{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:33:29Z","timestamp":1774989209164,"version":"3.50.1"},"reference-count":49,"publisher":"American Association for Cancer Research (AACR)","issue":"3","funder":[{"DOI":"10.13039\/501100007287","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["14-1070"],"award-info":[{"award-number":["14-1070"]}],"id":[{"id":"10.13039\/501100007287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nascient Ltd"},{"name":"Kennedy Trust for Rheumatology Research"},{"name":"The Austrian Science Fund","award":["J-4102"],"award-info":[{"award-number":["J-4102"]}]},{"name":"Institut National contre le Cancer","award":["INCA\/TENPLAMET"],"award-info":[{"award-number":["INCA\/TENPLAMET"]}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["LNCC"],"award-info":[{"award-number":["LNCC"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARC","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}]},{"name":"Conacyt Mexico","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}]},{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French Ministry of Research","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}]},{"name":"Clarendon Fund Scholarship"},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"crossref","award":["20003"],"award-info":[{"award-number":["20003"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties of the extracellular matrix to create a microenvironment that enables their escape from immune surveillance. Using orthotopic grafting of mammary tumor cells in immunocompetent mice and autochthonous models of breast cancer, we discovered how tenascin-C, a matrix molecule absent from most healthy adult tissues but expressed at high levels and associated with poor patient prognosis in many solid cancers, controls the immune status of the tumor microenvironment. We found that, although host-derived tenascin-C promoted immunity via recruitment of proinflammatory, antitumoral macrophages, tumor-derived tenascin-C subverted host defense by polarizing tumor-associated macrophages toward a pathogenic, immune-suppressive phenotype. Therapeutic monoclonal antibodies that blocked tenascin-C activation of Toll-like receptor 4 reversed this phenotypic switch in vitro and reduced tumor growth and lung metastasis in vivo, providing enhanced benefit in combination with anti\u2013PD-L1 over either treatment alone. Combined tenascin-C:macrophage gene-expression signatures delineated a significant survival benefit in people with breast cancer. These data revealed a new approach to targeting tumor-specific macrophage polarization that may be effective in controlling the growth and spread of breast tumors.<\/jats:p>","DOI":"10.1158\/2326-6066.cir-19-0276","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T08:25:12Z","timestamp":1579076712000},"page":"368-382","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype"],"prefix":"10.1158","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-5123","authenticated-orcid":false,"given":"Claire","family":"Deligne","sequence":"first","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]},{"given":"Devadarssen","family":"Murdamoothoo","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"An\u00eds N.","family":"Gammage","sequence":"additional","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]},{"given":"Martha","family":"Gschwandtner","sequence":"additional","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]},{"given":"William","family":"Erne","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"Thomas","family":"Loustau","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"Anna M.","family":"Marzeda","sequence":"additional","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]},{"given":"Raphael","family":"Carapito","sequence":"additional","affiliation":[{"name":"3Laboratoire d'ImmunoRhumatologie Mol\u00e9culaire, GENOMAX platform, INSERM UMR_S 1109, Facult\u00e9 de M\u00e9decine, F\u00e9d\u00e9ration Hospitalo-Universitaire OMICARE, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), LabEx TRANSPLANTEX, Universit\u00e9 de Strasbourg, Strasbourg, France."}]},{"given":"Nicod\u00e8me","family":"Paul","sequence":"additional","affiliation":[{"name":"3Laboratoire d'ImmunoRhumatologie Mol\u00e9culaire, GENOMAX platform, INSERM UMR_S 1109, Facult\u00e9 de M\u00e9decine, F\u00e9d\u00e9ration Hospitalo-Universitaire OMICARE, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), LabEx TRANSPLANTEX, Universit\u00e9 de Strasbourg, Strasbourg, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-9542","authenticated-orcid":false,"given":"In\u00e9s","family":"Velazquez-Quesada","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"Imogen","family":"Mazzier","sequence":"additional","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"Gertraud","family":"Orend","sequence":"additional","affiliation":[{"name":"2University of Strasbourg, INSERM U1109, MN3T and The Tumor Microenvironment Laboratory, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France."}]},{"given":"Kim S.","family":"Midwood","sequence":"additional","affiliation":[{"name":"1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom."}]}],"member":"1086","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"2022060918575714000_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1470-2045(17)30904-X","article-title":"Tumor-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy","volume":"19","author":"Denkert","year":"2018","journal-title":"Lancet Oncol"},{"key":"2022060918575714000_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrclinonc.2015.215","article-title":"Clinical relevance of host immunity in breast cancer: from TILs to the clinic","volume":"13","author":"Savas","year":"2016","journal-title":"Nat Rev Clin Oncol"},{"key":"2022060918575714000_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-018-0142-8","article-title":"Cancer immunoediting and resistance to T cell-based immunotherapy","volume":"16","author":"O'Donnell","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"2022060918575714000_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fonc.2018.00049","article-title":"Targeting macrophages in cancer: from bench to bedside","volume":"8","author":"Poh","year":"2018","journal-title":"Front Oncol"},{"key":"2022060918575714000_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumor-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"2022060918575714000_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","article-title":"Macrophages as regulators of tumor immunity and immunotherapy","volume":"19","author":"DeNardo","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2022060918575714000_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrd.2018.169","article-title":"Targeting macrophages: therapeutic approaches in cancer","volume":"17","author":"Cassetta","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2022060918575714000_bib8","doi-asserted-by":"crossref","first-page":"a004903","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome\u2013an inventory of extracellular matrix constituents and functions","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2022060918575714000_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ni.3325","article-title":"The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis","volume":"17","author":"Amit","year":"2016","journal-title":"Nat Immunol"},{"key":"2022060918575714000_bib10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"2022060918575714000_bib11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"2022060918575714000_bib12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/PPO.0000000000000127","article-title":"The role of stroma in tumor development","volume":"21","author":"Werb","year":"2015","journal-title":"Cancer J"},{"key":"2022060918575714000_bib13","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm.2379","article-title":"Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs","volume":"17","author":"Oskarsson","year":"2011","journal-title":"Nat Med"},{"key":"2022060918575714000_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ijc.11509","article-title":"Tenascin-C regulates angiogenesis in tumor through the regulation of vascular endothelial growth factor expression","volume":"108","author":"Tanaka","year":"2004","journal-title":"Int J Cancer"},{"key":"2022060918575714000_bib15","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.celrep.2016.11.012","article-title":"Tenascin-C orchestrates glioblastoma angiogenesis by modulation of pro- and anti-angiogenic signaling","volume":"17","author":"Rupp","year":"2016","journal-title":"Cell Rep"},{"key":"2022060918575714000_bib16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","article-title":"Genes that mediate breast cancer metastasis to lung","volume":"436","author":"Minn","year":"2005","journal-title":"Nature"},{"key":"2022060918575714000_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1369\/0022155418757443","article-title":"Internal affairs: tenascin-C as a clinically relevant, endogenous driver of innate immunity","volume":"66","author":"Marzeda","year":"2018","journal-title":"J Histochem Cytochem"},{"key":"2022060918575714000_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.matbio.2019.07.001","article-title":"Tenascin-C increases lung metastasis by impacting blood vessel invasions","volume":"83","author":"Sun","year":"2019","journal-title":"Matrix Biol"},{"key":"2022060918575714000_bib19","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.celrep.2014.07.044","article-title":"Transmembrane domain targeting peptide antagonizing ErbB2\/Neu inhibits breast tumor growth and metastasis","volume":"8","author":"Arpel","year":"2014","journal-title":"Cell Rep"},{"key":"2022060918575714000_bib20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/annrheumdis-2018-214294","article-title":"Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?","volume":"78","author":"Aungier","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2022060918575714000_bib21","doi-asserted-by":"crossref","first-page":"e1500107","DOI":"10.1080\/2162402X.2018.1500107","article-title":"Adipose PD-L1 modulates PD-1\/PD-L1 checkpoint blockade immunotherapy efficacy in breast cancer","volume":"7","author":"Wu","year":"2018","journal-title":"Oncoimmunology"},{"key":"2022060918575714000_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2022060918575714000_bib23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"2022060918575714000_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2022060918575714000_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2022060918575714000_bib26","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1093\/nar\/gkv1507","article-title":"TCGAbiolinks: an R\/Bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2022060918575714000_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.cell.2015.09.033","article-title":"Comprehensive molecular portraits of invasive lobular breast cancer","volume":"163","author":"Ciriello","year":"2015","journal-title":"Cell"},{"key":"2022060918575714000_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2022060918575714000_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"2022060918575714000_bib30","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1172\/JCI125890","article-title":"Stromal integrin alpha11 regulates PDGFR-beta signaling and promotes breast cancer progression","volume":"130","author":"Primac","year":"2019","journal-title":"J Clin Invest"},{"key":"2022060918575714000_bib31","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.0903359","article-title":"Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation","volume":"184","author":"Goh","year":"2010","journal-title":"J