{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:10:27Z","timestamp":1761729027300,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004435","name":"Association for International Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004435","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>\n                    Flaxseed (FS), rich in omega\u20103 fatty acids and lignans with known anti\u2010inflammatory and anti\u2010oxidant properties, is protective in experimental Acute Lung Injury (ALI). In this study FS was evaluated in a murine model of ischemia\/reperfusion injury (IRI), a common complication of lung transplantation. Animals fed either 10% FS\u2010supplemented or control diets (0% FS) for several weeks were anesthetized for tracheostomy and mechanical ventilation, and the entire left hilum was clamped (60 min) and unclamped to allow reperfusion (60 min). IRI was evaluated using real time arterial blood gases (ABG), histology, and bronchoalveolar lavage (BAL) protein and white blood cell (WBC) content measurements. Compared to sham operated mice, mice fed 0% FS before IRI had significant decreases in PaO\n                    <jats:sub>2<\/jats:sub>\n                    (100 vs. 54.5 mmHg), O\n                    <jats:sub>2<\/jats:sub>\n                    saturation (96 vs. 70%), and pH (7.28 vs. 7.02), an increase in BAL protein (0.27 vs. 1.0 mg\/ml), and marked perivascular and alveolar edema, intra\u2010alveolar hemorrhage, and WBC accumulation seen histologically. In contrast, as compared to 0% FS fed mice before IRI, mice fed 10% FS before IRI had significant increases in PaO\n                    <jats:sub>2<\/jats:sub>\n                    (54.5 vs. 81.4 mmHg), O\n                    <jats:sub>2<\/jats:sub>\n                    saturation (70 vs. 91%), and pH (7.02 vs. 7.15), a significant decrease in lung BAL protein (1.0 vs. 0.8 mg\/ml), and no histological evidence of IRI (all groups p&lt;0.05). We conclude that dietary FS is protective in experimental IRI as demonstrated by an improvement in physiologic, histologic, and biologic parameters.\n                  <\/jats:p>\n                  <jats:p>Funded by: NIH\/NCI, AICR and U. Penn Research Foundation (MCS).<\/jats:p>","DOI":"10.1096\/fasebj.21.6.a1218-b","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T13:19:16Z","timestamp":1624281556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Flaxseed is Protective in a Murine Model of Lung Ischemia\/Reperfusion Injury"],"prefix":"10.1096","volume":"21","author":[{"given":"James C","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pennsylvania Abramson Research Center Philadelphia PA 19104"}]},{"given":"C. C.","family":"Solomides","sequence":"additional","affiliation":[{"name":"Department of Pathology Temple University 3401 N. Broad Street Philadelphia PA 19140"}]},{"given":"Evguenia","family":"Arguiri","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Abramson Research Center Philadelphia PA 19104"}]},{"given":"Faiz","family":"Bhora","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Ambramson Research Center Philadelphia PA 19104"}]},{"given":"Melpo Christofidou","family":"Solomidou","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Abramson Research Center Philadelphia PA 19104"}]}],"member":"311","published-online":{"date-parts":[[2007,4]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:47:22Z","timestamp":1761702442000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.21.6.A1218-b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1096\/fasebj.21.6.A1218-b"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.21.6.a1218-b","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}