{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:45:41Z","timestamp":1771976741329,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":10382,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1016\/s0021-9258(19)50215-0","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T10:59:50Z","timestamp":1609930790000},"page":"10168-10176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Point mutations which drastically affect the polymerization activity of encephalomyocarditis virus RNA-dependent RNA polymerase correspond to the active site of Escherichia coli DNA polymerase I."],"prefix":"10.1016","volume":"267","author":[{"given":"S","family":"Sankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-9258(19)50215-0_bib1","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1093\/nar\/16.21.9909","volume":"16","author":"Argos","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(19)50215-0_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0006-291X(75)80137-9","volume":"62","author":"Auld","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0021-9258(19)50215-0_bib3","doi-asserted-by":"crossref","first-page":"12359","DOI":"10.1016\/S0021-9258(18)33721-9","volume":"257","author":"Baron","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(19)50215-0_bib4","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1073\/pnas.87.12.4610","volume":"87","author":"Bernad","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-1119(91)90346-D","volume":"100","author":"Blanco","year":"1991","journal-title":"Gene (Amst.)"},{"key":"10.1016\/S0021-9258(19)50215-0_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/nar\/19.2.217","volume":"19","author":"Bruenn","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(19)50215-0_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0042-6822(68)90219-5","volume":"35","author":"Calguiri","year":"1968","journal-title":"Virology"},{"key":"10.1016\/S0021-9258(19)50215-0_bib8","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1002\/j.1460-2075.1985.tb03943.x","volume":"4","author":"Cour","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/S0021-9258(19)50215-0_bib9","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1073\/pnas.76.6.2679","volume":"76","author":"Dasgupta","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0092-8674(80)90516-4","volume":"19","author":"Dasgupta","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(19)50215-0_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/protein\/3.6.461","volume":"3","author":"Delarue","year":"1990","journal-title":"Protein Eng."},{"key":"10.1016\/S0021-9258(19)50215-0_bib12","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/jvi.65.5.2714-2717.1991","volume":"65","author":"Dmitrieva","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1128\/jvi.64.3.1394-1397.1990","volume":"64","author":"Dorsky","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib14","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1073\/pnas.74.9.3677","volume":"74","author":"Flanegan","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib15","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/j.1460-2075.1990.tb08329.x","volume":"9","author":"Guinea","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/S0021-9258(19)50215-0_bib16","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1021\/bi00776a006","volume":"11","author":"Hardman","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/S0021-9258(19)50215-0_bib17","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1128\/jvi.61.12.3946-3949.1987","volume":"61","author":"Inokuchi","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib18","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1128\/jvi.65.9.4565-4572.1991","volume":"65","author":"Jablonski","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0042-6822(91)90840-8","volume":"184","author":"Joung","year":"1991","journal-title":"Virology"},{"key":"10.1016\/S0021-9258(19)50215-0_bib20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0968-0004(87)90143-5","volume":"12","author":"Joyce","year":"1987","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0021-9258(19)50215-0_bib21","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1093\/nar\/12.18.7269","volume":"12","author":"Kamer","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(19)50215-0_bib22","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1099\/0022-1317-72-9-2197","volume":"72","author":"Koonin","year":"1991","journal-title":"J. Gen. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib23","series-title":"DNA Replication","first-page":"67","author":"Romberg","year":"1980"},{"key":"10.1016\/S0021-9258(19)50215-0_bib24","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1128\/jvi.63.12.5302-5309.1989","volume":"63","author":"Kroner","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(19)50215-0_bib26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/327716a0","volume":"327","author":"Larder","year":"1987","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(19)50215-0_bib27","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1073\/pnas.86.13.4803","volume":"86","author":"Larder","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib28","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1002\/j.1460-2075.1991.tb04960.x","volume":"10","author":"Le Grice","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S0021-9258(19)50215-0_bib29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0092-8674(90)90653-V","volume":"60","author":"Lundblad","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(19)50215-0_bib30","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1128\/jvi.64.12.5883-5890.1990","volume":"64","author":"Marcy","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.3898366","volume":"230","author":"McCormick","year":"1985","journal-title":"Science"},{"key":"10.1016\/S0021-9258(19)50215-0_bib32","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1016\/S0021-9258(18)67398-3","volume":"261","author":"Misumi","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(19)50215-0_bib33","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1016\/S0021-9258(17)30077-7","volume":"254","author":"Modak","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(19)50215-0_bib34","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1073\/pnas.84.17.6050","volume":"84","author":"Morrow","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib35","first-page":"33","volume":"4","author":"Nicklin","year":"1986","journal-title":"Bio\/Technology"},{"key":"10.1016\/S0021-9258(19)50215-0_bib36","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/313762a0","volume":"313","author":"Ollis","year":"1985","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(19)50215-0_bib37","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/nar\/12.6.2969","volume":"12","author":"Palmenberg","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(19)50215-0_bib38","doi-asserted-by":"crossref","first-page":"7744","DOI":"10.1021\/bi00398a031","volume":"26","author":"Pandey","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/S0021-9258(19)50215-0_bib39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/jvi.63.1.216-225.1989","volume":"63","author":"Plotch","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib40","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/j.1460-2075.1989.tb08565.x","volume":"8","author":"Poch","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/S0021-9258(19)50215-0_bib41","doi-asserted-by":"crossref","first-page":"14579","DOI":"10.1016\/S0021-9258(18)77342-0","volume":"265","author":"Polesky","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(19)50215-0_bib42","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1073\/pnas.69.12.3815","volume":"69","author":"Rosenberg","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(19)50215-0_bib43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0042-6822(88)90542-9","volume":"164","author":"Rothstein","year":"1988","journal-title":"Virology"},{"key":"10.1016\/S0021-9258(19)50215-0_bib44","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1128\/jvi.65.6.2993-3000.1991","volume":"65","author":"Sankar","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","volume":"67","author":"Smith","year":"1988","journal-title":"Gene (Amst.)"},{"key":"10.1016\/S0021-9258(19)50215-0_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/jvi.41.1.313-318.1982","volume":"41","author":"Tershak","year":"1982","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib47","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1128\/jvi.18.2.375-382.1976","volume":"18","author":"Traub","year":"1976","journal-title":"J. Virol."},{"key":"10.1016\/S0021-9258(19)50215-0_bib48","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1016\/S0021-9258(18)34768-9","volume":"257","author":"Van Dyke","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(19)50215-0_bib49","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/j.1460-2075.1982.tb01366.x","volume":"1","author":"Watson","year":"1982","journal-title":"EMBO J."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819502150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819502150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:55:17Z","timestamp":1758210917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819502150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":49,"journal-issue":{"issue":"14","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["S0021925819502150"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9258(19)50215-0","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1992,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Point mutations which drastically affect the polymerization activity of encephalomyocarditis virus RNA-dependent RNA polymerase correspond to the active site of Escherichia coli DNA polymerase I.","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0021-9258(19)50215-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1992 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}