{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:21:48Z","timestamp":1790896908368,"version":"4.1.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2020,2,18]]},"DOI":"10.1001\/jama.2019.21782","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T11:48:03Z","timestamp":1582026483000},"page":"627","source":"Crossref","is-referenced-by-count":323,"title":["Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease"],"prefix":"10.1001","volume":"323","author":[{"given":"Jonathan D.","family":"Mosley","sequence":"first","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Tan","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn S.","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassianne","family":"Robinson-Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt O'Brien Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Psaty","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Epidemiology and Health Services, University of Washington School of Public Health; and Kaiser Permanente Washington Health Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I","family":"Rotter","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California"},{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, California12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee"},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Gerszten","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"10","key":"joi190150r1","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association.","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"25","key":"joi190150r2","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines.","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"issue":"14","key":"joi190150r3","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1001\/jama.2014.2630","article-title":"Validation of the atherosclerotic cardiovascular disease pooled cohort risk equations.","volume":"311","author":"Muntner","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"joi190150r4","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1001\/jamainternmed.2019.0142","article-title":"Precision preventive medicine-ready for prime time?","volume":"179","author":"Greenland","year":"2019","journal-title":"JAMA Intern Med"},{"issue":"9","key":"joi190150r5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41576-018-0018-x","article-title":"The personal and clinical utility of polygenic risk scores.","volume":"19","author":"Torkamani","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"3","key":"joi190150r6","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.cell.2019.03.028","article-title":"Polygenic prediction of weight and obesity trajectories from birth to adulthood.","volume":"177","author":"Khera","year":"2019","journal-title":"Cell"},{"issue":"9","key":"joi190150r7","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s41588-018-0183-z","article-title":"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.","volume":"50","author":"Khera","year":"2018","journal-title":"Nat Genet"},{"issue":"16","key":"joi190150r8","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jacc.2018.07.079","article-title":"Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention.","volume":"72","author":"Inouye","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"joi190150r9","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1161\/CIRCGENETICS.116.001522","article-title":"Clinical utility of multimarker genetic risk scores for prediction of incident coronary heart disease: a cohort study among over 51 000 individuals of European ancestry.","volume":"9","author":"Iribarren","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"joi190150r10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002481","article-title":"Validation of genome-wide polygenic risk scores for coronary artery disease in French Canadians.","volume":"12","author":"W\u00fcnnemann","year":"2019","journal-title":"Circ Genom Precis Med"},{"issue":"3","key":"joi190150r11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002546","article-title":"Cardiovascular disease: the rise of the genetic risk score.","volume":"15","author":"Knowles","year":"2018","journal-title":"PLoS Med"},{"issue":"7726","key":"joi190150r12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/d41586-018-06956-3","article-title":"The approach to predictive medicine that is taking genomics research by storm.","volume":"562","author":"Warren","year":"2018","journal-title":"Nature"},{"issue":"4","key":"joi190150r13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk in Communities (ARIC) study: design and objectives. The ARIC investigators.","volume":"129","author":"The ARIC investigators","year":"1989","journal-title":"Am J Epidemiol"},{"issue":"9","key":"joi190150r14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design.","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"10","key":"joi190150r15","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat Genet"},{"issue":"2","key":"joi190150r16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","article-title":"Inference of population structure using multilocus genotype data.","volume":"155","author":"Pritchard","year":"2000","journal-title":"Genetics"},{"issue":"6","key":"joi190150r17","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1161\/CIRCGENETICS.116.001530","article-title":"Defining a contemporary ischemic heart disease genetic risk profile using historical