{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:41:33Z","timestamp":1775011293391,"version":"3.50.1"},"reference-count":203,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/12\/40\/29712"],"award-info":[{"award-number":["FS\/12\/40\/29712"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005617","name":"BHF Centre of Research Excellence, Oxford","doi-asserted-by":"publisher","award":["RE\/13\/1\/30181"],"award-info":[{"award-number":["RE\/13\/1\/30181"]}],"id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["201543\/B\/16\/Z"],"award-info":[{"award-number":["201543\/B\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NIHR-HCS-D13-04-006"],"award-info":[{"award-number":["NIHR-HCS-D13-04-006"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014748","name":"Clarendon Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Muscle Res Cell Motil"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10974-017-9487-3","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:27:21Z","timestamp":1510129641000},"page":"303-316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies"],"prefix":"10.1007","volume":"38","author":[{"given":"Mehroz","family":"Ehsan","sequence":"first","affiliation":[]},{"given":"He","family":"Jiang","sequence":"additional","affiliation":[]},{"given":"Kate","family":"L.Thomson","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-1844","authenticated-orcid":false,"given":"Katja","family":"Gehmlich","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"9487_CR1","doi-asserted-by":"publisher","first-page":"e0145284","DOI":"10.1371\/journal.pone.0145284","volume":"10","author":"O Akininade","year":"2015","unstructured":"Akininade O, Koskenvuo JW, Alastalo TP (2015a) Prevalence of Titin truncating variants in general population. PLoS One 10:e0145284. https:\/\/doi.org\/10.1371\/journal.pone.0145284","journal-title":"PLoS One"},{"key":"9487_CR2","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1093\/eurheartj\/ehv253","volume":"36","author":"O Akinrinade","year":"2015","unstructured":"Akinrinade O et al (2015b) Genetics and genotype-phenotype correlations in Finnish patients with dilated cardiomyopathy. Eur Heart J 36:2327\u20132337. https:\/\/doi.org\/10.1093\/eurheartj\/ehv253","journal-title":"Eur Heart J"},{"key":"9487_CR3","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/gim.2014.205","volume":"17","author":"AA Alfares","year":"2015","unstructured":"Alfares AA et al (2015) Results of clinical genetic testing of 2912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity. Genet Med 17:880\u2013888. https:\/\/doi.org\/10.1038\/gim.2014.205","journal-title":"Genet Med"},{"key":"9487_CR4","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/ejhg.2012.283","volume":"21","author":"C Andreasen","year":"2013","unstructured":"Andreasen C et al (2013) New population-based exome data are questioning the pathogenicity of previously cardiomyopathy-associated genetic variants. Eur J Hum Genet 21:918\u2013928. https:\/\/doi.org\/10.1038\/ejhg.2012.283","journal-title":"Eur J Hum Genet"},{"key":"9487_CR5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1101\/gad.10.3.289","volume":"10","author":"S Arber","year":"1996","unstructured":"Arber S, Caroni P (1996) Specificity of single LIM motifs in targeting and LIM\/LIM interactions in situ. Genes Dev 10:289\u2013300","journal-title":"Genes Dev"},{"key":"9487_CR6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0092-8674(94)90192-9","volume":"79","author":"S Arber","year":"1994","unstructured":"Arber S, Halder G, Caroni P (1994) Muscle LIM protein, a novel essential regulator of myogenesis promotes myogenic differentiation. Cell 79:221\u2013231","journal-title":"Cell"},{"key":"9487_CR7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)81878-4","volume":"88","author":"S Arber","year":"1997","unstructured":"Arber S et al (1997) MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and. heart failure. Cell 88:393\u2013403","journal-title":"Cell"},{"key":"9487_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cub.2009.11.022","volume":"20","author":"V Arndt","year":"2010","unstructured":"Arndt V et al (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol 20:143\u2013148. https:\/\/doi.org\/10.1016\/j.cub.2009.11.022","journal-title":"Curr Biol"},{"key":"9487_CR9","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1242\/dmm.016170","volume":"7","author":"A Asnani","year":"2014","unstructured":"Asnani A, Peterson RT (2014) The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Dis Model Mech 7:763\u2013767. https:\/\/doi.org\/10.1242\/dmm.016170","journal-title":"Dis Model Mech"},{"key":"9487_CR10","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/ncpcardio1182","volume":"5","author":"MM Awad","year":"2008","unstructured":"Awad MM, Calkins H, Judge DP (2008) Mechanisms of disease: molecular genetics of arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Nat Clin Pract Cardiovasc Med 5:258\u2013267. https:\/\/doi.org\/10.1038\/ncpcardio1182","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"9487_CR11","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1161\/hh2301.100981","volume":"89","author":"ML Bang","year":"2001","unstructured":"Bang ML et al (2001) The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res 89:1065\u20131072","journal-title":"Circ Res"},{"key":"9487_CR12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jacbts.2016.05.004","volume":"1","author":"RL Begay","year":"2016","unstructured":"Begay RL et al (2016) FLNC gene splice mutations cause dilated cardiomyopathy. JACC Basic Transl Sci 1:344\u2013359. https:\/\/doi.org\/10.1016\/j.jacbts.2016.05.004","journal-title":"JACC Basic Transl Sci"},{"key":"9487_CR13","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1006\/jmbi.1996.0367","volume":"259","author":"PM Bennett","year":"1996","unstructured":"Bennett PM, Gautel M (1996) Titin domain patterns correlate with the axial disposition of myosin at the end of the thick filament. J Mol Biol 259:896\u2013903. https:\/\/doi.org\/10.1006\/jmbi.1996.0367","journal-title":"J Mol Biol"},{"key":"9487_CR14","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1161\/CIRCRESAHA.116.304030","volume":"116","author":"CR Bezzina","year":"2015","unstructured":"Bezzina CR, Lahrouchi N, Priori SG (2015) Genetics of sudden cardiac death. Circ Res 116:1919\u20131936. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.304030","journal-title":"Circ Res"},{"key":"9487_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.yjmcc.2009.04.006","volume":"47","author":"SY Boateng","year":"2009","unstructured":"Boateng SY, Senyo SE, Qi L, Goldspink PH, Russell B (2009) Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein. J Mol Cell Cardiol 47:426\u2013435. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.04.006","journal-title":"J Mol Cell Cardiol"},{"key":"9487_CR16","doi-asserted-by":"publisher","first-page":"140041","DOI":"10.1098\/rsob.140041","volume":"4","author":"J Bogomolovas","year":"2014","unstructured":"Bogomolovas J, Gasch A, Simkovic F, Rigden DJ, Labeit S, Mayans O (2014) Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line. Open Biol 4:140041. https:\/\/doi.org\/10.1098\/rsob.140041","journal-title":"Open Biol"},{"key":"9487_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ymgme.2005.10.008","volume":"88","author":"JM Bos","year":"2006","unstructured":"Bos JM et al (2006) Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Mol Genet Metab 88:78\u201385. https:\/\/doi.org\/10.1016\/j.ymgme.2005.10.008","journal-title":"Mol Genet Metab"},{"key":"9487_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/humu.22942","volume":"37","author":"A Brodehl","year":"2016","unstructured":"Brodehl A et al (2016) Mutations in FLNC are associated with familial restrictive cardiomyopathy. Hum Mutat 37:269\u2013279. https:\/\/doi.org\/10.1002\/humu.22942","journal-title":"Hum Mutat"},{"key":"9487_CR19","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86898","author":"MA Burke","year":"2016","unstructured":"Burke MA et al (2016) Molecular profiling of dilated cardiomyopathy that progresses to heart failure. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.86898","journal-title":"JCI Insight"},{"key":"9487_CR20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0733-8651(05)70154-5","volume":"18","author":"BS Burlew","year":"2000","unstructured":"Burlew BS, Weber KT (2000) Connective tissue and the heart functional significance regulatory mechanisms. Cardiol Clin 18:435\u2013442","journal-title":"Cardiol Clin"},{"key":"9487_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00424-011-0961-2","volume":"462","author":"B Buyandelger","year":"2011","unstructured":"Buyandelger B, Ng KE, Miocic S, Piotrowska I, Gunkel S, Ku CH, Knoll R (2011) MLP (muscle LIM protein) as a stress sensor in the heart. Pflugers Arch 462:135\u2013142. https:\/\/doi.org\/10.1007\/s00424-011-0961-2","journal-title":"Pflugers Arch"},{"key":"9487_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-3-319-15263-9_11","volume-title":"Cardiac cytoarchitecture: how to maintain a working heart","author":"J Cahill","year":"2015","unstructured":"Cahill J, Gehmlich T K (2015) How cardiac cytoarchitecture can go wrong: hypertrophic cardiomyopathy as a paradigm for genetic disease of the heart. In: Ehler E (ed) Cardiac cytoarchitecture: how to maintain a working heart. Springer, Cham, pp\u00a0227\u2013243. https:\/\/doi.org\/10.1007\/978-3-319-15263-9_11"},{"key":"9487_CR23","first-page":"70","volume":"6","author":"P Camacho","year":"2016","unstructured":"Camacho P, Fan H, Liu Z, He JQ (2016) Small mammalian animal models of heart disease. Am J Cardiovasc Dis 6:70\u201380","journal-title":"Am J Cardiovasc Dis"},{"key":"9487_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/ana.21089","volume":"61","author":"V Carmignac","year":"2007","unstructured":"Carmignac V et al (2007) C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol 61:340\u2013351. https:\/\/doi.org\/10.1002\/ana.21089","journal-title":"Ann Neurol"},{"key":"9487_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.RES.86.1.59","volume":"86","author":"O Cazorla","year":"2000","unstructured":"Cazorla O et al (2000) Differential expression of cardiac titin isoforms and modulation of cellular stiffness. Circ Res 86:59\u201367","journal-title":"Circ Res"},{"key":"9487_CR26","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1006\/jmbi.2001.4448","volume":"306","author":"T Centner","year":"2001","unstructured":"Centner T et al (2001) Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J Mol Biol 306:717\u2013726. https:\/\/doi.org\/10.1006\/jmbi.2001.4448","journal-title":"J Mol Biol"},{"key":"9487_CR27","first-page":"1425","volume":"3","author":"FC Chan","year":"2011","unstructured":"Chan FC et al (2011) Intercalated disc-associated protein, mXin-alpha, influences surface expression of ITO currents in ventricular myocytes. Front Biosci (Elite Ed) 3:1425\u20131442","journal-title":"Front Biosci (Elite Ed)"},{"key":"9487_CR28","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1093\/hmg\/ddt494","volume":"23","author":"C Chauveau","year":"2014","unstructured":"Chauveau C et al (2014a) Recessive TTN truncating mutations define novel forms of core myopathy with heart disease. Hum Mol Genet 23:980\u2013991. https:\/\/doi.org\/10.1093\/hmg\/ddt494","journal-title":"Hum Mol Genet"},{"key":"9487_CR29","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/humu.22611","volume":"35","author":"C Chauveau","year":"2014","unstructured":"Chauveau C, Rowell J, Ferreiro A (2014b) A rising titan: TTN review and mutation update. Hum Mutat 35:1046\u20131059. https:\/\/doi.org\/10.1002\/humu.22611","journal-title":"Hum Mutat"},{"key":"9487_CR30","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1038\/srep01642","volume":"3","author":"H Chen","year":"2013","unstructured":"Chen H, Chandrasekar S, Sheetz MP, Stossel TP, Nakamura F, Yan J (2013) Mechanical perturbation of filamin A immunoglobulin repeats 20\u201321 reveals potential non-equilibrium mechanochemical partner binding function. Sci Rep 3:1642. https:\/\/doi.org\/10.1038\/srep01642","journal-title":"Sci Rep"},{"key":"9487_CR31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/(SICI)1097-0177(200001)217:1<99::AID-DVDY9>3.0.CO;2-5","volume":"217","author":"W Chiang","year":"2000","unstructured":"Chiang W, Greaser ML, Lyons GE (2000) Filamin isogene expression during mouse myogenesis. Dev Dyn 217:99\u2013108. https:\/\/doi.org\/10.1002\/(SICI)1097-0177(200001)217:1<99::AID-DVDY9>3.0.CO;2-5","journal-title":"Dev Dyn"},{"key":"9487_CR32","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.yjmcc.2007.06.009","volume":"43","author":"C Chiu","year":"2007","unstructured":"Chiu C, Tebo M, Ingles J, Yeates L, Arthur JW, Lind JM, Semsarian C (2007) Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 43:337\u2013343. https:\/\/doi.org\/10.1016\/j.yjmcc.2007.06.009","journal-title":"J Mol Cell Cardiol"},{"key":"9487_CR33","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1172\/JCI70108","volume":"124","author":"DC Christodoulou","year":"2014","unstructured":"Christodoulou DC et al (2014) 5\u2032RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. J Clin Invest 124:1364\u20131370. https:\/\/doi.org\/10.1172\/JCI70108","journal-title":"J Clin Invest"},{"key":"9487_CR34","doi-asserted-by":"publisher","first-page":"6522","DOI":"10.1128\/MCB.00243-06","volume":"26","author":"I Dalkilic","year":"2006","unstructured":"Dalkilic I, Schienda J, Thompson TG, Kunkel LM (2006) Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure. Mol Cell Biol 26:6522\u20136534. https:\/\/doi.org\/10.1128\/MCB.00243-06","journal-title":"Mol Cell Biol"},{"key":"9487_CR35","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.cell.2016.04.002","volume":"165","author":"J Davis","year":"2016","unstructured":"Davis J et al (2016) A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy. Cell 165:1147\u20131159. https:\/\/doi.org\/10.1016\/j.cell.2016.04.002","journal-title":"Cell"},{"key":"9487_CR36","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.jacc.2006.07.016","volume":"48","author":"MM DeWitt","year":"2006","unstructured":"DeWitt MM, MacLeod HM, Soliven B, McNally EM (2006) Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy. J Am Coll Cardiol 48:1396\u20131398. https:\/\/doi.org\/10.1016\/j.jacc.2006.07.016","journal-title":"J Am Coll Cardiol"},{"key":"9487_CR37","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.ajhg.2011.04.021","volume":"88","author":"RM Duff","year":"2011","unstructured":"Duff RM et al (2011) Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy. Am J Hum Genet 88:729\u2013740. https:\/\/doi.org\/10.1016\/j.ajhg.2011.04.021","journal-title":"Am J Hum Genet"},{"key":"9487_CR38","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1083\/jcb.153.4.763","volume":"153","author":"E Ehler","year":"2001","unstructured":"Ehler E et al (2001) Alterations at the intercalated disk associated with the absence of muscle LIM protein. J Cell Biol 153:763\u2013772","journal-title":"J Cell Biol"},{"key":"9487_CR39","doi-asserted-by":"crossref","first-page":"H3101-3112","DOI":"10.1152\/ajpheart.2000.279.6.H3101","volume":"279","author":"G Esposito","year":"2000","unstructured":"Esposito G, Santana LF, Dilly K, Cruz JD, Mao L, Lederer WJ, Rockman HA (2000) Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol 279:H3101\u2013H3112","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"Pt 9","key":"9487_CR40","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/jcs.113.9.1553","volume":"113","author":"MJ Flick","year":"2000","unstructured":"Flick MJ, Konieczny SF (2000) The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin. J Cell Sci 113(Pt 9):1553\u20131564","journal-title":"J Cell Sci"},{"key":"9487_CR41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1432-1033.1996.00317.x","volume":"235","author":"A Freiburg","year":"1996","unstructured":"Freiburg A, Gautel M (1996) A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy. Eur J Biochem 235:317\u2013323","journal-title":"Eur J Biochem"},{"key":"9487_CR42","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1093\/hmg\/dds157","volume":"21","author":"FW Friedrich","year":"2012","unstructured":"Friedrich FW et al (2012) Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy. Hum Mol Genet 21:3237\u20133254. https:\/\/doi.org\/10.1093\/hmg\/dds157","journal-title":"Hum Mol Genet"},{"key":"9487_CR43","doi-asserted-by":"crossref","first-page":"12950","DOI":"10.1016\/S0021-9258(18)51579-9","volume":"264","author":"J Fujii","year":"1989","unstructured":"Fujii J, Maruyama K, Tada M, MacLennan DH (1989) Expression and site-specific mutagenesis of phospholamban. Studies of residues involved in phosphorylation and pentamer formation. J Biol Chem 264:12950\u201312955","journal-title":"J Biol Chem"},{"key":"9487_CR44","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1242\/jcs.028019","volume":"121","author":"A Fukuzawa","year":"2008","unstructured":"Fukuzawa A et al (2008) Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci 121:1841\u20131851. https:\/\/doi.org\/10.1242\/jcs.028019","journal-title":"J Cell Sci"},{"key":"9487_CR45","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2828(95)90064-0","volume":"27","author":"DO F\u00fcrst","year":"1995","unstructured":"F\u00fcrst DO, Gautel M (1995) The anatomy of a molecular giant: how the sarcomere cytoskeleton is assembled from immunoglobulin superfamily molecules. J Mol Cell Cardiol 27:951\u2013959","journal-title":"J Mol Cell Cardiol"},{"key":"9487_CR46","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1002\/j.1460-2075.1993.tb06061.x","volume":"12","author":"M Gautel","year":"1993","unstructured":"Gautel M, Leonard K, Labeit S (1993) Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts. EMBO J 12:3827\u20133834","journal-title":"EMBO J"},{"key":"9487_CR47","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00441-004-0873-y","volume":"317","author":"K Gehmlich","year":"2004","unstructured":"Gehmlich K, Geier C, Osterziel KJ, Van der Ven PF, Furst DO (2004) Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy. Cell Tissue Res 317:129\u2013136. https:\/\/doi.org\/10.1007\/s00441-004-0873-y","journal-title":"Cell Tissue Res"},{"key":"9487_CR48","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1161\/01.CIR.0000056522.82563.5F","volume":"107","author":"C Geier","year":"2003","unstructured":"Geier C et al (2003) Mutations in the human muscle LIM protein gene in