{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:40:30Z","timestamp":1776109230406,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:00:00Z","timestamp":1613260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773279"],"award-info":[{"award-number":["81773279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2016A050502015"],"award-info":[{"award-number":["2016A050502015"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2013B021800062"],"award-info":[{"award-number":["2013B021800062"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2012B061700082"],"award-info":[{"award-number":["2012B061700082"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012678","name":"Young Teacher Foundation of Sun Yat-sen University","doi-asserted-by":"publisher","award":["17ykzd33"],"award-info":[{"award-number":["17ykzd33"]}],"id":[{"id":"10.13039\/501100012678","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Breast cancer is the second leading cause of death in women, thus a reliable prognostic model for overall survival (OS) in breast cancer is needed to improve treatment and care. Ferroptosis is an iron-dependent cell death. It is already known that siramesine and lapatinib could induce ferroptosis in breast cancer cells, and some ferroptosis-related genes were closely related with the outcomes of treatments regarding breast cancer. The relationship between these genes and the prognosis of OS remains unclear. The data of gene expression and related clinical information was downloaded from public databases. Based on the TCGA-BRCA cohort, an 8-gene prediction model was established with the least absolute shrinkage and selection operator (LASSO) cox regression, and this model was validated in patients from the METABRIC cohort. Based on the median risk score obtained from the 8-gene model, patients were stratified into high- or low-risk groups. Cox regression analyses identified that the risk score was an independent predictor for OS. The findings from CIBERSORT and ssGSEA presented noticeable differences in enrichment scores for immune cells and pathways between the abovementioned two risk groups. To sum up, this prediction model has potential to be widely applied in future clinical settings.<\/jats:p>","DOI":"10.3390\/biology10020151","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T08:53:56Z","timestamp":1613292836000},"page":"151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Novel Ferroptosis-Related Gene Signature Predicts Overall Survival of Breast Cancer Patients"],"prefix":"10.3390","volume":"10","author":[{"given":"Haifeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"given":"Cong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"given":"Riqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"given":"Anqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"given":"Xin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-8049","authenticated-orcid":false,"given":"Yanxia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China"},{"name":"State Key Laboratory of Oncology in South China, Guangzhou 510060 Guangdong, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10549-015-3383-6","article-title":"A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer","volume":"151","author":"Diaby","year":"2015","journal-title":"Breast Cancer Res. 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