{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:10:01Z","timestamp":1775841001399,"version":"3.50.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","award":["2014\/R"],"award-info":[{"award-number":["2014\/R"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003942","name":"Istituto di Scienze e Tecnologie della Cognizione","doi-asserted-by":"publisher","award":["Aging program 2012-2018"],"award-info":[{"award-number":["Aging program 2012-2018"]}],"id":[{"id":"10.13039\/501100003942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We executed a replication study of an innovative approach for relieving MS fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517720528","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T04:46:20Z","timestamp":1501476380000},"page":"1366-1374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis"],"prefix":"10.1177","volume":"24","author":[{"given":"Andrea","family":"Cancelli","sequence":"first","affiliation":[{"name":"Laboratory of Electrophysiology for Translational neuroScience (LET\u2019S) \u2013 ISTC \u2013 CNR, Rome, Italy"}]},{"given":"Carlo","family":"Cottone","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology for Translational neuroScience (LET\u2019S) \u2013 ISTC \u2013 CNR, Rome, Italy"}]},{"given":"Alessandro","family":"Giordani","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences &amp; Orthopedics, Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy\/Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy"}]},{"given":"Simone","family":"Migliore","sequence":"additional","affiliation":[{"name":"Clinical Psychology Service, University Campus Bio-Medico, Rome, Italy\/LIRH Foundation, Rome, Italy"}]},{"given":"Domenico","family":"Lupoi","sequence":"additional","affiliation":[{"name":"Neuroscience and Imaging, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy"}]},{"given":"Camillo","family":"Porcaro","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology for Translational neuroScience (LET\u2019S) \u2013 ISTC \u2013 CNR, Rome, Italy"}]},{"given":"Massimiliano","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences &amp; Orthopedics, Institute of Neurology, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Rome, Italy"}]},{"given":"Paolo Maria","family":"Rossini","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences &amp; Orthopedics, Institute of Neurology, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Rome, Italy"}]},{"given":"Maria Maddalena","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroscience and Imaging, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy"}]},{"given":"Franca","family":"Tecchio","sequence":"additional","affiliation":[{"name":"Laboratory of Electrophysiology for Translational neuroScience (LET\u2019S) \u2013 ISTC \u2013 CNR, Rome, Italy"}]}],"member":"179","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70193-9"},{"key":"e_1_3_3_3_2","volume-title":"Fatigue guidelines development panel of the multiple sclerosis council for clinical practice guidelines. 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