families with. hypertrophic cardiomyopathy. Circulation 107:1390\u20131395","journal-title":"Circulation"},{"key":"9487_CR49","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1093\/hmg\/ddn160","volume":"17","author":"C Geier","year":"2008","unstructured":"Geier C et al (2008) Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Genet 17:2753\u20132765. https:\/\/doi.org\/10.1093\/hmg\/ddn160","journal-title":"Hum Mol Genet"},{"key":"9487_CR50","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90274-I","volume":"62","author":"AA Geisterfer-Lowrance","year":"1990","unstructured":"Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG (1990) A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell 62:999\u20131006","journal-title":"Cell"},{"key":"9487_CR51","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/ng815","volume":"30","author":"B Gerull","year":"2002","unstructured":"Gerull B et al (2002) Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet 30:201\u2013204. https:\/\/doi.org\/10.1038\/ng815","journal-title":"Nat Genet"},{"key":"9487_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2546-5","author":"E Giacomelli","year":"2017","unstructured":"Giacomelli E, Mummery CL, Bellin M (2017) Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-017-2546-5","journal-title":"Cell Mol Life Sci"},{"key":"9487_CR53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001584","author":"J Gomez","year":"2017","unstructured":"Gomez J et al (2017) Screening of the Filamin C gene in a large cohort of hypertrophic cardiomyopathy patients. Circ Cardiovasc Genet. https:\/\/doi.org\/10.1161\/CIRCGENETICS.116.001584","journal-title":"Circ Cardiovasc Genet"},{"key":"9487_CR54","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1242\/jcs.02484","volume":"118","author":"Y Gontier","year":"2005","unstructured":"Gontier Y et al (2005) The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. J Cell Sci 118:3739\u20133749. https:\/\/doi.org\/10.1242\/jcs.02484","journal-title":"J Cell Sci"},{"key":"9487_CR55","doi-asserted-by":"publisher","first-page":"562","DOI":"10.15252\/emmm.201505047","volume":"7","author":"M Gramlich","year":"2015","unstructured":"Gramlich M et al (2015) Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy. EMBO Mol Med 7:562\u2013576. https:\/\/doi.org\/10.15252\/emmm.201505047","journal-title":"EMBO Mol Med"},{"key":"9487_CR56","doi-asserted-by":"publisher","first-page":"14589","DOI":"10.1073\/pnas.1411493111","volume":"111","author":"HL Granzier","year":"2014","unstructured":"Granzier HL et al (2014) Deleting titin\u2019s I-band\/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function. Proc Natl Acad Sci USA 111:14589\u201314594. https:\/\/doi.org\/10.1073\/pnas.1411493111","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR57","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1083\/jcb.143.4.1013","volume":"143","author":"CC Gregorio","year":"1998","unstructured":"Gregorio CC et al (1998) The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol 143:1013\u20131027","journal-title":"J Cell Biol"},{"key":"9487_CR58","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ajhg.2009.07.015","volume":"85","author":"L Gueneau","year":"2009","unstructured":"Gueneau L et al (2009) Mutations of the FHL1 gene cause Emery\u2013Dreifuss muscular dystrophy. Am J Hum Genet 85:338\u2013353. https:\/\/doi.org\/10.1016\/j.ajhg.2009.07.015","journal-title":"Am J Hum Genet"},{"key":"9487_CR59","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nm.2693","volume":"18","author":"W Guo","year":"2012","unstructured":"Guo W et al (2012) RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med 18:766\u2013773. https:\/\/doi.org\/10.1038\/nm.2693","journal-title":"Nat Med"},{"key":"9487_CR60","doi-asserted-by":"publisher","first-page":"H2680","DOI":"10.1152\/ajpheart.00806.2007","volume":"293","author":"EA Gustafson-Wagner","year":"2007","unstructured":"Gustafson-Wagner EA et al (2007) Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol 293:H2680\u2013H2692. https:\/\/doi.org\/10.1152\/ajpheart.00806.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9487_CR61","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1073\/pnas.1013987108","volume":"108","author":"KN Ha","year":"2011","unstructured":"Ha KN, Masterson LR, Hou Z, Verardi R, Walsh N, Veglia G, Robia SL (2011) Lethal Arg9Cys phospholamban mutation hinders Ca2+-ATPase regulation and phosphorylation by protein kinase A. Proc Natl Acad Sci USA 108:2735\u20132740. https:\/\/doi.org\/10.1073\/pnas.1013987108","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR62","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/eurheartj\/ehu301","volume":"36","author":"J Haas","year":"2015","unstructured":"Haas J et al (2015) Atlas of the clinical genetics of human dilated cardiomyopathy. Eur Heart J 36:1123\u20131135a. https:\/\/doi.org\/10.1093\/eurheartj\/ehu301","journal-title":"Eur Heart J"},{"key":"9487_CR63","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1086\/342380","volume":"71","author":"P Hackman","year":"2002","unstructured":"Hackman P et al (2002) Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. Am J Hum Genet 71:492\u2013500. https:\/\/doi.org\/10.1086\/342380","journal-title":"Am J Hum Genet"},{"key":"9487_CR64","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1172\/JCI17892","volume":"111","author":"K Haghighi","year":"2003","unstructured":"Haghighi K et al (2003) Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest 111:869\u2013876. https:\/\/doi.org\/10.1172\/JCI17892","journal-title":"J Clin Invest"},{"key":"9487_CR65","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1073\/pnas.0510519103","volume":"103","author":"K Haghighi","year":"2006","unstructured":"Haghighi K et al (2006) A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci USA 103:1388\u20131393. https:\/\/doi.org\/10.1073\/pnas.0510519103","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR66","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.yjmcc.2011.11.012","volume":"52","author":"K Haghighi","year":"2012","unstructured":"Haghighi K et al (2012) The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na\/K-ATPase. J Mol Cell Cardiol 52:773\u2013782. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.11.012","journal-title":"J Mol Cell Cardiol"},{"key":"9487_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0263-9","author":"N Hamdani","year":"2017","unstructured":"Hamdani N, Herwig M, Linke WA (2017) Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes. Biophys Rev. https:\/\/doi.org\/10.1007\/s12551-017-0263-9","journal-title":"Biophys Rev"},{"key":"9487_CR68","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1161\/CIRCGENETICS.113.000245","volume":"6","author":"H Hartmannova","year":"2013","unstructured":"Hartmannova H et al (2013) Isolated X-linked hypertrophic cardiomyopathy caused by a novel mutation of the four-and-a-half LIM domain 1 gene. Circ Cardiovasc Genet 6:543\u2013551. https:\/\/doi.org\/10.1161\/CIRCGENETICS.113.000245","journal-title":"Circ Cardiovasc Genet"},{"key":"9487_CR69","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1161\/CIRCGENETICS.116.001431","volume":"9","author":"R Hastings","year":"2016","unstructured":"Hastings R et al (2016) Combination of whole genome sequencing, linkage, and functional studies implicates a missense mutation in titin as a cause of autosomal dominant cardiomyopathy with features of left ventricular noncompaction. Circ Cardiovasc Genet 9:426\u2013435. https:\/\/doi.org\/10.1161\/CIRCGENETICS.116.001431","journal-title":"Circ Cardiovasc Genet"},{"key":"9487_CR70","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0006-3495(01)75811-0","volume":"81","author":"JG Head","year":"2001","unstructured":"Head JG, Houmeida A, Knight PJ, Clarke AR, Trinick J, Brady RL (2001) Stability and folding rates of domains spanning the large A-band super-repeat of titin. Biophys J 81:1570\u20131579","journal-title":"Biophys J"},{"key":"9487_CR71","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1073\/pnas.0405488102","volume":"102","author":"J Heineke","year":"2005","unstructured":"Heineke J et al (2005) Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci USA 102:1655\u20131660. https:\/\/doi.org\/10.1073\/pnas.0405488102","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR72","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1161\/CIRCGENETICS.116.001594","volume":"9","author":"E Helle","year":"2016","unstructured":"Helle E, Parikh VN (2016) Wrestling the giant: new approaches for assessing titin variant pathogenicity. Circ Cardiovasc Genet 9:392\u2013394. https:\/\/doi.org\/10.1161\/CIRCGENETICS.116.001594","journal-title":"Circ Cardiovasc Genet"},{"key":"9487_CR73","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/01.RES.84.11.1339","volume":"84","author":"M Helmes","year":"1999","unstructured":"Helmes M, Trombitas K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H (1999) Mechanically driven contour-length adjustment in rat cardiac titin\u2019s unique N2B sequence: titin is an adjustable spring. Circ Res 84:1339\u20131352","journal-title":"Circ Res"},{"key":"9487_CR74","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/cm.10102","volume":"54","author":"JR