{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:24:25Z","timestamp":1794266665385,"version":"4.9.0"},"reference-count":0,"publisher":"American Medical Association (AMA)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2017,6,20]]},"DOI":"10.1001\/jama.2017.7112","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T12:32:14Z","timestamp":1497961934000},"page":"2402","source":"Crossref","is-referenced-by-count":2723,"title":["Risks of Breast, Ovarian, and Contralateral Breast Cancer for\n                    <i>BRCA1<\/i>\n                    and\n                    <i>BRCA2<\/i>\n                    Mutation Carriers"],"prefix":"10.1001","volume":"317","author":[{"given":"Karoline B.","family":"Kuchenbaecker","sequence":"first","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly-Anne","family":"Phillips","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia4Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia5Department of Medicine, St Vincent\u2019s Hospital, University of Melbourne, Parkville, Australia6Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea M.","family":"Mooij","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9","family":"Roos-Blom","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands8Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jervis","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England9Mathematics Institute, University of Warwick, Coventry, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora E.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia10Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Andrieu","sequence":"additional","affiliation":[{"name":"Inserm U900, Paris, France12Institut Curie, Paris, France13Mines ParisTech, Fontainebleau, France14PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Goldgar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti A.","family":"Rookus","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis C.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the BRCA1 and BRCA2 Cohort Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"McGuffog","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Barrowdale","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Frost","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Adlard","sequence":"additional","affiliation":[{"name":"Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-ren","family":"Ong","sequence":"additional","affiliation":[{"name":"West Midlands Regional Genetics Service, Birmingham Women\u2019s Hospital Healthcare NHS Trust, Birmingham, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[{"name":"Clinical Genetics, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Tischkowitz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros","family":"Eeles","sequence":"additional","affiliation":[{"name":"Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, St George\u2019s, University of London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Ellis","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nogues","sequence":"additional","affiliation":[{"name":"Oncog\u00e9n\u00e9tique Clinique, H\u00f4pital Ren\u00e9 Huguenin\/Institut Curie, Saint-Cloud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lasset","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pr\u00e9vention et d\u2019Epid\u00e9miologie G\u00e9n\u00e9tique, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Stoppa-Lyonnet","sequence":"additional","affiliation":[{"name":"Institut Curie, Department of Tumour Biology, Paris, France28Institut Curie, INSERM U830, Paris, France29Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Fricker","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Oncog\u00e9n\u00e9tique, Centre Paul Strauss, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Faivre","sequence":"additional","affiliation":[{"name":"Centre de Lutte Contre le Cancer Georges Fran\u00e7ois Leclerc, Dijon, France32Centre de G\u00e9n\u00e9tique, H\u00f4pital d\u2019Enfants, CHU Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascaline","family":"Berthet","sequence":"additional","affiliation":[{"name":"Centre Fran\u00e7ois Baclesse, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje J.","family":"Hooning","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizet E.","family":"van der Kolk","sequence":"additional","affiliation":[{"name":"Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien M.","family":"Kets","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel A.","family":"Adank","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Cancer Prevention Institute of California, Fremont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Departments of Pedicatrics and Medicine, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada41Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Southey","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saundra S.","family":"Buys","sequence":"additional","affiliation":[{"name":"Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Osorio","sequence":"additional","affiliation":[{"name":"Human Genetics Group, Spanish National Cancer Centre, Madrid, Spain46Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Engel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany48LIFE\u2013Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kast","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Dresden, Germany50National Center for Tumor Diseases, Partner Site Dresden, Dresden, Germany51German Cancer Consortium, Dresden and German Cancer Research Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita K.","family":"Schmutzler","sequence":"additional","affiliation":[{"name":"Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinidad","family":"Caldes","sequence":"additional","affiliation":[{"name":"Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigaci\u00f3n Sanitaria San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jakubowska","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Simard","sequence":"additional","affiliation":[{"name":"Genomics Center, Centre Hospitalier Universitaire de Qu\u00e9bec Research Center and Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, University of New South Wales, Sydney, Australia57Department of Medical Oncology, Prince of Wales Hospital, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue-Anne","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia58Department of Medical Oncology, St Vincent\u2019s Hospital, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Machackova","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Foretova","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Y.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria61QIMR Berghofer Medical Research Institute, Herston, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Olah","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Copenhagen University Hospital Rigshospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brita","family":"Arver","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lund University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jama.jamanetwork.com\/ama\/content_public\/journal\/jama\/936309\/jama_kuchenbaecker_2017_oi_170057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T16:11:56Z","timestamp":1683303116000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2017.7112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":0,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017,6,20]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2017.7112","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,20]]}}}