{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:11:41Z","timestamp":1776013901080,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007130","name":"Okazaki National Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007130","name":"Okazaki National Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","award":["150238"],"award-info":[{"award-number":["150238"]}],"id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K15147"],"award-info":[{"award-number":["17K15147"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25113002"],"award-info":[{"award-number":["25113002"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185050","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T20:05:37Z","timestamp":1505851537000},"page":"e0185050","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Probing the stochastic property of endoreduplication in cell size determination of Arabidopsis thaliana leaf epidermal tissue"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-4567","authenticated-orcid":true,"given":"Kensuke","family":"Kawade","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-4538","authenticated-orcid":true,"given":"Hirokazu","family":"Tsukaya","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1245075","DOI":"10.1126\/science.1245075","article-title":"Cell biology. On being the right (cell) size","volume":"348","author":"MB Ginzberg","year":"2015","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature08054","article-title":"Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle","volume":"459","author":"SG Martin","year":"2009","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature08074","article-title":"A spatial gradient coordinates cell size and mitotic entry in fission yeast","volume":"459","author":"JB Moseley","year":"2009","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.1174294","article-title":"Cell growth and size homeostasis in proliferating animal cells","volume":"325","author":"A Tzur","year":"2009","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/j.cub.2015.10.008","article-title":"Active control of cell size generates spatial detail during plant organogenesis","volume":"25","author":"A Serrano-Mislata","year":"2015","journal-title":"Curr Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.bpj.2013.10.033","article-title":"Analytic approaches to stochastic gene expression in multicellular systems","volume":"105","author":"AN Boettiger","year":"2013","journal-title":"Biophys J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e19131","DOI":"10.7554\/eLife.19131","article-title":"Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the <italic>Arabidopsis<\/italic> sepal","volume":"6","author":"HM Meyer","year":"2017","journal-title":"eLife"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.bpj.2017.04.050","article-title":"Analysis of noise mechanisms in cell-size control","volume":"112","author":"S Modi","year":"2017","journal-title":"Biophys J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1003957","DOI":"10.1371\/journal.pcbi.1003957","article-title":"Live imaging-based model selection reveals periodic regulation of the stochastic G1\/S phase transition in vertebrate axial development","volume":"10","author":"M Sugiyama","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1000367","DOI":"10.1371\/journal.pbio.1000367","article-title":"Variability in the control of cell division underlies sepal epidermal patterning in <italic>Arabidopsis thaliana<\/italic>","volume":"8","author":"AH Roeder","year":"2010","journal-title":"PLoS Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1002952","DOI":"10.1371\/journal.pcbi.1002952","article-title":"Spatial pattern dynamics of 3D stem cell loss of pluripotency via rules-based computational modeling","volume":"9","author":"DE White","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04599","article-title":"Stochastic protein expression in individual cells at the single molecule level","volume":"440","author":"L Cai","year":"2006","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic gene expression in a single cell","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"168302","DOI":"10.1103\/PhysRevLett.97.168302","article-title":"Linking stochastic dynamics to population distribution: an analytical framework of gene expression","volume":"97","author":"N Friedman","year":"2006","journal-title":"Phys Rev Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1469-8137.2010.03514.x","article-title":"Epidermis: the formation and functions of a fundamental plant tissue","volume":"189","author":"M Javelle","year":"2011","journal-title":"New Phytol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.arplant.47.1.351","article-title":"What chimeras can tell us about plant development","volume":"47","author":"EJ Szymkowiak","year":"1996","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0168-9525(89)90101-7","article-title":"Genetic mosaics and cell lineage analysis in plants","volume":"5","author":"S Poethig","year":"1989","journal-title":"Trends Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/aob\/mcs005","article-title":"Spatiotemporal variation of leaf epidermal cell growth: a quantitative analysis of <italic>Arabidopsis thaliana<\/italic> wild-type and triple <italic>cyclinD3<\/italic> mutant plants","volume":"109","author":"J Elsner","year":"2012","journal-title":"Ann Bot"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1105\/tpc.5.11.1661","article-title":"Relationship between endopolyploidy and cell size in epidermal tissue of Arabidopsis","volume":"5","author":"JE Melaragno","year":"1993","journal-title":"Plant Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.cub.2013.03.044","article-title":"ANGUSTIFOLIA3 signaling coordinates proliferation between clonally distinct cells in leaves","volume":"23","author":"K Kawade","year":"2013","journal-title":"Curr Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1001531","DOI":"10.1371\/journal.pbio.1001531","article-title":"Synthesis of very-long-chain fatty acids in the epidermis controls plant organ growth by restricting cell proliferation","volume":"11","author":"T Nobusawa","year":"2013","journal-title":"PLoS Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature05618","article-title":"The