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G H Fernald Capriotti E Daneshjou R Karczewski K J R B Altman Bioinformatics challenges for personalized medicine 2011 Bioinformatics 27 13 1741 1748 10.1093\/bioinformatics\/btr295","DOI":"10.1093\/bioinformatics\/btr295"},{"key":"ref101","doi-asserted-by":"crossref","unstructured":"101. Kerkhoven R Enckevort F H Van Boekhorst J Molenaar D R J Siezen Visualization for genomics: the microbial genome viewerBioinformatics 2004 1812 1814 10.1093\/bioinformatics\/bth159","DOI":"10.1093\/bioinformatics\/bth159"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/article\/803\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openaccesspub.org\/article\/803\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:59:06Z","timestamp":1790942346000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/biotechnology-and-biomedical-science\/article\/the-emerging-role-of-bioinformatics-in-biotechnology-803"}},"issued":{"date-parts":[[2018]]},"references-count":101,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-18-2173","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2018]]}},{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:12:24Z","timestamp":1761156744755,"version":"3.41.2"},"reference-count":32,"publisher":"Open Access Pub","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Breast cancer has high incidence in women from both developed and developing countries. Approximately 2 million women are diagnosed with breast cancer in 2018. In Asia, unfortunately Pakistan leads the highest number of breast cancer patients. Various treatment strategies are present but they are not well developed. There is a great need to develop effective methods for early detection and treatment of the disease. For cancer treatment chemotherapeutic interventions have always been a method of choice. One of the mechanisms involved in cancerous cell proliferation is Mevalonate (MVA) pathway. It is hypothesized that arresting MVA pathway leads to cell death hence cancer cell growth is suppressed. Various inhibitors of MVA pathway have been studied that can suppress cell proliferation. Nitrogen containing bisphosphonates are MVA pathway inhibitor and clinically used for treatment of bone diseases. Their anticancer efficacy is also reported. Current study focuses on alendronate, a nitrogen containing bisphosphonate to examine their anticancer effect on breast cancer cell line. Results of this study may help in addition of new anticancer drug for breast cancer.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-19-2953","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T10:14:02Z","timestamp":1569060842000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of Anticancer Effect of Alendronate in Breast Cancer: An In vitro Study"],"prefix":"10.14302","volume":"2","author":[{"given":"Nida Syed Amber","family":"Ilyas","sequence":"first","affiliation":[{"name":"National Center for Proteomics, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamshad","family":"Zarina","sequence":"additional","affiliation":[{"name":"National Center for Proteomics, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Hashim","sequence":"additional","affiliation":[{"name":"National Center for Proteomics, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2019,8,3]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.Hanahan D, R A Weinberg. 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(2000) Bisphosphonates induce apoptosis in human breast cancer cell lines\u201d. , Br J Cancer 82, 1459-68.","DOI":"10.1054\/bjoc.1999.1131"},{"key":"ref20","unstructured":"21.Blanchette P S, Pritchard K I. (2015) The role of bisphosphonates in early- and advanced-stage breast cancer: have we finally optimized care?\u201d Oncology (Williston Park)25595283. 29, 23-30."},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.Coxon F P, Ebetino F H, Mules E H, Seabra M C, McKenna C E et al. (2005) inhibitors of rabgeranylgeranyltransferase disrupt the prenylation and membrane localization of rab proteins in osteoclasts in vitro and in vivo\u201d. , Bone 37, 349-358.","DOI":"10.1016\/j.bone.2005.04.021"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.Xu N, Shen N, Wang X. (2015) Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation\u201d. , Sci. 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Clin Cancer Res 23, 1684-1689.","DOI":"10.1158\/1078-0432.ccr-16-0547"},{"key":"ref26","unstructured":"27.Virtanen S S.Vaananen H K,HarkonenP L,LakkakorpiP T (2002).\u201cAlendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway\u201d. , CancerResearch 11980672, 2708-2714."},{"key":"ref27","unstructured":"28.Morii T SusaM, Yabe H. (2009) Alendronate inhibits growthof high-grade chondrosarcoma cells\u201d. , Anticancer Research, PMID: 19528443, 1879-1888."},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.Tsubaki M, Satou T ItohT. (2013) Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cellsvia inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. , Biochemical Pharmacology 85, 163-172.","DOI":"10.1016\/j.bcp.2012.10.009"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30.Jiang X, Pan H, NabhanJ F. (2012) A novel EST-derived RNA is creen reveals a critical role for farnesyl diphosphate synthase in\ud835\udefd2-adrenergic receptor internalization and down-regulation\u201d. , The FASEB Journal 26, 1995-2007.","DOI":"10.1096\/fj.11-193870"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.Thaler R, Spitzer S, KarlicH BergerC, Klaushofer K, Varga F. (2013) Ibandronate increases the expression of the proapoptotic gene FAS by epigenetic mechanisms in tumor cells\u201d. , Biochemical Pharmacology 85, 173-185.","DOI":"10.1016\/j.bcp.2012.10.016"},{"key":"ref31","unstructured":"32.Gambino A, P G Arduino, Polidoro S.Broccoletti R (2014)\u201cEffects of bisphosphonate treatment on. DNA methylation in osteonecrosis of the jaw\u201d. Annali di Stomatologia,5,11\u201312. PMCID: PMC4377696 ."}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T10:14:09Z","timestamp":1569060849000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1136"}},"editor":[{"given":"Aiping","family":"Zheng","sequence":"additional","affiliation":[{"name":"China"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2019,8,3]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,8,3]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-19-2953","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2019,8,3]]},"article-number":"1136"},{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T11:13:26Z","timestamp":1718882006586},"reference-count":0,"publisher":"Open Access Pub","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"DOI":"10.14302\/issn.2576-6694.jbbs-17-1860","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T05:15:51Z","timestamp":1517894151000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Benzoate Concentration and Cooperativity by a Substrate for Benzoate 1,2-dioxygenase from Benzoate-Degrading Rhodococcus Opacus 1CP"],"prefix":"10.14302","volume":"1","author":[{"given":"Elena V.","family":"Emelyanova","sequence":"first","affiliation":[{"name":"Laboratory of biosensor, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences, Pushchino, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna P.","family":"Solyanikova","sequence":"additional","affiliation":[{"name":"Laboratory of enzymatic degradation of organic compounds, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences, Pushchino, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2017,12,7]]},"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T05:01:29Z","timestamp":1519016489000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/636"}},"editor":[{"given":"Syed Shamsul","family":"Hassan","sequence":"additional","affiliation":[{"name":"Ocean college Zhejiang University"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2017,12,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,12,7]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-17-1860","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2017,12,7]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:13:22Z","timestamp":1753884802805,"version":"3.41.2"},"reference-count":24,"publisher":"Open Access Pub","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>In this research work Mg0.45Mn0.55-xNixFe2O4 ferrite particles of varying compositions (x=0.05, x=0.15, x=0.25, x=0.45 and x=0.55) were synthesized using cost effectual co-precipitation route. The synthesized ferrite particles were characterized by collection of techniques. XRD analysis confirmed the formation of cubic spinel structure of the ferrite particles. SEM and AFM analyses illustrated the morphology and size distribution of obtained ferrite particles. FT-IR study exposed that the absence of any additional peak related to second phase. VSM results indicated magnetic analyses such as saturation magnetization (MS), Coercivity (HC) and Remanence (Mr) of ferrite particles. The major objective of the present investigation is to synthesize MgMnNiFe2O4 ferrite particles on cotton fabrics in order to obtain finished fabrics; it is very significant in biological applications. The antibacterial activities of the ferrite particles coated cotton fabrics were tested against selected Gram positive and Gram negative bacteria which showed tremendous results via formation of inhibition zones. The fabricated ferrite particles on cotton fabrics showed great durability evidenced by their antibacterial activities even after 20 washing cycles. Hence, the functionalized cotton fabrics could be used as potential antibacterial agent.