{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:48:19Z","timestamp":1774921699830,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida parapsilosis<\/jats:named-content>\n            is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the\n            <jats:italic>MRR1<\/jats:italic>\n            transcription factor gene were identified in fluconazole- and voriconazole-resistant strains. Independent expression of\n            <jats:italic>MRR1<\/jats:italic>\n            genes harboring these mutations showed that G1747A (G583R) and A2619C (K873N) are gain-of-function mutations responsible for azole resistance, the first described in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. parapsilosis<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00842-15","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T01:31:15Z","timestamp":1438047075000},"page":"6629-6633","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in\n            <i>MRR1<\/i>\n            Transcription Factor Gene"],"prefix":"10.1128","volume":"59","author":[{"given":"Joana","family":"Branco","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Ana P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Raquel M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine (iBiMED) and IEETA, University of Aveiro, Aveiro, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"}]},{"given":"Ana","family":"Silva-Dias","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Cid\u00e1lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Geraldine","family":"Butler","sequence":"additional","affiliation":[{"name":"UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland"}]},{"given":"Ac\u00e1cio G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12539"},{"key":"e_1_3_2_3_2","first-page":"661","article-title":"Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013","volume":"18","author":"Montagna MT","year":"2014","unstructured":"Montagna MT, Lovero G, Borghi E, Amato G, Andreoni S, Campion L, Lo Cascio G, Lombardi G, Luzzaro F, Manso E, Mussap M, Pecile P, Perin S, Tangorra E, Tronci M, Iatta R, Morace G. 2014. 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