{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:55:11Z","timestamp":1792803311829,"version":"4.5.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,12,10]]},"DOI":"10.1001\/jama.2019.18037","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T11:01:13Z","timestamp":1575975673000},"page":"2203","source":"Crossref","is-referenced-by-count":102,"title":["Association Between Fertility Treatment and Cancer Risk in Children"],"prefix":"10.1001","volume":"322","author":[{"given":"Marie","family":"Hargreave","sequence":"first","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete Kj\u00e6r","family":"Hansen","sequence":"additional","affiliation":[{"name":"Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette Falck","family":"Winther","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark"},{"name":"Department of Gynecology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"19","key":"joi190129r4","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects.","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"joi190129r5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? systematic review and meta-analysis.","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"issue":"1","key":"joi190129r6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.fertnstert.2013.03.017","article-title":"Fertility treatment and childhood cancer risk: a systematic meta-analysis.","volume":"100","author":"Hargreave","year":"2013","journal-title":"Fertil Steril"},{"issue":"20","key":"joi190129r7","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","article-title":"DNA methylation and gene expression differences in children conceived in vitro or in vivo.","volume":"18","author":"Katari","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"3","key":"joi190129r8","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/GCO.0000000000000071","article-title":"The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders.","volume":"26","author":"Uyar","year":"2014","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"12","key":"joi190129r9","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1002\/ijc.v144.12","article-title":"Cancer risk among children conceived by fertility treatment.","volume":"144","author":"Wang","year":"2019","journal-title":"Int J Cancer"},{"issue":"11","key":"joi190129r10","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1093\/humrep\/16.11.2451","article-title":"Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF.","volume":"16","author":"Klip","year":"2001","journal-title":"Hum Reprod"},{"issue":"8","key":"joi190129r11","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1002\/ijc.29235","article-title":"Maternal use of fertility drugs and risk of cancer in children\u2014a nationwide population-based cohort study in Denmark.","volume":"136","author":"Hargreave","year":"2015","journal-title":"Int J Cancer"},{"issue":"9","key":"joi190129r12","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1093\/oxfordjournals.aje.a010101","article-title":"Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children\u2019s Cancer Group and the Pediatric Oncology Group.","volume":"150","author":"Olshan","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"19","key":"joi190129r13","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1056\/NEJMoa1301675","article-title":"Cancer risk among children born after assisted conception.","volume":"369","author":"Williams","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"joi190129r14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/humrep\/dex333","article-title":"Cancer risk in children born after donor ART.","volume":"33","author":"Williams","year":"2018","journal-title":"Hum Reprod"},{"issue":"2","key":"joi190129r15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1542\/peds.2009-3225","article-title":"Cancer risk in children and young adults conceived by in vitro fertilization.","volume":"126","author":"K\u00e4ll\u00e9n","year":"2010","journal-title":"Pediatrics"},{"issue":"8","key":"joi190129r16","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/0895-4356(96)00018-2","article-title":"Validation of the Danish Birth Registration.","volume":"49","author":"Kristensen","year":"1996","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"joi190129r17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10654-018-0356-1","article-title":"The Danish Medical Birth Register.","volume":"33","author":"Bliddal","year":"2018","journal-title":"Eur J Epidemiol"},{"issue":"7","key":"joi190129r18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System.","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"7","key":"joi190129r20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register.","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand J Public Health"},{"issue":"5","key":"joi190129r21","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1080\/j.1600-0412.2000.079005384.x","article-title":"Danish National IVF Registry 1994 and 1995: treatment, pregnancy outcome and complications during