{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T03:17:02Z","timestamp":1766546222593,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010400","name":"Children\u2019s Mercy Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> This study explored the possible role of FGF23 in pediatric hypercalciuria.<jats:italic> Methods.<\/jats:italic> Plasma FGF23 was measured in 29 controls and 58 children and adolescents with hypercalciuria: 24 before treatment (Pre-Treated) and 34 after 6 months of treatment (Treated). Hypercalciuric patients also measured serum PTH hormone, 25(OH)vitD, phosphate, calcium, creatinine, and 24\u2009h urine calcium, phosphate, and creatinine.<jats:italic> Results.<\/jats:italic> There were no differences in age, gender, ethnicity, or body mass index either between controls and patients, or between Pre-Treated and Treated patients. Median plasma FGF23 in controls was 72 compared with all patients, 58\u2009RU\/mL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.0019<\/mml:mn><\/mml:math>). However, whereas FGF23 in Pre-Treated patients, 73\u2009RU\/mL, was not different from controls, in Treated patients it was 50\u2009RU\/mL, significantly lower than in both controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.0001<\/mml:mn><\/mml:math>) and Pre-Treated patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.02<\/mml:mn><\/mml:math>). In all patients, there was a correlation between FGF23 and urinary calcium (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.325<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.0014<\/mml:mn><\/mml:math>). Treated patients had significantly lower urinary calcium (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.0001<\/mml:mn><\/mml:math>), higher TP\/GFR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.001<\/mml:mn><\/mml:math>), and higher serum phosphate (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.007<\/mml:mn><\/mml:math>) versus Pre-Treated patients.<jats:italic> Conclusions.<\/jats:italic> Pharmacological treatment of hypercalciuric patients resulted in significantly lower urinary calcium excretion, lower serum FGF23, and elevated TP\/GFR and serum phosphate concentration, without significant changes in PTH. Further studies are indicated. This trial is registered with Clinical Registration Number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ensaiosclinicos.gov.br\/rg\/?q=8W27X5\">RBR 8W27X5<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2017\/3781525","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T18:31:51Z","timestamp":1514745111000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Role of FGF23 in Pediatric Hypercalciuria"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-3861","authenticated-orcid":true,"given":"Maria Goretti","family":"Moreira Guimar\u00e3es Penido","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Unit, Clinics Hospital, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"Pediatric Nephrology Unit, The Nephrology Center, Santa Casa de Belo Horizonte Hospital, Belo Horizonte, MG, Brazil"}]},{"given":"Marcelo","family":"de Sousa Tavares","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Clinics Hospital, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"Pediatric Nephrology Unit, The Nephrology Center, Santa Casa de Belo Horizonte Hospital, Belo Horizonte, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-8593","authenticated-orcid":true,"given":"Uri","family":"Saggie Alon","sequence":"additional","affiliation":[{"name":"Bone and Mineral Disorders Clinic, Section of Pediatric Nephrology, Children\u2019s Mercy Hospital and Clinics, University of Missouri at Kansas City, Kansas City, MO, USA"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.107"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-1036-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00381.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001778"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2008.01.005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.473"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.675"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050064"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1422-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000325505"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-010-0299-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00796.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1606"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07060714"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10030913"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283223db7"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100622"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2175-z"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2466-z"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0412"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088488-9.50071-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1159\/000057388"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.13"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1983.193"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13251215"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009030276"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114245"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3781525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3781525.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/3781525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T18:31:56Z","timestamp":1514745116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/3781525\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":27,"alternative-id":["3781525","3781525"],"URL":"https:\/\/doi.org\/10.1155\/2017\/3781525","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2017]]}}}