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Here we explore terminal cell fate establishment during homeostasis using the enteroendocrine cells (\n                    <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\n                    s) of the adult\n                    <jats:italic>Drosophila<\/jats:italic>\n                    midgut as a paradigm. Our data argue against the existence of local feedback signals, and we identify Numb as an intrinsic regulator of\n                    <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\n                    fate. Our data further indicate that Numb, with alpha\u2010adaptin, acts upstream or in parallel of known regulators of\n                    <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\n                    fate to limit Notch signaling, thereby facilitating\n                    <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\n                    fate acquisition. We find that Numb is regulated in part through its asymmetric and symmetric distribution during stem cell divisions; however, its\n                    <jats:italic>de novo<\/jats:italic>\n                    synthesis is also required during the differentiation of the\n                    <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\n                    cell. Thus, this work identifies Numb as a crucial factor for cell fate choice in the adult\n                    <jats:italic>Drosophila<\/jats:italic>\n                    intestine. Furthermore, our findings demonstrate that cell\u2010intrinsic control mechanisms of terminal cell fate acquisition can result in a balanced tissue\u2010wide production of terminally differentiated cell types.\n                  <\/jats:p>","DOI":"10.15252\/embj.201695622","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T20:10:39Z","timestamp":1495483839000},"page":"1928-1945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Intrinsic regulation of enteroendocrine fate by Numb"],"prefix":"10.1038","volume":"36","author":[{"given":"J\u00e9r\u00e9my","family":"Sall\u00e9","sequence":"first","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris France"}]},{"given":"Louis","family":"Gervais","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris France"}]},{"given":"Benjamin","family":"Boumard","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris France"},{"name":"D\u00e9partement de Biologie \u00c9cole Normale Sup\u00e9rieure de Lyon Lyon France"}]},{"given":"Marine","family":"Stefanutti","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris France"}]},{"given":"Katarzyna","family":"Siudeja","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-4465","authenticated-orcid":false,"given":"Allison J","family":"Bardin","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University CNRS UMR 3215, INSERM U934 Stem Cells and Tissue Homeostasis Group Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 6 Paris 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