{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:06:28Z","timestamp":1789639588184,"version":"4.0.0"},"reference-count":29,"publisher":"American Medical Association (AMA)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,6,25]]},"DOI":"10.1001\/jama.2019.8001","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:35:09Z","timestamp":1561484109000},"page":"2448","source":"Crossref","is-referenced-by-count":45,"title":["Did This Patient Have Cardiac Syncope?"],"prefix":"10.1001","volume":"321","author":[{"given":"Omar T.","family":"Albassam","sequence":"first","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Cardiology, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Redelmeier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Shadowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aatif M.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Neurology, Duke University Medical Center, Durham, North Carolina"},{"name":"Neuroscience Medicine, Duke Clinical Research Institute, Durham, North Carolina"},{"name":"Neurodiagnostic Center, Veterans Affairs Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Simel","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Duke Veterans Affairs Medical Center, Durham, North Carolina"},{"name":"Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Etchells","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"jrc190001r1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"jrc190001r2","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"ESC Guidelines for the Diagnosis and Management of Syncope.","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"issue":"4","key":"jrc190001r3","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s11739-018-1788-z","article-title":"Outcomes in syncope research: a systematic review and critical appraisal.","volume":"13","author":"Solbiati","year":"2018","journal-title":"Intern Emerg Med"},{"issue":"3","key":"jrc190001r4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ccl.2015.04.006","article-title":"How to differentiate syncope from seizure.","volume":"33","author":"Sheldon","year":"2015","journal-title":"Cardiol Clin"},{"issue":"16","key":"jrc190001r5","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/archinte.163.16.1945","article-title":"Clinical spectrum and prevalence of neurologic events provoked by tilt table testing.","volume":"163","author":"Passman","year":"2003","journal-title":"Arch Intern Med"},{"issue":"2","key":"jrc190001r6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/(ISSN)1531-8249","article-title":"Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia.","volume":"36","author":"Lempert","year":"1994","journal-title":"Ann Neurol"},{"issue":"12","key":"jrc190001r7","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1056\/NEJMoa012407","article-title":"Incidence and prognosis of syncope.","volume":"347","author":"Soteriades","year":"2002","journal-title":"N Engl J Med"},{"key":"jrc190001r8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s10286-004-1003-3","article-title":"Epidemiology of reflex syncope.","volume":"14","author":"Colman","year":"2004","journal-title":"Clin Auton Res"},{"issue":"21","key":"jrc190001r10","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1093\/eurheartj\/ehy309","article-title":"Optimal management of syncope: the new ESC Guidelines and novel insights into its underlying causes.","volume":"39","author":"L\u00fcscher","year":"2018","journal-title":"Eur Heart J"},{"issue":"4","key":"jrc190001r11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Biases in the assessment of diagnostic tests.","volume":"6","author":"Begg","year":"1987","journal-title":"Stat Med"},{"issue":"8","key":"jrc190001r12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"issue":"13","key":"jrc190001r14","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1001\/jama.1983.03330370053031","article-title":"If nothing goes wrong, is everything all right? interpreting zero numerators.","volume":"249","author":"Hanley","year":"1983","journal-title":"JAMA"},{"issue":"12","key":"jrc190001r15","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.jclinepi.2009.02.007","article-title":"Differences between univariate and bivariate models for summarizing diagnostic accuracy may not be large.","volume":"62","author":"Simel","year":"2009","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"jrc190001r16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3414\/ME09-01-0001","article-title":"Bivariate random-effects meta-analysis of sensitivity and specificity with SAS PROC GLIMMIX.","volume":"49","author":"Menke","year":"2010","journal-title":"Methods Inf Med"},{"issue":"3","key":"jrc190001r17","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/eurheartj\/ehi584","article-title":"Diagnostic criteria for vasovagal syncope based on a quantitative history.","volume":"27","author":"Sheldon","year":"2006","journal-title":"Eur Heart J"},{"issue":"2","key":"jrc190001r18","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijcard.2010.10.013","article-title":"NT-pro-BNP for diagnostic and prognostic evaluation in patients hospitalized for syncope.","volume":"155","author":"Pfister","year":"2012","journal-title":"Int J Cardiol"},{"issue":"1","key":"jrc190001r19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ijcard.2007.11.082","article-title":"NT-pro-BNP for differential diagnosis in patients with syncope.","volume":"133","author":"Pfister","year":"2009","journal-title":"Int J Cardiol"},{"issue":"2015","key":"jrc190001r20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/515370","article-title":"Validation of EGSYS score in prediction of cardiogenic syncope.","author":"Kariman","year":"2015","journal-title":"Emerg Med Int"},{"issue":"12","key":"jrc190001r21","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1136\/hrt.2008.143123","article-title":"Clinical predictors of cardiac syncope at initial evaluation in patients referred urgently to a general hospital: the EGSYS score.","volume":"94","author":"Del Rosso","year":"2008","journal-title":"Heart"},{"issue":"10","key":"jrc190001r22","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/j.amjcard.2005.07.047","article-title":"Relation of clinical presentation of syncope to the age of patients.","volume":"96","author":"Del Rosso","year":"2005","journal-title":"Am J Cardiol"},{"key":"jrc190001r23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/(ISSN)1532-5415","article-title":"Role of early symptoms in assessment of syncope in elderly people: results from the Italian Group for the Study of Syncope in the Elderly.","volume":"57","author":"Galizia","year":"2009","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"jrc190001r24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.amjmed.2014.09.021","article-title":"Diagnostic and prognostic value of high-sensitivity cardiac troponin T in patients with syncope.","volume":"128","author":"Christ","year":"2015","journal-title":"Am J Med"},{"issue":"23","key":"jrc190001r25","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1093\/eurheartj\/ehp314","article-title":"Diagnosing vasovagal syncope based on quantitative history-taking: validation of the Calgary Syncope Symptom Score.","volume":"30","author":"Romme","year":"2009","journal-title":"Eur Heart J"},{"issue":"1","key":"jrc190001r26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10840-014-9923-x","article-title":"The role of NT-proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations.","volume":"41","author":"Stryjewski","year":"2014","journal-title":"J Interv Card Electrophysiol"},{"key":"jrc190001r27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.118.038358","article-title":"B-Type natriuretic peptides and cardiac troponins for diagnosis and risk-stratification of syncope.","author":"du Fay de Lavallaz","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"jrc190001r28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0735-1097(02)01940-X","article-title":"Historical criteria that distinguish syncope from seizures.","volume":"40","author":"Sheldon","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"jrc190001r29","first-page":"e60","article-title":"2017 ACC\/AHA\/HRS Guideline for the Evaluation and Management of Patients With Syncope: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.","volume":"136","author":"Shen","year":"2017","journal-title":"Circulation"},{"key":"jrc190001r9","first-page":"111","volume-title":"Epilepsy Across the Spectrum: Promoting Health and Understanding","author":"Institute of Medicine","year":"2012"},{"key":"jrc190001r13","volume-title":"The Rational Clinical Examination","author":"Simel","year":"2009"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jama\/article-pdf\/321\/24\/2448\/17671816\/jama_albassam_2019_rc_190001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:35:12Z","timestamp":1561484112000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2019.8001"}},"subtitle":["The Rational Clinical Examination Systematic Review"],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":29,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2019,6,25]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.8001","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,25]]}}}