{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:47:05Z","timestamp":1785347225619,"version":"3.55.0"},"reference-count":52,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2018,8,7]]},"DOI":"10.1001\/jama.2018.4190","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T16:00:34Z","timestamp":1533657634000},"page":"485","source":"Crossref","is-referenced-by-count":105,"title":["Screening for Atrial Fibrillation With Electrocardiography"],"prefix":"10.1001","volume":"320","author":[{"given":"Daniel E.","family":"Jonas","sequence":"first","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Medicine, University of North Carolina at Chapel Hill"},{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila C.","family":"Kahwati","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D. Y.","family":"Yun","sequence":"additional","affiliation":[{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill"},{"name":"Department of Family Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Cook","family":"Middleton","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manny","family":"Coker-Schwimmer","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary N.","family":"Asher","sequence":"additional","affiliation":[{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill"},{"name":"Department of Family Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"21","key":"jus180006r1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"jus180006r2","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study.","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"jus180006r3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4997\/JRCPE","article-title":"How can we best detect atrial fibrillation?","volume":"42","author":"Harris","year":"2012","journal-title":"J R Coll Physicians Edinb"},{"issue":"9658","key":"jus180006r4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0140-6736(09)60040-4","article-title":"Mechanisms of thrombogenesis in atrial fibrillation: Virchow\u2019s triad revisited.","volume":"373","author":"Watson","year":"2009","journal-title":"Lancet"},{"issue":"6","key":"jus180006r5","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1212\/01.wnl.0000267275.68538.8d","article-title":"Independent predictors of stroke in patients with atrial fibrillation: a systematic review.","volume":"69","author":"Stroke Risk in Atrial Fibrillation Working Group","year":"2007","journal-title":"Neurology"},{"issue":"2","key":"jus180006r6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000068743","article-title":"Atrial fibrillation is associated with severe acute ischemic stroke.","volume":"22","author":"Dulli","year":"2003","journal-title":"Neuroepidemiology"},{"issue":"2","key":"jus180006r7","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1161\/01.STR.32.2.392","article-title":"Characteristics, outcome, and care of stroke associated with atrial fibrillation in Europe: data from a multicenter multinational hospital-based registry (the European Community Stroke Project).","volume":"32","author":"Lamassa","year":"2001","journal-title":"Stroke"},{"issue":"10","key":"jus180006r8","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/01.STR.27.10.1760","article-title":"Stroke severity in atrial fibrillation: the Framingham Study.","volume":"27","author":"Lin","year":"1996","journal-title":"Stroke"},{"issue":"10","key":"jus180006r9","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics\u20142017 update: a report from the American Heart Association.","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"issue":"4","key":"jus180006r10","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.amjcard.2009.10.018","article-title":"Thromboembolism in atrial fibrillation.","volume":"105","author":"Menke","year":"2010","journal-title":"Am J Cardiol"},{"issue":"5","key":"jus180006r11","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/01.STR.14.5.664","article-title":"Duration of atrial fibrillation and imminence of stroke: the Framingham Study.","volume":"14","author":"Wolf","year":"1983","journal-title":"Stroke"},{"issue":"9","key":"jus180006r12","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/01.STR.26.9.1527","article-title":"Newly diagnosed atrial fibrillation and acute stroke: the Framingham Study.","volume":"26","author":"Lin","year":"1995","journal-title":"Stroke"},{"issue":"1","key":"jus180006r13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000255973","article-title":"Stroke associated with atrial fibrillation\u2014incidence and early outcomes in the North Dublin Population Stroke Study.","volume":"29","author":"Hannon","year":"2010","journal-title":"Cerebrovasc Dis"},{"issue":"3","key":"jus180006r15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials.","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"11","key":"jus180006r16","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Quantifying heterogeneity in a meta-analysis.","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"7414","key":"jus180006r17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses.","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"19","key":"jus180006r19","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.117.030583","article-title":"Assessment