{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:59:24Z","timestamp":1769075964546,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002811","name":"Cathay General Hospital","doi-asserted-by":"publisher","award":["105CGH-TMU-05"],"award-info":[{"award-number":["105CGH-TMU-05"]}],"id":[{"id":"10.13039\/501100002811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["105CGH-TMU-05"],"award-info":[{"award-number":["105CGH-TMU-05"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium (SOC) channels, which control calcium signaling and cell proliferation pathways. Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. However, the clinical relevance of STIM1 in breast cancer is still unclear. Here, we recruited 348 breast cancer patients and conducted a genetic association study to address this question. Four tagging germline single nucleotide variants (SNVs) in STIM1 were selected and RNA sequencing data of 525 breast cancer samples from The Cancer Genome Atlas (TCGA) database were evaluated. The results show that rs2304891 and rs3750996 were correlated with clinical stage of breast cancer. Expression quantitative trait loci (eQTL) analysis indicated that risk G allele of STIM1 contributed to the higher expression of STIM1. In addition, we found an increased risk of rs2304891 G allele and rs3750996 A allele in estrogen receptor (ER) positive and progesterone receptor (PR) positive patients. In conclusion, our results suggest that germline SNV, rs2304891 and rs3750996 as well as STIM1 expression are important biomarkers for the prediction of clinical outcomes in breast cancer patients.<\/jats:p>","DOI":"10.3390\/jpm10040287","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T21:21:49Z","timestamp":1608240109000},"page":"287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Germline Genetic Association between Stromal Interaction Molecule 1 (STIM1) and Clinical Outcomes in Breast Cancer Patients"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-4776","authenticated-orcid":false,"given":"Chi-Cheng","family":"Huang","sequence":"first","affiliation":[{"name":"Comprehensive Breast Health Center, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"School of Public Health, College of Public Health, National Taiwan University, Taipei 10617, Taiwan"},{"name":"Department of Surgery, Cathay General Hospital, Taipei 106, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-1984","authenticated-orcid":false,"given":"Min-Rou","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"}]},{"given":"Yu-Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}]},{"given":"Yu-Wen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Academia Sinica, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Medicine, The University of Chicago, Chicago, IL 60611, USA"}]},{"given":"Henry Sung-Ching","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"}]},{"given":"Wei-Chiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei 23561, Taiwan"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7314\/APJCP.2016.17.S3.43","article-title":"Incidence and Mortality and Epidemiology of Breast Cancer in the World","volume":"17","author":"Ghoncheh","year":"2016","journal-title":"Asian Pac. 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