{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:12:47Z","timestamp":1773259967517,"version":"3.50.1"},"reference-count":123,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2013-44739 and SAF2016-76504-R"],"award-info":[{"award-number":["SAF2013-44739 and SAF2016-76504-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERONC 16\/12\/00295"],"award-info":[{"award-number":["CIBERONC 16\/12\/00295"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Worldwide Cancer Research","award":["AICR-12-1057 and WWCR-16-0295"],"award-info":[{"award-number":["AICR-12-1057 and WWCR-16-0295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stress, cells evoke an adaptive signalling network, the unfolded protein response (UPR), aimed at recovering protein homeostasis. Tumour cells must confront intrinsic and extrinsic pressures during cancer progression that produce a proteostasis imbalance and ER stress. To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. UPR activation has been documented in most types of human tumours and accumulating evidence supports a crucial role for UPR in the establishment, progression, metastasis and chemoresistance of tumours as well as its involvement in the acquisition of other hallmarks of cancer. In this review, we will analyse the role of UPR in cancer development highlighting the ability of tumours to exploit UPR signalling to promote epithelial-mesenchymal transition (EMT).<\/jats:p>","DOI":"10.3390\/jcm8050624","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:22:35Z","timestamp":1557400955000},"page":"624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["UPR: An Upstream Signal to EMT Induction in Cancer"],"prefix":"10.3390","volume":"8","author":[{"given":"Patricia G.","family":"Santamar\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, 28029 Madrid, Spain"},{"name":"IdiPAZ, 28029 Madrid, Spain"},{"name":"CIBERONC, 28029 Madrid, Spain"}]},{"given":"Mar\u00eda J.","family":"Maz\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, 28029 Madrid, Spain"},{"name":"IdiPAZ, 28029 Madrid, Spain"}]},{"given":"Pilar","family":"Eraso","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, 28029 Madrid, Spain"},{"name":"IdiPAZ, 28029 Madrid, Spain"}]},{"given":"Francisco","family":"Portillo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, 28029 Madrid, Spain"},{"name":"IdiPAZ, 28029 Madrid, Spain"},{"name":"CIBERONC, 28029 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb0805-766","article-title":"ERAD: The long road to destruction","volume":"7","author":"Meusser","year":"2005","journal-title":"Nat. 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