of remote heart rhythm sampling using the AliveCor heart monitor to screen for atrial fibrillation: the REHEARSE-AF study.","volume":"136","author":"Halcox","year":"2017","journal-title":"Circulation"},{"issue":"25","key":"jus180006r20","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1161\/CIRCULATIONAHA.114.014343","article-title":"Mass screening for untreated atrial fibrillation: the STROKESTOP study.","volume":"131","author":"Svennberg","year":"2015","journal-title":"Circulation"},{"issue":"1","key":"jus180006r21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/europace\/eus217","article-title":"Population screening of 75- and 76-year-old men and women for silent atrial fibrillation (STROKESTOP).","volume":"15","author":"Friberg","year":"2013","journal-title":"Europace"},{"issue":"3","key":"jus180006r23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/fampra\/cmu011","article-title":"Is screening for AF worthwhile? stroke risk in a screened population from the SAFE study.","volume":"31","author":"Fitzmaurice","year":"2014","journal-title":"Fam Pract"},{"issue":"7616","key":"jus180006r24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/bmj.39280.660567.55","article-title":"Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trial.","volume":"335","author":"Fitzmaurice","year":"2007","journal-title":"BMJ"},{"issue":"7616","key":"jus180006r25","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1136\/bmj.39227.551713.AE","article-title":"Accuracy of diagnosing atrial fibrillation on electrocardiogram by primary care practitioners and interpretative diagnostic software: analysis of data from Screening for Atrial Fibrillation in the Elderly (SAFE) trial.","volume":"335","author":"Mant","year":"2007","journal-title":"BMJ"},{"issue":"40","key":"jus180006r26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta9400","article-title":"A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over: the SAFE study.","volume":"9","author":"Hobbs","year":"2005","journal-title":"Health Technol Assess"},{"key":"jus180006r27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2261-4-12","article-title":"A randomised controlled trial and cost effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in the over 65s: (SAFE) [ISRCTN19633732].","volume":"4","author":"Swancutt","year":"2004","journal-title":"BMC Cardiovasc Disord"},{"issue":"478","key":"jus180006r28","first-page":"373","article-title":"Randomised trial of two approaches to screening for atrial fibrillation in UK general practice.","volume":"52","author":"Morgan","year":"2002","journal-title":"Br J Gen Pract"},{"issue":"8631","key":"jus180006r29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0140-6736(89)91200-2","article-title":"Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study.","volume":"1","author":"Petersen","year":"1989","journal-title":"Lancet"},{"issue":"22","key":"jus180006r30","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1056\/NEJM199011293232201","article-title":"The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation.","volume":"323","author":"Singer","year":"1990","journal-title":"N Engl J Med"},{"issue":"12","key":"jus180006r31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1056\/NEJM199003223221232","article-title":"Preliminary report of the Stroke Prevention in Atrial Fibrillation study.","volume":"322","author":"Stroke Prevention in Atrial Fibrillation Study Group Investigators","year":"1990","journal-title":"N Engl J Med"},{"issue":"2","key":"jus180006r32","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1161\/01.CIR.84.2.527","article-title":"Stroke Prevention in Atrial Fibrillation study: final results.","volume":"84","year":"1991","journal-title":"Circulation"},{"issue":"2","key":"jus180006r33","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0735-1097(91)90585-W","article-title":"Canadian Atrial Fibrillation Anticoagulation (CAFA) study.","volume":"18","author":"Connolly","year":"1991","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"jus180006r34","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1056\/NEJM199211123272002","article-title":"Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation.","volume":"327","author":"Ezekowitz","year":"1992","journal-title":"N Engl J Med"},{"issue":"2","key":"jus180006r35","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/01.STR.0000198839.61112.ee","article-title":"Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke Trial.","volume":"37","author":"Sato","year":"2006","journal-title":"Stroke"},{"issue":"3","key":"jus180006r36","first-page":"CD001927","article-title":"Oral anticoagulants for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.","author":"Aguilar","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"jus180006r37","first-page":"CD001925","article-title":"Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.","author":"Aguilar","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"jus180006r38","doi-asserted-by":"publisher","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"issue":"13","key":"jus180006r39","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials.","volume":"154","year":"1994","journal-title":"Arch