{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:23:16Z","timestamp":1740176596096,"version":"3.37.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005954","name":"Children\u2019s Cancer Foundation","doi-asserted-by":"crossref","award":["ID0EQXAE123"],"award-info":[{"award-number":["ID0EQXAE123"]}],"id":[{"id":"10.13039\/501100005954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardio-Oncology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s40959-018-0035-0","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T00:40:50Z","timestamp":1545439250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers"],"prefix":"10.1186","volume":"4","author":[{"given":"Vivian Wing-yi","family":"Li","sequence":"first","affiliation":[]},{"given":"Anthony Pak-yin","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Karin Kar-Huen","family":"Ho","sequence":"additional","affiliation":[]},{"given":"Jeffrey Ping-Wa","family":"Yau","sequence":"additional","affiliation":[]},{"given":"Daniel Ka-leung","family":"Cheuk","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-4992","authenticated-orcid":false,"given":"Yiu-fai","family":"Cheung","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"35_CR1","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1200\/JCO.2005.12.121","volume":"23","author":"SE Lipshultz","year":"2005","unstructured":"Lipshultz SE, Lipsitz SR, Sallan SE, Dalton VM, Mone SM, Gelber RD, et al. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 2005;23:2629\u20136.","journal-title":"J Clin Oncol"},{"key":"35_CR2","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.echo.2007.04.007","volume":"20","author":"J Ganame","year":"2007","unstructured":"Ganame J, Claus P, Uyttebroeck A, Renard M, D\u2019hooge J, Bijnens B, et al. Myocardial dysfunction late after low-dose anthracycline treatment in asymptomatic pediatric patients. J Am Soc Echocardiogr. 2007;20:1351\u20138.","journal-title":"J Am Soc Echocardiogr"},{"key":"35_CR3","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/hrt.2010.194118","volume":"96","author":"YF Cheung","year":"2010","unstructured":"Cheung YF, Hong WJ, Chan GC, Wong SJ, Ha SY. Left ventricular myocardial deformation and mechanical dyssynchrony in children with normal ventricular shortening fraction after anthracycline therapy. Heart. 2010;96:1137\u201341.","journal-title":"Heart"},{"key":"35_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF02368505","volume":"20","author":"DA Kass","year":"1992","unstructured":"Kass DA, Kelly RP. Ventriculo-arterial coupling: concepts, assumptions, and applications. Ann Biomed Eng. 1992;20:41\u201362.","journal-title":"Ann Biomed Eng"},{"key":"35_CR5","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/0002-8703(93)90756-Y","volume":"125","author":"MR Starling","year":"1993","unstructured":"Starling MR. Left ventricular\u2013arterial coupling relations in the normal human heart. Am Heart J. 1993;125:1659\u201366.","journal-title":"Am Heart J"},{"key":"35_CR6","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1161\/CIRCULATIONAHA.116.024811","volume":"135","author":"MM Fidler","year":"2017","unstructured":"Fidler MM, Reulen RC, Henson K, Kelly J, Cutter D, Levitt GA, et al. Population based long-term cardiac-specific mortality among 34 489 five-year survivors of childhood cancer in Great Britain. Circulation. 2017;135:951\u201363.","journal-title":"Circulation"},{"key":"35_CR7","doi-asserted-by":"publisher","first-page":"b4606","DOI":"10.1136\/bmj.b4606","volume":"339","author":"DA Mulrooney","year":"2009","unstructured":"Mulrooney DA, Yeazel MW, Kawashima T, Mertens AC, Mitby P, Stovall M, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the childhood cancer survivor study cohort. BMJ. 2009;339:b4606.","journal-title":"BMJ"},{"key":"35_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.7326\/M15-0424","volume":"164","author":"DA Mulrooney","year":"2016","unstructured":"Mulrooney DA, Armstrong GT, Huang S, Ness KK, Ehrhardt MJ, Joshi VM, et al. Cardiac outcomes in a cohort of adult survivors of childhood cancer exposed to carditoxic therapy: a cross sectional study from St. Jude Lifetime cohort. Ann Intern Med. 2016;164:93\u2013101.","journal-title":"Ann Intern Med"},{"key":"35_CR9","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1161\/CIRCULATIONAHA.116.025778","volume":"135","author":"CJ Bright","year":"2017","unstructured":"Bright CJ, Hawkins MM, Guha J, Henson KE, Winter DL, Kelly JS, et al. Risk of cerebrovascular events in 178 962 five-year survivors of cancer diagnosed at 15 to 39 years of age: the TYACSS (teenage and young adult cancer survivor study). Circulation. 2017;135:1194\u2013210.","journal-title":"Circulation"},{"key":"35_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/10623320490904124","volume":"11","author":"V Kaushal","year":"2004","unstructured":"Kaushal V, Kaushal GP, Mehta P. Differential toxicity of anthracyclines on cultured endothelial cells. Endothelium. 