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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Tumor development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we established a genetically tractable model, demonstrating that the same gene is relevant both cell autonomously and noncell autonomously for tumorigenesis. Deletion of\n                    <jats:italic>p27<\/jats:italic>\n                    , down-regulated in many tumors, predominantly leads to development of murine pituitary tumors. SOX2, transcriptionally derepressed in absence of P27, is important for tumorigenesis in this and other models, but little is known about its interaction. Using loss-of-function and lineage tracing approaches, we establish its regulatory interaction in vivo and show that SOX2 is required independently, both in endocrine and stem cells, to orchestrate tumorigenesis in absence of P27, establishing a powerful model to investigate mechanisms of tumor development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2017115118","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T15:46:11Z","timestamp":1613058371000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in\n                    <i>p27<\/i>\n                    -null mice"],"prefix":"10.1073","volume":"118","author":[{"given":"Veronica","family":"Moncho-Amor","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}]},{"given":"Probir","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Bioinformatics Core, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-9381","authenticated-orcid":false,"given":"Christophe","family":"Galichet","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}]},{"given":"Ander","family":"Matheu","sequence":"additional","affiliation":[{"name":"Cellular Oncology Group, Biodonostia Health Research Institute, E-20014 San Sebastian, Spain;"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), 28029 Madrid, Spain;"},{"name":"IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-4179","authenticated-orcid":false,"given":"Robin","family":"Lovell-Badge","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-5452","authenticated-orcid":false,"given":"Karine","family":"Rizzoti","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}]}],"member":"341","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170934"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.07.004"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0056-x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00282-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.200436.112"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1407"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0146"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1157238"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81239-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81238-6"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81237-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0091"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01885-08"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1319-1328.2001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.09.014"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16570"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4199"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4307"},{"key":"e_1_3_4_19_2","first-page":"2376","article-title":"SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary","volume":"143","author":"Goldsmith S.","year":"2016","unstructured":"S. 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