{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:30:30Z","timestamp":1791819030903,"version":"4.3.4"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,10,1]]},"DOI":"10.1001\/jama.2019.11455","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T11:30:50Z","timestamp":1569929450000},"page":"1283","source":"Crossref","is-referenced-by-count":201,"title":["Association of General Anesthesia vs Procedural Sedation With Functional Outcome Among Patients With Acute Ischemic Stroke Undergoing Thrombectomy"],"prefix":"10.1001","volume":"322","author":[{"given":"Silvia","family":"Sch\u00f6nenberger","sequence":"first","affiliation":[{"name":"Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia L\u00f6whagen","family":"Hend\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Z.","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Uhlmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Klose","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A. R.","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neuroendovascular Service, Texas Stroke Institute, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif H.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ringleb","sequence":"additional","affiliation":[{"name":"Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wick","sequence":"additional","affiliation":[{"name":"Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinhard","family":"Kieser","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A.","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Section of Neuroanesthesia, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Rentzos","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"B\u00f6sel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"10029","key":"joi190084r1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"joi190084r2","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/STROKEAHA.109.574194","article-title":"Comparison of safety and clinical and radiographic outcomes in endovascular acute stroke therapy for proximal middle cerebral artery occlusion with intubation and general anesthesia versus the nonintubated state.","volume":"41","author":"Jumaa","year":"2010","journal-title":"Stroke"},{"issue":"2","key":"joi190084r3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/ALN.0b013e318242a5d2","article-title":"Anesthetic management and outcome in patients during endovascular therapy for acute stroke.","volume":"116","author":"Davis","year":"2012","journal-title":"Anesthesiology"},{"issue":"5","key":"joi190084r4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1161\/STROKEAHA.115.008699","article-title":"Type of anesthesia and differences in clinical outcome after intra-arterial treatment for ischemic stroke.","volume":"46","author":"van den Berg","year":"2015","journal-title":"Stroke"},{"issue":"7","key":"joi190084r5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1212\/WNL.0000000000002976","article-title":"The effect of anesthetic management during intra-arterial therapy for acute stroke in MR CLEAN.","volume":"87","author":"Berkhemer","year":"2016","journal-title":"Neurology"},{"issue":"8","key":"joi190084r6","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1161\/STROKEAHA.115.008761","article-title":"Impact of general anesthesia on safety and outcomes in the endovascular arm of Interventional Management of Stroke (IMS) III trial.","volume":"46","author":"Abou-Chebl","year":"2015","journal-title":"Stroke"},{"issue":"3","key":"joi190084r7","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3174\/ajnr.A4159","article-title":"Conscious sedation versus general anesthesia during endovascular acute ischemic stroke treatment: a systematic review and meta-analysis.","volume":"36","author":"Brinjikji","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"joi190084r8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1474-4422(17)30407-6","article-title":"Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.","volume":"17","author":"Campbell","year":"2018","journal-title":"Lancet Neurol"},{"issue":"11","key":"joi190084r9","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1136\/neurintsurg-2015-011998","article-title":"Anesthetic variation and potential impact of anesthetics used during endovascular management of acute ischemic stroke.","volume":"8","author":"Sivasankar","year":"2016","journal-title":"J Neurointerv Surg"},{"issue":"19","key":"joi190084r10","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1001\/jama.2016.16623","article-title":"Effect of conscious sedation vs general anesthesia on early neurological improvement among patients with ischemic stroke undergoing endovascular thrombectomy: a randomized clinical trial.","volume":"316","author":"Sch\u00f6nenberger","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"joi190084r11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1161\/STROKEAHA.117.016554","article-title":"General anesthesia versus conscious sedation for endovascular treatment of acute ischemic stroke: the AnStroke trial (anesthesia during stroke).","volume":"48","author":"L\u00f6whagen