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It had been reported that BBB injury is one of\nthe main risk factors for early death in patients with cerebral ischemia. Numerous investigations focus\non the study of BBB injury which have been carried out.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The objective of this study was to investigate the treatment function of the activation of the\nHippo\/Yes-Associated Protein (YAP) signaling pathway by combined Ischemic Preconditioning (IPC)\nand resveratrol (RES) before brain Ischemia\/Reperfusion (BI\/R) improves Blood-Brain Barrier (BBB)\ndisruption in rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Sprague-Dawley (SD) rats were pretreated with 20 mg\/kg RES and IPC and then subjected\nto 2 h of ischemia and 22 h of reperfusion. The cerebral tissues were collected; the cerebral infarct\nvolume was determined; the Evans Blue (EB) level, the brain Water Content (BWC), and apoptosis\nwere assessed; and the expressions of YAP and TAZ were investigated in cerebral tissues.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Both IPC and RES preconditioning reduced the cerebral infarct size, improved BBB permeability,\nlessened apoptosis, and upregulated expressions of YAP and transcriptional co-activator with\nPDZ-binding motif (TAZ) compared to the Ischemia\/Reperfusion (I\/R) group, while combined IPC\nand RES significantly enhanced this action.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>combined ischemic preconditioning and resveratrol improved blood-brain barrier breakdown\nvia Hippo\/YAP\/TAZ signaling pathway.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871527318666191021144126","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T11:36:51Z","timestamp":1574077011000},"page":"713-722","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Combined Ischemic Preconditioning and Resveratrol Improved Bloodbrain Barrier Breakdown <i>via<\/i> Hippo\/YAP\/TAZ Signaling Pathway"],"prefix":"10.2174","volume":"18","author":[{"given":"Ganji","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China"}]},{"given":"Ying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhejiang Chinese Medical University, The Third Clinical Medicine, Hangzhou, Zhejiang, China"}]},{"given":"Yali","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China"}]},{"given":"Jianer","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}]},{"given":"Fei","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China"}]},{"given":"Qilin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"Zhao B.","year":"2011","unstructured":"Zhao B.; Tumaneng K.; Guan K.L.; The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. 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