{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:38:04Z","timestamp":1777873084379,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Facial Plast Surg"],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the effect of administration of a low-molecular-weight heparin derivative, enoxaparin, on the rate of arterial thrombosis in a rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective, randomized, blinded study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A standard microarterial anastomosis tuck injury was created in both femoral arteries of 25 Long Evans retired breeder rats. Thirteen animals received a subcutaneous injection of 50 IU\/kg of enoxaparin 2 hours before the procedure, while 12 control animals received vehicle (isotonic sodium chloride solution) alone. Sites of injury\/repair were assessed 2 hours after the procedure for anastomotic patency or thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six (23%) of 26 vessels in the drug-treated group developed an arterial thrombosis at the site of repair, while 6 (25%) of 24 vessels in the control group developed thrombosis. There was no statistically significant difference at the 95% confidence limit between the 2 groups based on a comparison-of-proportions test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preoperative subcutaneous administration of 50 IU\/kg of enoxaparin did not alter the rate of arterial thrombosis following the creation of a thrombogenic tuck injury\/repair of the rat femoral artery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/archfaci.5.1.36","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T19:07:45Z","timestamp":1267470465000},"page":"36-39","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Subcutaneously Administered Low-Molecular-Weight Heparin on Microarterial Thrombosis in the Rat"],"prefix":"10.1177","volume":"5","author":[{"given":"Tessa A.","family":"Hadlock","sequence":"first","affiliation":[{"name":"From the Departments of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Departments of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Deschler","sequence":"additional","affiliation":[{"name":"From the Departments of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(75)90175-7"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197505152922002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.9.771.35210"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00006534-199408000-00021","article-title":"Improvement of patency in small veins following dextran and\/or low molecular weight heparin treatment","volume":"94","author":"Zhang B","year":"1994","unstructured":"Zhang B, , Wieslander J. Improvement of patency in small veins following dextran and\/or low molecular weight heparin treatment. Plast Reconstr Surg. 1994; 94:352-358.","journal-title":"Plast Reconstr Surg"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/00365529009095502","article-title":"Gastric mucosal bleeding after unfractionated and low molecular weight heparin in rats","volume":"25","author":"Bang C","year":"1990","unstructured":"Bang C, , Berstad A, , Talstad I. Gastric mucosal bleeding after unfractionated and low molecular weight heparin in rats. Scand J Gastroenterol. 1990; 25:379-382.","journal-title":"Scand J Gastroenterol"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/bmj.284.6313.375","article-title":"Low molecular weight heparin and prevention of postoperative deep vein thrombosis","volume":"284","author":"Kakkar VV","year":"1982","unstructured":"Kakkar VV, , Djazazeri B, , Fok J, et al. Low molecular weight heparin and prevention of postoperative deep vein thrombosis. Br Med J (Clin Res Ed). 1982; 284:375-379.","journal-title":"Br Med J (Clin Res Ed)"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/micr.1920130602","article-title":"Low molecular weight heparin exerts an early antithrombotic effect in small arteries and veins following severe trauma","volume":"13","author":"Zhang B","year":"1992","unstructured":"Zhang B, , Wieslander J. Low molecular weight heparin exerts an early antithrombotic effect in small arteries and veins following severe trauma. 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Role of low-molecular-weight heparins in the management of patients with unstable angina pectoris and non-Q-wave acute myocardial infarction. Am J Cardiol. 2000; 85:2C-9C.","journal-title":"Am J Cardiol"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/00000542-199805000-00023","article-title":"Ketorolac and enoxaparin affect arterial thrombosis and bleeding in the rabbit","volume":"88","author":"Delaporte-Cerceau S","year":"1998","unstructured":"Delaporte-Cerceau S, , Samama CM, , Riou B, et al. Ketorolac and enoxaparin affect arterial thrombosis and bleeding in the rabbit. 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