Immunol"},{"key":"2022060918575714000_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.canlet.2006.02.017","article-title":"Tenascin-C induced signaling in cancer","volume":"244","author":"Orend","year":"2006","journal-title":"Cancer Lett"},{"key":"2022060918575714000_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/cvr\/cvx221","article-title":"Local production of tenascin-C acts as a trigger for monocyte\/macrophage recruitment that provokes cardiac dysfunction","volume":"114","author":"Abbadi","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2022060918575714000_bib34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/cvr\/cvy244","article-title":"Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization","volume":"115","author":"Kimura","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2022060918575714000_bib35","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1056\/NEJMoa1809615","article-title":"Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer","volume":"379","author":"Schmid","year":"2018","journal-title":"N Engl J Med"},{"key":"2022060918575714000_bib36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1158\/2326-6066.CIR-16-0284","article-title":"A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice","volume":"5","author":"Foote","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"2022060918575714000_bib37","doi-asserted-by":"crossref","first-page":"30576","DOI":"10.18632\/oncotarget.15736","article-title":"Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"2022060918575714000_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/modpathol.3880010","article-title":"Tenascin expression patterns and cells of monocyte lineage: relationship in human gliomas","volume":"13","author":"Kulla","year":"2000","journal-title":"Mod Pathol"},{"key":"2022060918575714000_bib39","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/01.CIR.99.10.1284","article-title":"Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque","volume":"99","author":"Wallner","year":"1999","journal-title":"Circulation"},{"key":"2022060918575714000_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0960-8966(96)00391-4","article-title":"Tenascin-C expression correlates with macrophage invasion in Duchenne muscular dystrophy and in myositis","volume":"7","author":"Gullberg","year":"1997","journal-title":"Neuromuscul Disord"},{"key":"2022060918575714000_bib41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF02473236","article-title":"Differential expression of tenascin in the skin during hapten-induced dermatitis","volume":"106","author":"Koyama","year":"1996","journal-title":"Histochem Cell Biol"},{"key":"2022060918575714000_bib42","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1167\/iovs.10-5750","article-title":"Impaired angiogenic response in the cornea of mice lacking tenascin C","volume":"52","author":"Sumioka","year":"2011","journal-title":"Invest Opthalmol Vis Sci"},{"key":"2022060918575714000_bib43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/jcmm.13332","article-title":"Tenascin-c renders a proangiogenic phenotype in macrophage via annexin II","volume":"22","author":"Wang","year":"2018","journal-title":"J Cell Mol Med"},{"key":"2022060918575714000_bib44","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/bjc.2017.356","article-title":"TAMeless traitors: macrophages in cancer progression and metastasis","volume":"117","author":"Aras","year":"2017","journal-title":"Br J Cancer"},{"key":"2022060918575714000_bib45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41467-017-02481-5","article-title":"Macrophages orchestrate breast cancer early dissemination and metastasis","volume":"9","author":"Linde","year":"2018","journal-title":"Nat Commun"},{"key":"2022060918575714000_bib46","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3389\/fimmu.2017.02004","article-title":"Monocytes differentiate to immune suppressive precursors of metastasis-associated macrophages in mouse models of metastatic breast cancer","volume":"8","author":"Kitamura","year":"2017","journal-title":"Front Immunol"},{"key":"2022060918575714000_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/his.12156","article-title":"Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor","volume":"63","author":"Chen","year":"2013","journal-title":"Histopathology"},{"key":"2022060918575714000_bib48","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.18632\/oncotarget.13819","article-title":"Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"key":"2022060918575714000_bib49","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.7150\/jca.25155","article-title":"Stromal infiltration of tumor-associated macrophages conferring poor prognosis of patients with basal-like breast carcinoma","volume":"9","author":"Yang","year":"2018","journal-title":"J Cancer"}],"container-title":["Cancer Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerimmunolres\/article-pdf\/8\/3\/368\/2356555\/368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerimmunolres\/article-pdf\/8\/3\/368\/2356555\/368.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T16:30:24Z","timestamp":1654792224000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerimmunolres\/article\/8\/3\/368\/470067\/Matrix-Targeting-Immunotherapy-Controls-Tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,2]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2326-6066.cir-19-0276","relation":{"has-preprint":[{"id-type":"doi","id":"10.1158\/2326-6066.22543632.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2326-6066.c.6550338","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2326-6066.c.6550338.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2326-6066.22543632","asserted-by":"object"}]},"ISSN":["2326-6066","2326-6074"],"issn-type":[{"value":"2326-6066","type":"print"},{"value":"2326-6074","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,1]]}}}