Henderson","year":"2003","unstructured":"Henderson JR, Pomies P, Auffray C, Beckerle MC (2003) ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell Motil Cytoskeleton 54:254\u2013265. https:\/\/doi.org\/10.1002\/cm.10102","journal-title":"Cell Motil Cytoskeleton"},{"key":"9487_CR75","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJMoa1110186","volume":"366","author":"DS Herman","year":"2012","unstructured":"Herman DS et al (2012) Truncations of titin causing dilated cardiomyopathy. N Engl J Med 366:619\u2013628. https:\/\/doi.org\/10.1056\/NEJMoa1110186","journal-title":"N Engl J Med"},{"key":"9487_CR76","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1752-8062.2008.00017.x","volume":"1","author":"RE Hershberger","year":"2008","unstructured":"Hershberger RE et al (2008) Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. Clin Transl Sci 1:21\u201326. https:\/\/doi.org\/10.1111\/j.1752-8062.2008.00017.x","journal-title":"Clin Transl Sci"},{"key":"9487_CR77","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","volume":"10","author":"RE Hershberger","year":"2013","unstructured":"Hershberger RE, Hedges DJ, Morales A (2013) Dilated cardiomyopathy: the complexity of a diverse genetic architecture. Nat Rev Cardiol 10:531\u2013547. https:\/\/doi.org\/10.1038\/nrcardio.2013.105","journal-title":"Nat Rev Cardiol"},{"key":"9487_CR78","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1021\/bi026501+","volume":"42","author":"M Himmel","year":"2003","unstructured":"Himmel M, Van Der Ven PF, Stocklein W, Furst DO (2003) The limits of promiscuity: isoform-specific dimerization of filamins. Biochemistry 42:430\u2013439. https:\/\/doi.org\/10.1021\/bi026501+","journal-title":"Biochemistry"},{"key":"9487_CR79","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1126\/science.aaa5458","volume":"349","author":"JT Hinson","year":"2015","unstructured":"Hinson JT et al (2015) HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science 349:982\u2013986. https:\/\/doi.org\/10.1126\/science.aaa5458","journal-title":"Science"},{"key":"9487_CR80","doi-asserted-by":"publisher","first-page":"28996","DOI":"10.1074\/jbc.M804782200","volume":"283","author":"Z Hou","year":"2008","unstructured":"Hou Z, Kelly EM, Robia SL (2008) Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex. J Biol Chem 283:28996\u201329003. https:\/\/doi.org\/10.1074\/jbc.M804782200","journal-title":"J Biol Chem"},{"key":"9487_CR81","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1006\/bbrc.2002.6448","volume":"291","author":"M Itoh-Satoh","year":"2002","unstructured":"Itoh-Satoh M et al (2002) Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun 291:385\u2013393. https:\/\/doi.org\/10.1006\/bbrc.2002.6448","journal-title":"Biochem Biophys Res Commun"},{"key":"9487_CR82","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13043","author":"A Janin","year":"2017","unstructured":"Janin A et al (2017) Truncating mutations on myofibrillar myopathies causing genes as prevalent molecular explanations on patients with dilated cardiomyopathy. Clin Genet. https:\/\/doi.org\/10.1111\/cge.13043","journal-title":"Clin Genet"},{"key":"9487_CR83","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fnagi.2014.00339","volume":"6","author":"H Jungbluth","year":"2014","unstructured":"Jungbluth H, Gautel M (2014) Pathogenic mechanisms in centronuclear myopathies. Front Aging Neurosci 6:339. https:\/\/doi.org\/10.3389\/fnagi.2014.00339","journal-title":"Front Aging Neurosci"},{"key":"9487_CR84","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/nrm1499","volume":"5","author":"JL Kadrmas","year":"2004","unstructured":"Kadrmas JL, Beckerle MC (2004) The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol 5:920\u2013931. https:\/\/doi.org\/10.1038\/nrm1499","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9487_CR85","doi-asserted-by":"publisher","first-page":"e0168486","DOI":"10.1371\/journal.pone.0168486","volume":"11","author":"M Kaneko","year":"2016","unstructured":"Kaneko M, Hashikami K, Yamamoto S, Matsumoto H, Nishimoto T (2016) Phospholamban ablation using CRISPR\/Cas9 system improves mortality in a murine heart failure. Model PLoS One 11:e0168486. https:\/\/doi.org\/10.1371\/journal.pone.0168486","journal-title":"Model PLoS One"},{"key":"9487_CR86","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11010-010-0492-8","volume":"342","author":"P Kemecsei","year":"2010","unstructured":"Kemecsei P et al (2010) Hearts of surviving MLP-KO mice show transient changes of intracellular calcium handling. Mol Cell Biochem 342:251\u2013260. https:\/\/doi.org\/10.1007\/s11010-010-0492-8","journal-title":"Mol Cell Biochem"},{"key":"9487_CR87","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/abbi.1997.0108","volume":"342","author":"K Kinbara","year":"1997","unstructured":"Kinbara K, Sorimachi H, Ishiura S, Suzuki K (1997) Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs. Arch Biochem Biophys 342:99\u2013107. https:\/\/doi.org\/10.1006\/abbi.1997.0108","journal-title":"Arch Biochem Biophys"},{"key":"9487_CR88","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1093\/brain\/awm271","volume":"130","author":"RA Kley","year":"2007","unstructured":"Kley RA et al (2007) Clinical and morphological phenotype of the filamin myopathy: a study of 31 german patients. Brain 130:3250\u20133264. https:\/\/doi.org\/10.1093\/brain\/awm271","journal-title":"Brain"},{"key":"9487_CR89","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1074\/mcp.M112.023176","volume":"12","author":"RA Kley","year":"2013","unstructured":"Kley RA et al (2013a) A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients. Mol Cell Proteom 12:215\u2013227. https:\/\/doi.org\/10.1074\/mcp.M112.023176","journal-title":"Mol Cell Proteom"},{"key":"9487_CR90","doi-asserted-by":"publisher","first-page":"422","DOI":"10.4161\/auto.22921","volume":"9","author":"RA Kley","year":"2013","unstructured":"Kley RA, van der Ven PF, Olive M, Hohfeld J, Goldfarb LG, Furst DO, Vorgerd M (2013b) Impairment of protein degradation in myofibrillar myopathy caused by FLNC\/filamin C mutations. Autophagy 9:422\u2013423. https:\/\/doi.org\/10.4161\/auto.22921","journal-title":"Autophagy"},{"key":"9487_CR91","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/ana.21839","volume":"67","author":"H Knoblauch","year":"2010","unstructured":"Knoblauch H et al (2010) Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Ann Neurol 67:136\u2013140. https:\/\/doi.org\/10.1002\/ana.21839","journal-title":"Ann Neurol"},{"key":"9487_CR92","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0092-8674(02)01226-6","volume":"111","author":"R Knoll","year":"2002","unstructured":"Knoll R et al (2002) The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111:943\u2013955","journal-title":"Cell"},{"key":"9487_CR93","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1161\/CIRCRESAHA.109.206243","volume":"106","author":"R Knoll","year":"2010","unstructured":"Knoll R et al (2010) A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res 106:695\u2013704. https:\/\/doi.org\/10.1161\/CIRCRESAHA.109.206243","journal-title":"Circ Res"},{"key":"9487_CR94","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1128\/MCB.17.8.4750","volume":"17","author":"Y Kong","year":"1997","unstructured":"Kong Y, Flick MJ, Kudla AJ, Konieczny SF (1997) Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol 17:4750\u20134760","journal-title":"Mol Cell Biol"},{"key":"9487_CR95","doi-asserted-by":"publisher","first-page":"9905","DOI":"10.1074\/jbc.R110.173260","volume":"286","author":"M Kruger","year":"2011","unstructured":"Kruger M, Linke WA (2011) The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem 286:9905\u20139912. https:\/\/doi.org\/10.1074\/jbc.R110.173260","journal-title":"J Biol Chem"},{"key":"9487_CR96","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s00395-012-0262-8","volume":"107","author":"C Kuhn","year":"2012","unstructured":"Kuhn C et al (2012) Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP). Basic Res Cardiol 107:262. https:\/\/doi.org\/10.1007\/s00395-012-0262-8","journal-title":"Basic Res Cardiol"},{"key":"9487_CR97","doi-asserted-by":"publisher","first-page":"12592","DOI":"10.1073\/pnas.1606444113","volume":"113","author":"U Kuzmanov","year":"2016","unstructured":"Kuzmanov U et al (2016) Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci USA 113:12592\u201312597. https:\/\/doi.org\/10.1073\/pnas.1606444113","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR98","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx424","author":"A Laddach","year":"2017","unstructured":"Laddach A, Gautel M, Fraternali F (2017) TITINdb\u2014a computational tool to assess titin\u2019s role as a disease gene. Bioinformatics. https:\/\/doi.org\/10.1093\/bioinformatics\/btx424","journal-title":"Bioinformatics"},{"key":"9487_CR99","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1161\/01.RES.0000115522.52554.86","volume":"94","author":"S Lahmers","year":"2004","unstructured":"Lahmers S, Wu Y, Call DR, Labeit S, Granzier H (2004) Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res 94:505\u2013513. https:\/\/doi.org\/10.1161\/01.RES.0000115522.52554.86","journal-title":"Circ Res"},{"key":"9487_CR100","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ahj.2010.08.001","volume":"161","author":"AP