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Durch ihre Wirkung auf die Bauchspeicheldr\u00fcse und das Gehirn verst\u00e4rken sie die Insulinsekretion, induzieren einen Gewichtsverlust und halten die Normoglyk\u00e4mie aufrecht. Allerdings wird die Inkretin\u2010Therapie mit Nebenwirkungen wie \u00dcbelkeit und Magen\u2010Darm\u2010St\u00f6rungen in Verbindung gebracht. Hier stellen wir ein neuartiges photoschaltbares Inkretin\u2010Mimetikum vor, das auf Liraglutid, einem spezifischen Agonisten des Glucagon\u2010artigen Peptid\u20101\u2010Rezeptors (GLP\u20101R), basiert. Dieses Peptid, genannt <jats:bold>LirAzo<\/jats:bold>, enth\u00e4lt eine Azobenzoleinheit, wodurch der GLP\u20101R mit Lichtempfindlichkeit und isomerabh\u00e4ngigen Signaleigenschaften ausgestattet wird. W\u00e4hrend das <jats:italic>trans<\/jats:italic>\u2010Isomer in erster Linie den Ca<jats:sup>2+<\/jats:sup>\u2010Einstrom in das Zytosol beeinflusst, beg\u00fcnstigt das <jats:italic>cis<\/jats:italic>\u2010Isomer vorwiegend die Bildung von cAMP. Somit erm\u00f6glicht <jats:bold>LirAzo<\/jats:bold> die optische Kontrolle der Insulinsekretion und des Zellen\u00fcberlebens.<\/jats:p>","DOI":"10.1002\/ange.201506384","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T10:02:09Z","timestamp":1446458529000},"page":"15786-15790","source":"Crossref","is-referenced-by-count":12,"title":["Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter"],"prefix":"10.1002","volume":"127","author":[{"given":"Johannes","family":"Broichhagen","sequence":"first","affiliation":[]},{"given":"Tom","family":"Podewin","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Meyer\u2010Berg","sequence":"additional","affiliation":[]},{"given":"Yorrick","family":"von\u2005Ohlen","sequence":"additional","affiliation":[]},{"given":"Natalie R.","family":"Johnston","sequence":"additional","affiliation":[]},{"given":"Ben J.","family":"Jones","sequence":"additional","affiliation":[]},{"given":"Stephen R.","family":"Bloom","sequence":"additional","affiliation":[]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[]},{"given":"Anja","family":"Hoffmann\u2010R\u00f6der","sequence":"additional","affiliation":[]},{"given":"David J.","family":"Hodson","sequence":"additional","affiliation":[]},{"given":"Dirk","family":"Trauner","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_3_1_2","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.010"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.018"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60614-4"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1499"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"e_1_2_3_7_2","unstructured":"\u00a0"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1314078"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3231-y"},{"key":"e_1_2_3_10_2","unstructured":"\u00a0"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9909645"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.140"},{"key":"e_1_2_3_13_2","unstructured":"\u00a0"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja413063e"},{"key":"e_1_2_3_15_2","doi-asserted-by":"crossref","unstructured":"J. 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