Hend\u00e9n","year":"2017","journal-title":"Stroke"},{"issue":"4","key":"joi190084r12","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1001\/jamaneurol.2017.4474","article-title":"Effect of general anesthesia and conscious sedation during endovascular therapy on infarct growth and clinical outcomes in acute ischemic stroke: a randomized clinical trial.","volume":"75","author":"Simonsen","year":"2018","journal-title":"JAMA Neurol"},{"issue":"9","key":"joi190084r13","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/S1474-4422(09)70182-6","article-title":"Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study.","volume":"8","author":"Mazighi","year":"2009","journal-title":"Lancet Neurol"},{"issue":"1","key":"joi190084r14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s41235-017-0081-4","article-title":"The effect of testing can increase or decrease misinformation susceptibility depending on the retention interval.","volume":"2","author":"Thomas","year":"2017","journal-title":"Cogn Res Princ Implic"},{"issue":"5","key":"joi190084r15","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/sim.7141","article-title":"Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ.","volume":"36","author":"Burke","year":"2017","journal-title":"Stat Med"},{"key":"joi190084r16","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3389\/fneur.2018.00702","article-title":"Impact of anesthetic management on safety and outcomes following mechanical thrombectomy for ischemic stroke in SWIFT PRIME cohort.","volume":"9","author":"Eker","year":"2018","journal-title":"Front Neurol"},{"issue":"1","key":"joi190084r17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/jnis.2009.001768","article-title":"Is periprocedural sedation during acute stroke therapy associated with poorer functional outcomes?","volume":"2","author":"Nichols","year":"2010","journal-title":"J Neurointerv Surg"},{"issue":"7","key":"joi190084r18","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3174\/ajnr.A5183","article-title":"Impact of anesthesia on the outcome of acute ischemic stroke after endovascular treatment with the solitaire stent retriever.","volume":"38","author":"Slezak","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"11","key":"joi190084r19","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/S1474-4422(16)30177-6","article-title":"Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial.","volume":"15","author":"Bracard","year":"2016","journal-title":"Lancet Neurol"},{"issue":"3","key":"joi190084r20","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1148\/radiol.2017171002","article-title":"Effect of general anesthesia versus conscious sedation for stroke thrombectomy on angiographic workflow in a randomized trial: a post hoc analysis of the SIESTA trial.","volume":"286","author":"Pfaff","year":"2018","journal-title":"Radiology"},{"issue":"9","key":"joi190084r21","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1161\/STROKEAHA.115.009808","article-title":"Hypotension during endovascular treatment of ischemic stroke is a risk factor for poor neurological outcome.","volume":"46","author":"L\u00f6whagen Hend\u00e9n","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"joi190084r22","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3174\/ajnr.A4992","article-title":"Even small decreases in blood pressure during conscious sedation affect clinical outcome after stroke thrombectomy: an analysis of hemodynamic thresholds.","volume":"38","author":"Whalin","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"joi190084r23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1136\/neurintsurg-2017-012988","article-title":"A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia.","volume":"10","author":"Treurniet","year":"2018","journal-title":"J Neurointerv Surg"},{"issue":"6","key":"joi190084r24","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/STROKEAHA.117.019709","article-title":"Association of blood pressure with short- and long-term functional outcome after stroke thrombectomy: post hoc analysis of the SIESTA trial.","volume":"49","author":"Sch\u00f6nenberger","year":"2018","journal-title":"Stroke"},{"issue":"6","key":"joi190084r25","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.bja.2018.01.039","article-title":"The influence of blood pressure management on neurological outcome in endovascular therapy for acute ischaemic stroke.","volume":"120","author":"Rasmussen","year":"2018","journal-title":"Br J Anaesth"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2752061\/jama_schnenberger_2019_oi_190084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:00:51Z","timestamp":1576839651000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2752061"}},"subtitle":["A Systematic Review and Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":25,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.11455","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736694085.793568038","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.736694085.793566034","asserted-by":"object"}]},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}