"published":{"date-parts":[[2024,10,3]]},"article-number":"1436461"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:09:48Z","timestamp":1753891788001,"version":"3.41.2"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Allergic rhinitis (AR) is a common chronic inflammatory disease that significantly impacts the quality of life of patients. However, there is limited research on the relationship between the Dietary Inflammatory Index (DII) and the risk of AR. Our study aimed to assess the association between DII and AR in a sample of adults from North China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case\u2013control study, we selected 166 cases of AR and 166 age- and gender-matched controls. Dietary intake was assessed using a validated food frequency questionnaire. The energy-adjusted DII (E-DII) scores were calculated based on the quantity of diet components with inflammatory or anti-inflammatory potential. We used conditional logistic regression models to examine the association between E-DII and AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings indicate a positive correlation between E-DII and AR risk. After controlling for confounders, individuals in the highest E-DII tertile exhibited a 4.41-fold increased risk of AR compared to those in the lowest tertile (OR 4.41, 95% CI 2.31\u20138.41). Additionally, stratified analysis showed that E-DII was positively associated with AR subtype (seasonal vs. perennial), duration (\u22646\u2009years vs. &amp;gt;6\u2009years), severity (mild vs. moderate\u2013severe), and onset time (intermittent vs. persistent). Furthermore, individuals in the highest E-DII tertile had higher intake of total fat, SFA, PUFAs, and n-6 PUFAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, we realized that there is a positive association between the E-DII score and AR. The consumption of diets abundant in anti-inflammatory nutrients and low in pro-inflammatory nutrient contents is recommended as a preventative strategy against AR.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1418305","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T04:47:31Z","timestamp":1719463651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The association between the dietary inflammatory index and allergic rhinitis: a case\u2013control study"],"prefix":"10.3389","volume":"11","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niuniu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3760\/cma.j.cn115330-20211228-00828","article-title":"Chinese guideline for diagnosis and treatment of allergic rhinitis","volume":"57","year":"2022","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.jaci.2020.07.007","article-title":"Rhinitis 2020: a practice parameter update","volume":"146","author":"Dykewicz","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e114950","DOI":"10.1371\/journal.pone.0114950","article-title":"Epidemiological characterization and risk factors of allergic rhinitis in the general population in Guangzhou City in China","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4168\/aair.2015.7.2.148","article-title":"Prevalence of allergic rhinitis among adults in urban and rural areas of China: a population-based cross-sectional survey","volume":"7","author":"Zheng","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1111\/all.14067","article-title":"Recent developments and highlights in allergic rhinitis","volume":"74","author":"Meng","year":"2019","journal-title":"Allergy"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1111\/all.15454","article-title":"Update on pathomechanisms and treatments in allergic rhinitis","volume":"77","author":"Zhang","year":"2022","journal-title":"Allergy"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1111\/all.15044","article-title":"Advances and highlights in allergic rhinitis","volume":"76","author":"Zhang","year":"2021","journal-title":"Allergy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3390\/ijerph18041397","article-title":"Association between physical activity and respiratory diseases in adolescents: an 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Nutr."],"abstract":"<jats:p>Both sleep\u2013wake disturbance and malnutrition are common in cirrhosis and might be associated with similar adverse outcomes, such as impaired health-related quality of life, hepatic encephalopathy, and sarcopenia, but there is no study investigating the relationship between these two. We aimed to explore the relationship between sleep\u2013wake disturbance [estimated by the Pittsburgh Sleep Quality Index (PSQI)] and malnutrition risk [estimated by the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT)]. About 150 patients with cirrhosis were prospectively recruited. The nutritional risk is classified as low (0 points), moderate (1 point), and high (2\u20137 points) according to the RFH-NPT score. A global PSQI &amp;gt;5 indicated poor sleepers. Furthermore, multivariate linear regression analyses were performed to determine the relationship between<jats:italic>sleep\u2013wake<\/jats:italic>disturbance and malnutrition. The median PSQI was seven, and RFH-NPT was two in the entire cohort, with 60.67 and 56.67% rated as poor sleep quality and high malnutrition risk, respectively. Patients with cirrhosis with poor sleep quality had significantly higher RFH-NPT score (3 vs. 1,<jats:italic>P<\/jats:italic>= 0.007). Our multivariate analyses indicated that male patients (\u03b2 = 0.279,<jats:italic>P<\/jats:italic>&amp;lt; 0.001), ascites (\u03b2 = 0.210,<jats:italic>P<\/jats:italic>= 0.016), and PSQI (\u03b2 = 0.262,<jats:italic>P<\/jats:italic>= 0.001) were independent predictors of malnutrition. In addition, the differences regarding PSQI score were more significant in male patients, as well as those &amp;gt;65 years or with Child-Turcotte-Pugh class A\/B (CTP-A\/B) or the median model for end-stage liver disease (MELD) &amp;lt;15. Taken together, the sleep\u2013wake disturbance is strongly correlated with high malnutrition risk in patients with cirrhosis. Given sleep\u2013wake disturbance is remediable, it is tempting to incorporate therapies to reverse poor sleep quality for improving nutritional status in patients with cirrhosis.