{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:36:00Z","timestamp":1776465360547,"version":"3.51.2"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":122,"URL":"http:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_13065"],"award-info":[{"award-number":["MC_PC_13065"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001306","name":"Health Protection Agency","doi-asserted-by":"publisher","award":["109502"],"award-info":[{"award-number":["109502"]}],"id":[{"id":"10.13039\/501100001306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001306","name":"Health Protection Agency","doi-asserted-by":"publisher","award":["109506"],"award-info":[{"award-number":["109506"]}],"id":[{"id":"10.13039\/501100001306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2020,7,9]]},"DOI":"10.1021\/acs.jmedchem.0c00328","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T16:57:57Z","timestamp":1591721877000},"page":"6941-6958","source":"Crossref","is-referenced-by-count":21,"title":["New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria"],"prefix":"10.1021","volume":"63","author":[{"given":"Pietro","family":"Picconi","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]},{"given":"Charlotte K.","family":"Hind","sequence":"additional","affiliation":[{"name":"National Infections Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K."}]},{"given":"Kazi S.","family":"Nahar","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]},{"given":"Shirin","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]},{"given":"Lucia","family":"Di Maggio","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]},{"given":"Naima","family":"Saeed","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]},{"given":"Bonnie","family":"Evans","sequence":"additional","affiliation":[{"name":"National Infections Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K."}]},{"given":"Jessica","family":"Solomons","sequence":"additional","affiliation":[{"name":"National Infections Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K."}]},{"given":"Matthew E.","family":"Wand","sequence":"additional","affiliation":[{"name":"National Infections Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K."}]},{"given":"J. Mark","family":"Sutton","sequence":"additional","affiliation":[{"name":"National Infections Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-8648","authenticated-orcid":true,"given":"Khondaker Miraz","family":"Rahman","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London SE1 9NH, U.K."}]}],"member":"316","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization.  Global Antimicrobial Resistance Surveillance\nSystem (GLASS) Report: Early Implementation 2017\u20132018, 2018."},{"key":"ref2\/cit2","volume-title":"Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations","author":"Review on Antimicrobial Resistance","year":"2014"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0141-x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/cr100120f"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/med.20212"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ja00952a050"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/jm301882a"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01849"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ml100131b"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/ja902986x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jm020124h"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510610"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00062"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00130"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks127"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr044"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13598"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060666"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm051199z"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth895"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1128\/aac.03475-14"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jm981124d"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1988.tb00050.x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(18)30513-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/jb.01479-12"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00352-17"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00141-06"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2036282100"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl504"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00108"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky379"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23205"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2018-0472"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.0c00328","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.0c00328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T20:35:54Z","timestamp":1681590954000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.0c00328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7,9]]}},"alternative-id":["10.1021\/acs.jmedchem.0c00328"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00328","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]}}}