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L. (2021). Global prevalence of gaming disorder: A systematic review and meta-analysis. Australian and New Zealand Journal of Psychiatry, 55(6), 553-568. doi:10.1177\/0004867420962851","DOI":"10.1177\/0004867420962851"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Yen, J. Y., Yen, C. F., Chen, C. H., Chen, S. H., & Ko, C. H. (2007). Efficacy of short-term treatment of internet addiction: A meta-analysis. Cyberpsychology & Behavior, 10(5), 567-576. doi:10.1089\/cyber.2007.0073","DOI":"10.1089\/cpb.2006.9948"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Kuss, D. J., Griffiths, M. D., & King, D. L. (2017). Internet gaming disorder in children and adolescents: A systematic review of empirical research. Clinical Psychology Review, 57, 105-122. doi:10.1016\/j.cpr.2017.08.001","DOI":"10.1016\/j.cpr.2017.08.001"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (DSM-5-TR). American Psychiatric Publishing.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"King, D. L., Delfabbro, P. H., Gradisar, M., & Griffiths, M. D. (2019). Treatments of internet gaming disorder: A systematic review of the evidence. 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Transthyretin cardiac amyloidosis (ATTR-CA) affects an estimated 4% to 16% of patients with severe AS referred for aortic valve replacement, and this dual pathology confers a substantially worse prognosis than either condition alone. Despite growing awareness, CA remains underdiagnosed in AS populations, and optimal screening, diagnostic, and therapeutic strategies for patients with concomitant AS and CA are still evolving. Objective: To synthesize the current evidence on the epidemiological overlap, shared pathophysiological mechanisms, diagnostic approaches, prognostic implications, and therapeutic strategies for patients with concomitant cardiac amyloidosis and aortic stenosis, and to translate that evidence into a stepwise screening algorithm for clinical practice. Methods: A comprehensive literature search was conducted across PubMed\/MEDLINE, Scopus, Cochrane Library, and ClinicalTrials.gov from January 2017 through February 2026. Priority was given to randomized controlled trials, meta-analyses, prospective cohort studies, and clinical practice guidelines from major cardiovascular societies. The GRADE framework was applied to assess the quality of evidence. Results: The pooled prevalence of ATTR-CA among patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) is approximately 13%. Patients with dual pathology (AS-CA) have significantly higher all-cause mortality than those with AS alone (RR = 2.60; 95% CI: 1.48\u20134.57). A multiparametric diagnostic approach integrating clinical red flags, electrocardiographic voltage-mass discordance, advanced echocardiography with strain imaging, bone scintigraphy (99mTc-PYP\/DPD\/HMDP), and cardiac magnetic resonance imaging is essential for accurate identification. TAVR appears safe and is associated with improved survival compared with medical therapy or surgical aortic valve replacement in AS-CA patients. Disease-modifying therapies including TTR stabilizers (tafamidis, acoramidis) and gene-silencing agents (patisiran, vutrisiran) have demonstrated efficacy in ATTR-CA and represent promising adjunctive treatments. Conclusions: The recognition of concomitant CA in AS patients is crucial for optimal risk stratification and therapeutic decisionmaking. Systematic screening protocols integrating multimodality imaging should be implemented in elderly patients with AS. TAVR combined with disease-specific ATTR-CA therapy represents the most evidence-supported approach for this patient population. Future prospective trials are needed to refine screening algorithms and to evaluate the synergistic benefit of combined valve intervention and amyloidosis-directed therapy.<\/jats:p>","DOI":"10.68179\/innoj.v4i1.17","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:19:22Z","timestamp":1788992362000},"page":"17-27","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Amyloidosis in Aortic Stenosis: From Suspicion to Treatment. 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Clinical correlates posterior reversible encephalopathy syndrome in pregnancy. J Clin Hypertens 2016;18:522-7. DOI: 10.1111\/jch.12656","DOI":"10.1111\/jch.12656"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"De la Torre T, Miranda A, G\u00f3mez M, Nava J, et al. Encefalopat\u00eda posterior reversible durante el puerperio, secundaria a eclampsia. Reporte de dos casos. Ginecol Obstet Mex 2018; 86 (12): 815-22. https:\/\/doi.org\/10.24245\/gom. v86i12.2343","DOI":"10.24245\/gom"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Verhaegen J, Peeters F, Debois P, Jacquemyn Y. Posterior reversible encephalopathy syndrome as a complication of pre-eclampsia in the early postpartum period. BMJ Case Rep 2019; 12 (7): e228954. https:\/\/doi.org\/10.1136\/bcr2018-228954","DOI":"10.1136\/bcr2018-228954"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Tetsuka S, Ogawa T. 