<\/jats:p>","DOI":"10.3389\/fnut.2021.719176","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T20:19:26Z","timestamp":1630700366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship Between Sleep\u2013Wake Disturbance and Risk of Malnutrition in Hospitalized Patients With Cirrhosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Yangyang","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangmao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S248","DOI":"10.21037\/jtd-cus-2020-012","article-title":"Sleep disorder in patients with chronic liver disease: a narrative review","volume":"12","author":"Shah","year":"2020","journal-title":"J Thorac Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/j.1478-3231.2009.02089.x","article-title":"Night-time sleep disturbance does not correlate with neuropsychiatric impairment in patients with cirrhosis","volume":"29","author":"Montagnese","year":"2009","journal-title":"Liver Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/MEG.0000000000000786","article-title":"Improvement of sleep architecture parameters in cirrhotic patients with recurrent hepatic encephalopathy with the use of rifaximin","volume":"29","author":"Bruyneel","year":"2017","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"B4","first-page":"1271","article-title":"Most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life","volume-title":"Clin Gastroenterol Hepatol.","author":"Ghabril","year":"2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.sleep.2012.02.005","article-title":"Non-apnea sleep disorders will increase subsequent liver cancer risk\u2013a nationwide population-based cohort study","volume":"13","author":"Liang","year":"2012","journal-title":"Sleep Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/hep.29003","article-title":"A practical approach to nutritional screening and assessment in cirrhosis","volume":"65","author":"Tandon","year":"2017","journal-title":"Hepatology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jhep.2018.06.024","article-title":"Electronic address eee, European Association for the Study of the L. 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Nutr."],"abstract":"<jats:p>Lactic acid-fermented soymilk as a new plant-based food has aroused extensive attention because of its effects on nutrition and health. This study was conducted to delve into the antioxidative and anti-inflammatory activities of lactic acid-fermented soymilk. To elucidate the key factors that affect the antioxidant properties of fermented soymilk, the strains and preparation process were investigated. Findings show that the fermented soymilk prepared using hot-water blanching method (BT-80) demonstrated a better antioxidant activity than that using conventional method (CN-20). Besides, a huge difference was observed among the soymilks fermented with different strains. Among them, the YF-L903 fermented soymilk demonstrated the highest ABTS radical scavenging ability, which is about twofold of that of unfermented soymilk and 1.8-fold of that of L571 fermented soy milk. <jats:italic>In vitro<\/jats:italic> antioxidant experiments and the analysis of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced oxidative damage model in Caco-2 cells showed that lactic acid-fermentation could improve the DPPH radical scavenging ability, ABTS radical scavenging ability, while reducing the content of reactive oxygen species (ROS) and malondialdehyde (MDA) in Caco-2 cells induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, and increasing the content of superoxide dismutase (SOD). Consequently, cells are protected from the damage caused by active oxidation, and the repair ability of cells is enhanced. To identify the role of fermented soymilk in intestinal health, we investigate its preventive effect on dextran sodium sulfate-induced colitis mouse models. Results revealed that the fermented soymilk can significantly improve the health conditions of the mice, including alleviated of weight loss, relieved colonic injury, balanced the spleen-to-body weight ratio, reduced the disease index, and suppressed the inflammatory cytokines and oxidant indexes release. These results suggest that YF-L903 fermented soymilk is a promising natural antioxidant sources and anti-inflammatory agents for the food industry. We believe this work paves the way for elucidating the effect of lactic acid-fermented soymilk on intestinal health, and provides a reference for the preparation of fermented soymilk with higher nutritional and health value.<\/jats:p>","DOI":"10.3389\/fnut.2022.1088949","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T13:22:10Z","timestamp":1673011330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Antioxidant properties of fermented soymilk and its anti-inflammatory effect on DSS-induced colitis in 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Nutr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/fermentation7030123","article-title":"The antioxidant, anti-diabetic, and anti-adipogenesis potential and probiotic properties of lactic acid bacteria isolated from human and fermented foods","volume":"7","author":"Jeong","year":"2021","journal-title":"Fermentation."