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-22-4179","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T04:08:45Z","timestamp":1671854925000},"page":"30-43","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Activities of Ni Substituted Ferrite Particles for Biological Applications"],"prefix":"10.14302","volume":"2","author":[{"given":"Subbiah Rammohan","family":"Chitra","sequence":"first","affiliation":[{"name":"Head of Physics Department, P.K.N Arts and Science College, Tirumangalam in Madurai District, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suruliappan Subramanian","family":"Anjanapriya","sequence":"additional","affiliation":[{"name":"Assistant Professor in Microbiology Department, P.K.N Arts and Science College, Tirumangalam in Madurai District, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref0","unstructured":"1.Shahzeidi Z S, Amiri Gh. (2015) Antibacterial activity of Fe3O4nanoparticles. , Int. J. Bio-Inorg. Hybr. Nanomater 4(3), 135-140."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.Katerina. (2009) Superparamagnetic maghemite nanoparticles from solid-state synthesis \u2013 Their functionalization towards peroral MRI contrast agent and magnetic carrier for tryps in immobilization. , Biomaterials 30(15), 2855-2863.","DOI":"10.1016\/j.biomaterials.2009.02.023"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.Vishal. (2016) Synthesis and characterization of nickel cobalt ferrite nanoparticles via heat treatment method. Advance Materials Proceedings 1(1), 76-80.","DOI":"10.5185\/amp.2016\/114"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.Wu Wei. 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Mater 272, 2253-2254.","DOI":"10.1016\/j.jmmm.2003.12.564"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.Balakumaran. (2016) In vitro biological properties and characterization of nanosilver coated cotton fabrics: An application for antimicrobial textile finishing. , Int. Biodeter. Biodegrad 107, 48-55.","DOI":"10.1016\/j.ibiod.2015.11.011"},{"key":"ref17","unstructured":"18.Sathianarayanan. (2010) Antibacterial finish for cotton fabric from herbal products. , Indian J. Fibre Textile Res 35, 50-58."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.Perelshtein. (2009) Sonochemical coating of silver nanoparticles on textile fabrics (nylon, polyester and cotton) and their antibacterial activity. , Nanotechnol 19, 245705.","DOI":"10.1088\/0957-4484\/19\/24\/245705"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.Raghupati K R, Koodali R T, Manna A C. (2011) Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. , Langmuir 27, 4020-4028.","DOI":"10.1021\/la104825u"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"21.Mahapatra. (2008) Ultrafine dispersed CuO nanoparticles and their antibacterial activity. , J. Exp Nanosci 3, 185-193.","DOI":"10.1080\/17458080802395460"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"22.Tran. (2010) Bactericidal effects of iron oxide nanoparticles on Staphylococcus aureus. , Int J. Nanomedicine 5, 277-283.","DOI":"10.2147\/IJN.S9220"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.El-Rafie. (2014) Characterization of nanosilver coated cotton fabrics and evaluation of its antibacterial efficacy. , Carbohydr. Polym 107, 174-181.","DOI":"10.1016\/j.carbpol.2014.02.024"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.El-Rafie. (2012) Bio-synthesis and applications of silver nanoparticles onto cotton fabrics. , Carbohydr. Polym 90, 915-920.","DOI":"10.1016\/j.carbpol.2012.06.020"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T04:08:55Z","timestamp":1671854935000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1861"}},"editor":[{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[{"name":"Medical & Molecular Genetics, HS 5013 MMGE, Indianapolis."}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2022,10,10]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,10,29]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-22-4179","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2022,10,10]]},"article-number":"1861"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:12:56Z","timestamp":1753884776028,"version":"3.41.2"},"reference-count":36,"publisher":"Open Access Pub","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>The present study aimed to evaluate the effect of the Trivedi Effect\u00ae- Biofield Energy Treated\/Blessed Test formulation\/item (TI) composed of minerals (magnesium, zinc, copper, calcium, selenium, and iron), vitamins (ascorbic acid, pyridoxine HCl, alpha tocopherol, cyanocobalamin, and cholecalciferol), Panax ginseng extract, CBD isolates, and \u03b2-carotene on elasticity of skin, heart, muscle, and neuronal cells in the H9C2 (rat cardiomyocytes), C2C12 (mouse myoblast cells), HaCaT (human keratinocytes), and SH-SY5Y (human neuroblastoma cells) cell line in DMEM medium. The test formulation constituents were divided into two parts; one section was defined as untreated test formulation (UT), while the other portion of test formulation received Biofield Energy Healing\/Blessing Treatment (BT) by a renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi. The test items were treated with Biofield Energy Healing\/Blessing Treatment and divided as Biofield Energy Treated\/Blessed (BT) and untreated (UT) test items. MTT data showed that the test formulation in various concentrations was found as safe and nontoxic in the tested concentrations with viability range from 73% to 307%. Young\u2019s modulus (YM) is a measure of cell stiffness, a decrease in YM value indicates increase elasticity of the cells and vice-versa. YM in H9C2 cells were decreased by 9.6% and 66.1% in the BT-DMEM + UT-TI group at 0.1 and 1 \u00b5g\/mL respectively, as compared with untreated test group. However, C2C21 cells showed increased YM by 443.9% at 1 \u00b5g\/mL in the UT-DMEM + BT-TI group, while 869.6% increased YM in the BT-DMEM + UT-TI group at 1 \u00b5g\/mL as compared with untreated test group. However, 314% increased YM was reported in the BT-DMEM + BT-TI group at 1 \u00b5g\/mL as compared with the untreated test group. However, the value of YM was significantly decreased in the HaCaT cell line by 247.7% (at 1 \u00b5g\/mL), 225.8% (at 0.1 \u00b5g\/mL), and 97.9% (at 1 \u00b5g\/mL) in the UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI group respectively, as compared with the untreated group. In addition, YM was significantly decreased in the SH-SY5Y cell line by 92.6%, 18.1%, and 26.6% at 1 \u00b5g\/mL in the UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI group respectively, as compared with the untreated group. Overall, the results showed the significant decreased YM among the SH-SY5Y, HaCaT, and H9C2 cells, while it was increased in the C2C21 cell line. Thus, the mechanical properties of cells such as cellular function, including shape, motility, differentiation, division, and adhesion to its surrounding extracellular matrix were improved. Overall, it can be useful in many disease progressions with improved cellular elasticity and its associated complications\/symptoms.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-21-3819","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T10:19:00Z","timestamp":1627726740000},"page":"19-29","source":"Crossref","is-referenced-by-count":0,"title":["Elasticity Profile of Skin, Neuronal, Cardiac, and Skeletal Muscle Cells after Treatment with the Biofield Energy Healing-Based Proprietary Test Formulation"],"prefix":"10.14302","volume":"2","author":[{"given":"Mahendra Kumar","family":"Trivedi","sequence":"first","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Branton","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahryn","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehasis","family":"Jana","sequence":"additional","affiliation":[{"name":"Trivedi Science Research Laboratory Pvt. Ltd., Thane (W), Maharashtra, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Kuznetsova T G, Starodubtseva M N, Yegorenkov N I, Chizhik S A, Zhdanov R I. (2007) Atomic force microscopy probing of cell elasticity. , Micron 38, 824-833.","DOI":"10.1016\/j.micron.2007.06.011"},{"key":"ref1","unstructured":"2.Pasikowska M, Kobiela T, Duli\u0144ska M I, Eris I. (2015) The impact of anti-aging peptides on mechanical properties of fibroblasts. Proceedings\u201323. IFSCC Conference (http:\/\/tst.pg2.at\/abstracts\/data\/full_papers\/full_paper_134.pdf) , Zurich ."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.Kobiela T, Lelen-Kaminska K, Stepulak M, Lekka M, Malejczyk M et al. 