{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T16:05:15Z","timestamp":1768147515761,"version":"3.49.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007848","name":"Institutes of Biomedical Sciences, Fudan University","doi-asserted-by":"publisher","award":["IBMS-CRC101-P01"],"award-info":[{"award-number":["IBMS-CRC101-P01"]}],"id":[{"id":"10.13039\/501100007848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glycosylation is important for biological functions of proteins and greatly affected by diseases. Exploring the glycosylation profile of the protein-specific glycosylation and\/or the site-specific glycosylation may help understand disease etiology, differentiate diseases and ultimately develop therapeutics. Patients with multiple sclerosis (MS) and patients with neuromyelitis optica spectrum disorder (NMOSD) are sometimes difficult to differentiate due to the similarity in their clinical symptoms. The disease-related glycosylation profiles of MS and NMOSD have not yet been well studied. Here, we analyzed site-specific glycan profiles of serum proteins of these patients by using a recently developed mass spectrometry technique. A total of 286 glycopeptides from 49 serum glycoproteins were quantified and compared between healthy controls (n\u00a0=\u00a06), remitting MS (n\u00a0=\u00a045) and remitting NMOSD (n\u00a0=\u00a023) patients. Significant differences in the levels of site-specific N-glycans on inflammation-associated components [IgM, IgG1, IgG2, complement components 8b (CO8B) and attractin], central nerve system-damage-related serum proteins [apolipoprotein D (APOD), alpha-1-antitrypsin, plasma kallikrein and ADAMTS-like protein 3] were observed among three study groups. We furthered demonstrated that site-specific N-glycans on APOD on site 98, CO8B on sites 243 and 553 are potential markers to differentiate MS from NMOSD with an area under receiver operating curve value\u00a0&amp;gt;\u00a00.75. All these observations indicate that remitting MS or NMOSD patients possess a unique disease-associated glyco-signature in their serum proteins. We conclude that monitoring one\u2019s serum protein glycan profile using this high-throughput analysis may provide an additional diagnostic criterion for differentiating diseases, monitoring disease status and estimating response-to-treatment effect.<\/jats:p>","DOI":"10.1093\/glycob\/cwab053","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T13:37:20Z","timestamp":1623850640000},"page":"1230-1238","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of site-specific glycan profiles of serum proteins in patients with multiple sclerosis or neuromyelitis optica spectrum disorder\u2014a pilot study"],"prefix":"10.1093","volume":"31","author":[{"given":"Peng Peng","family":"Ip","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Qiongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California Davis, One Shields Avenue, Davis, CA 95616, USA"}]},{"given":"Wei-Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Chien-Ching","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Cathy Shen-Jang","family":"Fann","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Huan-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Fu-Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]},{"given":"Carlito B","family":"Lebrilla","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California Davis, One Shields Avenue, Davis, CA 95616, USA"}]},{"given":"Chih-Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei 100, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-7425","authenticated-orcid":false,"given":"Fang","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, No.128, Sec. 2, Academia Road, Taipei 115, Taiwan"}]}],"member":"286","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2021092216122779800_ref1","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1126\/science.1083182","article-title":"Antibody domain exchange is an immunological solution to carbohydrate cluster recognition","volume":"300","author":"Calarese","year":"2003","journal-title":"Science"},{"key":"2021092216122779800_ref2","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.18632\/oncotarget.7059","article-title":"Identification of novel plasma glycosylation-associated markers of 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of protein patterns for diagnosis of neurological diseases","volume":"4","author":"Reiber","year":"1998","journal-title":"Mult Scler"},{"key":"2021092216122779800_ref53","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2021092216122779800_ref54","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/BST20200763","article-title":"Aberrant protein glycosylation in cancer: Implications in targeted therapy","volume":"49","author":"Rodrigues","year":"2021","journal-title":"Biochem Soc Trans"},{"key":"2021092216122779800_ref55","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1021\/pr2010605","article-title":"Association of medication with the human plasma N-glycome","volume":"11","author":"Saldova","year":"2012","journal-title":"J Proteome 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apolipoprotein D","volume":"30","author":"Seguin","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"2021092216122779800_ref59","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1074\/jbc.M210665200","article-title":"The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity","volume":"278","author":"Shinkawa","year":"2003","journal-title":"J Biol Chem"},{"key":"2021092216122779800_ref60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.msard.2017.09.021","article-title":"Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis","volume":"18","author":"Shu","year":"2017","journal-title":"Mult Scler Relat 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