{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:50:33Z","timestamp":1792889433392,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2017,9,5]]},"DOI":"10.1001\/jama.2017.11137","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T12:31:01Z","timestamp":1504614661000},"page":"825","source":"Crossref","is-referenced-by-count":483,"title":["Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing"],"prefix":"10.1001","volume":"318","author":[{"given":"Diana","family":"Mandelker","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Kemel","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia K.","family":"Stadler","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijai","family":"Joseph","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Zehir","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Arnold","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Li","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop R.","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijazuddin","family":"Syed","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Prasad","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khedoudja","family":"Nafa","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Carlo","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Cadoo","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan H.","family":"Fleischut","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Salo-Mullen","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magan","family":"Trottier","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Lipkin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lincoln","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanti","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Cambria","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Galle","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Abida","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia E.","family":"Arcila","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryma","family":"Benayed","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Shah","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Yu","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Bajorin","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Leach","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve A.","family":"Lowery","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Garcia-Aguilar","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Kantoff","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Sawyers","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura N.","family":"Dickler","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Saltz","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Motzer","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M.","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard I.","family":"Scher","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Baselga","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Klimstra","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Solit","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Hyman","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Berger","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ladanyi","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Robson","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"},{"name":"Sloan Kettering Institute, New York, New York"},{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"jpc170004r1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1001\/jamaoncol.2015.5208","article-title":"Germline variants in targeted tumor sequencing using matched normal DNA.","volume":"2","author":"Schrader","year":"2016","journal-title":"JAMA Oncol"},{"issue":"16","key":"jpc170004r2","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1158\/1078-0432.CCR-16-0015","article-title":"Germline analysis from tumor-germline sequencing dyads to identify clinically actionable secondary findings.","volume":"22","author":"Seifert","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"283","key":"jpc170004r3","doi-asserted-by":"publisher","first-page":"283ra53","DOI":"10.1126\/scitranslmed.aaa7161","article-title":"Personalized genomic analyses for cancer mutation discovery and interpretation.","volume":"7","author":"Jones","year":"2015","journal-title":"Sci Transl Med"},{"issue":"5","key":"jpc170004r4","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1001\/jamaoncol.2015.5699","article-title":"Diagnostic yield of clinical tumor and germline whole-exome sequencing for children with solid tumors.","volume":"2","author":"Parsons","year":"2016","journal-title":"JAMA Oncol"},{"issue":"9","key":"jpc170004r5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1001\/jama.2015.10080","article-title":"Integrative clinical sequencing in the management of refractory or relapsed cancer in youth.","volume":"314","author":"Mody","year":"2015","journal-title":"JAMA"},{"issue":"5","key":"jpc170004r6","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1093\/annonc\/mdw018","article-title":"Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol.","volume":"27","author":"Meric-Bernstam","year":"2016","journal-title":"Ann Oncol"},{"issue":"24","key":"jpc170004r7","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1056\/NEJMoa1508054","article-title":"Germline mutations in predisposition genes in pediatric cancer.","volume":"373","author":"Zhang","year":"2015","journal-title":"N Engl J Med"},{"issue":"1","key":"jpc170004r8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/gim.2014.147","article-title":"A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.","volume":"17","author":"Hampel","year":"2015","journal-title":"Genet Med"},{"issue":"3","key":"jpc170004r11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology.","volume":"17","author":"Cheng","year":"2015","journal-title":"J Mol Diagn"},{"issue":"6","key":"jpc170004r12","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nm.4333","article-title":"Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.","volume":"23","author":"Zehir","year":"2017","journal-title":"Nat Med"},{"issue":"7483","key":"jpc170004r13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nature12981","article-title":"Realizing the promise of cancer predisposition