{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:25:13Z","timestamp":1792113913124,"version":"4.4.0"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2018,11,13]]},"DOI":"10.1001\/jama.2018.14280","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T01:56:32Z","timestamp":1540432592000},"page":"1872","source":"Crossref","is-referenced-by-count":252,"title":["Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS"],"prefix":"10.1001","volume":"320","author":[{"name":"Writing Group for the PReVENT Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne D.","family":"Simonis","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ary","family":"Serpa Neto","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Critical Care Medicine, Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Binnekade","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarije","family":"Braber","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Gelre Hospitals, Apeldoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina C. M.","family":"Bruin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Westfriesgasthuis, Hoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier M.","family":"Determann","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert-Jan","family":"Goekoop","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Westfriesgasthuis, Hoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Heidt","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Tergooi, Hilversum, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Innemee","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Tergooi, Hilversum, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole P.","family":"Juffermans","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Spronk","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Gelre Hospitals, Apeldoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte M.","family":"Steuten","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Roel","family":"Tuinman","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & REVIVE Research VUmc Intensive Care, VU Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob B.P.","family":"de Wilde","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijn","family":"Vriends","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & REVIVE Research VUmc Intensive Care, VU Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Gama de Abreu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"22","key":"joi180108r1","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1056\/NEJMra1208707","article-title":"Ventilator-induced lung injury.","volume":"369","author":"Slutsky","year":"2013","journal-title":"N Engl J Med"},{"issue":"18","key":"joi180108r2","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.","volume":"342","author":"Acute Respiratory Distress Syndrome Network,","year":"2000","journal-title":"N Engl J Med"},{"issue":"8","key":"joi180108r3","doi-asserted-by":"publisher","first-page":"566","DOI":"10.7326\/0003-4819-151-8-200910200-00011","article-title":"Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury.","volume":"151","author":"Putensen","year":"2009","journal-title":"Ann Intern Med"},{"issue":"2","key":"joi180108r4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1164\/rccm.201409-1598OC","article-title":"Timing of low tidal volume ventilation and ICU mortality in ARDS: a prospective cohort study.","volume":"191","author":"Needham","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"joi180108r5","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1378\/chest.97.2.430","article-title":"Are low tidal volumes safe?","volume":"97","author":"Lee","year":"1990","journal-title":"Chest"},{"issue":"1","key":"joi180108r6","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1186\/cc8230","article-title":"Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial.","volume":"14","author":"Determann","year":"2010","journal-title":"Crit Care"},{"issue":"7","key":"joi180108r7","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s00134-014-3318-4","article-title":"Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis.","volume":"40","author":"Serpa Neto","year":"2014","journal-title":"Intensive Care Med"},{"issue":"10","key":"joi180108r8","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1097\/CCM.0000000000001189","article-title":"Lung-protective ventilation with low tidal volumes and the occurrence of pulmonary complications in patients without acute respiratory distress syndrome: a systematic review and individual patient data analysis.","volume":"43","author":"Neto","year":"2015","journal-title":"Crit Care Med"},{"issue":"16","key":"joi180108r9","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1001\/jama.2012.14509","article-title":"Low tidal volumes for all?","volume":"308","author":"Ferguson","year":"2012","journal-title":"JAMA"},{"issue":"1","key":"joi180108r10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/01.CCM.0000194538.32158.AF","article-title":"Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome.","volume":"34","author":"Kallet","year":"2006","journal-title":"Crit Care Med"},{"issue":"10","key":"joi180108r11","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1177\/002013240104601005","article-title":"Implementation of a low tidal volume ventilation protocol for patients with acute lung injury or acute respiratory distress syndrome.","volume":"46","author":"Kallet","year":"2001","journal-title":"Respir Care"},{"issue":"4","key":"joi180108r12","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1164\/rccm.201605-1081CP","article-title":"Mechanical ventilation to minimize progression of lung injury in acute respiratory failure.","volume":"195","author":"Brochard","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"joi180108r13","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1097\/CCM.0b013e31825b8ade","article-title":"Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium.","volume":"40","author":"Seymour","year":"2012","journal-title":"Crit Care Med"},{"key":"joi180108r14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13063-015-0759-1","article-title":"PReVENT\u2013protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial.","volume":"16","author":"Simonis","year":"2015","journal-title":"Trials"},{"issue":"23","key":"joi180108r15","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition.","volume":"307","author":"ARDS Definition Task Force,","year":"2012","journal-title":"JAMA"},{"issue":"3","key":"joi180108r16","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00134-003-2004-8","article-title":"Post-traumatic stress disorder after critical illness requiring general intensive care.","volume":"30","author":"Cuthbertson","year":"2004","journal-title":"Intensive Care Med"},{"issue":"3","key":"joi180108r17","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00003246-200103000-00019","article-title":"Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care.","volume":"29","author":"Jones","year":"2001","journal-title":"Crit Care Med"},{"issue":"12","key":"joi180108r18","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1007\/s00134-010-1972-8","article-title":"Post-traumatic stress disorder after weaning from prolonged mechanical ventilation.","volume":"36","author":"Jubran","year":"2010","journal-title":"Intensive Care Med"},{"issue":"5","key":"joi180108r19","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1007\/s00134-010-1842-4","article-title":"Depressive disorders during weaning from prolonged mechanical ventilation.","volume":"36","author":"Jubran","year":"2010","journal-title":"Intensive Care Med"},{"issue":"12","key":"joi180108r20","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1007\/s00134-001-1132-2","article-title":"The impact of delirium in the intensive care unit on hospital length of stay.","volume":"27","author":"Ely","year":"2001","journal-title":"Intensive Care Med"},{"issue":"3","key":"joi180108r21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.ccc.2009.04.005","article-title":"Cognitive functioning, mental health, and quality of life in ICU survivors: an overview.","volume":"25","author":"Jackson","year":"2009","journal-title":"Crit Care Clin"},{"issue":"14","key":"joi180108r22","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1001\/jama.2016.2691","article-title":"Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis.","volume":"315","author":"van Vught","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"joi180108r23","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1186\/cc3955","article-title":"The clinical value of daily routine chest radiographs in a mixed medical-surgical intensive care unit is low.","volume":"10","author":"Graat","year":"2006","journal-title":"Crit Care"},{"issue":"7","key":"joi180108r24","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1097\/00003246-200107000-00012","article-title":"Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU).","volume":"29","author":"Ely","year":"2001","journal-title":"Crit Care Med"},{"issue":"11","key":"joi180108r25","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/S2213-2600(16)30305-8","article-title":"Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study.","volume":"4","author":"Neto","year":"2016","journal-title":"Lancet Respir Med"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2710774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:38:47Z","timestamp":1775252327000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2018.14280"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":25,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2018,11,13]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2018.14280","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,13]]}}}