2004;11:253\u20138.","journal-title":"Endothelium"},{"key":"35_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1200\/JCO.2009.23.8527","volume":"28","author":"N Chaosuwannakit","year":"2010","unstructured":"Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, et al. Aortic stiffness increases upon receipt of anthracycline chemotherapy. J Clin Oncol. 2010;28:166\u201372.","journal-title":"J Clin Oncol"},{"key":"35_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40885-015-0016-7","volume":"21","author":"SH Moon","year":"2015","unstructured":"Moon SH, Moon JC, Heo DH, Lim YH, Choi JH, Kim SY, et al. Increased pulse wave velocity and augmentation index after isometric handgrip exercise in patients with coronary artery disease. Clin Hypertens. 2015;21:5.","journal-title":"Clin Hypertens"},{"key":"35_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.amjcard.2013.10.050","volume":"113","author":"RH Chen","year":"2014","unstructured":"Chen RH, Wong SJ, Wong WH, Cheung YF. Arterial mechanics at rest and during exercise in adolescents and young adults after arterial switch operation for complete transposition of the great arteries. Am J Cardiol. 2014;113:713\u20138.","journal-title":"Am J Cardiol"},{"key":"35_CR14","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","volume":"111","author":"DL Mann","year":"2005","unstructured":"Mann DL, Bristow MR. Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation. 2005;111:2837\u201349.","journal-title":"Circulation"},{"key":"35_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1053\/euhj.2001.2614","volume":"22","author":"E Braunwald","year":"2001","unstructured":"Braunwald E. The Denolin lecture. Congestive heart failure: a half century perspective. Eur Heart J. 2001;22:825\u201336.","journal-title":"Eur Heart J"},{"key":"35_CR16","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1161\/01.CIR.84.6.2418","volume":"84","author":"JM Arnold","year":"1991","unstructured":"Arnold JM, Marchiori GE, Imrie JR, Burton GL, Plfugfelder PW, Kostuk WJ. Large artery function in patients with chronic heart failure: studies of brachial artery diameter and hemodynamics. Circulation. 1991;84:2418\u201325.","journal-title":"Circulation"},{"key":"35_CR17","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S0735-1097(02)01755-2","volume":"39","author":"C Giannattasio","year":"2002","unstructured":"Giannattasio C, Achilli F, Failla M, Capra A, Vincenzi A, Valagussa F, et al. Radial, carotid and aortic distensibility in congestive heart failure: effects of high-dose angiotensin-converting enzyme inhibitor or low-dose association with angiotensin type 1 receptor blockade. J Am Coll Cardiol. 2002;39:1275\u201382.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR18","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1161\/01.CIR.80.1.78","volume":"80","author":"T Hirai","year":"1989","unstructured":"Hirai T, Sasayama S, Kawasaki T, Yagi SI. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation. 1989;80:78\u201386.","journal-title":"Circulation"},{"key":"35_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1291\/hypres.30.219","volume":"30","author":"K Takazawa","year":"2007","unstructured":"Takazawa K, Kobayashi H, Shindo N, Tanaka N, Yamashina A. Relationship between radial and central arterial pulse wave and evaluation of central aortic pressure using the radial arterial pulse wave. Hypertens Res. 2007;30:219\u201328.","journal-title":"Hypertens Res"},{"key":"35_CR20","doi-asserted-by":"publisher","first-page":"681","DOI":"10.5603\/KP.2013.0154","volume":"71","author":"K Mizia-Stec","year":"2013","unstructured":"Mizia-Stec K, Goscinska A, Mizia M, Haberka M, Chmiel A, Poborski W, et al. Anthracycline chemotherapy impairs the structure and diastolic function of the left ventricle and induces negative arterial remodelling. Kardiol Pol. 2013;71:681\u201390.","journal-title":"Kardiol Pol"},{"key":"35_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12253-012-9589-6","volume":"19","author":"Z Jenei","year":"2013","unstructured":"Jenei Z, Bardi E, Magyar MT, Horvath A, Paragh G, Kiss C. Anthracycline causes impaired vascular endothelial function and aortic stiffness in long term survivors of childhood cancer. Pathol Oncol Res. 2013;19:375\u201383.","journal-title":"Pathol Oncol Res"},{"key":"35_CR22","first-page":"389","volume":"35","author":"V Herceg-Cavrak","year":"2011","unstructured":"Herceg-Cavrak V, Ahel V, Batinica M, Matee L, Kardo D. Increased arterial stiffness in children treated with anthracyclines for malignant disease. Coll Antropol. 2011;35:389\u201395.","journal-title":"Coll Antropol"},{"key":"35_CR23","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/pbc.25547","volume":"62","author":"JI Krystal","year":"2015","unstructured":"Krystal JI, Reppucci M, Mayr T, Fish JD, Sethna C. Arterial stiffness in childhood cancer survivors. Pediatr Blood Cancer. 