Intern Med"},{"issue":"11","key":"jus180006r40","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/archinte.1997.00440320143013","article-title":"The efficacy of aspirin in patients with atrial fibrillation: analysis of pooled data from 3 randomized trials.","volume":"157","author":"Atrial Fibrillation Investigators","year":"1997","journal-title":"Arch Intern Med"},{"issue":"4","key":"jus180006r41","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1161\/STROKEAHA.108.526988","article-title":"Effect of age on stroke prevention therapy in patients with atrial fibrillation.","volume":"40","author":"van Walraven","year":"2009","journal-title":"Stroke"},{"issue":"5","key":"jus180006r42","doi-asserted-by":"publisher","first-page":"e003206","DOI":"10.1161\/JAHA.116.003206","article-title":"Comparative effectiveness of interventions for stroke prevention in atrial fibrillation: a network meta-analysis","volume":"5","author":"Tereshchenko","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"jus180006r43","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/ijcp.2011.66.issue-1","article-title":"Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation.","volume":"66","author":"Coleman","year":"2012","journal-title":"Int J Clin Pract"},{"issue":"8","key":"jus180006r45","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1161\/CIRCULATIONAHA.112.126656","article-title":"Stepwise screening of atrial fibrillation in a 75-year-old population: implications for stroke prevention.","volume":"127","author":"Engdahl","year":"2013","journal-title":"Circulation"},{"issue":"5","key":"jus180006r46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/clc.22387","article-title":"Feasibility of extended ambulatory electrocardiogram monitoring to identify silent atrial fibrillation in high-risk patients: the Screening Study for Undiagnosed Atrial Fibrillation (STUDY-AF).","volume":"38","author":"Turakhia","year":"2015","journal-title":"Clin Cardiol"},{"issue":"9","key":"jus180006r47","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.amjmed.2004.06.024","article-title":"Misdiagnosis of atrial fibrillation and its clinical consequences.","volume":"117","author":"Bogun","year":"2004","journal-title":"Am J Med"},{"issue":"20","key":"jus180006r48","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1001\/jama.290.20.2685","article-title":"Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice?","volume":"290","author":"Go","year":"2003","journal-title":"JAMA"},{"issue":"29","key":"jus180006r49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta21290","article-title":"Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis.","volume":"21","author":"Welton","year":"2017","journal-title":"Health Technol Assess"},{"key":"jus180006r51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ahj.2016.02.011","article-title":"Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: the mHealth Screening To Prevent Strokes (mSToPS) trial.","volume":"175","author":"Steinhubl","year":"2016","journal-title":"Am Heart J"},{"key":"jus180006r52","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s13063-015-1006-5","article-title":"Detecting and Diagnosing Atrial Fibrillation (D2AF): study protocol for a cluster randomised controlled trial.","volume":"16","author":"Uittenbogaart","year":"2015","journal-title":"Trials"},{"key":"jus180006r14","unstructured":"U.S. Preventive Services Task Force. U.S. Preventive Services Task Force Procedure Manual, Appendix VI. https:\/\/www.uspreventiveservicestaskforce.org\/Page\/Name\/methods-and-processes. Published 2015. Accessed May 17, 2017."},{"key":"jus180006r18","unstructured":"Population Health Research Institute. Home-based screening for early detection of atrial fibrillation in primary care patients aged 75 years and older (SCREEN-AF) [NCT02392754]. ClinicalTrials.gov website. https:\/\/ClinicalTrials.gov\/show\/NCT02392754. Cited 2017. Accessed April 6, 2018."},{"key":"jus180006r22","unstructured":"Karolinska University Hospital. Systematic ECG screening for atrial fibrillation among 75 year old subjects in the region of Stockholm and Halland, Sweden [NCT01593553]. ClinicalTrials.gov website. https:\/\/ClinicalTrials.gov\/show\/NCT01593553. Accessed April 6, 2018."},{"key":"jus180006r44","unstructured":"MatherM. Fact sheet: aging in the United States. Population Reference Bureau website. https:\/\/www.prb.org\/aging-unitedstates-fact-sheet\/. Published 2016. Accessed May 16, 2017."},{"key":"jus180006r50","unstructured":"UtrechtUMC. Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick (IDEAL-MD) [NCT02270151]. ClinicalTrials.gov website. https:\/\/ClinicalTrials.gov\/show\/NCT02270151. Cited 2017. Accessed April 6, 2018."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2695677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T16:00:50Z","timestamp":1533657650000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2018.4190"}},"subtitle":["Evidence Report and Systematic Review for the US Preventive Services Task Force"],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8,7]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2018.4190","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,7]]}}}