{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:39:40Z","timestamp":1741066780003,"version":"3.38.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Helse Vest Research Fund"},{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["223250"],"award-info":[{"award-number":["223250"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dam Foundation, Norwegian Breast Cancer Society","award":["2018\/FO201362"],"award-info":[{"award-number":["2018\/FO201362"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> To determine the frequency and discuss possible implications of early breast cancer with particularly good prognosis and defined by tumor diameter and cell proliferation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p> Detection of small and slowly growing tumors presents a challenge in breast cancer management, due to the risk of over-treatment. Here, we attempted to define a group of such tumors by combining small diameter (\u226410\u2009mm, T1ab tumors) with low tumor cell proliferation (\u226410% Ki67 expression rate). These tumors were termed small low proliferation cancers (SLPC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Two population-based cohorts were studied: a small research series ( n\u2009=\u2009534), and a nation-wide registry-based series of prospectively collected routine data ( n\u2009=\u20098433). In the latter, we stratified by detection mode; screen-detected, interval, and breast cancers detected outside of screening. Patients were treated according to national guidelines at time of their diagnosis. For both cohorts, we compared tumor histopathology and risk of breast cancer death using a log-rank test for cases with SLPC versus non-SLPC. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In the research series (median follow-up 151\u2009months), the frequency of SLPC was 10% (54\/534), with one breast cancer death compared with 78 among the remaining 480 cases of non-SLPC ( p\u2009=\u20090.008). In the registry series (median follow-up 42\u2009months), the frequency of SLPC was 10% (854\/8433), with five deaths compared to 187 among the remaining 7579 cases ( p\u2009=\u20090.0004). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> SLPC was associated with very low risk of breast cancer death. Prospective randomized trials are needed to clarify whether less aggressive treatment could be a safe option for women with such early breast cancers. <\/jats:p><\/jats:sec>","DOI":"10.1177\/09691413211023970","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:14:48Z","timestamp":1624421688000},"page":"32-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection and significance of small and low proliferation breast cancer"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-8939","authenticated-orcid":false,"given":"Solveig","family":"Hofvind","sequence":"first","affiliation":[{"name":"Cancer Registry of Norway, Oslo, Norway"},{"name":"Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway"}]},{"given":"G\u00f8ril","family":"Knutsvik","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Section for Pathology, University of Bergen, Bergen, Norway"},{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"}]},{"given":"\u00c5sne S","family":"Holen","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway, Oslo, Norway"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-6237","authenticated-orcid":false,"given":"Kaitlyn M","family":"Tsuruda","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway, Oslo, Norway"},{"name":"Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway"}]},{"given":"Lars A","family":"Akslen","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Section for Pathology, University of Bergen, Bergen, Norway"},{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"}]}],"member":"179","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"bibr1-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.0499"},{"key":"bibr2-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4168-x"},{"key":"bibr3-09691413211023970","unstructured":"Badve SS, Beitsch PD, Bose S, et al. Part XI, Breast. In: Amin MB, Edge S, Greene F, et al. (eds). AJCC cancer staging manual. 8th edition. [ISBN: 978-3-319-40617-6]. Cham: Springer International Publishing, 2017."},{"key":"bibr4-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv221"},{"key":"bibr5-09691413211023970","unstructured":"Hofvind S, Tsuruda K, Mangerud G, et\u00a0al. The Norwegian breast cancer screening program, 1996-2016: celebrating 20 years of organised mammographic screening. In: Cancer in Norway 2016 - Cancer incidence, mortality, survival and prevalence in Norway. Oslo: Cancer Registry of Norway, 2017, pp.S1\u2013S72."},{"key":"bibr6-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112121"},{"key":"bibr7-09691413211023970","unstructured":"Kreftregisterforskriften, https:\/\/lovdata.no\/dokument\/SF\/forskrift\/2001-12-21-1477. Lovdata. March 2021 (accessed 29 May 2021)."},{"key":"bibr8-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt303"},{"key":"bibr9-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.037"},{"key":"bibr10-09691413211023970","first-page":"48","volume-title":"Medical statistics in clinical and epidemiological research","author":"Lydersen SFM","year":"2012"},{"key":"bibr11-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1669817"},{"key":"bibr12-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2017.09.016"},{"key":"bibr13-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.177"},{"key":"bibr14-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1177\/0969141313517676"},{"key":"bibr15-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012082"},{"key":"bibr16-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1953"},{"key":"bibr17-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60123-4"},{"key":"bibr18-09691413211023970","doi-asserted-by":"publisher","DOI":"10.1177\/0969141315587344"}],"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09691413211023970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09691413211023970","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09691413211023970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:56:44Z","timestamp":1741006604000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09691413211023970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/09691413211023970"],"URL":"https:\/\/doi.org\/10.1177\/09691413211023970","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"type":"print","value":"0969-1413"},{"type":"electronic","value":"1475-5793"}],"subject":[],"published":{"date-parts":[[2021,6,22]]}}}