{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:20:36Z","timestamp":1772749236407,"version":"3.50.1"},"reference-count":64,"publisher":"The Company of Biologists","issue":"18","license":[{"start":{"date-parts":[[1999,9,15]],"date-time":"1999-09-15T00:00:00Z","timestamp":937353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In the developing vertebrate nervous system, both neural crest and sensory neurons form at the boundary between non-neural ectoderm and the neural plate. From an in situ hybridization based expression analysis screen, we have identified a novel zebrafish mutation, narrowminded (nrd), which reduces the number of early neural crest cells and eliminates Rohon-Beard (RB) sensory neurons. Mosaic analysis has shown that the mutation acts cell autonomously suggesting that nrd is involved in either the reception or interpretation of signals at the lateral neural plate boundary. Characterization of the mutant phenotype indicates that nrd is required for a primary wave of neural crest cell formation during which progenitors generate both RB sensory neurons and neural crest cells. Moreover, the early deficit in neural crest cells in nrd homozygotes is compensated later in development. Thus, we propose that a later wave can compensate for the loss of early neural crest cells but, interestingly, not the RB sensory neurons. We discuss the implications of these findings for the possibility that RB sensory neurons and neural crest cells share a common evolutionary origin.<\/jats:p>","DOI":"10.1242\/dev.126.18.3969","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:44:02Z","timestamp":1619408642000},"page":"3969-3979","source":"Crossref","is-referenced-by-count":87,"title":["Zebrafish <i>narrowminded<\/i> suggests a genetic link between formation of neural crest and primary sensory neurons"],"prefix":"10.1242","volume":"126","author":[{"given":"Kristin Bruk","family":"Artinger","sequence":"first","affiliation":[{"name":"1 Cardiovascular Research Center, Massachusetts General Hospital\/Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA"},{"name":"2 Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA"}]},{"given":"Ajay B.","family":"Chitnis","sequence":"additional","affiliation":[{"name":"1 Cardiovascular Research Center, Massachusetts General Hospital\/Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA"}]},{"given":"Mark","family":"Mercola","sequence":"additional","affiliation":[{"name":"2 Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA"}]},{"given":"Wolfgang","family":"Driever","sequence":"additional","affiliation":[{"name":"1 Cardiovascular Research Center, Massachusetts General Hospital\/Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA"}]}],"member":"237","published-online":{"date-parts":[[1999,9,15]]},"reference":[{"key":"2023090607474617000_DEVELOP_126_18_3969C1","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1523\/JNEUROSCI.14-06-03475.1994","article-title":"Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head","volume":"6","author":"Akimenko","year":"1994","journal-title":"J. Neurosci"},{"key":"2023090607474617000_DEVELOP_126_18_3969C2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1242\/dev.125.3.371","article-title":"Regulation of neuronal specification in the zebrafish spinal cord by Delta function","volume":"135","author":"Appel","year":"1998","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0012-1606(92)90271-H","article-title":"Partial restriction in the developmental potential of late emigrating neural crest cells","volume":"149","author":"Artinger","year":"1992","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0925-4773(97)00132-9","article-title":"The origins of the neural crest. Part I: embryonic induction","volume":"69","author":"Baker","year":"1997","journal-title":"Mech. Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C5","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1242\/dev.124.16.3077","article-title":"Early-and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo","volume":"124","author":"Baker","year":"1997","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C6","first-page":"1","article-title":"Analyse experimentale de la regionalisaton et des capacites morphogenetiquers de la crete neurale chez l Amphibien Urodele Pleurodeles waltiii Michah","volume":"36","author":"Chibon","year":"1965","journal-title":"Mem. Soc. Fr. Zool"},{"key":"2023090607474617000_DEVELOP_126_18_3969C7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/375761a0","article-title":"Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta","volume":"375","author":"Chitnis","year":"1995","journal-title":"Nature"},{"key":"2023090607474617000_DEVELOP_126_18_3969C8","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0092-8674(93)90247-N","article-title":"Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos","volume":"73","author":"Coffman","year":"1993","journal-title":"Cell"},{"key":"2023090607474617000_DEVELOP_126_18_3969C9","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1242\/dev.124.12.2335","article-title":"Dorsoventral