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For this, a randomized, placebo-controlled, triple-blinded clinical trial of 80 qualified subjects was conducted. Subjects were randomized into two groups, a treatment group (n=40) and a control (placebo) group (n=40). Metrics of emotional stress assessed were a subjective rating of the level of emotional stress and salivary cortisol levels, both obtained at 3 timepoints: before treatment (baseline), immediately following completion of the TSST, and after 20 minutes of rest following completion of the TSST. Results showed that the treatment group had a statistically greater decrease in the subjective rating of stress relative to the control group both immediately following the TSST and 20 minutes after the TSST. Salivary cortisol levels in the treatment group were also lower than the control group at those same time points. These results suggest that bilateral alternating somatosensory stimulation may be effective in reducing subjective levels of stress and anxiety. It also may actively attenuate stress-related cortisol levels, which may reflect a mechanism for reducing cortisol-induced inflammation back to baseline after exposure to stressful situations.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-19-2784","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T04:37:12Z","timestamp":1562215032000},"page":"22-30","source":"Crossref","is-referenced-by-count":2,"title":["A Triple-Blind, Placebo-Controlled Randomized Trial of the Effect of Bilateral Alternating Somatosensory Stimulation on Reducing Stress-Related Cortisol and Anxiety During and After the Trier Social Stress Test"],"prefix":"10.14302","volume":"2","author":[{"given":"Ernesto Cesar Pinto","family":"Leal-Junior","sequence":"first","affiliation":[{"name":"Laboratory of Phototherapy and Innovative Technologies in Health, Nove de Julho University \u2013 UNINOVE, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heliodora Le\u00e3o","family":"Casalechi","sequence":"additional","affiliation":[{"name":"Laboratory of Phototherapy and Innovative Technologies in Health, Nove de Julho University \u2013 UNINOVE, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline dos Santos Monteiro","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Phototherapy and Innovative Technologies in Health, Nove de Julho University \u2013 UNINOVE, Sao Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Serin","sequence":"additional","affiliation":[{"name":"The Touchpoint Solution, Serin Center, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan S.","family":"Hageman","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA, Los Angeles, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas Scott","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Cliffside Group, Michigan, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Kalia M. 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S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Mattoso","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Casarin","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Grando","family":"M\u00c3\u00b3dolo","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Mazzuchelli-de-Souza","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Franco de Carvalho","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diva Denelle","family":"Spadacci Morena","sequence":"additional","affiliation":[{"name":"Pathophysiology Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Be\u00c3\u00a7ak","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de Cassia","family":"Stocco","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Butantan Institute, S\u00c3\u00a3o Paulo-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2017,12,19]]},"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:55:34Z","timestamp":1519635334000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/648"}},"editor":[{"given":"Syed Shams ul","family":"Hassan","sequence":"additional","affiliation":[{"name":"Ocean college Zhejiang University"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2017,12,19]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,12,7]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-17-1869","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2017,12,19]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:41Z","timestamp":1753884701477,"version":"3.41.2"},"reference-count":47,"publisher":"Open Access Pub","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Lead removal efficiency of the bacterial strain, Bacillus subtilis (MTCC 2423) was tested with 200, 400, 600, 800 and 1000 ppm of lead in minimal broth for a period of ten days. Samples were tested for the level of lead every two days in each concentration and maximum removal was observed after six days of treatment. With the increase in lead concentration, both biomass and lead removal efficiency showed an increase. When tested with immobilized, dead and live cells, maximum removal was observed for immobilized cells. Among the sugars tested, monosaccharide sugars enhanced the biomass of B. subtilis during lead treatment and the results are discussed.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-20-3419","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T05:27:08Z","timestamp":1596518828000},"page":"1-14","source":"Crossref","is-referenced-by-count":3,"title":["Biosorption of Lead Using the Bacterial Strain, Bacillus subtilis (MTCC 2423)"],"prefix":"10.14302","volume":"2","author":[{"given":"Shivani","family":"Gupta","sequence":"first","affiliation":[{"name":"PG Department of Microbiology, The American College, Madurai, Tamil Nadu, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Surendran","sequence":"additional","affiliation":[{"name":"PG & Research Department of Zoology, The American College, Madurai, Tamil Nadu, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Joseph Thatheyus","sequence":"additional","affiliation":[{"name":"PG & Research Department of Zoology, The American College, Madurai, Tamil Nadu, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Sardar K, Ali S, Hameed S, Afzal S, H M Tauqeer. 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(2010) Comparative study of biosorption of Zn2+byPseudomonas aeruginosaandBacillus cereus\u201d.Int.Biodeter.Biodegr. 64, 734-741.","DOI":"10.1016\/j.ibiod.2010.08.007"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45.Ji Y, Gao H, Sun J, Cai F. (2011) Experimental probation on the binding kinetics and thermodynamics of Au(III) ontoBacillus subtilis\u201d.Chem. , Eng 172, 122-128.","DOI":"10.1016\/j.cej.2011.05.077"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46.A H Hawari, C N Mulligan. (2006) Biosorption of lead (II), cadmium (II), copper (II) and nickel (II) by anaerobic granular biomass\u201d.Bioresource. Technol.97 692-700.","DOI":"10.1016\/j.biortech.2005.03.033"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"47.Li H, Lin Y, Guan W, Jiali Ch, Xu L et al. (2010) Biosorption of Zn (II) by live and dead cells ofStreptomycesciscaucasicusstrain CCNWHX 72\u201314\u201d.J. , Hazard.Mater 179, 151-159.","DOI":"10.1016\/j.jhazmat.2010.02.072"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T05:27:24Z","timestamp":1596518844000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1401"}},"editor":[{"given":"Yitong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of ONCOLOGY"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2020,7,13]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,7,13]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-20-3419","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2020,7,13]]},"article-number":"1401"},{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:14:28Z","timestamp":1793240068635,"version":"4.5.0"},"reference-count":23,"publisher":"Open Access Pub","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>This study evaluated the bacteriological quality of groundwater from Imiringi in Ogbia Local government area of Bayelsa State, Nigeria. Groundwater samples were obtained in triplicates from four locations in the study area and analyzed for the bacteria quality using standard protocols. Results showed that the microbial density ranged from 2.97 \u2013 6.03 x 104 cfu\/ml (for total heterotrophic bacteria counts), 4.17 \u2013 5.43 x 102 cfu\/ml (for Enterobacteriaceae bacteria counts) and 0.00 \u2013 1.48 x 102 cfu\/ml (for Salmonella-Shigella counts). Statistically, there was no significant difference (p&gt;0.05) across the various locations for each of the parameters. The density observed were higher than the allowable limit of 1.0 x 102 cfu\/ml for drinking water as recommended by World Health Organization\/Food and Agricultural Organization, and maximum permissible level of 10cfu\/ml for total coliform as specified by Standard Organization of Nigeria. The prevalence of bacteria isolated in the water samples were Aeromonas species (8.00%), Citrobacter species (7.50%), Escherichiacoli (20.75%), Klebsiella species (5.50%), Pseudomonas species (12.00%), Salmonella species (2.25%), Shigella species (3.25%) and Staphylococcus species (40.75%). From the bacteria density and diversity, the water is not potable. Some of the bacterial found are of public health importance. Hence, there is a need to adequately treat the water using chlorination and boiling techniques before drinking.