epidermis both drives and restricts plant shoot growth","volume":"446","author":"S Savaldi-Goldstein","year":"2007","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.devcel.2011.11.011","article-title":"Exit from proliferation during leaf development in <italic>Arabidopsis thaliana<\/italic>: a not-so-gradual process","volume":"22","author":"M Andriankaja","year":"2012","journal-title":"Dev Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/dbio.1999.9443","article-title":"Cell cycling and cell enlargement in developing leaves of <italic>Arabidopsis<\/italic>","volume":"215","author":"PM Donnelly","year":"1999","journal-title":"Dev Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/pcp\/pcq051","article-title":"The mechanism of cell cycle arrest front progression explained by a KLUH\/CYP78A5-dependent mobile growth factor in developing leaves of <italic>Arabidopsis thaliana<\/italic>","volume":"51","author":"T Kazama","year":"2010","journal-title":"Plant Cell Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pbi.2010.10.006","article-title":"Developmental control of endocycles and cell growth in plants","volume":"13","author":"C Breuer","year":"2010","journal-title":"Curr Opin Plant Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fpls.2014.00362","article-title":"Leaf development: a cellular perspective","volume":"5","author":"S Kalve","year":"2014","journal-title":"Front Plant Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1242\/dev.130021","article-title":"The coordination of ploidy and cell size differs between cell layers in leaves","volume":"143","author":"Y Katagiri","year":"2016","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1105\/tpc.104.024398","article-title":"The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis","volume":"16","author":"V Boudolf","year":"2004","journal-title":"Plant Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1104\/pp.109.140269","article-title":"CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset","volume":"150","author":"V Boudolf","year":"2009","journal-title":"Plant Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.devcel.2016.06.016","article-title":"Variable cell growth yields reproducible organ development through spatiotemporal averaging","volume":"38","author":"L Hong","year":"2016","journal-title":"Dev Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1038\/emboj.2013.197","article-title":"Differential proliferation rates generate patterns of mechanical tension that orient tissue growth","volume":"32","author":"Y Mao","year":"2013","journal-title":"EMBO J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bpj.2010.04.049","article-title":"Analysis of kinetic intermediates in single-particle dwell-time distributions","volume":"99","author":"DL Floyd","year":"2010","journal-title":"Biophys J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0006-3495(03)74648-7","article-title":"General methods for analysis of sequential &quot;n-step&quot; kinetic mechanisms: application to single turnover kinetics of helicase-catalyzed DNA unwinding","volume":"85","author":"AL Lucius","year":"2003","journal-title":"Biophys J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1105\/tpc.105.037309","article-title":"The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in <italic>Arabidopsis<\/italic> endoreduplication","volume":"18","author":"KK Imai","year":"2006","journal-title":"Plant Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4161\/psb.5.9.12479","article-title":"How does the plant proteasome control leaf size?","volume":"5","author":"K Sako","year":"2010","journal-title":"Plant Signal Behav"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-313X.2009.03932.x","article-title":"Regulation of leaf organ size by the Arabidopsis RPT2a 19S proteasome subunit","volume":"60","author":"Y Sonoda","year":"2009","journal-title":"Plant J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"Quantifying <italic>E<\/italic>. <italic>coli<\/italic> proteome and transcriptome with single-molecule sensitivity in single cells","volume":"329","author":"Y Taniguchi","year":"2010","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e0134547","DOI":"10.1371\/journal.pone.0134547","article-title":"Stimulation of cell elongation by tetraploidy in hypocotyls of dark-grown Arabidopsis seedlings","volume":"10","author":"H Narukawa","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"17809","DOI":"10.1073\/pnas.1000852107","article-title":"Impact of natural genetic variation on the transcriptome of autotetraploid Arabidopsis thaliana","volume":"107","author":"Z Yu","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/jxb\/erm052","article-title":"A model describing cell polyploidization in tissues of growing fruit as related to cessation of cell proliferation","volume":"58","author":"N Bertin","year":"2007","journal-title":"J. Exp. Bot"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cub.2016.03.004","article-title":"A mechanical feedback restricts sepal growth and shape in <italic>Arabidopsis<\/italic>","volume":"26","author":"N Hervieux","year":"2016","journal-title":"Curr Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1105\/tpc.111.084160","article-title":"Pause-and-stop: the effects of osmotic stress on cell proliferation during early leaf development in <italic>Arabidopsis<\/italic> and a role for ethylene signaling in cell cycle arrest","volume":"23","author":"A Skirycz","year":"2011","journal-title":"Plant Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature02257","article-title":"Summing up the noise in gene networks","volume":"427","author":"J Paulsson","year":"2004","journal-title":"Nature"},{"key":"ref45","first-page":"636","article-title":"Nature Genet","volume":"38","author":"A Bar-Even","year":"2006","journal-title":"Nature Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:47:00Z","timestamp":1588963620000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185050"}},"subtitle":[],"editor":[{"given":"Natalia L.","family":"Komarova","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,9,19]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185050","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,19]]}}}