patterning of the vertebrate neural tube is conserved in a protochordate","volume":"124","author":"Corbo","year":"1997","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1242\/dev.123.1.37","article-title":"A genetic screen for mutations affecting embrogenesis in zebrafish","volume":"123","author":"Driever","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C11","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1242\/dev.121.7.2099","article-title":"Dorsalization of the neural tube by the non-neural ectoderm","volume":"121","author":"Dickinson","year":"1995","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000147529","article-title":"Cranial and spinal nerve organizations in amphioxus and lamreys: evidence for an ancestral craniate pattern","volume":"148","author":"Fritzsch","year":"1993","journal-title":"Acta Anat"},{"key":"2023090607474617000_DEVELOP_126_18_3969C13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S0896-6273(00)80989-7","article-title":"The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons","volume":"20","author":"Fode","year":"1998","journal-title":"Neuron"},{"key":"2023090607474617000_DEVELOP_126_18_3969C14","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1093\/emboj\/17.14.4029","article-title":"The SCL gene specifies haemangioblast development from early mesoderm","volume":"17","author":"Gering","year":"1998","journal-title":"EMBO J"},{"key":"2023090607474617000_DEVELOP_126_18_3969C15","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1073\/pnas.92.10.4557","article-title":"A conserved family of elav-like genes in vertebrates","volume":"92","author":"Good","year":"1995","journal-title":"Proc. Natn. Acad. Sci. USA"},{"key":"2023090607474617000_DEVELOP_126_18_3969C16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1242\/dev.125.3.359","article-title":"Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis","volume":"125","author":"Haddon","year":"1998","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/dev.123.1.1","article-title":"The identifcation of genes with unique and essential functions in the development of the zebrafish, Danio rerio","volume":"123","author":"Haffter","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(SICI)1520-6408(1996)18:1&lt;11::AID-DVG2&gt;3.0.CO;2-4","article-title":"Screen for mutations affecting development of Zebrafish neural crest","volume":"18","author":"Henion","year":"1996","journal-title":"Dev. Genet"},{"key":"2023090607474617000_DEVELOP_126_18_3969C19","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1242\/dev.122.9.2911","article-title":"Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest","volume":"122","author":"Holland","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1242\/dev.123.1.205","article-title":"Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio","volume":"123","author":"Jiang","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1242\/dev.123.1.369","article-title":"Analysis of neural crest develoment using zebrafish pigmentation mutations","volume":"123","author":"Kelsh","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0304-3940(97)00908-7","article-title":"Overexpression of neurogenin induces ectopic expression of HuC in zebrafish","volume":"239","author":"Kim","year":"1997","journal-title":"Neurosci. Lett"},{"key":"2023090607474617000_DEVELOP_126_18_3969C23","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1126\/science.3738507","article-title":"Cell recognition by neuronal growth cones in a simple vertebrate embryo","volume":"233","author":"Kuwada","year":"1986","journal-title":"Science"},{"key":"2023090607474617000_DEVELOP_126_18_3969C24","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/cne.901890208","article-title":"Rohon-Beard cells and other large neurons in Xenopus embryos originate during gastrulation","volume":"189","author":"Lamborghini","year":"1980","journal-title":"J. Comp. Neurol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/cne.902640105","article-title":"Disappearance of Rohon-Beard neurons from the spinal cord of larval Xenopus laevis","volume":"264","author":"Lamborghini","year":"1987","journal-title":"J. Comp. Neurol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C26","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1242\/dev.125.13.2403","article-title":"Neural crest induction in Xenopus: evidence for a two-signal model","volume":"13","author":"LaBonne","year":"1998","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C27","volume-title":"The Neural Crest","author":"Le Douarin","year":"1982"},{"key":"2023090607474617000_DEVELOP_126_18_3969C28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0925-4773(94)90062-0","article-title":"Expression of two zebrafish orthodenticle-related genes in the embryonic brain","volume":"3","author":"Li","year":"1994","journal-title":"Mech. Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C29","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0092-8674(95)90276-7","article-title":"Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm","volume":"82","author":"Liem","year":"1995","journal-title":"Cell"},{"key":"2023090607474617000_DEVELOP_126_18_3969C30","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0896-6273(00)80988-5","article-title":"neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia","volume":"20","author":"Ma","year":"1998","journal-title":"Neuron"},{"key":"2023090607474617000_DEVELOP_126_18_3969C31","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1101\/gad.13.13.1717","article-title":"Neurogenin1 and Neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia","volume":"13","author":"Ma","year":"1999","journal-title":"Genes Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0092-8674(00)81321-5","article-title":"Identification of neurogenin, a vertebrate neuronal determination gene","volume":"87","author":"Ma","year":"1996","journal-title":"Cell"},{"key":"2023090607474617000_DEVELOP_126_18_3969C33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/dbio.1997.8634","article-title":"Role of FGF and noggin in neural crest induction","volume":"189","author":"Mayor","year":"1997","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C34","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1242\/dev.121.3.767","article-title":"Induction of the prospective neural crest of Xenopus","volume":"121","author":"Mayor","year":"1995","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C35","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1242\/dev.110.2.491","article-title":"Primary neurons that express the L2\/HNK-1 carbohydrate during early development in the zebrafish","volume":"100","author":"Metcalfe","year":"1990","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C36","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1242\/dev.122.12.3981","article-title":"valentino: a zebrafish gene required for normal hindbrain segmentation","volume":"122","author":"Moens","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C37","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1523\/JNEUROSCI.09-08-02919.1989","article-title":"Quantitative lineage analysis of the origin of frog primary motor and sensory neurons from cleavage stage blastomeres","volume":"9","author":"Moody","year":"1989","journal-title":"J. Neurosci"},{"key":"2023090607474617000_DEVELOP_126_18_3969C38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/0012-1606(89)90295-9","article-title":"Neural fold formation at newly created boundaries between neural plate and epidermis in the axolotl","volume":"133","author":"Moury","year":"1989","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C39","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0012-1606(90)90380-2","article-title":"The origns of neural crest cells in the axolotl","volume":"141","author":"Moury","year":"1990","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C40","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0925-4773(97)00659-X","article-title":"A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish","volume":"62","author":"Neave","year":"1997","journal-title":"Mech. Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/dbio.1998.8927","article-title":"Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b\/swirl pathway of genes","volume":"199","author":"Nguyen","year":"1998","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C42","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1126\/science.7513443","article-title":"Control of cell behavior during vertebrate development by Slug, a zinc finger gene","volume":"264","author":"Nieto","year":"1994","journal-title":"Science"},{"key":"2023090607474617000_DEVELOP_126_18_3969C43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0925-4773(96)00625-9","article-title":"Conservation of BMP signaling in zebrafish mesoderm patterning","volume":"61","author":"Nikaido","year":"1997","journal-title":"Mech. Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000114388","article-title":"Vertebrate craniofacial development: the relation between ontogenetic process and morphological outcome","volume":"38","author":"Noden","year":"1991","journal-title":"Brain, Behavior and Evolution"},{"key":"2023090607474617000_DEVELOP_126_18_3969C45","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s004270050179","article-title":"Fork head domain genes in zebrafish","volume":"208","author":"Odenthal","year":"1998","journal-title":"Dev. Genes Evol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C46","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/nar\/21.5.1087","article-title":"Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development","volume":"21","author":"Oxtoby","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"2023090607474617000_DEVELOP_126_18_3969C47","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/BF00636333","article-title":"On the formation of the neural keel and neural tube in zebrafish Danio (Brachydanio) rerio","volume":"203","author":"Papan","year":"1994","journal-title":"Wilhelm Roux\u2019s Arch. Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/aja.1001950104","article-title":"Segregation and early dispersal of neural crest cells in the embryonic zebrafish","volume":"195","author":"Raible","year":"1992","journal-title":"Dev. Dyn"},{"key":"2023090607474617000_DEVELOP_126_18_3969C49","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1242\/dev.120.3.495","article-title":"Restriction of neural crest cell fate in the trunk of the embryonic zebrafish","volume":"120","author":"Raible","year":"1994","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C50","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1242\/dev.122.2.501","article-title":"Regulative interactions in zebrafish neural crest","volume":"122","author":"Raible","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C51","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dev.123.1.165","article-title":"Mutations affecting the development of the embryonic zebrafish brain","volume":"123","author":"Schier","year":"1996","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C52","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1242\/dev.124.2.327","article-title":"The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail","volume":"124","author":"Schier","year":"1997","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C53","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/BF00363214","article-title":"Neurulation in the anterior trunk region of the zebrafish Brachydanio rerio","volume":"203","author":"Schmitz","year":"1993","journal-title":"Wilhelm Roux\u2019s Arch. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C54","first-page":"843","article-title":"Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos","volume":"120","author":"Schulte-Merker","year":"1994","journal-title":"Developmen"},{"key":"2023090607474617000_DEVELOP_126_18_3969C55","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1242\/dev.121.2.525","article-title":"Origins of the avian neural crest: the role of neural plate-epidermal interactions","volume":"121","author":"Selleck","year":"1995","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C56","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1242\/dev.106.4.809","article-title":"Vital dye analysis of the timing and pathways of avian trunk neural crest cell migration","volume":"106","author":"Serbedzija","year":"1989","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C57","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1242\/dev.120.9.2443","article-title":"Microtubule arrays of the zebrafish yolk cell: organization and function during epiboly","volume":"120","author":"Solnica-Krezel","year":"1994","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C58","first-page":"293","volume":"291","author":"Streisinger","year":"1981","journal-title":"Production of clones of homozygous diploid zebra fish (Brachydanio rerio) Nature"},{"key":"2023090607474617000_DEVELOP_126_18_3969C59","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1006\/dbio.1995.0007","article-title":"Expression of snail2, a second member of the zebrafish family, in cephalic mesendoderm and presumptive neural crest of wild type and spadetail mutant embryos","volume":"172","author":"Thisse","year":"1995","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C60","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1242\/dev.119.4.1203","article-title":"Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos","volume":"119","author":"Thisse","year":"1993","journal-title":"Development"},{"key":"2023090607474617000_DEVELOP_126_18_3969C61","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1101\/gad.8.12.1434","article-title":"Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate","volume":"8","author":"Turner","year":"1994","journal-title":"Genes Dev"},{"key":"2023090607474617000_DEVELOP_126_18_3969C62","volume-title":"The Zebrafish Book. Eugene, Orgeon","author":"Westerfield","year":"1994"},{"key":"2023090607474617000_DEVELOP_126_18_3969C63","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0012-1606(66)90015-7","article-title":"Temporal factors affecting the localization of neural crest cells in chick embryos","volume":"14","author":"Weston","year":"1966","journal-title":"Dev. Biol"},{"key":"2023090607474617000_DEVELOP_126_18_3969C64","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0092-8674(00)80918-6","article-title":"Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/126\/18\/3969\/3133459\/develop_126_18_3969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/126\/18\/3969\/3133459\/develop_126_18_3969.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:47:56Z","timestamp":1693986476000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/126\/18\/3969\/40326\/Zebrafish-narrowminded-suggests-a-genetic-link"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9,15]]},"references-count":64,"journal-issue":{"issue":"18","published-print":{"date-parts":[[1999,9,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.126.18.3969","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9,15]]}}}