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Intracranial teratomas are rare germ cell tumors, and rupture of a mature teratoma into the ventricular system has been reported only occasionally. There is no established approach to the hydrocephalus that follows rupture. Case presentation. A 40-year-old man had a 1-year history of holocranial headache, followed by cognitive decline over 6 months, gait instability over 2 months, and nausea and vomiting over 3 weeks; visual acuity was 20\/50 in both eyes, with papilledema. Magnetic resonance imaging (MRI) showed a 3 \u00d7 2 \u00d7 1.9 cm heterogeneous midline suprasellar lesion with fibrous and cystic components, loss of signal on fat-suppressed sequences, intraventricular extension, obstructive hydrocephalus, and a fat\u2013fluid level that suggested rupture. Through a bifrontal craniotomy assisted by ultrasonography and neuroendoscopy, we found an ependymal defect connecting the tumor cavity with the ventricles, and turbid, oily cerebrospinal fluid (CSF) with hair and lipid-rich debris. We achieved gross-total resection, irrigated the ventricles, performed an endoscopic third ventriculostomy (ETV), and left an external ventricular drain (EVD) for 14 days. Histology showed a mature cystic teratoma and the wall of a degenerated cysticercus. At 12 months the patient was neurologically stable, without recurrence and without a permanent shunt. Conclusions. Neuroendoscopy confirmed the rupture suggested on MRI and showed the extent of CSF contamination, which led us to combine resection with ventricular lavage, ETV, and temporary drainage.<\/jats:p>","DOI":"10.68179\/innoj.v4i2.13","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:29:26Z","timestamp":1792614566000},"page":"13-17","source":"Crossref","is-referenced-by-count":0,"title":["Mature Cystic Intracranial Teratoma with Intraventricular Rupture: Case Report and Management of Secondary Hydrocephalus"],"prefix":"10.68179","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4634-775X","authenticated-orcid":false,"given":"Carlos A.","family":"Quintero-Flores","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hospital Regional \"Dr. Valent\u00edn G\u00f3mez Far\u00edas\", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE); Universidad de Guadalajara. Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-4515","authenticated-orcid":false,"given":"Mart\u00edn E.","family":"De la O-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Regional \"Dr. Valent\u00edn G\u00f3mez Far\u00edas\", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE); Universidad de Guadalajara. Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"57965","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. 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Urgencias psiqui\u00e1tricas en ni\u00f1os y adolescentes. Manual de Salud Mental Infantil y Adolescente de la IACAPAP. 2018:1-33."},{"key":"ref2","unstructured":"Appleby L, Rodway C, Tham SG, Raphael J, Kapur N, Shaw J, Ibrahim S. Suicide by children and young people. National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH)."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Witt KG, Hetrick SE, Rajaram G, Hazell P, Salisbury TL, Townsend E, Hawton K. Interventions for self \u2010 harm in children and adolescents. Cochrane database of systematic reviews. 2021(3).","DOI":"10.1002\/14651858.CD013667.pub2"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Inno J 2023, 1(1):1. https:\/\/doi.org\/10.17613\/b548-ns07","DOI":"10.17613\/b548-ns07"}],"container-title":["Innoscience Journal"],"language":"en","link":[{"URL":"https:\/\/www.innoj.org\/assets\/pdf\/vol-1\/issue-1\/a12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.innoj.org\/assets\/pdf\/vol-1\/issue-1\/a12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:16:44Z","timestamp":1789409804000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.innoj.org\/collections\/vol-1\/issue-1\/a12\/"}},"issued":{"date-parts":[[2023,10]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.68179\/innoj.v1i1.29","relation":{"is-identical-to":[{"id-type":"doi","id":"10.5281\/zenodo.10223229","asserted-by":"subject"}]},"ISSN":["3005-8953"],"issn-type":[{"value":"3005-8953","type":"electronic"}],"published":{"date-parts":[[2023,10]]}},{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:49:41Z","timestamp":1792630181225,"version":"4.5.0"},"reference-count":18,"publisher":"Innoscience Journal","issue":"2","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inno J"],"abstract":"<jats:p>Background. Cystic nephroma is a benign multilocular renal tumour with a bimodal age distribution and fewer than 200 reported cases. In adults it presents almost exclusively in women in the fourth decade, and imaging cannot separate it reliably from a malignant cystic mass, so the lesion is usually classified as Bosniak II or III and treated with total or partial nephrectomy. Case presentation. A 44-year-old woman had six months of colicky left upper quadrant pain with early satiety. Ultrasonography showed a septated cystic structure of 127 x 114 x 96 mm with ipsilateral renal atrophy, and contrast-enhanced computed tomography showed thickened irregular septa with apparent enhancement in a lesion of 92 x 95 x 97 mm (approximately 443 mL), classified as Bosniak