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-20-3340","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T10:55:55Z","timestamp":1594032955000},"page":"34-40","source":"Crossref","is-referenced-by-count":19,"title":["Bacteriological Quality of Groundwater in Imiringi Town, Bayelsa State, Nigeria"],"prefix":"10.14302","volume":"2","author":[{"given":"Enetimi Idah","family":"Seiyaboh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Okponanabofa","family":"Youkparigha","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvester Chibueze","family":"Izah","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikpilavi Deborah","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5410","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref0","unstructured":"1.Izah S C, Ineyougha E R. 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[Epub ahead of print] 2014 10.1016\/j.apmr.2014.03.029 S0003-9993(14)00280-9"},{"key":"ref022","doi-asserted-by":"crossref","unstructured":"22. Lee S Bacha F Gungor N Arslanian S Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponection, and inflammatory biomarkers 2008 J. pediatr 152 177 184 10.1016\/j.jpeds.2007.07.053","DOI":"10.1016\/j.jpeds.2007.07.053"},{"key":"ref023","doi-asserted-by":"crossref","unstructured":"23. Franco O H Massaro J M Civil J Trajectories of entering the metabolic syndrome: The Framingham Herat study 2009 Circulation 120 1943 50 10.1161\/circulationaha.109.855817","DOI":"10.1161\/CIRCULATIONAHA.109.855817"},{"key":"ref024","doi-asserted-by":"crossref","unstructured":"24. Morimoto A Nishimura R Kanda A Sano H Matsudaira T Miyashita Y Shirasawa T Takahashi E Kawaguchi T Tajima N Waist circumference estimation from BMI in Japanese children 2007 Diabetes Res Clin. Pr 75 96 98 10.1016\/j.diabres.2006.05.022","DOI":"10.1016\/j.diabres.2006.05.022"},{"key":"ref025","doi-asserted-by":"crossref","unstructured":"25. L De Koning A T Merchant Pogue J S Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies 2007 Eur. Heart. J 28 850 856 10.1093\/eurheartj\/ehm026","DOI":"10.1093\/eurheartj\/ehm026"},{"key":"ref026","unstructured":"26. Teixeira da Silva MdeL Martins Renofio Midori Shiroma J Ortolani G C Mika Horie M L Nutritional recommendation alone does not change the obesity profile of health professionals 2008 Nutr. Hosp 23 429 432"},{"key":"ref027","doi-asserted-by":"crossref","unstructured":"27. I S Okosun Liao Y C N Rotimi Choi S R S Cooper Predictive values of waist circumference for dyslipidemia, type 2 diabetes and hypertension in overweight White, Black and Hispanic American adults 2000 J. Clin. Epidemiol 53 401 408 10.1016\/s0895-4356(99)00217-6","DOI":"10.1016\/S0895-4356(99)00217-6"},{"key":"ref028","doi-asserted-by":"crossref","unstructured":"28. M A Ashwell S D Hsieh Six reasons why the waist-to-height ratio is rapid and effective global indicator for the health risks of obesity and how its use could simplify the international public health usage on obesity 2005 Int. J. Food Sci. Nutr 56 303 307 10.1080\/09637480500195066","DOI":"10.1080\/09637480500195066"},{"key":"ref029","doi-asserted-by":"crossref","unstructured":"29. D S Freedman H S Kahn Mei Z Strawn L M G W H Dietz S R Relation of body mass index and waist-to-height ratio to cardiovascular risk factors in children and adolescents: the Bogalusa heart study 2007 Am. J. Clin. Nutr 86 33 40 10.1093\/ajcn\/86.1.33","DOI":"10.1093\/ajcn\/86.1.33"},{"key":"ref030","doi-asserted-by":"crossref","unstructured":"30. M S Burgos L T Burgos Camargo Franke Para S I R D Vargas da Silva A M Borges T S P F Reckziegel M B Reuter P C Relationship between anthropometric measures and cardiovascular risk factors in children and adolescents. Arq Bras Cardiol 2013 vol.101 no.4 S\u00e3o PauloOct.2013 EpubAug27,2013 10.5935\/abc.20130169","DOI":"10.5935\/abc.20130169"},{"key":"ref031","doi-asserted-by":"crossref","unstructured":"31. Marotta T B F Russo Ferrara A Triglyceride-to-HDL-cholestrol ratio and metabolic syndrome as contributors to cardiovascular risk in overweight patients 2010 Obes 18 1608 1613 10.1038\/oby.2009.446","DOI":"10.1038\/oby.2009.446"},{"key":"ref032","unstructured":"32. World Health OrganizationWaist circumference and waist-hip ratio: Report of WHO Expert2011 consultation, 2011; Geneva, 8-11December,2008"},{"key":"ref033","doi-asserted-by":"crossref","unstructured":"33. Singh L C S P Sikri S L C G Garg L C M K Body Mass Index and Obesity Tailoring \u201ccut-off\u201d for an Asian Indian Male Population 2008 M.J.A.F.I 64 350 353 10.1016\/s0377-1237(08)80019-6","DOI":"10.1016\/S0377-1237(08)80019-6"},{"key":"ref034","doi-asserted-by":"crossref","unstructured":"34. N C Kesavachandran Bihari B Mathur N The normal range of body mass index with high body fat percentage among male residents of Lucknow city in north India 2012 Indian J. Med. Res 135 72 77 10.4103\/0971-5916.93427","DOI":"10.4103\/0971-5916.93427"},{"key":"ref035","unstructured":"35. J M Ryan V E Crowley Hensey O McGahey A Gorml J Waist circumference provides an indication of numerous cardio metabolic risk factors in adults with cerebral palsy\". Arch Phys Med Rehabil.2014Apr14.pii:S0003-9993(14)00280-9.doi: 10.1016\/j.apmr.2014.03.029.[Epub ahead of print] 2014 10.1016\/j.apmr.2014.03.029.[Epub S0003-9993(14)00280-9.doi:"},{"key":"ref036","doi-asserted-by":"crossref","unstructured":"36. Watts K L M Bell S M Byrne T W Jones E A Davies Waist circumference predicts cardio-metabolic risk in young Australian children 2008 J. Pediatr. Child. Health 44 709 715","DOI":"10.1111\/j.1440-1754.2008.01411.x"},{"key":"ref037","doi-asserted-by":"crossref","unstructured":"37. Genovesi S Antolini L Giussani M Pieruzzi F Galbiati S M G Valsecchi Usefulness of waist circumference for the identification of childhood hypertension 2008 J. Hypertens 26 1563 1570 10.1097\/hjh.0b013e328302842b","DOI":"10.1097\/HJH.0b013e328302842b"},{"key":"ref038","doi-asserted-by":"crossref","unstructured":"38. R S Sarni F I Souza D O Schoeps Catherino P M C Oliveira C E Pessoti Relationship between waist circumference and nutritional status, lipid profile and blood pressure in low socioeconomic level pre-school children 2006 Arq. Bras. Cardiol 87 153 158","DOI":"10.1590\/S0066-782X2006001500013"},{"key":"ref039","doi-asserted-by":"crossref","unstructured":"39. R W Taylor I E Jones S M Williams Goulding A Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass, as measured by dual-energy X-ray absorptiometry, in children aged 3-19 y 2000 Am. J. Clin., Nutr 72 490 495 10.1093\/ajcn\/72.2.490","DOI":"10.1093\/ajcn\/72.2.490"},{"key":"ref040","doi-asserted-by":"crossref","unstructured":"40. Peterson M D Haapala H J Hurvitz E A Predictors of cardiometabolic risk among adults with cerebral palsy 2012 Arch Phys Med Rehabil 93 816 821 10.1016\/j.apmr.2011.12.024","DOI":"10.1016\/j.apmr.2011.12.024"},{"key":"ref041","doi-asserted-by":"crossref","unstructured":"41. Zhu S S B Heymsfield Toyoshima H Wang Z Pietrobelli A Heshka S Race- ethnicity-specific circumference cut-offs for identifying cardiovascular disease risk factors 2005 Am J Clin Nutr 81 904 915","DOI":"10.1093\/ajcn.81.2.409"},{"key":"ref042","doi-asserted-by":"crossref","unstructured":"42. R P Wildman Gu D Reynolds K Duan X He J Appropriate body mass index and waist circumference cutoffs for categorization of overweight and central adiposity among Chinese adults 2004 Am J Clin Nutr 80 1136 10.1093\/ajcn\/80.5.1129","DOI":"10.1093\/ajcn\/80.5.1129"},{"key":"ref043","doi-asserted-by":"crossref","unstructured":"43. Seidell J C Waist circumference and waist\/hip ratio in relation to all-cause mortality, cancer and sleep apnea 2010 Eur. J. Clini. Nutr 64 35 41","DOI":"10.1038\/ejcn.2009.71"},{"key":"ref044","doi-asserted-by":"crossref","unstructured":"44. Asayama K Ozeki T Sugihara S Criteria for medical intervention in obese children: a new definition of \u201cobesity disease\u201d in Japanese children 2003 Pediatr. Int 45 642 646 10.1046\/j.1442-200x.2003.01795.x","DOI":"10.1046\/j.1442-200X.2003.01795.x"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/article\/665\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openaccesspub.org\/article\/665\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:57:09Z","timestamp":1790942229000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/biotechnology-and-biomedical-science\/article\/predictive-value-of-some-central-obesity-anthropometric-indicators-to-metabolic-risk-factors-in-syrian-adolescents-665"}},"issued":{"date-parts":[[2018]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-17-1850","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2018]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:39Z","timestamp":1753884699768,"version":"3.41.2"},"reference-count":25,"publisher":"Open Access Pub","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Background\nThe genetic material of the genetically modified crop has been altered to develop the necessary insect resistance features by introducing genes from the Bt (Bacillus thuringiensis) bacterium. The objective of this study was to find smuggled GM Bt crops in the Metema farming area and examine its environmental effects.