2015;62:1832\u20137.","journal-title":"Pediatr Blood Cancer"},{"key":"35_CR24","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/pbc.24829","volume":"61","author":"DR Dengel","year":"2014","unstructured":"Dengel DR, Kelly AS, Zhange L, Hodges JS, Baker KS, Steinberger J. Signs of early sub-clinical atherosclerosis in childhood cancer survivors. Pediatr Blood Cancer. 2014;61:532\u20137.","journal-title":"Pediatr Blood Cancer"},{"key":"35_CR25","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/jch.12391","volume":"16","author":"E Gkaliagkousi","year":"2014","unstructured":"Gkaliagkousi E, Gavriilaki E, Nikolaidou B, Triantafyllou G, Douma S. Exercise-induced pulse wave velocity changes in untreated patients with essential hypertension: the effect of an angiotensin receptor antagonist. J Clin Hypertens. 2014;16:482\u20137.","journal-title":"J Clin Hypertens"},{"key":"35_CR26","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.ejca.2005.01.020","volume":"41","author":"LD Dorresteijn","year":"2004","unstructured":"Dorresteijn LD, Kappelle AC, Scholz NMJ, Munneke M, Scholma JT, Blam AJM, et al. Increased carotid wall thickening after radiotherapy on the neck. Eur J Cancer. 2004;41:1026\u201330.","journal-title":"Eur J Cancer"},{"key":"35_CR27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1136\/pgmj.2008.068569","volume":"84","author":"M Shariat","year":"2008","unstructured":"Shariat M, Alias NAA, Biswal BM. Radiation effects on the intima-media thickness of the common carotid artery in post-radiotherapy patients with head and neck malignancy. Postgrad Med J. 2008;84:609\u201312.","journal-title":"Postgrad Med J"},{"key":"35_CR28","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/pbc.22111","volume":"53","author":"KA Meeske","year":"2009","unstructured":"Meeske KA, Siegel SE, Gilsanz V, Bernstein L, Nelson MB, Sposto R, et al. Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation. Pediatr Blood Cancer. 2009;53:615\u201321.","journal-title":"Pediatr Blood Cancer"},{"key":"35_CR29","doi-asserted-by":"publisher","first-page":"9130","DOI":"10.1200\/JCO.2005.01.4092","volume":"23","author":"J Nuver","year":"2005","unstructured":"Nuver J, Smit AJ, van der Meer J, van den Berg MP, van der Graaf WT, Meinardi MT, et al. Acute chemotherapy-induced cardiovascular changes in patients with testicular cancer. J Clin Oncol. 2005;23:9130\u20137.","journal-title":"J Clin Oncol"},{"key":"35_CR30","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1006\/jmcc.2002.2110","volume":"34","author":"S Wu","year":"2002","unstructured":"Wu S, Ko Y, Teng M, Ko YL, Hsu LA, Hsueh C, et al. Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol. 2002;34:1595\u2013607.","journal-title":"J Mol Cell Cardiol"},{"key":"35_CR31","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1016\/S0024-3205(01)01352-2","volume":"69","author":"T Murata","year":"2001","unstructured":"Murata T, Yamawaki H, Yoshimoto R, Hori M, Sato K, Ozaki H, et al. Chronic effect of doxorubicin on vascular endothelium assess by organ culture study. Life Sci. 2001;69:2685\u201395.","journal-title":"Life Sci"},{"key":"35_CR32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.pcad.2010.06.007","volume":"53","author":"DB Sawyer","year":"2010","unstructured":"Sawyer DB, Peng X, Chen B, Pentassuglia L, Lim CC. Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog Cardiovasc Dis. 2010;53:105\u201313.","journal-title":"Prog Cardiovasc Dis"},{"key":"35_CR33","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0378-4274(01)00329-0","volume":"121","author":"S Zhou","year":"2001","unstructured":"Zhou S, Palmeira CM, Wallace KB. Doxorubicin-induced persistent oxidative stress to cardiac myocytes. Toxicol Lett. 2001;121:151\u20137.","journal-title":"Toxicol Lett"},{"key":"35_CR34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1191\/1358863x03vm476oa","volume":"8","author":"D Duquaine","year":"2003","unstructured":"Duquaine D, Hirsch GA, Chakrabarti A, Han Z, Kehrer C, Brook R, et al. Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase. Vasc Med. 2003;8:101\u20137.","journal-title":"Vasc Med"},{"key":"35_CR35","doi-asserted-by":"publisher","first-page":"H1466","DOI":"10.1152\/ajpheart.00795.2008","volume":"296","author":"P Mukhopadhyay","year":"2009","unstructured":"Mukhopadhyay P, Pajesh M, Batkai S, Kashiwaya Y, Hasko G, Liaudet L, et al. Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol. 2009;296:H1466\u201383.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"35_CR36","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1200\/JCO.2005.03.5956","volume":"24","author":"AY Chow","year":"2006","unstructured":"Chow AY, Chin C, Dahl G, Rosenthal DN. Anthracyclines cause endothelial injury in pediatric cancer patients: a pilot study. J Clin Oncol. 