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This strategy is based on the generation of a cationic center in functionalized polyolefins by Lewis acid activation of a carbonyl group, rather than by electrophilic attack at a double bond. Starting from the monocyclic humulane trienone zerumbone, polycyclic sesquiterpenoid skeletons which are either not reported as natural products or biogenetically enigmatic in terms of the isoprenoid rule, were obtained by modulating the Lewis acid catalyst. In the course of these studies, the surprising formation of a strained <jats:italic>E<\/jats:italic>\u2010cyclooctene motif was observed in a cyclization reaction.<\/jats:p>","DOI":"10.1002\/ange.201703455","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T01:56:57Z","timestamp":1494381417000},"page":"8043-8046","source":"Crossref","is-referenced-by-count":3,"title":["Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries"],"prefix":"10.1002","volume":"129","author":[{"given":"Alberto","family":"Minassi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze del Farmaco Universit\u00e0 del Piemonte Orientale  L.go Donegani 2 28100 Novara Italy"}]},{"given":"Federica","family":"Pollastro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco Universit\u00e0 del Piemonte Orientale  L.go Donegani 2 28100 Novara Italy"}]},{"given":"Giuseppina","family":"Chianese","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia Universit\u00e0 di Napoli Federico II  Via Montesano 49 80131 Napoli Italy"}]},{"given":"Diego","family":"Caprioglio","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco Universit\u00e0 del Piemonte Orientale  L.go Donegani 2 28100 Novara Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8010-0180","authenticated-orcid":false,"given":"Orazio","family":"Taglialatela\u2010Scafati","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia Universit\u00e0 di Napoli Federico II  Via Montesano 49 80131 Napoli Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-9919","authenticated-orcid":false,"given":"Giovanni","family":"Appendino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco Universit\u00e0 del Piemonte Orientale  L.go Donegani 2 28100 Novara Italy"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr040623l"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0010709"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201206904"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201206904"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60302a002"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01060a078"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)85873-1"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.05.009"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201500237"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b908515g"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201270084"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8080449"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020249"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2012.09.016"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19740001598"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1270050309"},{"key":"e_1_2_2_16_1","first-page":"391","volume":"148","author":"Leonhardt R. 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