\n\nMethod\nAn experimental; Completely Randomized Design (CRD) was used to collect crop samples in the study area. The CTAB (Cetyltrimethyl ammonium bromide) technique was used to isolate DNA from all transported samples, and the purity was determined using a Nano Drop spectrophotometer. Conventional PCR with particular primers for different Bt gene events was used to detect the presence of genes. Furthermore, utilizing Bt cotton specific primer sets, the prevalence of GM cotton was measured, and amplified fragments were confirmed using agarose gel electrophoresis.\n\nResult\nThe PCR results revealed that 15 (33.3 percent) of the samples were Bt cotton smuggled from Sudan. The PCR assay also revealed the presence of GM maize. Moreover, the effects of GM genes on the environment were studied in diseased samples, and no transgenes were found. Furthermore, domestic and indigenous crops were used to determine horizontal gene transfers of GM genes to other crops, and the transgene was not found in any of the samples analyzed. Conclusion: In the current study, 28 (13.4%) of the 209 (100%) total analyzed samples were GM crops which indicated the presence of unauthorized GM seeds in the study area. Environmental impact studies and horizontal gene transfer data similarly revealed that the Bt gene was not transferred to other crops and had no harmful environmental effects. For a better understanding of the Impact of imported unauthorized GM seeds, more additional detection of GM events should be done by expanding the sampling site and sample types.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-22-4390","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T08:54:13Z","timestamp":1705136053000},"page":"16-27","source":"Crossref","is-referenced-by-count":0,"title":["Detection of Smuggled Genetically Modified Crops and Assessment of its Environmental Impact in the Ethio -Sudan Trans Boundary Area, North West Ethiopia"],"prefix":"10.14302","volume":"3","member":"5410","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.N A Abdallah. (2014) The story behind Bt cotton: Where does Sudan stand?. Biotechnology in Agriculture and the Food Chain,5(4): 241-243.","DOI":"10.1080\/21645698.2014.997119"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.Alessandra P, R Pascal Aurora, Daniele S, Timothy M V D, Jean-Miche M. (2009) . Visual Evidence of Horizontal Gene Transfer between Plants and Bacteria in the Phytosphere of Transplastomic Tobacco. Applied and environmental microbiology,;75(10): 3314-3322.","DOI":"10.1128\/aem.02632-08"},{"key":"ref2","unstructured":"3.Alka D, S K Tank. (2014) PCR based detection of transgenes cry1ac and cry2ab in mon-15985(bg-ii) bt-cotton in gujarat samples. , Asian Journal of Science and 5(7), 419-422."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.J C Anthony, R G Travis, Jan-Peter N. (2003) The release of genetically modified crops into the environment and Overview of ecological risk assessment. The Plant Journal.33:.","DOI":"10.1046\/j.0960-7412.2002.001607.x"},{"key":"ref4","unstructured":"5.Bosena T, Bekabil F, Berhanu G, Dirk H. (2011) Factors Affecting Cotton Supply at the Farm Level in Metema District of Ethiopia. , Journal of Agriculture, Biotechnology & Ecology.4 1, 40-51."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6.Burton K. (2004) Determination of DNA concentration with diphenylamine. Nucleic Acids,163\u2013166.","DOI":"10.1016\/0076-6879(67)12127-7"},{"key":"ref6","unstructured":"7.Doyle J, J L Doyle. (1990) Isolation of plant DNA from fresh tissue. 12(13), 39-40."},{"key":"ref7","unstructured":"8.James C. (2016) Global status of commercialized. , Biotech\/GM crops: ISAAA Brief No 52."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.Koppel R, Zimmerli F, Breitenmoser A. (2010) Multiplex real-time PCR for the simultaneous detection and quantification of DNA from three transgenic rice species and construction and application of an artificial oligonucleotide as reference molecule. , European Food and Research Technology 230, 731-736.","DOI":"10.1007\/s00217-010-1213-y"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.Lih-ching C, Yen-ling C, Jei-hwa Y, yang Daniel-, C.(2001).Detection of Four Types of Genetically Modified Maize by Polymerase Chain Reaction and Immuno-Kit Methods. , Journal of Food and Drug Analysis 9(1), 50-57.","DOI":"10.38212\/2224-6614.2813"},{"key":"ref10","unstructured":"11.J S Manjunath, Chandan K, Krishna H, Aparna G. (2018) Genetically modified crops:. , Journal of Pharmacognosy and Phytochemistry 7(1), 2405-2410."},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.R B Maria, Renata T B F, Rafael L-F, Paola C-L, D\u00e9borah M V G. (2013) Detection of genetically modified maize events in Brazilian maize-derived food products. , Food Science and 33(3), 399-403.","DOI":"10.1590\/s0101-20612013005000063"},{"key":"ref12","unstructured":"13.Maryam R, Mehrangiz M, Hossein R, Hossein V, Mahmoud A. (2013) Detection of Genetically Modified Maize in Processed Foods Sold Commercially in Iran by Qualitative PCR. , Iranian Journal of Pharmaceutical Research.12 1, 25-30."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.Mathur V, Javid L, Kulshrestha S, Mandal A, Reddy A. (2017) A. World Cultivation of Genetically Modified Crops: Opportunities and Risks. Sustainable Agriculture Reviews. 45-87.","DOI":"10.1007\/978-3-319-58679-3_2"},{"key":"ref14","unstructured":"15.Metz M. (2003) Bacillus thuringiensis: a cornerstone of modern agriculture. , Journal of new seed 5(1), 2-3."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.Mohamed S, Tawfik A. (2018) Genetically engineered (modified) crops (Bacillus thuringiensis crops) and the world controversy on their safety. , Abbas Egyptian Journal of Biological Pest Control 28, 52.","DOI":"10.1186\/s41938-018-0051-2"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.Z L Jinshui, Donghai P, Ming S. (2018) Whole genomic analysis of Bacillus thuringiensis revealing partial genes as a source of novel Cry toxins. , Applied Environmental Microbiology 8414, 00277-18.","DOI":"10.1128\/aem.00277-18"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.Molaee A, J K Gholamreza, Setareh A K A, Sassan R. (2019) A simple and accurate PCR method for detection of genetically modified rice. , Journal of Environmental Health Science and Engineering.17: 847-851.","DOI":"10.1007\/s40201-019-00401-x"},{"key":"ref18","unstructured":"19.C V Prakashan, V K, Matin Q. (2014) Bt Cotton and Ecosystem Impacts of Pesticide Reductions. Global Food Discussion Papers. No.41"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.Ruchir R. (2018) The impact of Genetically Modified (GM) crops in modern agriculture: A review. Biotechnology in Agriculture and the Food Chain 8(4), 195-208.","DOI":"10.1080\/21645698.2017.1413522"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21.Sanahuja G, Raviraj B, R M Twyman, Capell T, Christou P. (2011) Bacillus thuringiensis: A century of research, development and commercial applications. , Plant Biotechnology Journal 9, 283-300.","DOI":"10.1111\/j.1467-7652.2011.00595.x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.K B Santos, Neves P, A M Meneguim, B dos Santos R, Santos dos et al. (2009) Selection and characterization of the Bacillus thuringiensis strains toxic to Spodoptera eridania (Cramer), Spodoptera cosmioides (Walker) and Spodoptera frugiperda (Smith)(Lepidoptera: Noctuidae). , Biological Control 50(2), 157-163.","DOI":"10.1016\/j.biocontrol.2009.03.014"},{"key":"ref22","unstructured":"23.S D. (2007) . Bt cotton. www.utcrops.com\/cotton_insects\/pubs\/Wi29- Btcotton. Accessed on 14-06."},{"key":"ref23","unstructured":"24.Vidhya P, Shree S, Ramanjini H, K N Gowda, Yogendra T et al. (2012) Detection of Gm cotton seeds. , Indian Journal of Biotechnology.11: 176-181."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.Wu H-S, Shi X, Li J, Liu Y-D, Xu Y et al. (2016) Soil ecological safety evaluation for bivalent transgenic cotton plants: root exudates versus soil enzyme activities and soil microbial diversity. Applied ecology and environmental research. 