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Different Mycobacterium species promote the expression of TGF\u03b2 and IL-10, which, at the early stages of infection, block the formation of the phagolysosome, thereby securing mycobacterial survival upon phagocytosis, and at later stages, antagonize IFN\u03b3 production and functions. Despite the key role of IL-10 in mycobacterium infection, the signal transduction pathways leading to IL-10 expression in infected macrophages are poorly understood. Here, we report that Mycobacterium bovis BCG promotes IL-10 expression and cytokine production by establishing a SYK\/PKC\u03b1\/\u03b2 positive feedback loop that leads to STAT3 activation.<\/jats:p>","DOI":"10.1093\/femspd\/ftz032","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T19:15:24Z","timestamp":1559762124000},"source":"Crossref","is-referenced-by-count":7,"title":["<i>Mycobacterium bovis<\/i> BCG promotes IL-10 expression by establishing a SYK\/PKC\u03b1\/\u03b2 positive autoregulatory loop that sustains STAT3 activation"],"prefix":"10.1093","volume":"77","author":[{"given":"Tom\u00e1s","family":"Villase\u00f1or","sequence":"first","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuernavaca, Morelos 62271, M\u00e9xico"}]},{"given":"Edgardo","family":"Madrid-Paulino","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuernavaca, Morelos 62271, M\u00e9xico"}]},{"given":"Rafael","family":"Maldonado-Bravo","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuernavaca, Morelos 62271, M\u00e9xico"}]},{"given":"Leonor","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuernavaca, Morelos 62271, M\u00e9xico"}]},{"given":"Gustavo","family":"Pedraza-Alva","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuernavaca, Morelos 62271, M\u00e9xico"}]}],"member":"286","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"2021052203593263000_bib1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.0801212","article-title":"Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-Type immunity","volume":"183","author":"Almeida","year":"2009","journal-title":"J Immunol"},{"key":"2021052203593263000_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-3083.2005.01623.x","article-title":"Bioactivation of latent transforming growth factor beta1 by Mycobacterium tuberculosis in human mononuclear 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