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Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF\u20107 and MDA\u2010MB\u2010231), human colorectal carcinoma <jats:italic>p53<\/jats:italic> wild type (HCT116 <jats:italic>p53<\/jats:italic><jats:sup><jats:italic>+\/+<\/jats:italic><\/jats:sup>) and normal human prostate (PNT2) cell lines. The ferrocenyl \u03b2\u2010diketonate compounds are more than 18 times more cytotoxic than the ferrocenyl \u03b2\u2010ketoiminate analogues. Against MCF\u20107, compounds functionalized at the <jats:italic>meta<\/jats:italic> position are up to nine times more cytotoxic than when functionalized at the <jats:italic>para<\/jats:italic> position. The ferrocenyl \u03b2\u2010diketonate compounds have increased selectivity towards MCF\u20107 and MDA\u2010MB\u2010231, with several complexes having selectivity index (SI) values that are more than nine times (MCF\u20107) and more than six times (MDA\u2010MB\u2010231) that of carboplatin. The stability of these compounds in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) has been assessed by NMR spectroscopy and mass spectrometry studies, and the compounds show no oxidation of the iron center from Fe<jats:sup>II<\/jats:sup> to Fe<jats:sup>III<\/jats:sup>. Cytotoxicity screening was performed in both DMSO and DMF, with no significant differences observedin their potency.<\/jats:p>","DOI":"10.1002\/cbic.202000028","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T14:54:52Z","timestamp":1584370492000},"page":"1988-1996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u03b2\u2010Diketonate versus \u03b2\u2010Ketoiminate: The Importance of a Ferrocenyl Moiety in Improving the Anticancer Potency"],"prefix":"10.1002","volume":"21","author":[{"given":"Matthew","family":"Allison","sequence":"first","affiliation":[{"name":"School of Chemistry University of Leeds  Leeds LS2 9JT UK"}]},{"given":"Daniel","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Leeds  Leeds LS2 9JT UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-5069","authenticated-orcid":false,"given":"Christopher M.","family":"Pask","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Leeds  Leeds LS2 9JT UK"}]},{"given":"Patrick C.","family":"McGowan","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Leeds  Leeds LS2 9JT UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-129X","authenticated-orcid":false,"given":"Rianne M.","family":"Lord","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Norwich Research Park Norwich NR4 7TJ UK"},{"name":"School of Chemistry and Biosciences University of Bradford  Bradford BD7 1DP UK"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/205698a0"},{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0022-3565(24)38169-8","volume":"289","author":"Bergamo A.","year":"1999","journal-title":"J. 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