14(2), 319-336.","DOI":"10.15666\/aeer\/1402_319336"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T08:54:27Z","timestamp":1705136067000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1944"}},"issued":{"date-parts":[[2023,4,11]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2,20]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-22-4390","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2023,4,11]]},"article-number":"1944"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:41Z","timestamp":1753884701438,"version":"3.41.2"},"reference-count":41,"publisher":"Open Access Pub","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>L-tryptophan is an essential \u03b1-amino acid, necessary for the normal growth in newborns, nitrogen balance in adults, protein synthesis, precursor of serotonin, melatonin, niacin, and albeit inefficiently in human, also the precursor of indole alkaloids and auxins in plants. This current study was designed to investigate the impact of the Trivedi Effect\u00ae-Biofield Energy Healing Treatment (Blessing) on the structural properties and the isotopic abundance ratio of L-tryptophan using LC-MS analytical technique. L-tryptophan sample was divided into two parts, one part of L-tryptophan was considered as the control sample (no Biofield Energy Treatment was provided), while the second part was treated with the Trivedi Effect\u00ae-Consciousness Energy Healing Treatment\/Blessing remotely by a renowned Biofield Energy Healer, Dahryn Trivedi and termed as the treated sample. The mass spectra of both the control and treated samples with respect to the chromatographic peak at retention time (Rt) 2.1 minutes exhibited the mass of the molecular ion peak adduct with hydrogen ion at m\/z 205.08 (calcd for C11H13N2O2+, 205.1), along with low molecular fragmented mass peaks at m\/z 188, 159, and 102 for C11H12N2O2+, C10H11N2+, and C8H6+, respectively were also observed. The isotopic abundance ratio of PM+1\/PM (2H\/1H or 13C\/12C or 15N\/14Nor17O\/16O) in the treated L-tryptophan was significantly increased by 35.93% compared with the control sample. Hence,the 13C, 2H, 15N, and 17O contributions from C11H13N2O2+ to m\/z 206.08 in the treated L-tryptophan was significantly increased compared to the control sample. It could be hypothesized that the changes in the isotopic abundance and mass peak intensities due to the modification in nuclei possibly through the interference of neutrino particles using the Trivedi Effect\u00ae-Consciousness Energy Healing Treatment. The Biofield Energy Treated\/Blessed L-tryptophan with increased stable isotopic abundance ratio might have changed the physicochemical properties with higher force constant in the molecule. The new form of treated L-tryptophan would be a better and more stable in the supplements, nutraceutical, and pharmaceutical formulations, which would be advantageous for the prevention and treatment of pellagra, depression, kynurenine. It could also maintain the normal label of tryptophan and avoid increase of its metabolite, lower the neurotoxin and a metabotoxin behavior, glutaric aciduria type I (glutaric acidemia type I) disorder, eosinophilia-myalgia syndrome (EMS), incurable and sometimes fatal flu-like neurological condition, etc. As tryptophan is the precursor for the plant hormones like indole alkaloids and auxins, hence, this treated L-tryptophan would be advantageous for the improvement of yield, productivity, and quality of crops and other plants.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-21-3773","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:19:45Z","timestamp":1620051585000},"page":"10-18","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Isotopic Abundance Ratio of Consciousness Energy Healing Treated L-Tryptophan Using LC-MS Spectrometry"],"prefix":"10.14302","volume":"2","author":[{"given":"Dahryn","family":"Trivedi","sequence":"first","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra Kumar","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Branton","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehasis","family":"Jana","sequence":"additional","affiliation":[{"name":"Jana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"unstructured":"1. 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(2017) Effect of The biofield energy healing treatment on the pharmacokinetics of 25-hydroxyvitamin D3[25(OH)D3] in rats after a single oral dose of vitamin D3. , American Journal of Pharmacology and Phytotherapy 2, 11-18.","key":"ref12"},{"doi-asserted-by":"publisher","unstructured":"14.Trivedi M K, Branton A, Trivedi D, Nayak G, Sethi K K et al. (2016) Isotopic abundance ratio analysis of biofield energy treated indole using gas chromatography-mass spectrometry. , Science Journal of Chemistry 4, 41-48.","key":"ref13","DOI":"10.11648\/j.sjc.20160404.11"},{"doi-asserted-by":"publisher","unstructured":"15.Trivedi M K, TRR Mohan. (2016) Biofield energy signals, energy transmission and neutrinos. , American Journal of Modern Physics 5, 172-176.","key":"ref14","DOI":"10.11648\/j.ajmp.20160506.12"},{"doi-asserted-by":"publisher","unstructured":"16.Rubik B, Muehsam D, Hammerschlag R, Jain S. (2015) Biofield science and healing: history, terminology, and concepts. 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(2008) Complementary and alternative medicine use among adults and children: United States. , Natl Health Stat Report 12, 1-23.","key":"ref19","DOI":"10.1037\/e623942009-001"},{"doi-asserted-by":"publisher","unstructured":"21.Trivedi M K, Branton A, Trivedi D, Nayak G, Panda P et al. (2016) Evaluation of the isotopic abundance ratio in biofield energy treated resorcinol using gas chromatography-mass spectrometry technique. , Pharm Anal Acta 7, 481.","key":"ref20","DOI":"10.4172\/2153-2435.1000481"},{"doi-asserted-by":"publisher","unstructured":"22.Dabhade Tallapragada RMR, Trivedi M K. (2009) Effect of external energy on the atomic, crystalline, and powder characteristics of antimony and bismuth powders. , Bulletin of Materials Science 32, 471-479.","key":"ref21","DOI":"10.1007\/s12034-009-0070-4"},{"doi-asserted-by":"publisher","unstructured":"23.Trivedi M K, Nayak G, Patil S, Tallapragada R M, Latiyal O. 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(2015) Antimicrobial sensitivity pattern ofPseudomonas fluorescensafter biofield treatment. , J Infect Dis Ther 3, 222.","key":"ref25","DOI":"10.4172\/2332-0877.1000222"},{"doi-asserted-by":"publisher","unstructured":"27.Trivedi M K, Branton A, Trivedi D, Nayak G, Gangwar M et al. (2015) Agronomic characteristics, growth analysis, and yield response of biofield treated mustard, cowpea, horse gram, and groundnuts. , International Journal of Genetics and Genomics 3, 74-80.","key":"ref26","DOI":"10.11648\/j.ijgg.20150306.13"},{"doi-asserted-by":"publisher","unstructured":"28.Kinney J P, Trivedi M K, Branton A, Trivedi D, Nayak G et al. (2017) Overall skin health potential of the biofield energy healing based herbomineral formulation using various skin parameters. , American Journal of Life Sciences 5, 65-74.","key":"ref27","DOI":"10.11648\/j.ajls.20170502.15"},{"unstructured":"29.Singh J, Trivedi M K, Branton A, Trivedi D, Nayak G et al. 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(2011) Potential biomarkers in the urine of myocardial infarction rats: A metabolomic method and its application. , Mol Biosyst 7, 824-831.","key":"ref40","DOI":"10.1039\/c0mb00110d"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:20:17Z","timestamp":1620051617000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1617"}},"editor":[{"given":"John","family":"Akighir","sequence":"additional","affiliation":[{"name":"Federal University of Agriculture, Makurdi, UAM, Department of Veterinary Physiology, Pharmacology, and Biochemistry Master of Science."}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2021,4,15]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,10,29]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-21-3773","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2021,4,15]]},"article-number":"1617"},{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:52:48Z","timestamp":1792806768102,"version":"4.5.0"},"reference-count":39,"publisher":"Open Access Pub","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Allergy, despite its stereotyped symptomatic manifestations, continues to pose significant etiological, pathophysiological, and therapeutic challenges. In the interface between the body and the environment, the respiratory pathway is particularly stressed from an allergological perspective. Under the relationship between energy and matter signed by Einstein, it is possible to approach patients suffering from allergies with an Electraceutical 1 administration in a quantum modality.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-24-5001","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:01:48Z","timestamp":1715342508000},"page":"1-16","source":"Crossref","is-referenced-by-count":1,"title":["Quantum Approach to Allergic Pathology"],"prefix":"10.14302","volume":"3","author":[{"given":"Piergiorgio","family":"Spaggiari","sequence":"first","affiliation":[{"name":"Scientific medical association, between biochemistry and biophysics, accredited to the Italian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Tribbia","sequence":"additional","affiliation":[{"name":"Regional manager of AMBB, responsible for the Lombardy region, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisano","family":"Gianpaolo","sequence":"additional","affiliation":[{"name":"Scientific medical association, between biochemistry and biophysics, accredited to the Italian Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5410","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Famm K. 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Introduzione alla medicina Quantica.\u201d Named Ed., Lesmo (MB)."