{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:40Z","timestamp":1791498340105,"version":"4.3.4"},"reference-count":21,"publisher":"American Medical Association (AMA)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,5,7]]},"DOI":"10.1001\/jama.2019.4149","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:07:40Z","timestamp":1557256060000},"page":"1677","source":"Crossref","is-referenced-by-count":149,"title":["Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest"],"prefix":"10.1001","volume":"321","author":[{"given":"Per","family":"Nordberg","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Silvio","family":"Taccone","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatolij","family":"Truhlar","sequence":"additional","affiliation":[{"name":"Emergency Medical Services of the Hradec Kralove Region, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"},{"name":"Department of Anesthesiology and Intensive Care, Norrt\u00e4lje Hospital, Norrt\u00e4lje, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hollenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Cuny","sequence":"additional","affiliation":[{"name":"Emergency Department and SAMU, Centre Hospitalier R\u00e9gional Universitaire de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Emergency Department and SAMU, Centre Hospitalier R\u00e9gional Universitaire de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"Emergency Department, St Maria Hospital, Halle, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Higuet","sequence":"additional","affiliation":[{"name":"Emergency Department, St Maria Hospital, Halle, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carmona","family":"Jim\u00e9nes","sequence":"additional","affiliation":[{"name":"Sistema d'Emerg\u00e8ncies M\u00e8diques, Barcelona, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rosell","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Empresa P\u00fablica de Emergencias Sanitarias, Almer\u00eda, Andaluc\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Health and Social Work, University of Hertfordshire, Hertfordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Desruelles","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospitals of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Creteur","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Dillenbeck","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Busche","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University Hospital of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00f6rg","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University Hospital of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Ringh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institute, and Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institute, and Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Resuscitation Science, Karolinska Institute, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"8","key":"joi190036r1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.","volume":"346","author":"Hypothermia after Cardiac Arrest Study Group","year":"2002","journal-title":"N Engl J Med"},{"issue":"1-2","key":"joi190036r2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jns.2007.04.042","article-title":"Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care.","volume":"261","author":"Froehler","year":"2007","journal-title":"J Neurol Sci"},{"issue":"6","key":"joi190036r3","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1097\/CCM.0b013e318212020a","article-title":"Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest.","volume":"39","author":"Che","year":"2011","journal-title":"Crit Care Med"},{"issue":"22","key":"joi190036r4","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1161\/01.CIR.0000131940.19833.85","article-title":"Intra-arrest cooling improves outcomes in a murine cardiac arrest model.","volume":"109","author":"Abella","year":"2004","journal-title":"Circulation"},{"issue":"23","key":"joi190036r5","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33\u00b0C versus 36\u00b0C after cardiac arrest.","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"joi190036r6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.resuscitation.2015.07.018","article-title":"European Resuscitation Council and European Society of Intensive Care Medicine guidelines for post-resuscitation care 2015: section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015.","volume":"95","author":"Nolan","year":"2015","journal-title":"Resuscitation"},{"issue":"18","key":"joi190036r7","doi-asserted-by":"publisher","first-page":"S465","DOI":"10.1161\/CIR.0000000000000262","article-title":"Part 8: Post\u2013Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.","volume":"132","author":"Callaway","year":"2015","journal-title":"Circulation"},{"issue":"7","key":"joi190036r8","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1161\/CIRCULATIONAHA.109.906859","article-title":"Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial.","volume":"122","author":"Bernard","year":"2010","journal-title":"Circulation"},{"issue":"11","key":"joi190036r9","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1161\/CIRCULATIONAHA.116.021989","article-title":"Induction of therapeutic hypothermia during out-of-hospital cardiac arrest using a rapid infusion of cold saline: the RINSE Trial (rapid infusion of cold normal saline).","volume":"134","author":"Bernard","year":"2016","journal-title":"Circulation"},{"issue":"12","key":"joi190036r10","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1007\/s00134-014-3519-x","article-title":"Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest: a randomized controlled trial.","volume":"40","author":"Debaty","year":"2014","journal-title":"Intensive Care Med"},{"issue":"1","key":"joi190036r11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/jama.2013.282173","article-title":"Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial.","volume":"311","author":"Kim","year":"2014","journal-title":"JAMA"},{"issue":"7","key":"joi190036r12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1161\/CIRCULATIONAHA.109.931691","article-title":"Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness).","volume":"122","author":"Castr\u00e9n","year":"2010","journal-title":"Circulation"},{"issue":"8","key":"joi190036r13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.resuscitation.2010.04.027","article-title":"Safety and feasibility of nasopharyngeal evaporative cooling in the emergency department setting in survivors of cardiac arrest.","volume":"81","author":"Busch","year":"2010","journal-title":"Resuscitation"},{"key":"joi190036r14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-227X-13-21","article-title":"Design of the PRINCESS trial: pre-hospital resuscitation intra-nasal cooling effectiveness survival study (PRINCESS).","volume":"13","author":"Nordberg","year":"2013","journal-title":"BMC Emerg Med"},{"issue":"8","key":"joi190036r15","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1161\/STROKEAHA.110.613000","article-title":"Local brain temperature reduction through intranasal cooling with the RhinoChill device: preliminary safety data in brain-injured patients.","volume":"42","author":"Abou-Chebl","year":"2011","journal-title":"Stroke"},{"key":"joi190036r16","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.resuscitation.2010.08.002","article-title":"Part 1: executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.","volume":"81","author":"Nolan","year":"2010","journal-title":"Resuscitation"},{"key":"joi190036r17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.resuscitation.2014.11.002","article-title":"Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation.","volume":"96","author":"Perkins","year":"2015","journal-title":"Resuscitation"},{"issue":"7905","key":"joi190036r18","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","article-title":"Assessment of outcome after severe brain damage.","volume":"1","author":"Jennett","year":"1975","journal-title":"Lancet"},{"issue":"19","key":"joi190036r19","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1001\/jama.280.19.1690","article-title":"What\u2019s the relative risk? a method of correcting the odds ratio in cohort studies of common outcomes.","volume":"280","author":"Zhang","year":"1998","journal-title":"JAMA"},{"issue":"3","key":"joi190036r20","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1097\/CCM.0b013e3181cd1291","article-title":"Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest.","volume":"38","author":"Yu","year":"2010","journal-title":"Crit Care Med"},{"issue":"2","key":"joi190036r21","doi-asserted-by":"publisher","first-page":"R41","DOI":"10.1186\/cc11235","article-title":"Intra-arrest hypothermia during cardiac arrest: a systematic review.","volume":"16","author":"Scolletta","year":"2012","journal-title":"Crit Care"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jama\/article-pdf\/321\/17\/1677\/17555712\/jama_nordberg_2019_oi_190036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:07:41Z","timestamp":1557256061000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2019.4149"}},"subtitle":["The PRINCESS Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":21,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,5,7]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.4149","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,7]]}}}