data.","volume":"9","author":"Mosley","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"joi190150r18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"12","key":"joi190150r19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis.","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genet"},{"issue":"24","key":"joi190150r20","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1093\/bioinformatics\/bts606","article-title":"A high-performance computing toolset for relatedness and principal component analysis of SNP data.","volume":"28","author":"Zheng","year":"2012","journal-title":"Bioinformatics"},{"issue":"4","key":"joi190150r21","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","article-title":"Modeling linkage disequilibrium increases accuracy of polygenic risk scores.","volume":"97","author":"Vilhj\u00e1lmsson","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"18","key":"joi190150r22","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1001\/jama.1982.03320430047030","article-title":"Evaluating the yield of medical tests.","volume":"247","author":"Harrell","year":"1982","journal-title":"JAMA"},{"issue":"10","key":"joi190150r23","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1002\/sim.v34.10","article-title":"Tests of calibration and goodness-of-fit in the survival setting.","volume":"34","author":"Demler","year":"2015","journal-title":"Stat Med"},{"issue":"2","key":"joi190150r24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"issue":"1","key":"joi190150r25","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/EDE.0000000000000018","article-title":"Net reclassification indices for evaluating risk prediction instruments: a critical review.","volume":"25","author":"Kerr","year":"2014","journal-title":"Epidemiology"},{"issue":"22","key":"joi190150r26","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.1002\/sim.6195","article-title":"How to interpret a small increase in AUC with an additional risk prediction marker: decision analysis comes through.","volume":"33","author":"Baker","year":"2014","journal-title":"Stat Med"},{"issue":"10","key":"joi190150r27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.118.002324","article-title":"Coronary heart disease genetic risk score predicts cardiovascular disease risk in men, not women.","volume":"11","author":"Hajek","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"10","key":"joi190150r28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.7326\/0003-4819-149-10-200811180-00009","article-title":"Assessing the value of risk predictions by using risk stratification tables.","volume":"149","author":"Janes","year":"2008","journal-title":"Ann Intern Med"},{"issue":"8","key":"joi190150r29","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41436-018-0418-5","article-title":"The illusion of polygenic disease risk prediction.","volume":"21","author":"Wald","year":"2019","journal-title":"Genet Med"},{"issue":"9","key":"joi190150r30","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/aje\/kwh101","article-title":"Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker.","volume":"159","author":"Pepe","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"16","key":"joi190150r31","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis.","volume":"288","author":"Homocysteine Studies Collaboration","year":"2002","journal-title":"JAMA"},{"issue":"14","key":"joi190150r32","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction.","volume":"367","author":"Kaptoge","year":"2012","journal-title":"N Engl J Med"},{"issue":"10","key":"joi190150r33","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jacc.2014.06.1186","article-title":"A systematic examination of the 2013 ACC\/AHA pooled cohort risk assessment tool for atherosclerotic cardiovascular disease.","volume":"64","author":"Karmali","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"joi190150r34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/CIRCULATIONAHA.116.022335","article-title":"Long-term risk of atherosclerotic cardiovascular disease in US adults with the familial hypercholesterolemia phenotype.","volume":"134","author":"Perak","year":"2016","journal-title":"Circulation"},{"issue":"25","key":"joi190150r35","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1056\/NEJMoa055373","article-title":"Multiple biomarkers for the prediction of first major cardiovascular events and death.","volume":"355","author":"Wang","year":"2006","journal-title":"N Engl J Med"},{"key":"joi190150r36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fcvm.2017.00053","article-title":"Impact of a genetic risk score for coronary artery disease on reducing cardiovascular risk: a pilot randomized controlled study.","volume":"4","author":"Knowles","year":"2017","journal-title":"Front Cardiovasc Med"},{"issue":"12","key":"joi190150r37","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1161\/CIRCULATIONAHA.115.020109","article-title":"Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial).","volume":"133","author":"Kullo","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"joi190150r38","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13073-018-0610-x","article-title":"Polygenic risk scores: a biased prediction?","volume":"10","author":"De La Vega","year":"2018","journal-title":"Genome Med"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2761086\/jama_mosley_2020_oi_190150_1599860876.30762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T18:02:38Z","timestamp":1665856958000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2761086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,2,18]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.21782","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,18]]}}}