},{"key":"B60","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.cofs.2021.11.013","article-title":"Lactic acid fermentation as a useful strategy to recover antimicrobial and antioxidant compounds from food and by-products","volume":"43","author":"Khubber","year":"2022","journal-title":"Curr Opin Food Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jam.15342","article-title":"Functional relevance and health benefits of soymilk fermented by lactic acid bacteria","volume":"133","author":"Kumari","year":"2022","journal-title":"J Appl 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Fermented soy products and their potential health benefits: a review","volume":"10","author":"Prado","year":"2022","journal-title":"Microorganisms."}],"container-title":["Frontiers in Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1088949\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T13:22:14Z","timestamp":1673011334000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1088949\/full"}},"issued":{"date-parts":[[2023,1,6]]},"references-count":64,"alternative-id":["10.3389\/fnut.2022.1088949"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.1088949","ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"published":{"date-parts":[[2023,1,6]]},"article-number":"1088949"},{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T01:53:39Z","timestamp":1756000419932,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to examine associations of diet quality scores, including the dietary approaches to stop hypertension (DASH), alternate Healthy Eating Index (AHEI), and Chinese Healthy Eating Index (CHEI) with asthenoteratozoospermia risk in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 254 cases and 633 controls in a hospital-based case\u2013control study in Shenyang, Liaoning Province, China, DASH, AHEI, and CHEI were calculated using a validated food frequency questionnaire. Asthenotetrazoospermia was evaluated according to World Health Organization guidelines. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between quality diet scores and asthenoteratozoospermia risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the CHEI score was inversely associated with asthenoteratozoospermia risk, with ORs of 0.59 (95% CI 0.39, 0.88) and 0.59 (95% CI 0.39, 0.88) for the 2nd and 3rd tertiles vs. the 1st tertile, respectively (<jats:italic>P<\/jats:italic> trend &amp;lt; 0.05). In addition, our data indicated that each standard deviation increase in CHEI, AHEI-2010, and DASH score was associated with 19, 13, and 17% decreased risk of asthenoteratozoospermia, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that higher adherence to the CHEI, AHEI-2010, and DASH diet quality scores may reduce the risk of asthenoteratozoospermia, especially for younger participants.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.859143","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T08:05:58Z","timestamp":1649664358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Diet Quality Scores and Asthenoteratozoospermia Risk: Finding From a Hospital-Based Case\u2013Control Study in China"],"prefix":"10.3389","volume":"9","author":[{"given":"Qi","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ling","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.fertnstert.2018.01.010","article-title":"Dietary 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Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.859143\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T08:06:05Z","timestamp":1649664365000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.859143\/full"}},"issued":{"date-parts":[[2022,4,11]]},"references-count":38,"alternative-id":["10.3389\/fnut.2022.859143"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.859143","ISSN":["2296-861X"],"issn-type":[{"type":"electronic","value":"2296-861X"}],"published":{"date-parts":[[2022,4,11]]},"article-number":"859143"},{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:45:30Z","timestamp":1782308730285,"version":"3.54.5"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Milk tea and takeaway food consumption are increasingly prevalent among Chinese university students and may contribute to adverse mental health outcomes. However, the combined association of these dietary behaviors on psychological symptoms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter cross-sectional survey was conducted from September to November 2023 among 15,440 students from seven universities in four provinces of China. Single-factor associations between psychological symptom types and milk tea\/takeaway food consumption were examined using the Chi-square test. Multivariate logistic regression was then employed to assess independent associations, adjusting for demographic and lifestyle confounders. Finally, interaction models were used to explore the combined association of milk tea and takeaway food consumption, as well as the impact of specific consumption combinations, on depression symptoms, anxiety symptoms, and their comorbidity. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Milk tea consumption was associated with an increased likelihood of only anxiety symptoms (OR = 1.33, 95% CI: 1.18\u20131.50) and comorbidity (OR = 1.16, 95% CI: 1.06\u20131.26). Takeaway food consumption was associated with only anxiety symptoms (OR = 1.23, 95% CI: 1.09\u20131.40). Students who consumed both milk tea and takeaway food had a higher risk of only anxiety symptoms (OR = 1.67, 95% CI: 1.43\u20131.95) and comorbidity (OR = 1.24, 95% CI: 1.11\u20131.38). Several specific consumption combinations\u2014particularly cream cap milk tea with grilled\/deep-fried skewers\u2014were strongly linked to comorbidity (OR = 4.25, 95% CI: 3.61\u20135.