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The conidia are normally eliminated in the immunocompetent host by innate immune mechanisms, and aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical syndromes, are the only infections observed in such hosts. Thus, A. fumigatus was considered for years to be a weak pathogen. With increases in the number of immunosuppressed patients, however, there has been a dramatic increase in severe and usually fatal invasive aspergillosis, now the most common mold infection worldwide. In this review, the focus is on the biology of A. fumigatus and the diseases it causes. Included are discussions of (i) genomic and molecular characterization of the organism, (ii) clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunocompromised hosts, (iii) identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and (iv) problems associated with antifungal therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.12.2.310","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T12:31:26Z","timestamp":1539952286000},"page":"310-350","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1882,"title":["<i>Aspergillus fumigatus<\/i>\n                    and Aspergillosis"],"prefix":"10.1128","volume":"12","author":[{"given":"Jean-Paul","family":"Latge\u0301","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2333"},{"key":"e_1_3_2_3_2","unstructured":"Adams D. 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