Landstrom","year":"2011","unstructured":"Landstrom AP, Adekola BA, Bos JM, Ommen SR, Ackerman MJ (2011) PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing. Am Heart J 161:165\u2013171. https:\/\/doi.org\/10.1016\/j.ahj.2010.08.001","journal-title":"Am Heart J"},{"key":"9487_CR101","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1242\/jcs.00181","volume":"115","author":"S Lange","year":"2002","unstructured":"Lange S, Auerbach D, McLoughlin P, Perriard E, Schafer BW, Perriard JC, Ehler E (2002) Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL\/FHL-2. J Cell Sci 115:4925\u20134936","journal-title":"J Cell Sci"},{"key":"9487_CR102","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1126\/science.1110463","volume":"308","author":"S Lange","year":"2005","unstructured":"Lange S et al (2005) The kinase domain of titin controls muscle gene expression and protein turnover. Science 308:1599\u20131603. https:\/\/doi.org\/10.1126\/science.1110463","journal-title":"Science"},{"key":"9487_CR103","doi-asserted-by":"publisher","first-page":"12120","DOI":"10.1038\/ncomms12120","volume":"7","author":"S Lange","year":"2016","unstructured":"Lange S et al (2016) MLP and CARP are linked to chronic PKCalpha signalling in dilated cardiomyopathy. Nat Commun 7:12120. https:\/\/doi.org\/10.1038\/ncomms12120","journal-title":"Nat Commun"},{"key":"9487_CR104","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1093\/hmg\/ddw135","volume":"25","author":"Y Leber","year":"2016","unstructured":"Leber Y et al (2016) Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Hum Mol Genet 25:2776\u20132788. https:\/\/doi.org\/10.1093\/hmg\/ddw135","journal-title":"Hum Mol Genet"},{"key":"9487_CR105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-1119(98)00302-3","volume":"216","author":"SM Lee","year":"1998","unstructured":"Lee SM et al (1998) Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1). Gene 216:163\u2013170","journal-title":"Gene"},{"key":"9487_CR106","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0006-3495(97)78123-2","volume":"73","author":"WA Linke","year":"1997","unstructured":"Linke WA, Ivemeyer M, Labeit S, Hinssen H, Ruegg JC, Gautel M (1997) Actin\u2013titin interaction in cardiac myofibrils: probing a physiological role. Biophys J 73:905\u2013919. https:\/\/doi.org\/10.1016\/S0006-3495(97)78123-2","journal-title":"Biophys J"},{"key":"9487_CR107","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.146.3.631","volume":"146","author":"WA Linke","year":"1999","unstructured":"Linke WA, Rudy DE, Centner T, Gautel M, Witt C, Labeit S, Gregorio CC (1999) I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure. J Cell Biol 146:631\u2013644","journal-title":"J Cell Biol"},{"key":"9487_CR108","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.ejcb.2010.04.004","volume":"89","author":"A Linnemann","year":"2010","unstructured":"Linnemann A et al (2010) The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin. Eur J Cell Biol 89:681\u2013692. https:\/\/doi.org\/10.1016\/j.ejcb.2010.04.004","journal-title":"Eur J Cell Biol"},{"key":"9487_CR109","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/jmedgenet-2012-101270","volume":"50","author":"LR Lopes","year":"2013","unstructured":"Lopes LR et al (2013) Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing. J Med Genet 50:228\u2013239. https:\/\/doi.org\/10.1136\/jmedgenet-2012-101270","journal-title":"J Med Genet"},{"key":"9487_CR110","doi-asserted-by":"crossref","first-page":"27484","DOI":"10.1074\/jbc.272.43.27484","volume":"272","author":"HA Louis","year":"1997","unstructured":"Louis HA, Pino JD, Schmeichel KL, Pomies P, Beckerle MC (1997) Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. J Biol Chem 272:27484\u201327491","journal-title":"J Biol Chem"},{"key":"9487_CR111","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1152\/physiolgenomics.00148.2011","volume":"44","author":"B Lu","year":"2012","unstructured":"Lu B, Yu H, Zwartbol M, Ruifrok WP, van Gilst WH, de Boer RA, Sillje HH (2012) Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models. Physiol Genom 44:443\u2013454. https:\/\/doi.org\/10.1152\/physiolgenomics.00148.2011","journal-title":"Physiol Genom"},{"key":"9487_CR112","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/01.RES.75.3.401","volume":"75","author":"W Luo","year":"1994","unstructured":"Luo W et al (1994) Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res 75:401\u2013409","journal-title":"Circ Res"},{"key":"9487_CR113","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0014-5793(02)03655-4","volume":"532","author":"K Ma","year":"2002","unstructured":"Ma K, Wang K (2002) Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin. FEBS Lett 532:273\u2013278","journal-title":"FEBS Lett"},{"key":"9487_CR114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1096\/fasebj.11.5.9141500","volume":"11","author":"K Maruyama","year":"1997","unstructured":"Maruyama K (1997) Connectin\/titin, giant elastic protein of muscle. FASEB J 11:341\u2013345","journal-title":"FASEB J"},{"key":"9487_CR115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/262058a0","volume":"262","author":"K Maruyama","year":"1976","unstructured":"Maruyama K, Natori R, Nonomura Y (1976) New elastic protein from muscle. Nature 262:58\u201360","journal-title":"Nature"},{"key":"9487_CR116","first-page":"317","volume":"82","author":"K Maruyama","year":"1977","unstructured":"Maruyama K, Matsubara S, Natori R, Nonomura Y, Kimura S (1977) Connectin, an elastic protein of muscle characterization function. J Biochem 82:317\u2013337","journal-title":"J Biochem"},{"key":"9487_CR117","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/oxfordjournals.jbchem.a134750","volume":"95","author":"K Maruyama","year":"1984","unstructured":"Maruyama K, Kimura S, Yoshidomi H, Sawada H, Kikuchi M (1984) Molecular size and shape of beta-connectin, an elastic protein of striated muscle. J Biochem 95:1423\u20131433","journal-title":"J Biochem"},{"key":"9487_CR118","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10974-005-9018-5","volume":"26","author":"Y Matsumoto","year":"2005","unstructured":"Matsumoto Y et al (2005) Functional analysis of titin\/connectin N2-B mutations found in cardiomyopathy. J Muscle Res Cell Motil 26:367\u2013374. https:\/\/doi.org\/10.1007\/s10974-005-9018-5","journal-title":"J Muscle Res Cell Motil"},{"key":"9487_CR119","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1113\/JP271622","volume":"594","author":"G Mazzocchi","year":"2016","unstructured":"Mazzocchi G et al (2016) Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol 594:3005\u20133030. https:\/\/doi.org\/10.1113\/JP271622","journal-title":"J Physiol"},{"key":"9487_CR120","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1172\/JCI62862","volume":"123","author":"EM McNally","year":"2013","unstructured":"McNally EM, Golbus JR, Puckelwartz MJ (2013) Genetic mutations and mechanisms in dilated cardiomyopathy. J Clin Invest 123:19\u201326. https:\/\/doi.org\/10.1172\/JCI62862","journal-title":"J Clin Invest"},{"key":"9487_CR121","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ejheart.2006.04.007","volume":"9","author":"M Medin","year":"2007","unstructured":"Medin M, Hermida-Prieto M, Monserrat L, Laredo R, Rodriguez-Rey JC, Fernandez X, Castro-Beiras A (2007) Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN \u201342 C>G mutation. Eur J Heart Fail 9:37\u201343. https:\/\/doi.org\/10.1016\/j.ejheart.2006.04.007","journal-title":"Eur J Heart Fail"},{"key":"9487_CR122","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0092-8674(00)81662-1","volume":"99","author":"S Minamisawa","year":"1999","unstructured":"Minamisawa S et al (1999) Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99:313\u2013322","journal-title":"Cell"},{"key":"9487_CR123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-291X(03)00526-6","volume":"304","author":"S Minamisawa","year":"2003","unstructured":"Minamisawa S et al (2003) Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy. Biochem Biophys Res Commun 304:1\u20134","journal-title":"Biochem Biophys Res Commun"},{"key":"9487_CR124","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1096-7192(03)00142-2","volume":"80","author":"B Mohapatra","year":"2003","unstructured":"Mohapatra B et al (2003) Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab 80:207\u2013215","journal-title":"Mol Genet Metab"},{"key":"9487_CR125","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1242\/jcs.152157","volume":"127","author":"S Molt","year":"2014","unstructured":"Molt S et al (2014) Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance. J Cell Sci 127:3578\u20133592. https:\/\/doi.org\/10.1242\/jcs.152157","journal-title":"J Cell Sci"},{"key":"9487_CR126","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(98)00501-8","volume":"428","author":"A Mues","year":"1998","unstructured":"Mues A, van der Ven PF, Young P, Furst DO, Gautel M (1998) Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin. FEBS Lett 428:111\u2013114","journal-title":"FEBS Lett"},{"key":"9487_CR127","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1042\/BJ20041058","volume":"384","author":"JT Murray","year":"2004","unstructured":"Murray