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both milk tea and takeaway food consumption are independently associated with higher risks of anxiety symptoms and comorbid depression\u2013anxiety among Chinese university students, with a significant combined association observed. High-fat, high-sugar milk tea combined with deep-fried or stir-fried takeaway food poses the greatest risk, highlighting the need for targeted dietary interventions to mitigate psychological symptom burden in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1693936","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:39:39Z","timestamp":1768372779000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Independent and combined association of milk tea and takeaway food consumption on depression, anxiety, and comorbid symptoms among Chinese university students"],"prefix":"10.3389","volume":"12","author":[{"given":"Juncheng","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Physical Education, Hainan Normal University, Haikou","place":["Hainan, China"]},{"name":"School of Physical Education, Shangrao Normal University, Shangrao","place":["Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkui","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shangrao Normal University, Shangrao","place":["Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shanghai Normal University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Physical Education and Health, Shanghai University of International Business and Economics","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Physical Education College, Jiangxi Normal University, Nanchang","place":["Jiangxi, 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Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Private caregivers are common in developing countries as supplements to healthcare human resources. However, the effects of private caregivers on inpatient conditions remain unclear. This study explored the effect of private caregivers on nutritional risk and anxiety in patients with dysphagia after ischemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational study included patients with dysphagia after ischemic stroke between 2022 and 2024 in central China. Participants were divided into non-caregiver and private caregiver groups. A single-factor analysis was used to explore the differences between the baseline assessments of the two groups. We then used propensity score matching (PSM) to balance significant baseline variables, including anxiety at admission, and demographic and clinical characteristics. In the matched sample, we used the average treatment effect on the treated (ATT) to uncover the influence of the patient groups on nutritional risks and anxiety on day 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,234 patients were included, and there were 766 cases in the private caregiver group. Before PSM, there were significant reductions in anxiety (47.00 vs. 32.86%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001) and nutritional risks (100.00 vs. 70.55%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001) from days 1 to 10. After PSM, there were no significant differences in any baseline assessments, and 766 pairs of cases were successfully captured. The ATT analysis showed that before and after PSM, there was no significant correlation between groups and nutritional risks (30.75 vs. 29.41%, <jats:italic>P<\/jats:italic> = 0.573), but there was a significant correlation between groups and anxiety on day 10 (34.89 vs. 23.40%, ATT = 0.234 after matching, <jats:italic>P<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Private caregivers can effectively reduce anxiety in hospitalized patients with dysphagia following ischemic stroke, but they do not have a significant impact on nutritional risks.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1513609","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:12:52Z","timestamp":1748578372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of private caregivers on nutritional risk and anxiety in stroke survivors 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Nutr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Allyl isothiocyanate is an excellent antimicrobial compound that has been applied in the development of active food packaging materials in the last years. However, the high volatility of this compound could prevent a lasting effect over time. In order to avoid this problem, cyclodextrin inclusion complexes have been proposed as an alternative, being beta-cyclodextrin (\u03b2-CD) as the main candidate. In addition, \u03b2-CD could act as a relative humidity-responsive nanoparticle. In this regard, the aim of this study was to develop inclusion complexes based on \u03b2-CD and AITC as relative humidity-responsive agents, which can be used in the design of active food packaging materials.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Two different \u03b2-CD:AITC inclusion complexes (2:1 and 1:1 molar ratios) were obtained by the co-precipitation method. Entrapment efficiency was determined by gas chromatography, while inclusion complexes were characterized through thermal, structural, and physicochemical techniques. Antifungal capacity of inclusion complexes was determined in a headspace system. Furthermore, the AITC release from inclusion complexes to headspace at different percentages of relative humidity was evaluated by gas chromatography, and this behavior was related with molecular dynamic studies.<\/jats:p><jats:p><jats:bold>Key Findings and Conclusions:<\/jats:bold>The entrapment efficiency of inclusion complexes was over to 60%. Two coexisting structures were proposed for inclusion complexes through spectroscopic analyses and molecular dynamic simulation. The water sorption capacity of inclusion complexes depended on relative humidity, and they exhibited a strong fungicide activity against<jats:italic>Botrytis cinerea<\/jats:italic>. Furthermore, the AITC release to headspace occurred in three stages, which were related with changes in \u03b2-CD conformational structure by water sorption and the presence of the different coexisting structures. In addition, a strong influence of relative humidity on AITC release was evidenced. These findings demonstrate that \u03b2-CD:AITC inclusion complexes could be used as potential antifungal agents for the design of food packaging materials, whose activity would be able to respond to relative humidity changes.