{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:29:55Z","timestamp":1772252995700,"version":"3.50.1"},"reference-count":147,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["GUP-2016-059"],"award-info":[{"award-number":["GUP-2016-059"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Mass-spectrometry-based and X-ray fluorescence-based techniques have allowed the study of the distribution of Zn2+ ions at extracellular and intracellular levels over the past few years. However, there are some issues during purification steps, sample preparation, suitability for quantification, and the instruments\u2019 availability. Therefore, work on fluorescent sensors based on 8-aminoquinoline as tools to detect Zn2+ ions in environmental and biological applications has been popular. Introducing various carboxamide groups into an 8-aminoquinoline molecule to create 8-amidoquinoline derivatives to improve water solubility and cell membrane permeability is also a recent trend. This review aims to present a general overview of the fluorophore 8-aminoquinoline and its derivatives as Zn2+ receptors for zinc sensor probes. Various fluorescent chemosensor designs based on 8-amidoquinoline and their effectiveness and potential as a recognition probe for zinc analysis were discussed. Based on this review, it can be concluded that derivatives of 8-amidoquinoline have vast potential as functional receptors for zinc ions primarily because of their fast reactivity, good selectivity, and bio-compatibility, especially for biological applications. To better understand the Zn2+ ion fluorophores\u2019 function, diversity of the coordination complex and geometries need further studies. This review provides information in elucidating, designing, and exploring new 8-amidoquinoline derivatives for future studies for the improvement of chemosensors that are selective and sensitive to Zn2+.<\/jats:p>","DOI":"10.3390\/s21010311","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T10:35:12Z","timestamp":1609842912000},"page":"311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The Role of 8-Amidoquinoline Derivatives as Fluorescent Probes for Zinc Ion Determination"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-877X","authenticated-orcid":false,"given":"Nur Syamimi","family":"Mohamad","sequence":"first","affiliation":[{"name":"Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"given":"Nur Hanis","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Faculty of Science &amp; Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"given":"Nurulhaidah","family":"Daud","sequence":"additional","affiliation":[{"name":"Pusat GENIUS@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"given":"Ling Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"given":"Goh Choo","family":"Ta","sequence":"additional","affiliation":[{"name":"Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"given":"Lee Yook","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Faculty of Science &amp; Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-4290","authenticated-orcid":false,"given":"Nurul Izzaty","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Faculty of Science &amp; Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1039\/b609548h","article-title":"Design of fluorescent materials for chemical sensing","volume":"36","year":"2007","journal-title":"Chem. 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