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This method uses a minimal catalytic amount of cerium(III), is stereoselective, and offers several unique features, such as compatibility with aryl, heterocyclic, alkenyl, and sensitive functional groups as well as the ability to prepare <jats:italic>N<\/jats:italic>\u2010acylhydrazones from highly hindered substrates. More strikingly, cerium(III) efficiently mediated the reaction with less reactive substrates such as diaryl and alkyl aryl ketones, when classical protocols without the catalyst were not effective. This method enables the synthesis of a structurally diverse library of <jats:italic>N<\/jats:italic>\u2010acylhydrazones that have applications in synthetic and medicinal chemistry.<\/jats:p>","DOI":"10.1002\/ejoc.201402609","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T06:29:44Z","timestamp":1409293784000},"page":"6411-6417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mild, Stereoselective, and Highly Efficient Synthesis of <i>N<\/i>\u2010Acylhydrazones Mediated by CeCl<sub>3<\/sub>\u00b77H<sub>2<\/sub>O in a Broad Range of Solvents"],"prefix":"10.1002","volume":"2014","author":[{"given":"Jos\u00e9 Maur\u00edcio","family":"dos Santos Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.01.028"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.07.011"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-010-9420-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.04.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.07.046"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.08.009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm300514y"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.02.009"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.05.026"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.07.068"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.08.047"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712798918789"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874126600802010077"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/12081910"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17055095"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.03.002"},{"key":"e_1_2_6_17_2","first-page":"64","volume":"10","author":"Toliwal S. 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