{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:53:48Z","timestamp":1793836428364,"version":"4.6.1"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2020,2,4]]},"DOI":"10.1001\/jama.2019.22450","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T18:00:30Z","timestamp":1580925630000},"page":"432","source":"Crossref","is-referenced-by-count":282,"title":["Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia"],"prefix":"10.1001","volume":"323","author":[{"given":"Myles","family":"Wolf","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rubin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Achebe","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Econs","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munro","family":"Peacock","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Imel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars L.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Non-clinical Research, Pharmacosmos A\/S, Holb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Brandenburg","sequence":"additional","affiliation":[{"name":"Rhein-Maas Klinikum W\u00fcrselen, W\u00fcrselen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Zoller","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"19","key":"joi190155r1","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-deficiency anemia.","volume":"372","author":"Camaschella","year":"2015","journal-title":"N Engl J Med"},{"issue":"10021","key":"joi190155r2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia.","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"joi190155r3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12185-017-2373-3","article-title":"Modern iron replacement therapy: clinical and pathophysiological insights.","volume":"107","author":"Girelli","year":"2018","journal-title":"Int J Hematol"},{"issue":"3","key":"joi190155r4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/ph11030082","article-title":"Intravenous irons: from basic science to clinical practice.","volume":"11","author":"Bhandari","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"3","key":"joi190155r5","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/ajh.24633","article-title":"A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia.","volume":"92","author":"Derman","year":"2017","journal-title":"Am J Hematol"},{"issue":"3","key":"joi190155r6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/vox.2017.112.issue-3","article-title":"Single-dose intravenous iron infusion or oral iron for treatment of fatigue after postpartum haemorrhage: a\u00a0randomized controlled trial.","volume":"112","author":"Holm","year":"2017","journal-title":"Vox Sang"},{"issue":"2","key":"joi190155r7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/trf.12289","article-title":"A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia.","volume":"54","author":"Onken","year":"2014","journal-title":"Transfusion"},{"issue":"4","key":"joi190155r8","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/ndt\/gft251","article-title":"Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial.","volume":"29","author":"Onken","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"joi190155r9","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jbmr.1923","article-title":"Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women.","volume":"28","author":"Wolf","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"23","key":"joi190155r10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124486","article-title":"Randomized trial of intravenous iron-induced hypophosphatemia.","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"joi190155r11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","article-title":"FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.","volume":"16","author":"Edmonston","year":"2020","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"joi190155r12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-200001000-00001","article-title":"Severe hypophosphatemia: pathophysiologic implications, clinical presentations, and treatment.","volume":"79","author":"Subramanian","year":"2000","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"joi190155r13","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MNH.0000000000000329","article-title":"Iron-induced hypophosphatemia: an emerging complication.","volume":"26","author":"Zoller","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"joi190155r14","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1182\/blood-2018-99-110199","article-title":"A single infusion of iron isomaltoside 1000 allows a more rapid hemoglobin increment than multiple doses of iron sucrose with a similar safety profile in patients with iron deficiency anemia.","volume":"132","author":"Auerbach","year":"2018","journal-title":"Blood"},{"key":"joi190155r15","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1182\/blood-2018-99-114386","article-title":"Hypophosphatemia after high dosage iron substitution with ferric carboxymaltose (FCM) and iron isomaltoside (IM): the randomised controlled Home Afers 1 trial.","volume":"132","author":"Emrich","year":"2018","journal-title":"Blood"},{"issue":"4","key":"joi190155r17","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/phar.2016.36.issue-4","article-title":"A randomized noninferiority trial of intravenous iron isomaltoside versus oral iron sulfate in patients with nonmyeloid malignancies and anemia receiving chemotherapy: the PROFOUND