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This study\naimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal\nstatus. To investigate the usefulness of cytokines in the therapeutic approach for periodontal\ndisease, the relationship between stimulated cytokine changes and the periodontitis treatment\noutcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by\ndentists as having chronic periodontitis. 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The differences of IL\u20106 levels (cut\npoint: 0.05\u2009<jats:italic>\u03bc<\/jats:italic>g\/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for\npredicting the periodontitis treatment outcome. 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