genes.","volume":"505","author":"Rahman","year":"2014","journal-title":"Nature"},{"issue":"2","key":"jpc170004r14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/gim.2016.190","article-title":"Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.","volume":"19","author":"Kalia","year":"2017","journal-title":"Genet Med"},{"issue":"1","key":"jpc170004r15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12920-017-0271-4","article-title":"Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing.","volume":"10","author":"Cheng","year":"2017","journal-title":"BMC Med Genomics"},{"issue":"5","key":"jpc170004r16","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-repair gene mutations in men with metastatic prostate cancer.","volume":"375","author":"Pritchard","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"jpc170004r17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00029","article-title":"Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making.","author":"Abida","year":"2017","journal-title":"JCO Precis Oncol"},{"issue":"5","key":"jpc170004r18","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"16","key":"jpc170004r19","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1093\/nar\/gkw520","article-title":"FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing.","volume":"44","author":"Shen","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"jpc170004r20","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/bioinformatics\/btt755","article-title":"MSIsensor: microsatellite instability detection using paired tumor-normal sequence data.","volume":"30","author":"Niu","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"jpc170004r23","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S1470-2045(09)70188-3","article-title":"Birt-Hogg-Dub\u00e9 syndrome: diagnosis and management.","volume":"10","author":"Menko","year":"2009","journal-title":"Lancet Oncol"},{"issue":"2","key":"jpc170004r24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/gcc.v53.2","article-title":"Expanding the clinical phenotype of hereditary BAP1 cancer predisposition syndrome, reporting three new cases.","volume":"53","author":"Pilarski","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"jpc170004r25","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).","volume":"97","author":"Thakker","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"7616","key":"jpc170004r27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans.","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"issue":"database issue","key":"jpc170004r32","doi-asserted-by":"publisher","first-page":"D805","DOI":"10.1093\/nar\/gku1075","article-title":"COSMIC: exploring the world\u2019s knowledge of somatic mutations in human cancer.","volume":"43","author":"Forbes","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"jpc170004r34","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1001\/jama.2013.276573","article-title":"Revealing the incidentalome when targeting the tumor genome.","volume":"310","author":"Bombard","year":"2013","journal-title":"JAMA"},{"issue":"9","key":"jpc170004r35","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/jnci\/95.9.669","article-title":"Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.","volume":"95","author":"Wang","year":"2003","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"jpc170004r36","doi-asserted-by":"publisher","first-page":"e1005160","DOI":"10.1371\/journal.pgen.1005160","article-title":"The DNA helicase RECQL4 is required for normal osteoblast expansion and osteosarcoma formation.","volume":"11","author":"Ng","year":"2015","journal-title":"PLoS Genet"},{"issue":"5","key":"jpc170004r38","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1053\/j.seminoncol.2016.10.002","article-title":"The future of clinical cancer genomics.","volume":"43","author":"Offit","year":"2016","journal-title":"Semin Oncol"},{"key":"jpc170004r37","volume-title":"GeneReviews","author":"Wang","year":"1993"},{"key":"jpc170004r9","unstructured":"National Comprehensive Cancer Network. Genetic\/Familial High-Risk Assessment: Breast and Ovarian, Version 1.2017. September 19, 2016. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_screening.pdf. Accessed September 23, 2016."},{"key":"jpc170004r10","unstructured":"National Comprehensive Cancer Network. Genetic\/Familial High-Risk Assessment: Colorectal, Version 2.2016. September 26, 2016. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_colon.pdf. Accessed September 23, 2016."},{"key":"jpc170004r21","doi-asserted-by":"crossref","unstructured":"UpToDate. Search. https:\/\/www.uptodate.com\/contents\/search. Accessed October 19, 2016.","DOI":"10.1097\/01.COT.0000494620.34618.ba"},{"key":"jpc170004r22","unstructured":"American Society of Clinical Oncology. Cancer Genetics Program. http:\/\/university.asco.org\/cancer-genetics-program. Accessed October 19, 2016."},{"key":"jpc170004r26","unstructured":"Exome Aggregation Consortium. ExAC Browser Beta. http:\/\/exac.broadinstitute.org\/about. Accessed August 24, 2016."},{"key":"jpc170004r28","unstructured":"International Genome Sample Resource. IGSR and the 1000 Genomes Project. http:\/\/www.internationalgenome.org\/. Accessed August 24, 2016."},{"key":"jpc170004r29","unstructured":"National Center for Biotechnology Information. dbSNP Short Genetic Variations. https:\/\/www.ncbi.nlm.nih.gov\/projects\/SNP\/. Accessed August 24, 2016."},{"key":"jpc170004r30","unstructured":"IBD Exomes Portal. IBD Exomes browser. https:\/\/ibd.broadinstitute.org\/. Accessed October 5, 2016."},{"key":"jpc170004r31","unstructured":"American Cancer Society. Cancer facts and figures 2016. https:\/\/www.cancer.org\/acs\/groups\/content\/@research\/documents\/document\/acspc-047079.pdf. Accessed December 19, 2016."},{"key":"jpc170004r33","unstructured":"Wellcome Trust Sanger Institute Genome Research Ltd. COSMIC: Catalogue of Somatic Mutations in Cancer. http:\/\/cancer.sanger.ac.uk\/cosmic. Accessed August 24, 2016."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2652651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:42:29Z","timestamp":1719412949000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2017.11137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9,5]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2017.11137","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}