}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/2108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:02:02Z","timestamp":1715342522000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/2108"}},"editor":[{"given":"Ian James","family":"Martins","sequence":"additional","affiliation":[{"name":"Principal Research Fellow Edith Cowan University"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"issued":{"date-parts":[[2024,4,27]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,27]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-24-5001","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2024,4,27]]},"article-number":"2108"},{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:30:23Z","timestamp":1793597423090,"version":"4.5.0"},"reference-count":35,"publisher":"Open Access Pub","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Plants used for medicinal practices which were discovered since prehistoric stone ages are termed Medicinal plants, which are also referred to as medicinal herbs, since plants produces bioactive chemical compounds (phytochemicals), this research however, is concerned with the extraction using Soxhlet extraction technique, phytochemical screening using various test methods, which reveals the presence of anthraquinones (free anthraquinones and combined anthraquinones), carbohydrates, cardiac glycosides, glycosides, flavonoids, saponins, steroids\/ terpenes, phenolic compounds and tannins, and absence of alkaloids for extracts of senna occidentalis and also, thin layer chromatography profiling which gives probable foundation for further structural elucidation amongst others. This research shows the presence of potent secondary metabolites present in the leaves of senna occidentalis (leaves).<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-19-2791","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T12:06:50Z","timestamp":1559218010000},"page":"12-21","source":"Crossref","is-referenced-by-count":24,"title":["Phytochemical Analysis and Thin Layer Chromatography Profiling of Crude Extracts from Senna Occidentalis(Leaves)"],"prefix":"10.14302","volume":"2","author":[{"given":"Lawal","family":"A.M","sequence":"first","affiliation":[{"name":"Department of Chemistry, Federal University Dutse, Jigawa State, P.M.B 7156"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi","family":"R","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University Dutse, Jigawa State, P.M.B 7156"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"M.S","sequence":"additional","affiliation":[{"name":"Department of Polymer and Textile Engineering, Ahmadu Bello University, Zaria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurfi","family":"M.Y","sequence":"additional","affiliation":[{"name":"Department of Pure and Industrial Chemistry, Bayero University Kano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"A","sequence":"additional","affiliation":[{"name":"Science Department, Great Icon International School, Zaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuhu","family":"M","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University Dutse, Jigawa State, P.M.B 7156"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5410","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Ahn K. (2017) The worldwide trend of using botanical drugs and strategies for developing global drugs. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5422022 , BMB Reports 50(3), 111-116.","DOI":"10.5483\/bmbrep.2017.50.3.221"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2.Smith-Hall C, H O Larsen, Pouliot M. (2012) People, plants and health: a conceptual framework for assessing changes in medicinal plant consumption. , JEthnobiolEthnomed 8, 10-1186.","DOI":"10.1186\/1746-4269-8-43"},{"key":"ref2","unstructured":"3.Schippmann U, D J Leaman, A B Cunningham. (2002) Impact of Cultivation and Gathering of Medicinal Plants on Biodiversity: Global Trends and Issues 2. Some Figures to start with ...\" Biodiversity and the Ecosystem Approach in Agriculture, Forestry and Fisheries. 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(2013) Evaluation of the content variation of anthraquinone glycosides in rhubarb by UPLC-PDA. , Chemistry Central Journal 7(1), 170-10.","DOI":"10.1186\/1752-153x-7-170"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.Hietala P, Marvola M, Parviainen T, Lainonen H. (1987) Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts. Pharmacology & toxicology 61(2), 6-153.","DOI":"10.1111\/j.1600-0773.1987.tb01794.x"},{"key":"ref12","unstructured":"13.Akolkar P.Pharmacognosy of Rhubarb. PharmaXChange.info. Retrieved from http:\/\/pharmaxchange.info\/press\/2012\/12\/pharmacognosy-of-rhubarb\/"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.Silva Da, C. (2013) The High Polyphenol Content of Grapevine Cultivar Tannat Berries Is Conferred Primarily by Genes That Are Not Shared with the Reference Genome\".The Plant Cell. 25(12), 4777-4788.","DOI":"10.1105\/tpc.113.118810"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"15.Muller-Schwarze D. (2006) Chemical Ecology of Vertebrates. 287-978.","DOI":"10.1017\/CBO9780511607233"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.Y S Lee, J S Park, S D Cho, J K Son, Cherdshewasart W et al. (2002) Requirement of metabolic activation for estrogenic activity of. Pueraria mirifica\".Journal of Veterinary Science,3(4), 273\u2013277. Archived from the original on 2008-11.","DOI":"10.4142\/jvs.2002.3.4.273"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"17.Delmonte P, J I Rader. (2006) Analysis of isoflavones in foods and dietary supplements.Journal of. , AOAC International 89(4), 46-1138.","DOI":"10.1093\/jaoac\/89.4.1138"},{"key":"ref17","unstructured":"18.D E Brown, N J Walton. (1999) Chemicals from Plants: Perspectives on Plant Secondary Products. World Scientific Publishing. 21-141."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.Albert-Puleo M. (1980) Fennel and anise as estrogenic agents.Journal of Ethnopharmacology,2(4). 44-337.","DOI":"10.1016\/s0378-8741(80)81015-4"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.E L Singsaas. (2000) Terpenes and the Thermotolerance of Photosynthesis. , New Phytologist. New York:Wiley 146(1), 10-1046.","DOI":"10.1046\/j.1469-8137.2000.00626.x"},{"key":"ref20","unstructured":"21.T. (1965) Reviewed Work: The Biosynthesis of Steroids, Terpenes and Acetogenins\". American Scientist. 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(1999) C-Glycosidic flavonoids from Cassia occidentalis.Phytochem. 52(7), 1379-1383.","DOI":"10.1016\/s0031-9422(99)00437-9"},{"key":"ref29","unstructured":"30.J B Harbone. (1973) Phytochemical Methods: A guide to modern technique of plant Analysis.Chapinanand Hall. , London 33-185."},{"key":"ref30","unstructured":"31.Sofowara A. (1993) Medicinal plants and Traditional medicine. in Africa. Ibadan, Nigeria:Spectrum Book LTD 289."},{"key":"ref31","unstructured":"32.G L Silva, Lee I, K A Douglas. (1998) . Special Problems with Extraction of Plants: Cannel, J.P.R. (ed.). Natural Products Isolation. Humana press publishers , New Jersey (USA) 356-358."},{"key":"ref32","unstructured":"33.K R Brain, T D. (1975) practical evaluation of phytopharmaceuticals(Vol. 1). , Bristol: Wright-Scientechnica"},{"key":"ref33","unstructured":"34.Cannel R J P. (2000) . Methods in Biotechnology.Natural Products Isolation.Humanpres , New Jersey 14-36."},{"key":"ref34","unstructured":"35.G E Trease, W C Evans. (1996) . Textbook of Pharmacognosy, 12th(Ed) Balliers Tindall Publisher Limited , London, United Kingdom 343-384."}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T05:21:37Z","timestamp":1608096097000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/1098"}},"editor":[{"given":"Xiou","family":"Cao","sequence":"additional","affiliation":[{"name":"Global Health Drug Discovery Institute (GHDDI), China."}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"issued":{"date-parts":[[2019,5,29]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,3,27]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-19-2791","ISSN":["2576-6694"],"issn-type":[{"value":"2576-6694","type":"electronic"}],"published":{"date-parts":[[2019,5,29]]},"article-number":"1098"},{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:12:58Z","timestamp":1760267578527,"version":"3.41.2"},"reference-count":11,"publisher":"Open Access Pub","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>The aim of present study was to describe the graphical technique how to go from Hill concentration constant to Michaelis constant.\n\nTo compare enzymatic processes, the kinetics of which is subjected to different regularities, it is possible to use constants that characterize catalytic activity (Vmax) and concentration constants that are the substrate concentration at which the rate of the enzymatic process is equal to a half of maximum permissible rate. Concentration constants are S0.5 for Hill equation and Km for Michaelis-Menton equation. The graphical approach was proposed in order to go from concentration constant of Hill equation to Michaelis concentration of the process that could be characterized by the same catalytic activity (the same values of minimum and maximum rates) similar to that observed in the process described by Hill equation.