trial.","volume":"36","author":"Birgeg\u00e5rd","year":"2016","journal-title":"Pharmacotherapy"},{"issue":"11","key":"joi190155r18","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1080\/00365521.2016.1196496","article-title":"High-dose fast infusion of parenteral iron isomaltoside is efficacious in inflammatory bowel disease patients with iron-deficiency anaemia without profound changes in phosphate or fibroblast growth factor 23.","volume":"51","author":"Dahlerup","year":"2016","journal-title":"Scand J Gastroenterol"},{"issue":"12","key":"joi190155r19","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1038\/ajg.2013.335","article-title":"A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1,000 (Monofer) compared with oral iron for treatment of anemia in IBD (PROCEED).","volume":"108","author":"Reinisch","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"joi190155r20","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1111\/j.1537-2995.2009.02327.x","article-title":"Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.","volume":"49","author":"Van Wyck","year":"2009","journal-title":"Transfusion"},{"issue":"4","key":"joi190155r21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094217","article-title":"Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women: PREFER a randomized, placebo-controlled study.","volume":"9","author":"Favrat","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"joi190155r22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1198\/sbr.2009.0049","article-title":"Stratified Wilson and Newcombe confidence intervals for multiple binomial proportions.","volume":"2","author":"Yan","year":"2010","journal-title":"Stat Biopharm Res"},{"issue":"12","key":"joi190155r23","doi-asserted-by":"publisher","first-page":"3820","DOI":"10.1172\/JCI36479","article-title":"Endocrine functions of bone in mineral metabolism regulation.","volume":"118","author":"Quarles","year":"2008","journal-title":"J Clin Invest"},{"issue":"15","key":"joi190155r24","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1056\/NEJM198904133201506","article-title":"The role of the vitamin D endocrine system in health and disease.","volume":"320","author":"Reichel","year":"1989","journal-title":"N Engl J Med"},{"issue":"3","key":"joi190155r25","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency.","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"issue":"3","key":"joi190155r26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1677\/joe.1.06057","article-title":"Parathyroid hormone: past and present.","volume":"187","author":"Potts","year":"2005","journal-title":"J Endocrinol"},{"issue":"46","key":"joi190155r27","doi-asserted-by":"publisher","first-page":"E1146","DOI":"10.1073\/pnas.1110905108","article-title":"Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.","volume":"108","author":"Farrow","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"joi190155r28","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.","volume":"19","author":"Shimada","year":"2004","journal-title":"J Bone Miner Res"},{"key":"joi190155r29","article-title":"Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration.","volume":"2018","author":"Klein","year":"2018","journal-title":"BMJ Case Rep"},{"issue":"6","key":"joi190155r30","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1053\/j.gastro.2016.09.050","article-title":"Blood and bone loser.","volume":"152","author":"Schaefer","year":"2017","journal-title":"Gastroenterology"},{"issue":"3","key":"joi190155r31","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/jbmr.v33.3","article-title":"Iron supplementation-induced phosphaturic osteomalacia: FGF23 is the culprit.","volume":"33","author":"Urbina","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"1","key":"joi190155r32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1055\/s-0038-1636970","article-title":"Iron-induced osteomalacia.","volume":"27","author":"Burckhardt","year":"2018","journal-title":"Osteologie"},{"issue":"2","key":"joi190155r33","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s12020-011-9512-z","article-title":"Evaluation of bone markers in hypophosphatemic rickets\/osteomalacia.","volume":"40","author":"Nagata","year":"2011","journal-title":"Endocrine"},{"issue":"6","key":"joi190155r34","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/jcp.35.6.625","article-title":"Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia.","volume":"35","author":"Peach","year":"1982","journal-title":"J Clin Pathol"},{"issue":"4","key":"joi190155r35","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/apt.15386","article-title":"Incidence of hypophosphatemia in patients with inflammatory bowel disease treated with ferric carboxymaltose or iron isomaltoside.","volume":"50","author":"Detlie","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"joi190155r16","unstructured":"US Food and Drug Administration. Highlights of prescribing information: Injectafer (ferric carboxymaltose injection). Vifor (International) Inc, Switzerland. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/203565s005lbl.pdf. Revised January 2018. Accessed October 22, 2019."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2760391\/jama_wolf_2020_oi_190155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T23:15:35Z","timestamp":1722381335000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2760391"}},"subtitle":["Two Randomized Clinical Trials"],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,2,4]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.22450","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,4]]}}}