JT, Campbell DG, Peggie M, Mora A, Cohen P (2004) Identification of filamin C as a new physiological substrate of PKBalpha using. KESTREL Biochem J 384:489\u2013494. https:\/\/doi.org\/10.1042\/BJ20041058","journal-title":"KESTREL Biochem J"},{"key":"9487_CR128","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.CIR.0000135591.37759.AF","volume":"110","author":"SF Nagueh","year":"2004","unstructured":"Nagueh SF et al (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 110:155\u2013162. https:\/\/doi.org\/10.1161\/01.CIR.0000135591.37759.AF","journal-title":"Circulation"},{"key":"9487_CR129","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1056\/NEJM199610173351603","volume":"335","author":"J Narula","year":"1996","unstructured":"Narula J et al (1996) Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335:1182\u20131189. https:\/\/doi.org\/10.1056\/NEJM199610173351603","journal-title":"N Engl J Med"},{"key":"9487_CR130","doi-asserted-by":"publisher","first-page":"H680","DOI":"10.1152\/ajpheart.00773.2001","volume":"282","author":"JH Omens","year":"2002","unstructured":"Omens JH, Usyk TP, Li Z, McCulloch AD (2002) Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. Am J Physiol Heart Circ Physiol 282:H680\u2013H687. https:\/\/doi.org\/10.1152\/ajpheart.00773.2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9487_CR131","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.jacc.2016.09.927","volume":"68","author":"MF Ortiz-Genga","year":"2016","unstructured":"Ortiz-Genga MF et al (2016) Truncating FLNC mutations are associated with high-risk dilated and arrhythmogenic cardiomyopathies. J Am Coll Cardiol 68:2440\u20132451. https:\/\/doi.org\/10.1016\/j.jacc.2016.09.927","journal-title":"J Am Coll Cardiol"},{"key":"9487_CR132","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/cvr\/cvp345","volume":"85","author":"J Otten","year":"2010","unstructured":"Otten J et al (2010) Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res 85:739\u2013750. https:\/\/doi.org\/10.1093\/cvr\/cvp345","journal-title":"Cardiovasc Res"},{"key":"9487_CR133","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1128\/MCB.00654-09","volume":"29","author":"V Papalouka","year":"2009","unstructured":"Papalouka V et al (2009) Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Mol Cell Biol 29:6046\u20136058. https:\/\/doi.org\/10.1128\/MCB.00654-09","journal-title":"Mol Cell Biol"},{"key":"9487_CR134","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ijcard.2013.11.037","volume":"171","author":"Y Peled","year":"2014","unstructured":"Peled Y et al (2014) Titin mutation in familial restrictive cardiomyopathy. Int J Cardiol 171:24\u201330. https:\/\/doi.org\/10.1016\/j.ijcard.2013.11.037","journal-title":"Int J Cardiol"},{"key":"9487_CR135","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.amjcard.2011.06.022","volume":"108","author":"M Petretta","year":"2011","unstructured":"Petretta M, Pirozzi F, Sasso L, Paglia A, Bonaduce D (2011) Review and metaanalysis of the frequency of familial dilated cardiomyopathy. Am J Cardiol 108:1171\u20131176. https:\/\/doi.org\/10.1016\/j.amjcard.2011.06.022","journal-title":"Am J Cardiol"},{"key":"9487_CR136","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1242\/jcs.00131","volume":"115","author":"V Pizon","year":"2002","unstructured":"Pizon V et al (2002) Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. J Cell Sci 115:4469\u20134482","journal-title":"J Cell Sci"},{"key":"9487_CR137","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00415-009-5372-3","volume":"257","author":"M Pollazzon","year":"2010","unstructured":"Pollazzon M et al (2010) The first Italian family with tibial muscular dystrophy caused by a novel titin mutation. J Neurol 257:575\u2013579. https:\/\/doi.org\/10.1007\/s00415-009-5372-3","journal-title":"J Neurol"},{"key":"9487_CR138","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.hrthm.2009.01.016","volume":"6","author":"MG Posch","year":"2009","unstructured":"Posch MG et al (2009) Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes. Heart Rhythm 6:480\u2013486. https:\/\/doi.org\/10.1016\/j.hrthm.2009.01.016","journal-title":"Heart Rhythm"},{"key":"9487_CR139","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ydbio.2008.03.024","volume":"318","author":"R Postel","year":"2008","unstructured":"Postel R, Vakeel P, Topczewski J, Knoll R, Bakkers J (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin\u2013ECM adhesion complex. Dev Biol 318:92\u2013101. https:\/\/doi.org\/10.1016\/j.ydbio.2008.03.024","journal-title":"Dev Biol"},{"key":"9487_CR140","doi-asserted-by":"publisher","first-page":"13385","DOI":"10.1073\/pnas.0805034105","volume":"105","author":"EM Puchner","year":"2008","unstructured":"Puchner EM et al (2008) Mechanoenzymatics of titin kinase. Proc Natl Acad Sci USA 105:13385\u201313390. https:\/\/doi.org\/10.1073\/pnas.0805034105","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR141","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/gim.2013.204","volume":"16","author":"TJ Pugh","year":"2014","unstructured":"Pugh TJ et al (2014) The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing. Genet Med 16:601\u2013608. https:\/\/doi.org\/10.1038\/gim.2013.204","journal-title":"Genet Med"},{"key":"9487_CR142","doi-asserted-by":"publisher","first-page":"29273","DOI":"10.1074\/jbc.M112.372839","volume":"287","author":"A Raskin","year":"2012","unstructured":"Raskin A et al (2012) A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem 287:29273\u201329284. https:\/\/doi.org\/10.1074\/jbc.M112.372839","journal-title":"J Biol Chem"},{"key":"9487_CR143","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-biophys-050511-102252","volume":"41","author":"Z Razinia","year":"2012","unstructured":"Razinia Z, Makela T, Ylanne J, Calderwood DA (2012) Filamins in mechanosensing and signaling. Annu Rev Biophys 41:227\u2013246. https:\/\/doi.org\/10.1146\/annurev-biophys-050511-102252","journal-title":"Annu Rev Biophys"},{"key":"9487_CR144","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1074\/mcp.M116.065425","volume":"16","author":"L Reimann","year":"2017","unstructured":"Reimann L et al (2017) Myofibrillar Z-discs are a protein phosphorylation hot spot with protein Kinase C (PKCalpha) modulating protein dynamics. Mol Cell Proteom 16:346\u2013367. https:\/\/doi.org\/10.1074\/mcp.M116.065425","journal-title":"Mol Cell Proteom"},{"key":"9487_CR145","doi-asserted-by":"publisher","first-page":"270ra276","DOI":"10.1126\/scitranslmed.3010134","volume":"7","author":"AM Roberts","year":"2015","unstructured":"Roberts AM et al (2015) Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med 7:270ra276. https:\/\/doi.org\/10.1126\/scitranslmed.3010134","journal-title":"Sci Transl Med"},{"key":"9487_CR146","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1093\/hmg\/ddw080","volume":"25","author":"AA Ruparelia","year":"2016","unstructured":"Ruparelia AA, Oorschot V, Ramm G, Bryson-Richardson RJ (2016) FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency. Hum Mol Genet 25:2131\u20132142. https:\/\/doi.org\/10.1093\/hmg\/ddw080","journal-title":"Hum Mol Genet"},{"key":"9487_CR147","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1253\/circj.CJ-14-0182","volume":"78","author":"K Sallam","year":"2014","unstructured":"Sallam K, Kodo K, Wu JC (2014) Modeling inherited cardiac disorders. Circ J 78:784\u2013794","journal-title":"Circ J"},{"key":"9487_CR148","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/hmg\/8.7.1329","volume":"8","author":"P Salmikangas","year":"1999","unstructured":"Salmikangas P, Mykkanen OM, Gronholm M, Heiska L, Kere J, Carpen O (1999) Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy. Hum Mol Genet 8:1329\u20131336","journal-title":"Hum Mol Genet"},{"key":"9487_CR149","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1006\/bbrc.1999.1221","volume":"262","author":"M Satoh","year":"1999","unstructured":"Satoh M, Takahashi M, Sakamoto T, Hiroe M, Marumo F, Kimura A (1999) Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene Biochem. Biophys Res Commun 262:411\u2013417. https:\/\/doi.org\/10.1006\/bbrc.1999.1221","journal-title":"Biophys Res Commun"},{"key":"9487_CR150","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/ng.3719","volume":"49","author":"S Schafer","year":"2017","unstructured":"Schafer S et al (2017) Titin-truncating variants affect heart function in disease cohorts and the general population. Nat Genet 49:46\u201353. https:\/\/doi.org\/10.1038\/ng.3719","journal-title":"Nat Genet"},{"key":"9487_CR151","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/brain\/awn325","volume":"132","author":"J Schessl","year":"2009","unstructured":"Schessl J et al (2009) Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1. Brain 132:452\u2013464. https:\/\/doi.org\/10.1093\/brain\/awn325","journal-title":"Brain"},{"key":"9487_CR152","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0092-8674(94)90191-0","volume":"79","author":"KL Schmeichel","year":"1994","unstructured":"Schmeichel KL, Beckerle MC (1994) The LIM domain is a modular protein-binding interface. Cell 79:211\u2013219","journal-title":"Cell"},{"key":"9487_CR153","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1091\/mbc.8.2.219","volume":"8","author":"KL