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-18-2280","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T08:22:17Z","timestamp":1537950137000},"page":"94-99","source":"Crossref","is-referenced-by-count":8,"title":["Graphical Approach to Compare Concentration Constants of Hill and Michaelis-Menten Equations"],"prefix":"10.14302","volume":"1","author":[{"given":"Elena","family":"V. Emelyanova","sequence":"first","affiliation":[{"name":"FSBIS G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Science, Pushchino, Moscow Region, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"unstructured":"1.Dixon M, E C Webb. (1958) . , Enzymes. Longman, Green and Co","key":"ref0"},{"unstructured":"2.Ferdinand W. (1976) The enzyme molecule.JohnWileyandSons.","key":"ref1"},{"unstructured":"3.Dixon M, Webb E C. (1979) . Enzymes.LongmanGroupLtd","key":"ref2"},{"unstructured":"4.B I Kurganov. (1982) Allosteric enzymes: Kinetic behavior. J.Wiley and Sons.","key":"ref3"},{"doi-asserted-by":"publisher","unstructured":"5.J-H S Hofmeyr, Cornish-Bowden A. (1997) The reversible Hill equation: how to incorporate cooperative enzymes into metabolic models. , Comput. Appl. Biosci 13(4), 377-385.","key":"ref4","DOI":"10.1093\/bioinformatics\/13.4.377"},{"doi-asserted-by":"publisher","unstructured":"6.D R Farr, R B Cain. (1968) Catechol oxygenase induction inPseudomonasaeruginose. , Biochem. J 106, 879-885.","key":"ref5","DOI":"10.1042\/bj1060879"},{"doi-asserted-by":"publisher","unstructured":"7.Solyanikova I P, Borzova O V, Emelyanova E V. (2017) Kinetics of interaction between substrates\/substrate analogs and benzoate 1,2-dioxygenase from benzoate-degradingRhodococcusopacus1CP. Folia Microbiol. 62(4), 355-362.","key":"ref6","DOI":"10.1007\/s12223-017-0505-z"},{"doi-asserted-by":"publisher","unstructured":"8.Wolfe M D, Altier D J, Stubna A, Popescu C V, M\u00fcnck E. (2002) Benzoate 1,2-dioxygenase fromPseudomonas putida: single turnover kinetics and regulation of a two-component Rieske dioxygenase. , Biochem 41, 9611-9626.","key":"ref7","DOI":"10.1021\/bi025912n"},{"doi-asserted-by":"publisher","unstructured":"9.Emelyanova E V, Solyanikova I P. (2017) Benzoate concentration and cooperativity by a substrate for benzoate 1,2-dioxygenase from benzoate-degradingRhodococcusopacus1CP. , J. Biotechnol. Biomedical Scienc 1(1), 38-46.","key":"ref8","DOI":"10.14302\/issn.2576-6694.jbbs-17-1860"},{"unstructured":"10.V I Krupyanko. (2015) Correction of Dixon plots. , Eur. Chem. Bull 4(3), 142-153.","key":"ref9"},{"unstructured":"11.Palmer T. (1985) Understanding enzymes. J.Wiley and Sons. 240-271.","key":"ref10"}],"container-title":["Journal of Biotechnology and Biomedical Science"],"language":"en","link":[{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T08:22:32Z","timestamp":1537950152000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jbbs\/article\/857"}},"editor":[{"given":"Hammad","family":"Afzal","sequence":"additional","affiliation":[{"name":"SZABIST, Karachi."}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2018,9,25]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,12]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2576-6694.jbbs-18-2280","ISSN":["2576-6694"],"issn-type":[{"type":"electronic","value":"2576-6694"}],"published":{"date-parts":[[2018,9,25]]},"article-number":"857"},{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:02:28Z","timestamp":1778695348864,"version":"3.51.4"},"reference-count":65,"publisher":"Open Access Pub","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBBS"],"abstract":"<jats:p>Callus and biomass culture of Catharanthus roseus L. were established to check for the presence of total alkaloid and its subsequent yield. Various treatments like strength of nutrient salts, sucrose concentrations and combinations of plant growth regulators (PGR\u2019s) were applied to both MS and B5 in agar as well as suspension medium to test their effects on enhanced alkaloid content and its yield. There was no significant difference in any of the observable parameters of fresh wt, dry wt, alkaloid content, production, productivity and yield if the culture were treated similarly in both types of media formulations (MS or B5 salts). Physical state (agar solidified or the liquid suspension) of the medium had significant effect on all the parameters particular on fresh wt, alkaloid content and yields. Although, the fresh wt. and dry wt. of biomass in suspension culture was 2-3 times less than that of callus obtained from agar medium. However, the alkaloid content and yield was 2-3 times higher in suspension culture compared to agar medium in similar treatments. The highest alkaloid content observed was 5.67mg\/g dwt in B5 suspension medium containing 3% sucrose and modified with 0.5mg\/l 2,4-Dichlorophenoxy acetic acid (2,4-D) + 1 mg\/l Kinetin (KIN) + 2mg\/l \u03b1- naphthalene acetic acid (NAA). The combined effects of these factors on the enhanced production of total alkaloids were expected to contain higher yield of anticancer vinblastine and vincristine in the cell suspension culture system.<\/jats:p>","DOI":"10.14302\/issn.2576-6694.jbbs-18-2475","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T11:15:56Z","timestamp":1545131756000},"page":"14-34","source":"Crossref","is-referenced-by-count":21,"title":["Enhanced Alkaloid Production from Cell Culture System of Catharanthus roseus in Combined Effect of Nutrient Salts, Sucrose and Plant Growth Regulators"],"prefix":"10.14302","volume":"1","author":[{"given":"Malay Ranjan","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Biotechnology, GITAM Institute of Technology, Gandhi Institute of Technology and Management, (GITAM) (Deemed to be University), Rushikonda, Visakhapatnam (A.P.), India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, GITAM Institute of Technology, Gandhi Institute of Technology and Management, (GITAM) (Deemed to be University), Rushikonda, Visakhapatnam (A.P.), India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, GITAM Institute of Technology, Gandhi Institute of Technology and Management, (GITAM) (Deemed to be University), Rushikonda, Visakhapatnam (A.P.), India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5410","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Pan Q, Mustafa N R, Tang K, Choi Y H, Verpoorte R. (2016) Monoterpenoid indole alkaloids biosynthesis and its regulation inCatharanthusroseusa literature review from genes to metabolites. Phytochemistry reviews. 15(2), 221-250.","DOI":"10.1007\/s11101-015-9406-4"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.Zhu J, Wang M, Wen W, Yu R. (2015) Biosynthesis and regulation of terpenoid indole alkaloids inCatharanthusroseus. Pharmacognosy reviews. 9(17), 24-28.","DOI":"10.4103\/0973-7847.156323"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.Ishikura M, Abe T, Choshi T, Hibino S. (2015) Simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Natural product reports. 32(10), 1389-1471.","DOI":"10.1039\/c5np00032g"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.Verpoorte R, Heijden R Van der, Schripsema J, JHC Hoge, Ten Hoopen HJG. (1993) Plant cell biotechnology for the production of alkaloids: present status and prospects. , J Nat Prod 56, 186-207.","DOI":"10.1021\/np50092a003"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5.Almagro L, Fern\u00e1ndez-P\u00e9rez F, Pedre\u00f1o M A. (2015) Indole alkaloids fromCatharanthusroseusbioproduction and their effect on human health. , Molecules20(2), 2973-3000.","DOI":"10.3390\/molecules20022973"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.Hughes E H, Shanks J V. (2002) Metabolic engineering of plants for alkaloid production., Metabolic Engineering 4(1), 41-48.","DOI":"10.1006\/mben.2001.0205"},{"key":"ref6","unstructured":"7.Naeem M, Aftab T, MMA Khan.(2017)Catharanthusroseus: Current Research and Future Prospects. , AG, Gewerbestrasse, Switzerland,pp 441."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.Shabbir A, Ali A, Sadiq Y, Jaleel H, Ahmad B. (2017) Unraveling the Cumulative Effect of Soil-Applied Radiation-Processed Sodium Alginate and. Polyacrylamide on Growth Attributes, Physiological Activities, and Alkaloids Production in Periwinkle [Catharanthusroseus , Cham 365-381.","DOI":"10.1007\/978-3-319-51620-2_16"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.Verpoorte R, Heijden R Van der, Moreno P R. (1997) Biosynthesis of terpenoid indole alkaloids inCatharanthusroseuscells. In The Alkaloids: Chemistry and Pharmacology, Academic Pres 49, 221-299.","DOI":"10.1016\/s0099-9598(08)60017-6"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"10.Creasey W A. (1979) The vinca alkaloids. In:Hahn,F.E.et al(eds)Antibiotics.5.Springer-Verlag , New York 414-438.","DOI":"10.1007\/978-3-642-46407-2_21"},{"key":"ref10","unstructured":"11.Lemmens R H, Bunyapraphatsara M J, Padua de LSN. (1999) . Plant Resources of South-East Asia No. 12(1). Medicinal Plants 1. 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