{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:55:05Z","timestamp":1773658505107,"version":"3.50.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Facial Plast Surg"],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and\/or occlusive dressings) in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and\/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylin-eosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Over a 42-day period, the APG-treated sites had statistically increased wound closure compared with controls by visual clinical assessment and by digital planimetry photographic measurements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264.02). On day 17, the percentage of closure was 81.1%\u00a0\u00b1\u00a02.5% (mean\u00a0\u00b1\u00a0SE) for the APG-treated sites and 57.2%\u00a0\u00b1\u00a05.9% for the control sites. Also, the APG wound closure velocities were significantly faster than those of the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.001). Histologically, over time, the APG-treated sites had similar cellularity, cellular replication, granulation tissue, vascularity, and epithelialization compared with controls. However, when the platelet count in the gel was more than 6 times the baseline intravascular platelet count in some subjects, epithelialization and granulation formation appeared 3 days earlier in the APG-treated group. Furthermore, in vitro testing of supplemental APG showed increased endothelial cell proliferation compared with controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness dermal wounds in healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/NCT00199992\">NCT00199992<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/archfaci.9.3.174","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T20:11:31Z","timestamp":1179778291000},"page":"174-183","source":"Crossref","is-referenced-by-count":104,"title":["The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds"],"prefix":"10.1177","volume":"9","author":[{"given":"David B.","family":"Hom","sequence":"first","affiliation":[{"name":"Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology\u2013Head and Neck Surgery, University of Minnesota School of Medicine and Hennepin County Medical Center, Minneapolis, Minn"},{"name":"Dr Hom is now with the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology\u2013Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley M.","family":"Linzie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hennepin County Medical Center, Minneapolis, Minn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Medtronic Inc, Minneapolis, Minn"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/2004363250"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.3.4.245"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.01.004"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03366.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.06.013"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00020840-200308000-00005","article-title":"The effects of tissue sealants, platelet gels, and growth factors on wound healing","volume":"11","author":"Brisset AE","year":"2003","unstructured":"Brisset AE, , Hom DB. The effects of tissue sealants, platelet gels, and growth factors on wound healing. Curr Opin Otolaryngol Head Neck Surg. 2003; 11:245-250. 14515071","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400908"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/01.iop.0000202092.73888.4c","article-title":"Use of autologous platelet concentrate in blepharoplasty surgery","volume":"22","author":"Vick VL","year":"2006","unstructured":"Vick VL, , Holds JB, , Hartstein ME, , Rich RM, , Davidson BR. Use of autologous platelet concentrate in blepharoplasty surgery. Ophthal Plast Reconstr Surg. 2006; 22:102-104. 16550052","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1524-475X.2003.11411.x","article-title":"A clinical model of dermal wound angiogenesis","volume":"11","author":"Lockhart AC","year":"2003","unstructured":"Lockhart AC, , Braun RD, , Yu D, et al. A clinical model of dermal wound angiogenesis. Wound Repair Regen. 2003; 11:306-313. 12846919","journal-title":"Wound Repair Regen"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2001.10.8.26109"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1067\/mjd.2001.117721","article-title":"Recombinant human platelet-derived growth factor gel speeds healing of acute full-thickness punch biopsy wounds","volume":"45","author":"Cohen MA","year":"2001","unstructured":"Cohen MA, , Eaglstein WH. Recombinant human platelet-derived growth factor gel speeds healing of acute full-thickness punch biopsy wounds. J Am Acad Dermatol. 2001; 45:857-862. 11712030","journal-title":"J Am Acad Dermatol"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0039-6109(02)00208-6","article-title":"Wound-healing trajectories","volume":"83","author":"Steed DL","year":"2003","unstructured":"Steed DL. Wound-healing trajectories. Surg Clin North Am. 2003; 83:547-555, vi-vii.12822725","journal-title":"Surg Clin North Am"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.7.3.163"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200101000-00037"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1172\/JCI114227","article-title":"Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices","volume":"84","author":"Clark RA","year":"1989","unstructured":"Clark RA, , Folkvord JM, , Hart CE, , Murray MJ, , McPherson JM. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest. 1989; 84:1036-1040. 2760210","journal-title":"J Clin Invest"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"12S","DOI":"10.1097\/01.prs.0000225430.42531.c2","article-title":"The basic science of wound healing","volume":"117","author":"Broughton G","year":"2006","unstructured":"Broughton GII, , Janis JE, , Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006; 117,(Suppl):12S-34S. 16799372","journal-title":"Plast Reconstr Surg"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/00034894921010S104","article-title":"Antibiotic prophylaxis in clean-contaminated head and neck oncologic surgery","volume":"155","author":"Weber RS","year":"1992","unstructured":"Weber RS, , Callender DL. Antibiotic prophylaxis in clean-contaminated head and neck oncologic surgery. Ann Otol Rhinol Laryngol Suppl. 1992; 155:16-20. 1728894","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000157852.01402.12"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040125"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2001.00347.x"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199406000-00012"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.3.483"},{"key":"e_1_3_1_24_2","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1016\/S0002-9610(98)00186-X","article-title":"The future of recombinant growth factors in wound healing","volume":"176","author":"Robson MC","year":"1998","unstructured":"Robson MC, , Mustoe TA, , Hunt TK. The future of recombinant growth factors in wound healing. Am J Surg. 1998; 176,(suppl):80S-82S. 9777977","journal-title":"Am J Surg"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00029"},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"143S","DOI":"10.1097\/01.prs.0000222526.21512.4c","article-title":"Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers","volume":"117","author":"Steed DL","year":"2006","unstructured":"Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg. 2006; 117,(suppl):143S-149S. 16799381","journal-title":"Plast Reconstr Surg"}],"container-title":["Archives of Facial Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1001\/archfaci.9.3.174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1001\/archfaci.9.3.174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1001\/archfaci.9.3.174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:56:17Z","timestamp":1773654977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1001\/archfaci.9.3.174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,1]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5,1]]}},"alternative-id":["10.1001\/archfaci.9.3.174"],"URL":"https:\/\/doi.org\/10.1001\/archfaci.9.3.174","relation":{},"ISSN":["1521-2491","1538-3660"],"issn-type":[{"value":"1521-2491","type":"print"},{"value":"1538-3660","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,1]]}}}