2006;24:925\u20138.","journal-title":"J Clin Oncol"},{"issue":"suppl 1","key":"35_CR37","first-page":"III27","volume":"109","author":"J Davigon","year":"2004","unstructured":"Davigon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(suppl 1):III27\u201332.","journal-title":"Circulation"},{"key":"35_CR38","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1161\/hc0202.101970","volume":"105","author":"IB Wilkinson","year":"2002","unstructured":"Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR. Nitric oxide regulates local arterial distensibility in vivo. Circulation. 2002;105:213\u20137.","journal-title":"Circulation"},{"key":"35_CR39","doi-asserted-by":"publisher","first-page":"17179","DOI":"10.1074\/jbc.M111604200","volume":"277","author":"S Kotamraju","year":"2002","unstructured":"Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B. Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis. J Biol Chem. 2002;277:17179\u201387.","journal-title":"J Biol Chem"},{"key":"35_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10522-013-9477-9","volume":"15","author":"A Bielak-Zmijewska","year":"2014","unstructured":"Bielak-Zmijewska A, Knuk M, Przybylska D, Grabowska W, Lewinska A, Alster O, et al. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta. Biogerontology. 2014;15:47\u201364.","journal-title":"Biogerontology"},{"key":"35_CR41","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.2147\/OTT.S126852","volume":"10","author":"I Mozos","year":"2017","unstructured":"Mozos I, Borzak G, Caraba A, Mihaescu R. Arterial stiffness in hematologic malignancies. Onco Targets Ther. 2017;10:1381\u20138.","journal-title":"Onco Targets Ther"},{"key":"35_CR42","first-page":"451","volume":"18","author":"VW Li","year":"2017","unstructured":"Li VW, Cheuk DK, Cheng FW, Yang JY, Yau JP, Ho KK, et al. Myocardial stiffness as assessed by diastolic wall strain in adult survivors of childhood leukaemias with preserved left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. 2017;18:451\u20138.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"35_CR43","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.jacc.2010.09.063","volume":"56","author":"SL Roche","year":"2011","unstructured":"Roche SL, Vogel M, Pitkanen O, Grant B, Slorach C, Fackoury C, et al. Isovolumic acceleration at rest and during exercise in children. J Am Coll Cardiol. 2011;56:1100\u20137.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR44","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.jcmg.2015.11.024","volume":"9","author":"HK Narayan","year":"2016","unstructured":"Narayan HK, French B, Khan AM, Plappert T, Hyman D, Bajulaiye A, et al. Noninvasive measures of ventricular-arterial coupling and circumferential strain predict cancer therapeutics-related cardiac dysfunction. J Am Coll Cardiol Img. 2016;9:1131\u201341.","journal-title":"J Am Coll Cardiol Img"},{"key":"35_CR45","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.jacc.2007.10.065","volume":"51","author":"SS Najjar","year":"2008","unstructured":"Najjar SS, Scuteri A, Shetty V, Wright JG, Muller DC, Fleg JL, et al. Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore longitudinal study of aging. J Am Coll Cardiol. 2008;51:1377\u201383.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR46","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1200\/JCO.2013.49.3205","volume":"31","author":"GT Armstrong","year":"2013","unstructured":"Armstrong GT, Oeffinger KC, Chen Y, Kawashima T, Yasui Y, Leisenring W, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31:3673\u201380.","journal-title":"J Clin Oncol"}],"container-title":["Cardio-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-018-0035-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40959-018-0035-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40959-018-0035-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T19:26:10Z","timestamp":1576956370000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiooncologyjournal.biomedcentral.com\/articles\/10.1186\/s40959-018-0035-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["35"],"URL":"https:\/\/doi.org\/10.1186\/s40959-018-0035-0","relation":{},"ISSN":["2057-3804"],"issn-type":[{"type":"electronic","value":"2057-3804"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"19 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All subjects gave written informed consent to participate in this study, which was approved by the Institutional Review Board of the University of Hong Kong\/ Hospital Authority West Cluster, Hong Kong. Ethical approval reference number UW 15-247.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent to participate in the study and the publication of research findings has been obtained from adult participants and the parents of minors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"9"}}