IIF\/III. At robot-assisted laparoscopy the mass had a high fluid content and few loculi, and the vascular anatomy put the remaining parenchyma at risk during a formal partial nephrectomy. We aspirated the cyst fluid and resected the cyst roof, together with the compartments that resembled intracystic cavities. She was discharged the following day. Histology showed a cyst wall of dense connective tissue with ovarian-type stroma lined by cuboidal epithelium; the stroma expressed oestrogen and progesterone receptors, the epithelium was PAX8-positive, and CAIX was negative, confirming cystic nephroma. Contrast-enhanced computed tomography six months after surgery showed no recurrence. Conclusions. Cyst de-roofing preserved the whole renal unit in a lesion that would conventionally have been treated by nephrectomy. The approach is defensible when imaging shows no solid enhancing component, the cyst is predominantly fluid-filled with few loculi, and the hilar anatomy makes parenchymal resection hazardous, provided histology is obtained and imaging follow-up continues.<\/jats:p>","DOI":"10.68179\/innoj.v4i2.8","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T20:42:40Z","timestamp":1788727360000},"page":"8-12","source":"Crossref","is-referenced-by-count":0,"title":["Adult Cystic Nephroma: Cyst De-roofing as a Parenchyma-sparing Alternative. A Case Report and Review of the Literature"],"prefix":"10.68179","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-9768","authenticated-orcid":false,"given":"Yitzhak S.","family":"Pantoja-Soto","sequence":"first","affiliation":[{"name":"Department of Urology, Hospital Regional \"Dr. Manuel Cardenas de la Vega\", ISSSTE, Culiacan, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Guzman-Karadima","sequence":"additional","affiliation":[{"name":"Department of Urology, Clinica Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Contreras-Melendez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinica Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Badia-Weil","sequence":"additional","affiliation":[{"name":"Department of Urology, Clinica Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1215-8431","authenticated-orcid":false,"given":"Cristobal","family":"Vidaurre-Winter","sequence":"additional","affiliation":[{"name":"Department of Urology, Clinica Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"57965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref1","unstructured":"Edmunds W. Cystic adenoma of the kidney. Trans Pathol Soc Lond. 1892;43:89-90."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Kuzgunbay B, Turunc T, Bolat F, Kilinc F. Adult cystic nephroma: a case report and a review of the literature. Urol Oncol. 2009;27(4):407-9.","DOI":"10.1016\/j.urolonc.2008.02.017"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Dell'Atti L. An unusual presentation of cystic nephroma in an adult man. Rare Tumors. 2015;7(2):5860.","DOI":"10.4081\/rt.2015.5860"},{"key":"ref4","unstructured":"Falidas E, Ntasi A, Mathioulakis S, Vlachos K, Anyfantakis G, Boutzouvis S, et al. Multicystic nephroma in an elderly man. Case report. G Chir. 2011;32(11-12):483-6."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Cajaiba MM, Khanna G, Smith EA, Gellert L, Chi YY, Mullen EA, et al. Pediatric cystic nephromas: distinctive features and frequent DICER1 mutations. 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Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. Radiology. 1983;146(2):309-21.","DOI":"10.1148\/radiology.146.2.6294736"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Silver IMF, Boag AH, Soboleski DA. Best cases from the AFIP: multilocular cystic renal tumor: cystic nephroma. Radiographics. 2008;28(4):1221-5.","DOI":"10.1148\/rg.284075184"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Hirai T, Ohishi H, Yamada R, Imai Y, Hirohashi S, Hirohashi R, et al. Usefulness of color Doppler flow imaging in differential diagnosis of multilocular cystic lesions of the kidney. J Ultrasound Med. 1995;14(10):771-6.","DOI":"10.7863\/jum.1995.14.10.771"},{"key":"ref12","unstructured":"Del Riego Mart\u00edn M, Landeras \u00c1lvaro R, L\u00f3pez Rasines G, Calabia de Diego A, Pagola Serrano MA, Guti\u00e9rrez Ba\u00f1os JL, et al. [Computerized axial tomography (CAT) and echography (US) of multilocular cystic nephroma]. Arch Esp Urol. 1996;49(6):619-21."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Wilkinson C, Palit V, Bardapure M, Thomas J, Browning AJ, Gill K, et al. Adult multilocular cystic nephroma: report of six cases with clinical, radio-pathologic correlation and review of literature. Urol Ann. 2013;5(1):13-7.","DOI":"10.4103\/0974-7796.106958"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Kettritz U, Semelka RC, Siegelman ES, Shoenut JP, Mitchell DG. Multilocular cystic nephroma: MR imaging appearance with current techniques, including gadolinium enhancement. J Magn Reson Imaging. 1996;6(1):145-8.","DOI":"10.1002\/jmri.1880060126"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Joshi VV, Beckwith JB. Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma. Terminology and criteria for diagnosis. 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