{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:25:10Z","timestamp":1758925510194,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100009082","name":"Catholic University of Cordoba","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009082","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To describe the presence of secretory leukocyte protease inhibitor (SLPI), a cationic peptide with antimicrobial and antiprotease activity in the innate immune reaction in a rat model of<jats:italic>Staphylococcus aureus<\/jats:italic>keratitis.<jats:italic>Methods<\/jats:italic>. Forty female Lewis rats were divided into 2 groups: the infectious keratitis and the epithelial defect groups. Eyes were processed for immunohistochemical studies for SLPI, interleukin-1, interleukin-6, tumor necrosis factor-alpha, and matrix metalloproteinase-8.<jats:italic>Results<\/jats:italic>. Immunohistochemical studies confirmed high levels of SLPI, IL-1, IL-6, TNF-\u03b1, and MMP-8 expression in eyes with<jats:italic>S. aureus<\/jats:italic>keratitis and with epithelial defects, in contrast to undetectable SLPI expression in the normal control corneas.<jats:italic>Conclusions<\/jats:italic>. To our knowledge, this paper is the first to demonstrate the presence of SLPI with increased amounts of proinflammatory cytokines in inflamed and infected corneas.<\/jats:p>","DOI":"10.1155\/2009\/259393","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T14:30:14Z","timestamp":1255617014000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Secretory Leukoprotease Inhibitor: A Native Antimicrobial Protein in the Innate Immune Response in a Rat Model of<i>S. aureus<\/i>Keratitis"],"prefix":"10.1155","volume":"2009","author":[{"given":"Victor E.","family":"Reviglio","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment Research, Pathology Department, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"},{"name":"Ophthalmology Service, Cornea Department, Cordoba Hospital, Cordoba, Argentina"}]},{"given":"Andres","family":"Grenat","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Research, Pathology Department, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"}]},{"given":"Federico","family":"Pegoraro","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, Cornea Department, Cordoba Hospital, Cordoba, Argentina"}]},{"given":"Ruben H.","family":"Sambuelli","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Research, Pathology Department, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"}]},{"given":"Tayyib","family":"Rana","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Department, Northern Virginia Eye Institute, Virginia, USA"}]},{"given":"Irene C.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.10.022"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2165\/00003088-199427020-00005","volume":"27","year":"1994","journal-title":"Clinical Pharmacokinetics"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1089\/10445490260099656"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.11.3.171.17351"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90115-U"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jlb.58.2.128","volume":"58","year":"1995","journal-title":"Journal of Leukocyte Biology"},{"key":"7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.iy.11.040193.000541","volume":"11","year":"1993","journal-title":"Annual Review of Immunology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.4.535"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/thx.53.2.114","volume":"53","year":"1998","journal-title":"Thorax"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/93857"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81880-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0897"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1165\/ajrcmb.11.6.7946401","volume":"11","year":"1994","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1086\/514098","volume":"176","year":"1997","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jlb.67.2.149","volume":"67","year":"2000","journal-title":"Journal of Leukocyte Biology"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.156.1.1","volume":"156","year":"1996","journal-title":"Journal of Immunology"},{"issue":"1","key":"17","first-page":"1","volume":"19","year":"1999","journal-title":"Critical Reviews in Immunology"},{"issue":"7","key":"18","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/IAI.67.7.3542-3547.1999","volume":"67","year":"1999","journal-title":"Infection and Immunity"},{"first-page":"307","volume-title":"Structure, genomic organization and tissue distribution of human secretory leukocyte-protease inhibitor (SLPI): a potent inhibitor of neutrophil elastase","year":"1986","key":"19"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01737-6"},{"issue":"4","key":"21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/02713689808951215","volume":"17","year":"1998","journal-title":"Current Eye Research"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/molehr\/7.6.573","volume":"7","year":"2001","journal-title":"Molecular Human Reproduction"},{"issue":"11","key":"23","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1128\/IAI.64.11.4520-4524.1996","volume":"64","year":"1996","journal-title":"Infection and Immunity"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2009\/259393.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2009\/259393.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2009\/259393.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T05:38:31Z","timestamp":1685165911000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/joph\/2009\/259393\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":23,"alternative-id":["259393","259393"],"URL":"https:\/\/doi.org\/10.1155\/2009\/259393","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"type":"print","value":"2090-004X"},{"type":"electronic","value":"2090-0058"}],"subject":[],"published":{"date-parts":[[2009]]}}}