Schmeichel","year":"1997","unstructured":"Schmeichel KL, Beckerle MC (1997) Molecular dissection of a LIM domain. Mol Biol Cell 8:219\u2013230","journal-title":"Mol Biol Cell"},{"key":"9487_CR154","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1126\/science.1081578","volume":"299","author":"JP Schmitt","year":"2003","unstructured":"Schmitt JP et al (2003) Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299:1410\u20131413. https:\/\/doi.org\/10.1126\/science.1081578","journal-title":"Science"},{"key":"9487_CR155","doi-asserted-by":"crossref","first-page":"C900","DOI":"10.1152\/ajpcell.1999.276.4.C900","volume":"276","author":"AG Schneider","year":"1999","unstructured":"Schneider AG, Sultan KR, Pette D (1999) Muscle LIM protein: expressed in slow muscle and induced in fast muscle by enhanced contractile activity. Am J Physiol 276:C900\u2013C906","journal-title":"Am J Physiol"},{"key":"9487_CR156","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1212\/01.WNL.0000123576.74801.75","volume":"62","author":"D Selcen","year":"2004","unstructured":"Selcen D, Engel AG (2004) Mutations in myotilin cause myofibrillar myopathy. Neurology 62:1363\u20131371","journal-title":"Neurology"},{"key":"9487_CR157","doi-asserted-by":"publisher","first-page":"e0136969","DOI":"10.1371\/journal.pone.0136969","volume":"10","author":"J Seppala","year":"2015","unstructured":"Seppala J, Tossavainen H, Rodic N, Permi P, Pentikainen U, Ylanne J (2015) Flexible structure of peptide-bound filamin a mechanosensor domain Pair 20\u201321. PLoS One 10:e0136969. https:\/\/doi.org\/10.1371\/journal.pone.0136969 21","journal-title":"PLoS One"},{"key":"9487_CR158","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.mad.2012.12.002","volume":"134","author":"DA Sequea","year":"2013","unstructured":"Sequea DA, Sharma N, Arias EB, Cartee GD (2013) Greater filamin C, GSK3alpha, and GSK3beta serine phosphorylation in insulin-stimulated isolated skeletal muscles of calorie restricted 24 month-old rats. Mech Ageing Dev 134:60\u201363. https:\/\/doi.org\/10.1016\/j.mad.2012.12.002","journal-title":"Mech Ageing Dev"},{"key":"9487_CR159","doi-asserted-by":"publisher","first-page":"3870","DOI":"10.1172\/JCI34472","volume":"118","author":"F Sheikh","year":"2008","unstructured":"Sheikh F et al (2008) An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest 118:3870\u20133880. https:\/\/doi.org\/10.1172\/JCI34472","journal-title":"J Clin Invest"},{"key":"9487_CR160","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.jmb.2007.02.018","volume":"368","author":"L Sjekloca","year":"2007","unstructured":"Sjekloca L et al (2007) Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23\u201324 dimer. J Mol Biol 368:1011\u20131023. https:\/\/doi.org\/10.1016\/j.jmb.2007.02.018","journal-title":"J Mol Biol"},{"key":"9487_CR161","first-page":"389","volume":"47","author":"SD Solomon","year":"1990","unstructured":"Solomon SD et al (1990) A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11\u2013q12. Am J Hum Genet 47:389\u2013394","journal-title":"Am J Hum Genet"},{"key":"9487_CR162","doi-asserted-by":"crossref","first-page":"H2665","DOI":"10.1152\/ajpheart.2001.280.6.H2665","volume":"280","author":"Z Su","year":"2001","unstructured":"Su Z et al (2001) Effects of deletion of muscle LIM protein on myocyte function. Am J Physiol Heart Circ Physiol 280:H2665\u2013H2673","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9487_CR163","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1161\/CIRCULATIONAHA.110.005405","volume":"124","author":"M Taylor","year":"2011","unstructured":"Taylor M et al (2011) Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation 124:876\u2013885. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.005405","journal-title":"Circulation"},{"key":"9487_CR164","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S1050-1738(97)00011-X","volume":"7","author":"G Thiene","year":"1997","unstructured":"Thiene G, Basso C, Danieli G, Rampazzo A, Corrado D, Nava A (1997) Arrhythmogenic right ventricular cardiomyopathy a still underrecognized clinic entity. Trends Cardiovasc Med 7:84\u201390. https:\/\/doi.org\/10.1016\/S1050-1738(97)00011-X","journal-title":"Trends Cardiovasc Med"},{"key":"9487_CR165","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.90.13.6270","volume":"90","author":"L Thierfelder","year":"1993","unstructured":"Thierfelder L et al (1993) A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2. Proc Natl Acad Sci USA 90:6270\u20136274","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR166","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(94)90054-X","volume":"77","author":"L Thierfelder","year":"1994","unstructured":"Thierfelder L et al (1994) Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 77:701\u2013712","journal-title":"Cell"},{"key":"9487_CR167","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2377-13-29","volume":"13","author":"C Toro","year":"2013","unstructured":"Toro C et al (2013) Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins. BMC Neurol 13:29. https:\/\/doi.org\/10.1186\/1471-2377-13-29","journal-title":"BMC Neurol"},{"key":"9487_CR168","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0022-2836(84)80007-8","volume":"180","author":"J Trinick","year":"1984","unstructured":"Trinick J, Knight P, Whiting A (1984) Purification and properties of native titin. J Mol Biol 180:331\u2013356","journal-title":"J Mol Biol"},{"key":"9487_CR169","doi-asserted-by":"publisher","first-page":"E1172","DOI":"10.1073\/pnas.1422326112","volume":"112","author":"L Tskhovrebova","year":"2015","unstructured":"Tskhovrebova L, Bennett P, Gautel M, Trinick J (2015) Titin ruler hypothesis not refuted. Proc Natl Acad Sci USA 112:E1172. https:\/\/doi.org\/10.1073\/pnas.1422326112","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR170","doi-asserted-by":"publisher","first-page":"H310-317","DOI":"10.1152\/ajpheart.00975.2008","volume":"296","author":"T Tsuji","year":"2009","unstructured":"Tsuji T et al (2009) Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol 296:H310-317. https:\/\/doi.org\/10.1152\/ajpheart.00975.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9487_CR171","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1080\/15548627.2015.1017186","volume":"11","author":"A Ulbricht","year":"2015","unstructured":"Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Hohfeld J (2015) Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle. Autophagy 11:538\u2013546. https:\/\/doi.org\/10.1080\/15548627.2015.1017186","journal-title":"Autophagy"},{"key":"9487_CR172","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2015.04.077","volume":"566","author":"E Vafiadaki","year":"2015","unstructured":"Vafiadaki E, Arvanitis DA, Sanoudou D (2015) Muscle LIM protein: master regulator of cardiac and skeletal muscle functions. Gene 566:1\u20137. https:\/\/doi.org\/10.1016\/j.gene.2015.04.077","journal-title":"Gene"},{"key":"9487_CR173","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.1038\/ncomms6326","volume":"5","author":"R Valdes-Mas","year":"2014","unstructured":"Valdes-Mas R et al (2014) Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy. Nat Commun 5:5326. https:\/\/doi.org\/10.1038\/ncomms6326","journal-title":"Nat Commun"},{"key":"9487_CR174","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1093\/eurheartj\/ehu050","volume":"35","author":"KY Spaendonck-Zwarts van","year":"2014","unstructured":"van Spaendonck-Zwarts KY et al (2014) Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy. Eur Heart J 35:2165\u20132173. https:\/\/doi.org\/10.1093\/eurheartj\/ehu050","journal-title":"Eur Heart J"},{"key":"9487_CR175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1247\/csf.22.163","volume":"22","author":"PF Ven van der","year":"1997","unstructured":"van der Ven PF, Furst DO (1997) Assembly of titin, myomesin and M-protein into the sarcomeric M band in differentiating human skeletal muscle cells in vitro. Cell Struct Funct 22:163\u2013171","journal-title":"Cell Struct Funct"},{"key":"9487_CR176","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(01)00072-6","volume":"1538","author":"A Flier van der","year":"2001","unstructured":"van der Flier A, Sonnenberg A (2001) Structural and functional aspects of filamins. Biochim Biophys Acta 1538:99\u2013117","journal-title":"Biochim Biophys Acta"},{"key":"9487_CR177","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1083\/jcb.151.2.235","volume":"151","author":"PF Ven van der","year":"2000","unstructured":"van der Ven PF et al (2000) Indications for a novel muscular dystrophy pathway gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. J Cell Biol 151:235\u2013248","journal-title":"J Cell Biol"},{"key":"9487_CR178","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1016\/j.yexcr.2006.03.015","volume":"312","author":"PF Ven van der","year":"2006","unstructured":"van der Ven PF et al (2006) Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena\/VASP. Exp Cell Res 312:2154\u20132167. https:\/\/doi.org\/10.1016\/j.yexcr.2006.03.015","journal-title":"Exp Cell Res"},{"issue":"Pt 2","key":"9487_CR179","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bj2860591","volume":"286","author":"H Verboomen","year":"1992","unstructured":"Verboomen H, Wuytack