<\/jats:p>","DOI":"10.3389\/fnut.2021.799779","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T13:52:33Z","timestamp":1641304353000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Development of Inclusion Complexes With Relative Humidity Responsive Capacity as Novel Antifungal Agents for Active Food 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Nutr."],"abstract":"<jats:p>In this study, a betaine\u2013ethylene glycol natural deep eutectic solvent (NADES) system was evaluated as a model extraction medium for preparing Tartary buckwheat starch (TBS). The extraction performance, granule morphology, selected physicochemical properties, and Pickering emulsion-forming behavior of NADES-extracted TBS (NADES-TBS) were compared with those of alkali-extracted TBS (AE-TBS). The highest starch content was obtained at a betaine\/ethylene glycol molar ratio of 1:4, water content of 15%, and extraction time of 4\u202fh. Under these conditions, the starch content of NADES-TBS was 87.34\u202f\u00b1\u202f0.81%, which was not significantly different from that of AE-TBS (87.84\u202f\u00b1\u202f0.66%), whereas the apparent amylose content was lower (22.95\u202f\u00b1\u202f0.08% vs. 24.14\u202f\u00b1\u202f0.38%). NADES-TBS showed a slightly larger mean particle size (9.194\u202f\u03bcm) than AE-TBS (8.329\u202f\u03bcm), while both samples retained the A-type crystalline pattern. The relative crystallinity changed only slightly from 30.39 to 31.11%. Compared with AE-TBS, NADES-TBS showed a higher pasting temperature, lower peak viscosity, and lower setback viscosity. In an MCT\u2013water model system, NADES-TBS showed lower oil\u2013water interfacial tension and a contact angle closer to 90\u00b0 than AE-TBS. Pickering emulsions stabilized by NADES-TBS showed smaller droplet sizes than those stabilized by AE-TBS under the tested short-term conditions. These results indicate that the selected NADES extraction process was associated with changes in granule morphology and selected physicochemical\/interfacial properties of TBS. However, because residual ethylene glycol, molecular-level structure, and long-term emulsion stability were not fully evaluated, food-related application and mechanistic conclusions require further verification.<\/jats:p>","DOI":"10.3389\/fnut.2026.1903939","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:47:31Z","timestamp":1783403251000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural characterization and Pickering emulsifying ability of Tartary buckwheat starch prepared by natural deep eutectic solvent method"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingsheng","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Geography and Tourism, Zhengzhou Normal University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School 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Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prior research suggests polyunsaturated fatty acids (PUFA) may prevent gallstones, but evidence on saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) is limited. This study aims to explore the associations between fatty acids and gallstones using a large sample of American population and Mendelian randomization (MR) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross-sectional study involved 6,629 participants from the National Health and Nutrition Examination Survey (NHANES) 2017\u20132020. Logistic regression and restricted cubic spline (RCS) analysis were conducted after stratifying by gender subgroups. Two-sample MR analysis was used to explore the causal relationship between fatty acids and gallstones without confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In females, higher SFA intake was positively associated with gallstone risk, while higher intake of n-3 and n-6 PUFA was negatively associated. No significant associations were found in males. No nonlinear correlations were found in any group by RCS analysis. MR analysis indicated that SFA, n-3, and n-6 PUFA could reduce gallstone risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The influence of dietary fatty acid composition on gallstone development differs by gender, providing insights into dietary prevention and treatment of gallstones.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1454648","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T04:51:28Z","timestamp":1723697488000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Dietary fatty acids and gallstone risk: insights from NHANES and Mendelian randomization analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Minghe","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"16024","DOI":"10.1038\/nrdp.2016.24","article-title":"Gallstones","volume":"2","author":"Lammert","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1111\/j.1572-0241.2006.00723.x","article-title":"The burden of gastrointestinal and liver diseases, 2006","volume":"101","author":"Shaheen","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1440-1746.2009.06146.x","article-title":"Natural history of gallstone disease: expectant management or active treatment? Results from a population-based cohort study","volume":"25","author":"Festi","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1053\/gast.2002.32978","article-title":"The burden of selected digestive diseases in the United States","volume":"122","author":"Sandler","year":"2002","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000323885","article-title":"Gallstones: environment, lifestyle and genes","volume":"29","author":"Stokes","year":"2011","journal-title":"Dig Dis Basel Switz"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/hep.20654","article-title":"Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs","volume":"41","author":"Katsika","year":"2005","journal-title":"Hepatol