{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:05:27Z","timestamp":1775606727653,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["2323"],"award-info":[{"award-number":["2323"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FASEB BioAdvances"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dynamic fission and fusion events regulate mitochondrial shape, distribution, and rejuvenation, and proper control of these processes is essential for neuronal homeostasis. Here, we report that Gas7, a known cytoskeleton regulator, controls mitochondrial dynamics within neurons of the central nervous system. In this study, we generated an improved\n                    <jats:italic>Gas7<\/jats:italic>\n                    \u2010knockout mouse and evaluated its mitochondrial phenotype. We first identified Gas7 in mitochondrial fractions from wild\u2010type brain tissue, and observed Gas7 colocalization with mitochondria in primary cortical neurons. In\n                    <jats:italic>Gas7<\/jats:italic>\n                    \u2010deficient brain tissue and neuronal cultures mitochondria were elongated with perinuclear clustering. These morphological abnormalities were associated with increased levels mitochondrial fusion proteins and increased PKA\u2010dependent phosphorylation of Drp\u20101 in brain tissues, suggesting an imbalance of mitochondrial fusion and fission. Moreover, expression of mitochondrial quality control kinase, PINK1, and PINK1\u2010specific phosphorylation of Mfn\u20102 (S442), Parkin (S65), and ubiquitin (S65) were all reduced in the knockout cells. Ectopic expression of Gas7 restored mitochondrial morphology and distribution, as well as PINK1 expression in\n                    <jats:italic>Gas7<\/jats:italic>\n                    \u2010null cortical neurons. Collectively, our results introduce a novel role of mouse Gas7 in determining the dynamics, morphology, and intracellular distribution of neuronal mitochondria, which are expected to be required for normal neuronal function.\n                  <\/jats:p>","DOI":"10.1096\/fba.2019-00091","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:26:02Z","timestamp":1578029162000},"page":"166-181","source":"Crossref","is-referenced-by-count":12,"title":["Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons"],"prefix":"10.1096","volume":"2","author":[{"given":"Jagannatham Naidu","family":"Bhupana","sequence":"first","affiliation":[{"name":"Molecular Cell Biology Taiwan International Graduate Program Institute of Molecular Biology Academia Sinica and Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan"},{"name":"Institute of Molecular Biology Academia Sinica Taipei Taiwan"}]},{"given":"Bo\u2010Tsang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology Academia Sinica Taipei Taiwan"}]},{"given":"Gunn\u2010Guang","family":"Liou","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology Academia Sinica Taipei Taiwan"}]},{"given":"Marcus J.","family":"Calkins","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology Academia Sinica Taipei Taiwan"}]},{"given":"Sue","family":"Lin\u2010Chao","sequence":"additional","affiliation":[{"name":"Molecular Cell Biology Taiwan International Graduate Program Institute of Molecular Biology Academia Sinica and Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan"},{"name":"Institute of Molecular Biology Academia Sinica Taipei 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