F, De Smedt H, Himpens B, Casteels R (1992) Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban. Biochem J 286(Pt 2):591\u2013595","journal-title":"Biochem J"},{"key":"9487_CR180","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1086\/431959","volume":"77","author":"M Vorgerd","year":"2005","unstructured":"Vorgerd M et al (2005) A mutation in the dimerization domain of filamin c causes a novel type of autosomal dominant myofibrillar myopathy. Am J Hum Genet 77:297\u2013304. https:\/\/doi.org\/10.1086\/431959","journal-title":"Am J Hum Genet"},{"key":"9487_CR181","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.mcp.2015.05.004","volume":"29","author":"S Waldmuller","year":"2015","unstructured":"Waldmuller S et al (2015) Targeted 46-gene and clinical exome sequencing for mutations causing cardiomyopathies. Mol Cell Probes 29:308\u2013314. https:\/\/doi.org\/10.1016\/j.mcp.2015.05.004","journal-title":"Mol Cell Probes"},{"key":"9487_CR182","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/gim.2016.90","volume":"19","author":"R Walsh","year":"2017","unstructured":"Walsh R et al (2017) Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples. Genet Med 19:192\u2013203. https:\/\/doi.org\/10.1038\/gim.2016.90","journal-title":"Genet Med"},{"key":"9487_CR183","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-4684-4703-3_25","volume":"170","author":"K Wang","year":"1984","unstructured":"Wang K (1984) Cytoskeletal matrix in striated muscle: the role of titin, nebulin and intermediate filaments. Adv Exp Med Biol 170:285\u2013305","journal-title":"Adv Exp Med Biol"},{"key":"9487_CR184","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0065-227X(96)81668-6","volume":"33","author":"K Wang","year":"1996","unstructured":"Wang K (1996) Titin\/connectin and nebulin: giant protein rulers of muscle structure and function. Adv Biophys 33:123\u2013134","journal-title":"Adv Biophys"},{"key":"9487_CR185","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1073\/pnas.81.12.3685","volume":"81","author":"K Wang","year":"1984","unstructured":"Wang K, Ramirez-Mitchell R, Palter D (1984) Titin is an extraordinarily long, flexible, and slender myofibrillar protein. Proc Natl Acad Sci USA 81:3685\u20133689","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR186","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0008-6363(03)00328-6","volume":"59","author":"CM Warren","year":"2003","unstructured":"Warren CM, Jordan MC, Roos KP, Krzesinski PR, Greaser ML (2003) Titin isoform expression in normal and hypertensive myocardium. Cardiovasc Res 59:86\u201394","journal-title":"Cardiovasc Res"},{"key":"9487_CR187","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1172\/JCI116038","volume":"90","author":"H Watkins","year":"1992","unstructured":"Watkins H, Thierfelder L, Hwang DS, McKenna W, Seidman JG, Seidman CE (1992) Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations. J Clin Invest 90:1666\u20131671. https:\/\/doi.org\/10.1172\/JCI116038","journal-title":"J Clin Invest"},{"key":"9487_CR188","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng0493-333","volume":"3","author":"H Watkins","year":"1993","unstructured":"Watkins H et al (1993) A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3. Nat Genet 3:333\u2013337. https:\/\/doi.org\/10.1038\/ng0493-333","journal-title":"Nat Genet"},{"key":"9487_CR189","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/ng1295-434","volume":"11","author":"H Watkins","year":"1995","unstructured":"Watkins H et al (1995) Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat Genet 11:434\u2013437. https:\/\/doi.org\/10.1038\/ng1295-434","journal-title":"Nat Genet"},{"key":"9487_CR190","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1056\/NEJMra0902923","volume":"364","author":"H Watkins","year":"2011","unstructured":"Watkins H, Ashrafian H, Redwood C (2011) Inherited cardiomyopathies. N Engl J Med 364:1643\u20131656. https:\/\/doi.org\/10.1056\/NEJMra0902923","journal-title":"N Engl J Med"},{"key":"9487_CR191","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1016\/S0021-9258(18)60487-9","volume":"264","author":"AD Wegener","year":"1989","unstructured":"Wegener AD, Simmerman HK, Lindemann JP, Jones LR (1989) Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J Biol Chem 264:11468\u201311474","journal-title":"J Biol Chem"},{"key":"9487_CR192","doi-asserted-by":"crossref","first-page":"28946","DOI":"10.1074\/jbc.270.48.28946","volume":"270","author":"R Weiskirchen","year":"1995","unstructured":"Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (1995) The cysteine-rich protein family of highly related LIM domain proteins. J Biol Chem 270:28946\u201328954","journal-title":"J Biol Chem"},{"key":"9487_CR193","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0022-2836(89)90381-1","volume":"205","author":"A Whiting","year":"1989","unstructured":"Whiting A, Wardale J, Trinick J (1989) Does titin regulate the length of muscle thick filaments? J Mol Biol 205:263\u2013268","journal-title":"J Mol Biol"},{"key":"9487_CR194","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/B978-0-12-386930-2.00004-5","volume":"124","author":"RN Wilkinson","year":"2014","unstructured":"Wilkinson RN, Jopling C, van Eeden FJ (2014) Zebrafish as a model of cardiac disease. Prog Mol Biol Transl Sci 124:65\u201391. https:\/\/doi.org\/10.1016\/B978-0-12-386930-2.00004-5","journal-title":"Prog Mol Biol Transl Sci"},{"key":"9487_CR195","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ajhg.2007.09.004","volume":"82","author":"C Windpassinger","year":"2008","unstructured":"Windpassinger C et al (2008) An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1. Am J Hum Genet 82:88\u201399. https:\/\/doi.org\/10.1016\/j.ajhg.2007.09.004","journal-title":"Am J Hum Genet"},{"key":"9487_CR196","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/01.CIR.0000029804.61510.02","volume":"106","author":"Y Wu","year":"2002","unstructured":"Wu Y, Bell SP, Trombitas K, Witt CC, Labeit S, LeWinter MM, Granzier H (2002) Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation 106:1384\u20131389","journal-title":"Circulation"},{"key":"9487_CR197","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nrcardio.2014.157","volume":"11","author":"MH Yacoub","year":"2014","unstructured":"Yacoub MH (2014) Decade in review\u2014cardiomyopathies: cardiomyopathy on the move. Nat Rev Cardiol 11:628\u2013629. https:\/\/doi.org\/10.1038\/nrcardio.2014.157","journal-title":"Nat Rev Cardiol"},{"key":"9487_CR198","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1093\/emboj\/17.6.1614","volume":"17","author":"P Young","year":"1998","unstructured":"Young P, Ferguson C, Banuelos S, Gautel M (1998) Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin. EMBO J 17:1614\u20131624. https:\/\/doi.org\/10.1093\/emboj\/17.6.1614","journal-title":"EMBO J"},{"key":"9487_CR199","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200102110","volume":"154","author":"P Young","year":"2001","unstructured":"Young P, Ehler E, Gautel M (2001) Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol 154:123\u2013136","journal-title":"J Cell Biol"},{"key":"9487_CR200","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.109.207423","volume":"106","author":"T Zhang","year":"2010","unstructured":"Zhang T et al (2010) Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res 106:354\u2013362. https:\/\/doi.org\/10.1161\/CIRCRESAHA.109.207423","journal-title":"Circ Res"},{"key":"9487_CR201","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1042\/BC20060126","volume":"99","author":"Q Zheng","year":"2007","unstructured":"Zheng Q, Zhao Y (2007) The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein\u2013protein interaction. Biol Cell 99:489\u2013502. https:\/\/doi.org\/10.1042\/BC20060126","journal-title":"Biol Cell"},{"key":"9487_CR202","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.tcm.2007.08.001","volume":"17","author":"X Zhou","year":"2007","unstructured":"Zhou X, Boren J, Akyurek LM (2007) Filamins in cardiovascular development. Trends Cardiovasc Med 17:222\u2013229. https:\/\/doi.org\/10.1016\/j.tcm.2007.08.001","journal-title":"Trends Cardiovasc Med"},{"key":"9487_CR203","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1161\/01.CIR.101.23.2674","volume":"101","author":"O Zolk","year":"2000","unstructured":"Zolk O, Caroni P, Bohm M (2000) Decreased expression of the cardiac LIM domain protein MLP in chronic human heart failure. Circulation 101:2674\u20132677","journal-title":"Circulation"}],"container-title":["Journal of Muscle Research and Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10974-017-9487-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-017-9487-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-017-9487-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T18:41:39Z","timestamp":1659811299000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10974-017-9487-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":203,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["9487"],"URL":"https:\/\/doi.org\/10.1007\/s10974-017-9487-3","relation":{},"ISSN":["0142-4319","1573-2657"],"issn-type":[{"value":"0142-4319","type":"print"},{"value":"1573-2657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}