Baltim 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Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1454648\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T04:51:31Z","timestamp":1723697491000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1454648\/full"}},"issued":{"date-parts":[[2024,8,15]]},"references-count":50,"alternative-id":["10.3389\/fnut.2024.1454648"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1454648","ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"published":{"date-parts":[[2024,8,15]]},"article-number":"1454648"},{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:34Z","timestamp":1758701254142,"version":"3.44.0"},"reference-count":166,"publisher":"Frontiers Media 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Nutr."],"abstract":"<jats:p>Human populations have developed distinct genetic adaptations to diet in response to changes in lifestyle and environments in which they live. Particularly contrasting patterns of dietary adaptations are expected in populations living in tropical versus extreme cold environments. This article explores the genetic, dietary, and microbiome-related adaptations in populations of South Asia and the Arctic. We review adaptations related to high-carbohydrate, plant-based diets in South Asians and compare these against adaptations in Arctic populations who have evolved to rely on fat- and protein-rich diets from marine and animal sources. We discuss how these genetic adaptations interact with traditional diets and microbiomes, and the implications for chronic disease risks as modern, westernized diets disrupt ancestral gene-diet-microbiome interactions. By comparing these regions, we highlight the need for genome-based nutrition created strategies that account for genetic diversity, local dietary traditions, and environmental context to promote precision health and prevent diet-related chronic diseases. This analysis offers new insights into how nutrition, culture, and genetics intersect in shaping population-specific health outcomes.<\/jats:p>","DOI":"10.3389\/fnut.2025.1638843","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:49:17Z","timestamp":1755179357000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision nutrition across climates: decoding diet, tradition, and genomic adaptations from South Asia to the Arctic"],"prefix":"10.3389","volume":"12","author":[{"given":"Ajai Kumar","family":"Pathak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kolesnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika 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Nutrition"],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1638843\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:49:21Z","timestamp":1755179361000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1638843\/full"}},"issued":{"date-parts":[[2025,8,14]]},"references-count":166,"alternative-id":["10.3389\/fnut.2025.1638843"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2025.1638843","ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"published":{"date-parts":[[2025,8,14]]},"article-number":"1638843"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:56Z","timestamp":1753891736098,"version":"3.41.2"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have suggested that a healthy diet is associated with improved male fertility outcomes. However, the joint and individual associations between the status of multiple vitamins and sperm quality remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate the associations between serum vitamin levels and sperm quality parameters in adult men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was conducted among 156 adult men seeking fertility care at a reproductive center from December 2023 to June 2024. Blood and semen were collected on the same day to determine the concentrations of nine kinds of vitamins (B1, B2, B6, B9, B12, C, A, D, E) and five parameters of sperm quality [total sperm number, sperm concentration, progressive motile sperm, morphologically normal rate, and DNA fragment index (DFI)]. The joint and individual associations between vitamin levels and sperm quality were analyzed using multiple linear regression and Bayesian kernel machine regression (BKMR) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased tertiles of vitamin B1 and 1,25-dihydroxyvitamin D3 [1,25\u2013(OH)<jats:sub>2<\/jats:sub>-D<jats:sub>3<\/jats:sub>] in serum were associated with higher sperm quality (all <jats:italic>P<\/jats:italic> for trends &amp;lt; 0.10). Compared with the lowest tertiles, the highest tertiles of vitamin B12 had \u03b2: 3.0 (95% CI: 0.8, 5.2) increasing in DFI, and vitamin A was negatively associated with progressive sperm motility (<jats:italic>P<\/jats:italic> for trends = 0.05). We generally found null results between multiple vitamin levels and the parameters of sperm quality in the BKMR models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These research findings imply that vitamins could have a dose-dependent dual effect on sperm quality. More specifically, the impact of vitamins varies according to their dosage levels and types. Personalized vitamin supplementation may be more effective than taking multivitamins in improving sperm quality.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1534309","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T05:58:46Z","timestamp":1743141526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint and individual associations between multiple vitamins and sperm quality in adult men"],"prefix":"10.3389","volume":"12","author":[{"given":"Wen","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Tuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiejun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal 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