{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:02:49Z","timestamp":1775869369868,"version":"3.50.1"},"reference-count":86,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007694","name":"AVRDC - The World Vegetable Center","doi-asserted-by":"publisher","award":["WKO #10000379"],"award-info":[{"award-number":["WKO #10000379"]}],"id":[{"id":"10.13039\/100007694","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rural Development Administration, Republic of Korea","award":["No. PJ01324302"],"award-info":[{"award-number":["No. PJ01324302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Type-2 diabetes mellitus is one of the most prevalent metabolic diseases in the world, and is characterized by hyperglycemia (i.e., high levels of glucose in the blood). Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects. Therefore, the development of inhibitors from natural products offers an alternative option for the control of hyperglycemia. In recent years, various studies have been conducted to identify alpha-glucosidases inhibitors from natural sources such as plants, and many candidates have transpired to be secondary metabolites including alkaloids, flavonoids, phenols, and terpenoids. In this review, we focus on the alpha-glucosidases inhibitors found in common vegetable crops and the major classes of phytochemicals responsible for the inhibitory activity, and also as potential\/natural drug candidates for the treatment of type-2 diabetes mellitus. In addition, possible breeding strategies for production of improved vegetable crops with higher content of the inhibitors are also described.<\/jats:p>","DOI":"10.3390\/plants9010002","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:23:12Z","timestamp":1577071392000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables"],"prefix":"10.3390","volume":"9","author":[{"given":"Samuel Tilahun","family":"Assefa","sequence":"first","affiliation":[{"name":"National Institute of Horticultural and Herbal Science (NIHHS), Rural Development Administration (RDA), Wanju-gun, Jellabuk-do 55365, Korea"},{"name":"Department of Horticulture, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju-si, Jeollabuk-do 54896, Korea"}]},{"given":"Eun-Young","family":"Yang","sequence":"additional","affiliation":[{"name":"National Institute of Horticultural and Herbal Science (NIHHS), Rural Development Administration (RDA), Wanju-gun, Jellabuk-do 55365, Korea"}]},{"given":"Soo-Young","family":"Chae","sequence":"additional","affiliation":[{"name":"National Institute of Horticultural and Herbal Science (NIHHS), Rural Development Administration (RDA), Wanju-gun, Jellabuk-do 55365, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-2786","authenticated-orcid":false,"given":"Mihye","family":"Song","sequence":"additional","affiliation":[{"name":"World Vegetable Center Korea Office (WKO), Wanju-gun, Jellabuk-do 55365, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-5702","authenticated-orcid":false,"given":"Jundae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Horticulture, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju-si, Jeollabuk-do 54896, Korea"}]},{"given":"Myeong-Cheoul","family":"Cho","sequence":"additional","affiliation":[{"name":"National Institute of Horticultural and Herbal Science (NIHHS), Rural Development Administration (RDA), Wanju-gun, Jellabuk-do 55365, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-3480","authenticated-orcid":false,"given":"Seonghoe","family":"Jang","sequence":"additional","affiliation":[{"name":"World Vegetable Center Korea Office (WKO), Wanju-gun, Jellabuk-do 55365, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.sbi.2005.10.008","article-title":"Recent structural insights into the expanding world of carbohydrate-active enzymes","volume":"15","author":"Davies","year":"2005","journal-title":"Curr. 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