{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:58:29Z","timestamp":1792677509228,"version":"4.5.0"},"reference-count":26,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2018,7,24]]},"DOI":"10.1001\/jama.2018.9071","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T23:31:38Z","timestamp":1532475098000},"page":"358","source":"Crossref","is-referenced-by-count":300,"title":["Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis"],"prefix":"10.1001","volume":"320","author":[{"given":"Idris V. R.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Phillips","sequence":"additional","affiliation":[{"name":"IPRO, Lake Success, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Alpern","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C.","family":"Angus","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, Pennsylvania"},{"name":"Associate Editor, JAMA, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Kissoon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care, BC Children\u2019s Hospital and Research Institute, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Lemeshow","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health, The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell M.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Critical Care & Sleep, Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Critical Care Medicine, Stony Brook Children\u2019s Hospital, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Terry","sequence":"additional","affiliation":[{"name":"IPRO, Lake Success, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Watson","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine, Seattle Children\u2019s Hospital and Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, The Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine, Seattle Children\u2019s Hospital and Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"9","key":"joi180074r1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1097\/PCC.0000000000000225","article-title":"Pediatric severe sepsis in US children\u2019s hospitals.","volume":"15","author":"Balamuth","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"2","key":"joi180074r2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"3","key":"joi180074r3","doi-asserted-by":"publisher","first-page":"e758","DOI":"10.1542\/peds.2010-2895","article-title":"Implementation of goal-directed therapy for children with suspected sepsis in the emergency department.","volume":"127","author":"Cruz","year":"2011","journal-title":"Pediatrics"},{"issue":"6","key":"joi180074r4","doi-asserted-by":"publisher","first-page":"e1585","DOI":"10.1542\/peds.2010-3513","article-title":"An emergency department septic shock protocol and care guideline for children initiated at triage.","volume":"127","author":"Larsen","year":"2011","journal-title":"Pediatrics"},{"issue":"2","key":"joi180074r7","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/CCM.0b013e31819323c6","article-title":"Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine [published correction appears in Crit Care Med. 2009;37(4):1536].","volume":"37","author":"Brierley","year":"2009","journal-title":"Crit Care Med"},{"issue":"1","key":"joi180074r8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"issue":"23","key":"joi180074r9","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to treatment and mortality during mandated emergency care for sepsis.","volume":"376","author":"Seymour","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"joi180074r10","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/jgs.1999.47.issue-6","article-title":"Assessment and control for confounding by indication in observational studies.","volume":"47","author":"Psaty","year":"1999","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"joi180074r11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1542\/peds.2006-2353","article-title":"Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis.","volume":"119","author":"Odetola","year":"2007","journal-title":"Pediatrics"},{"issue":"5","key":"joi180074r12","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1164\/rccm.200207-682OC","article-title":"The epidemiology of severe sepsis in children in the United States.","volume":"167","author":"Watson","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"joi180074r13","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1164\/rccm.200405-630OC","article-title":"Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children.","volume":"171","author":"Leclerc","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"joi180074r14","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/01.CCM.0000256726.80998.BF","article-title":"Occurrence and outcomes of sepsis: influence of race.","volume":"35","author":"Dombrovskiy","year":"2007","journal-title":"Crit Care Med"},{"issue":"10","key":"joi180074r17","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1097\/01.CCM.0000142704.36378.E9","article-title":"Guidelines and levels of care for pediatric intensive care units.","volume":"32","author":"Rosenberg","year":"2004","journal-title":"Crit Care Med"},{"issue":"4","key":"joi180074r18","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1055\/s-0038-1634008","article-title":"Building multivariable regression models with continuous covariates in clinical epidemiology: with an emphasis on fractional polynomials.","volume":"44","author":"Royston","year":"2005","journal-title":"Methods Inf Med"},{"issue":"6, pt 1","key":"joi180074r19","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1111\/hesr.2010.45.issue-6p1","article-title":"Ranking hospitals on surgical mortality: the importance of reliability adjustment.","volume":"45","author":"Dimick","year":"2010","journal-title":"Health Serv Res"},{"issue":"3","key":"joi180074r20","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1542\/peds.2008-0856","article-title":"Readmission and late mortality after pediatric severe sepsis.","volume":"123","author":"Czaja","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"joi180074r21","doi-asserted-by":"publisher","first-page":"S153","DOI":"10.1542\/peds.2012-0055I","article-title":"Standard 6: age groups for pediatric trials.","volume":"129","author":"Williams","year":"2012","journal-title":"Pediatrics"},{"issue":"9","key":"joi180074r23","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/PCC.0000000000000858","article-title":"Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis.","volume":"17","author":"Balamuth","year":"2016","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"joi180074r24","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1097\/CCM.0000000000002425","article-title":"American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock.","volume":"45","author":"Davis","year":"2017","journal-title":"Crit Care Med"},{"issue":"1","key":"joi180074r25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1542\/hpeds.2012-0015","article-title":"A quality improvement project to improve compliance with the joint commission children\u2019s asthma care-3 measure.","volume":"3","author":"Kuhlmann","year":"2013","journal-title":"Hosp Pediatr"},{"issue":"8","key":"joi180074r26","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3).","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"joi180074r22","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87959-8","volume-title":"Applying Quantitative Bias Analysis to Epidemiologic Data","author":"Lash","year":"2009"},{"key":"joi180074r5","unstructured":"DwyerJ. An infection, unnoticed, turns unstoppable. The New York Times. https:\/\/www.nytimes.com\/2012\/07\/12\/nyregion\/in-rory-stauntons-fight-for-his-life-signs-that-went-unheeded.html. Published July 11, 2012. Accessed July 20, 2017."},{"key":"joi180074r6","unstructured":"New York State Department of Health. New York State report on sepsis care improvement initiative: hospital quality performance. https:\/\/www. health.ny.gov\/ press\/ reports\/ docs\/2015_sepsis_care_improvement_initiative.pdf. Published March 2017. Accessed December 22, 2017."},{"key":"joi180074r15","unstructured":"New York State Department of Health. Statewide Planning and Research Cooperative System (SPARCS). https:\/\/www.health.ny.gov\/statistics\/sparcs\/. Accessed May 18, 2018."},{"key":"joi180074r16","unstructured":"New York State Department of Health. Health facility certification information. https:\/\/health.data.ny.gov\/Health\/Health-Facility-Certification-Information\/2g9y-7kqm\/data. Accessed January 4, 2018."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2688568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T23:32:02Z","timestamp":1532475122000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2018.9071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,24]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7,24]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2018.9071","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,24]]}}}