pregnancy.","volume":"79","author":"Westergaard","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"7","key":"joi190129r22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry.","volume":"39","author":"Kildemoes","year":"2011","journal-title":"Scand J Public Health"},{"issue":"5","key":"joi190129r23","first-page":"535","article-title":"The Danish Cancer Registry\u2014history, content, quality and use.","volume":"44","author":"Storm","year":"1997","journal-title":"Dan Med Bull"},{"issue":"4","key":"joi190129r24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/00008469-200208000-00007","article-title":"Validity of breast cancer in the Danish Cancer Registry: a study based on clinical records from one county in Denmark.","volume":"11","author":"Jensen","year":"2002","journal-title":"Eur J Cancer Prev"},{"issue":"4","key":"joi190129r25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1177\/0962280214521348","article-title":"Multiple imputation of covariates by fully conditional specification: accommodating the substantive model.","volume":"24","author":"Bartlett","year":"2015","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"joi190129r26","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-value.","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann Intern Med"},{"issue":"6","key":"joi190129r27","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2019.0392","article-title":"Association of in vitro fertilization with childhood cancer in the United States.","volume":"173","author":"Spector","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"4","key":"joi190129r28","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/humrep\/dey394","article-title":"Risk of cancer in children and young adults conceived by assisted reproductive technology.","volume":"34","author":"Spaan","year":"2019","journal-title":"Hum Reprod"},{"issue":"1","key":"joi190129r29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/1055-9965.EPI-05-0923","article-title":"High birthweight and cancer: evidence and implications.","volume":"15","author":"Ross","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"6","key":"joi190129r30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067614","article-title":"Cryopreservation causes genetic and epigenetic changes in zebrafish genital ridges.","volume":"8","author":"Riesco","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"joi190129r31","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cryobiol.2014.06.003","article-title":"A preliminary study on epigenetic changes during boar spermatozoa cryopreservation.","volume":"69","author":"Zeng","year":"2014","journal-title":"Cryobiology"},{"issue":"1","key":"joi190129r32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1530\/jrf.0.0910009","article-title":"An association between chromosomal abnormalities in rapidly frozen 2-cell mouse embryos and the ice-forming properties of the cryoprotective solution.","volume":"91","author":"Shaw","year":"1991","journal-title":"J Reprod Fertil"},{"key":"joi190129r34","article-title":"NTP 12th report on carcinogens.","volume":"12","author":"National Toxicology Program","year":"2011","journal-title":"Rep Carcinog"},{"key":"joi190129r2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-3-319-44667-7_14","volume-title":"Childlessness in Europe: Contexts, Causes, and Consequences","author":"Pr\u00e4g","year":"2017"},{"key":"joi190129r1","unstructured":"European Medical Journal. Review of the 34th European Society of Human Reproduction and Embryology congress 2018. https:\/\/www.emjreviews.com\/reproductive-health\/congress-review\/review-of-the-34th-european-society-of-human-reproduction-and-embryology-congress-2018\/. Accessed November 2, 2019."},{"key":"joi190129r3","unstructured":"Danish Fertility Society. Results for 2018. https:\/\/fertilitetsselskab.dk\/wp-content\/uploads\/2019\/03\/dfs2018-til-hjemmesiden.pdf. Accessed November 4, 2019."},{"key":"joi190129r19","unstructured":"Statistics Denmark. Accuracy and reliability. https:\/\/www.dst.dk\/en\/Statistik\/dokumentation\/documentationofstatistics\/highest-education-attained\/accuracy-and-reliability. Accessed November 4, 2019."},{"key":"joi190129r33","unstructured":"Danish Fertility Society. FER from 2013. https:\/\/fertilitetsselskab.dk\/wp-content\/uploads\/2018\/10\/fer_guidelines.anna-kaisa_poranen_130613.pdf. Accessed November 4, 2019."},{"key":"joi190129r35","unstructured":"Danish Fertility Society. IVF og ICSI procedurer 29.11.2006. https:\/\/fertilitetsselskab.dk\/kliniske-guidelines-arkiv\/. Accessed November 4, 2019."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2757228\/jama_hargreave_2019_oi_190129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T11:01:19Z","timestamp":1575975679000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2757228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":35,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2019,12,10]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.18037","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,10]]}}}